0.11%

0.04%

18.20%

10.37%

5.69%

4.05%

30.43%

15.85%

DMSO Erlotinib, 10µM

MP470, 10µM Erlotinib,10µM + MP470,10µM

Concentration (M)

0.1 1 10

Per

cent

Su

rviv

al

0

20

40

60

80

100

120

LNCaPDU145PC-3

0

2

4

6

8

10

12

14

16

18

Tarceva MP470 Tarceva (10 µM)+ MP470

[IC50

] u

M

1 uM 2 uM 5 uM 10 uM

Ap

op

tosi

s (%

)

0

10

20

30

40

50

DMSOErlotinibMP470Erlotinib+MP470

DM

SO

Erlo

tinib

MP47

0Im

atin

ib

Erl.+M

P470

Erl.+I

ma.

10M

PARP

Cleaved PARP

-actin

A B C

D E