Psi-Blast Morten Nielsen, CBS, BioCentrum, DTU. Objectives Understand why BLAST often fails for low sequence similarity See the beauty of sequence profiles.
Katia Koelle Sarah Cobey Bryan Grenfell Mercedes Pascual Epochal evolution shapes the phylodynamics of interpandemic influenza (H3N2) DIMACS, 9-10 October.
Protein Fold recognition Morten Nielsen, CBS, BioSys, DTU.
Protein Fold recognition Morten Nielsen, CBS, BioCentrum, DTU.
Protein threading algorithms 1.GenTHREADER Jones, D. T. JMB(1999) 287, 797-815 2.Protein Fold Recognition by Prediction-based Threading Rost, B., Schneider,
Protein structure and homology modeling Morten Nielsen, CBS, BioCentrum, DTU.
Protein Fold recognition Morten Nielsen, CBS, Department of Systems Biology, DTU.
1 Protein Structure Similarity. 2 Secondary Structure Elements: helices strands/sheets & loops.
Structure superposition ≠ Structure alignment Lecture 11 Chapter 16, Du and Bourne “Structural Bioinformatics”
Protein threading algorithms
Protein structure and homology modeling
A brief on: Domain Families & Classification. The discovery of domains in protein structures Domains at the sequence level Examples of “Domain Resources”
