Heuristic Local Alignerers 1.The basic indexing & extension technique 2.Indexing: techniques to improve sensitivity Pairs of Words, Patterns 3.Systems.
Evolution at the DNA level …ACGGTGCAGTTACCA… …AC----CAGTCCACCA… Mutation SEQUENCE EDITS REARRANGEMENTS Deletion Inversion Translocation Duplication.
CS273a Lecture 8, Win07, Batzoglou Evolution at the DNA level …ACGGTGCAGTTACCA… …AC----CAGTCCACCA… Mutation SEQUENCE EDITS REARRANGEMENTS Deletion Inversion.
CS273a Lecture 11, Aut 08, Batzoglou Multiple Sequence Alignment.
Some new sequencing technologies. Molecular Inversion Probes.
CS273a Lecture 10, Aut 08, Batzoglou Multiple Sequence Alignment.
CS273a Lecture 9/10, Aut 10, Batzoglou Multiple Sequence Alignment.
Building synteny maps Recommended local aligners BLASTZ Most accurate, especially for genes Chains local alignments WU-BLAST Good tradeoff of efficiency/sensitivity.
Short Primer on Comparative Genomics Today: Special guest lecture 12pm, Alway M108 Comparative genomics of animals and plants Adam Siepel Assistant Professor.
