Neoplasia Lecture 3 Dr. Maha Arafah Dr. Abdulmalik Alsheikh, MD, FRCPC CARCINOGENESIS Foundation block 2012 Pathology.
Joint Hospital Surgical Grand Round Gastrointestinal Stromal Tumor Dr. Tsui Ka Kin David Department of Surgery North District Hospital 20 th December 2003.
SIGNAL TRANSDUCTION 2) From the cell membrane to the nucleus Part B 1-TM RECEPTORS AND ASSOCIATED SIGNALLING CASCADES Erhard Hofer Department of Vascular.
Chap. 4 Monoclonal Antibodies in Therapeutic Applications
Chapter 28 Oncogenesandcancer. 28.1 Introduction 28.2 Transforming viruses carry oncogenes 28.3 Early genes of DNA transforming viruses have multifunction.
What is Cancer? Large number of complex diseases Behave differently depending upon cell type from which originate –Age on onset, invasiveness, response.
Neoplasia Lecture 4 Dr. Maha Arafah Dr. Abdulmalik Alsheikh, MD, FRCPC CARCINOGENESIS Foundation block 2014 Pathology.
Effects of DNA Mutations in Sex Cells… Genetic Disease or Birth Defects
What can we learn from the identification of specific molecular abnormalities in malignant disease? Insights into normal cell biology Targets for diagnosis.
PTEN ( P hosphatase and Ten sin Homolog) a.k.a. MMAC1 , TEP1
ASCO 2010 A Placebo-Controlled, Randomized Phase 2 Study of Conatumumab (C) or AMG 479 (A) or Placebo (P) + Gemcitabine (G) in Patients (pts) With Metastatic.
Insights into normal cell biology Targets for diagnosis and follow-up
