Colorectal Cancer. Epidemiology Second leading cause of cancer death in US - approx 148,000 cases/yr and 58,000 deaths Equal lifetime risk between men.
Mutations. Sickle Cell Anemia Mutations Can be a change in the DNA base sequence or a change in a chromosome Can be a change in the DNA base sequence.
Mutations
A few inborn errors Bruce R. Wall, MD, FACP October 10, 2005.
Gastrointestinal Stromal Tumours(GIST)
Tumors of the small and large intestines
Cancer Siklus Sel
Cancer and the Cell Cycle
RB and E2Fs - linking trx with cell cycle
TUMOR-SUPPRESSOR GENES Molecular Oncology 2009
Case History (Gross cont.)