Knock Out Technology (Final)
K Zoo
Kishor Presentation
IFPRI- NAIP - Capacity Building Program
Modelling and Identification of dynamical gene interactions Ronald Westra, Ralf Peeters Systems Theory Group Department of Mathematics Maastricht University.
Analysis of gene function Loss-of-function Many gene knock-out have no obvious phenotypes Redundancy? No perfect redundancy => subtle phenotype Gain-of-function.
Analysis of gene function Loss-of-function Many gene knock-out have no obvious phenotypes
“CRISPR genome editing” Precise gene regulation/modification using the simple CRISPR/Cas9 system
ASSIGNING GENE FUNCTION BY EXPERIMENTAL ANALYSIS 1.Gene inactivation (loss-of-function) - mutate gene (“knock-out”) and observe change in phenotype (i)Deletion.
Modelling and Identification of dynamical gene interactions
bic.uci
ASSIGNING GENE FUNCTION BY EXPERIMENTAL ANALYSIS
