Time (hours)

Glu

cose

co

nce

ntr

atio

n (

mg

/dl)

Insu

lin c

on

cen

trat

ion

(n

g/d

l)

0

50

100

150

200

250

0 8 16 24 32 40 48

Adaptation (G=I=1200h)Fast adaptation (G=I= 4h)

glucose

insulin

(a)

Time (hours)

Bra

in g

luco

se c

on

cen

trat

ion

(m

g/d

l)

15

18

21

24

27

30

0 8 16 24 32 40 48

Adaptation (G=I=1200h)Fast adaptation (G=I= 4h)

(b)