The Novartis Malaria Initiative Der Weg zur Eliminierung von Malaria
Silvio Gabriel, BASAID
April 2012
Malaria is an African tragedy!More than 90% of malaria deaths occur in Africa2/60a
Malaria is preventable and treatable, yet nearly 655,000 lives are lost to the disease every year2/73a
Children under 5 years old and pregnant women are most at risk1/2a
Most of the older treatments (e.g. chloroquine) are not effective anymore because of resistance3/14a
Artemisinin-based Combination Therapies (ACTs) have transformed the treatment of malaria in the past decade
Estimated incidence of malaria per 1,000 population in 20102/221-2
Source: WHO Malaria Report 2011
0-4 5-49 50-100 100-150 >150Data not available
2 | BASAID | Silvio Gabriel | April 2012 | Der Weg zur Eliminierung von Malaria | Business Use Only
The Novartis Malaria Initiative A holistic approach to best serve patients needs
Capacity building – patient-focused education and information Best practice sharing workshops for public health officials responsible for malaria control
State-of-the-art packaging and patient information developed specifically for not yet literate populations
Training material made available free of charge in several local languages
Access – affordability and availability are keyTreatment provided without profit to governments and NGOs
A 25-fold production increase since 200413
SMS for life: using mobile technology to help avoid stock-outs at health facility level14/3a
R&D – leading the path to malaria eliminationMass screening and targeted treatment of asymptomatic carriers10/ 1a; 11/1a
Next generation of malaria treatments12/1179a/22
Treatment – Coartem®,a story of firstsFirst fixed-dose ACT brought to market in 1999 and > 95% cure rate* with demonstrated safety profile4/940a,b; 5/547a,b; 6/251a,254b; 7/246a; 8/1824a
First ACT pre-qualified by the WHO for its efficacy, safetyand quality9/1a
First dispersible sweet- tasting ACT specifically developed for infants and children8/1820a
* 28-day PCR-corrected in evaluable population
3 | BASAID | Silvio Gabriel | April 2012 | Der Weg zur Eliminierung von Malaria | Business Use Only
500 million Coartem® treatments deliveredImpacting more than 1 million lives20
4.01.30.10.29
62
66
74
Treatmentsin millions
84
Funding uncertainGlobal policy uncertain
125%
580%
7%
12%
14%
Erraticorders
Supply challenges
ACT policy
adoption
ACT roll-out in public
sector
82
- 2%
Increase in production capacity (2001–2011)
Deliveries
100 100 100 100 100
Success in patient impact results in mortality reduction
Available production capacity
Novartis Malaria Initiative | April 20124
10022%
Together with our partners, and with our continued patient-centric approach…
5 | BASAID | Silvio Gabriel | April 2012 | Der Weg zur Eliminierung von Malaria | Business Use Only
6 | BASAID | Silvio Gabriel | April 2012 | Der Weg zur Eliminierung von Malaria | Business Use Only
The Novartis Malaria Initiative Four pillars of activities
7 | BASAID | Silvio Gabriel | April 2012 | Der Weg zur Eliminierung von Malaria | Business Use Only
No one should die of malaria.
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