Synthetic Oxygen Carriers
Mohamed DorghamAssisstent Lecturer in
Anaesthesiology Depatement Ain-Shams University.
Red Blood Cell Substitute
O2 Carriers
Lack coagulation
Immune functionNutrition
Plasma protiens
HB Solutions PFC
HBTetramer
Monomers Dimers
1. Filtered by the kidney2.NO scavenger3.Increase plasma osmotic
pressure4.High O2 affinity
1. Ultrastructural modification1. Ultrastructural modification
2. Artificial Blood Cells2. Artificial Blood Cells
HB Solutions
Cross linking
Conjugantion
Polymerization
Microspheres
Recombinent DNA
Monomers and Dimers
1. Ultrastructural modification1. Ultrastructural modification
Tetramers
Ultra purification
2. Artificial Blood Cells2. Artificial Blood Cells
Liposomes=
Pseudoerythrocyte
Nanocapsules
Encapsulated Hb in cell like structure
Coated withPhospholipid Bilayer and Cholesterol
Coated withPolylactide
Adverse Effects
Of Hb Solutions
Adverse Effects
Of Hb Solutions
ImmunsuppressionDecreased
phagocytic activity
NephrotoxicityRBC membrane
CoagulopathyRBC membrane
Free radicalsArtificial RBC
VasoconstrictionNO inactivation
Endothelins
NeurotoxicityNO inactivation
Lab Interference
PFC
Synthetic organic liquid compounds
8-10 carbon atomsH+ atoms Halogens
Flourine Bromine
Iodine !st GenerationFluosol 20%• Stored Frozen• Limited O2 carrying capacity.Allergic reaction
!st GenerationFluosol 20%• Stored Frozen• Limited O2 carrying capacity.Allergic reaction
2nd GenerationOxygent 90%• Stored at 4’c•High O2 Carrynig capacity
2nd GenerationOxygent 90%• Stored at 4’c•High O2 Carrynig capacity
1. Higher O2 Solubility Coefficient.
2. V. low viscosity
3. High Density
4. High N2 Solubility5. Inactivate NO
• Resuscitation•Preop Blood donation•Periop hemodilution•Organ preservation
•Sickle crisis•Vascular diseases•Synthetic vessels (CPB,ECMO, HD)•Alveolar recruitment•Liquid ventilation•Decompression sickness•Septic shock
Adverse Effects
Of PFC
Adverse Effects
Of PFC
AllergyEspecially 1st Gen
Bleeding TendencyDecrease Plt Count
Increase Liver
Enzymes
•Acute Rt sided Failure Pulmonary Plt microemboli•Pulmonary Hage•Pulmonary edema
•Early: Headache
•Late: Flu like symptoms
Thank You
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