Subject Index
abscess 280 acetyl salicylic acid
386, 387 233, 377,
acute febrile mucocutaneous lymph node syndrome 152
acute phase protein 127 adeno virus 191, 438 adenyl cyclase 291, 385 adjuvant 108, 183
see also Freund's adjuvant adjuvant arthritis 220, 290, 372,
400 adrenalectomy 396 adrenalitis 437 agammaglobulinaemia 18 agglutinator 164
see also antibody agonists
autonomic - 20 autopharmacological 20
albumin albumin/globulin ratio 252 bovine serum - 28, 34, 86,
94, 124, 158 125J-labelled 29, 95
egg white - 141, 165 human serum - 107, 132, 165,
182, 198 125J -labelled 107, 182
in mycoplasma infection 251 aldosterone 259, 288 Aleutian mink disease 152
- virus 191 ALG
see anti-lymphocyte serum alkylation 395 allantoic fluid 241 allergic response
antibody-mediated 6, 34, 44 auto-allergic - 123, 141 cell-mediated 6, 17, 34, 44, 53,
118, 140 detection of auto-allergic - 141
to drugs site of -type I -
82 391
439 allergic rhinitis 82 Allison-Ghormley bodies 278 allogeneic cells 193, 395 allogeneic effect 53, 432 allogeneic factor 432 amino acid
- transport 399 - tRNA binding 411
£-aminocaproic acid 138, 321 amniotic fluid 241 amyloid 74, 338
birefringence 342 deposi ts 339 - fibrils 74
anaphylactoid reactions 229 anaphylatoxin 100 anaphylaxis 96, 97, 122
shock 97 trigger 96
anemia 212, 243 autoimmune hemolytic - 52, 59,
71, 109, 402 anergy 397 aneurysma 154 angiitis
leucocytoclastic - 97 angioneurotic oedema 156 ankylosis 216, 293 antibiotics 233, 239, 259, 279, 304,
379, 400 antibody
affini ty 107 antibacter ial 119 anti Clq 129 anti C3 95, 198, 215 anti C4 198 anti HBs 198 anti-IgA 173 anti-IgG 85, 121, 167 anti-IgM 173
444
antibody anti-glomerular basement membrane
99 anti-immunoglobulin 118, 156,
197, 431 anti-macrophage 263 anti-microsomal 438 anti-nuclear 52, 71, 109, 197,
202, 423 anti-nucleic acid 191, 434 anti-salivary duct 346 anti-streptococcal 259, 440 anti-thyroglobulin 156, 438 anti-tissue - 422 autoantibody 49, 59, 200, 291,
345 autologous 265 avidity 111 BSA 95 chondroitin-sulfate 284 circulating - 49, 283 cold-reactive 153 collagen 216, 218, 437 complement-fixing - 281 C-polysaccharide 259, 263 cross-reacting - 200 DNA 55, 110, 433 DNAse B 259 double stranded DNA 55, 109 erysipelothrix bacteria 216, 238 erythrocytes 52, 203 fibrin 33 fluorescein-labelled - 95, 215,
238, 278 gelatin 437 y-chain 55 heterophil - 432 high affinity - 108, 433 HSA 182 125J-labelled - 278 local production 98 low affinity - 107, 108, 433 lymphocytes 52, 434 lymphocytotoxic - 204 ]..I-chain 55 native DNA 72, 109 natural - 164 neutralising - 439 N. meningitidis 182 non-precipitating - 164 P30 (feline) 74 peroxidase-labelled - 215 poly A 56 production 395 RF-like - 178 RNA 53, 433 RNA viral envelope antigen 74
7S- 53, 54, 250 19S- 53, 54, 250 SP 104 virions 74 stabilizing - 281 streptolysine 0 259 streptozyme 259 thymocytes 52 transferrin 110, 202
antigammaglobulins see rheumatoid factor
antigen -aggregated - 158 auto-antigen 124, 136, 143, 384,
437 bacterial - 118, 146, 384 bacterial somatic - 122 C-type viral - 60, 75 cross-reacting - 212 endogenous - 373, 423, 436 exogenous - 202, 422 foreign - 373 group-specific - 60, 212 HBs - 198 histocompatibility - 65, 66 host-coded - 189 interspecies-specific - 60 iodination 42 KB cell DNA - 55 local - 33 mesangial localization 158 mycoplasma - 241 non-biodegradable - 422 persistence of - 4, 114, 269,
278, 291, 373, 384, 422, 423 phagocytosis of - 373 reovirus - 212 - residues 425 rho- 200 seggregated - 200 "self" - 424 sequestration of - 374 soluble - 28 streptococcal - 119 systemic distribution 43 thymus-dependent 57 tissue - 422 transformation of lymphocytes 334 transport 43 trapping 4 type-specific - 60 ubiquitous 425 vascular localization 158 viral 53, 189, 424 virus-coded 189, 201 virus-induced 189, 201
antigen-antibody complexes see immune complexes
antigen elimination see immune elimination
antigenic stimulation, local -34
anti globulins see rheumatoid factor
antiinflammatory drugs see also drugs effect on connective tissue
metabolism 441 side-effects 419
anti lymphocyte serum 52, 84, 204, 397, 434
antimetabolites 401 antinuclear factor
see an tibody antitrypsin 198 arachidonic acid 259, 289, 381 arboviruses 196 Arteparon 411 arterioles 196 arteriolitis 119 arteritis 95
complement- and neutrophil-dependent 100
equine viral - 152 granulomatous - 119 immune complex-induced - 98, 100
arthritis allergic - 10 chlamydial - 425 chronic erosive - 12 chronic proliferative - 238 experimental - 243, 265 erysipelothrix - 221, 238, 425 immune complex-induced - 100,
182, 183, 196 arthritogenicity 238 Arthus reaction 5, 98, 100, 117,
146, 158 articular index 370 asparaginase 398 aspirin 377, 387
reduction of lymphocyte activity 387
athymic mouse 57 aurothiomalate 193 auto-immunity 52, 67, 98, 109, 178,
239, 258, 391, 430, 436 expression of - 435 predisposition to - 433 reversible - 431 short-lived - 431
autoradiography 42, 183, 305, 327 autosensitization 143 azathioprine 305, 316, 370, 392
413
445
bacterial cell wall fragments 238, 258, 290, 384 persistence of - 422
bacterial remnants 426 non-digestible 427
bacteriemia 220, 261 basement membrane 74, 154, 196, 437
deposits of Ig and C3 154 vascular - 131
see complement components B-cell
see also lymphocytes antibody forming precursor 431 antibody-releasing - 431 extravascular - 392 immunocompetent - 346 infected - 432 - nitrogens 64 transformed - 346
BCG 329 see also Mycobacteria
Behcets disease 82 biodegradation 353 bis-diazo-benzidine 132 blood cells 391 body weight
reduction of - 233 bone
destruction of - 261 erosion of - 11, 198, 245 - resorption 376
bone marrow 331, 430 - cells 398
Bordetella pertussis 372, 427 bowel disease 425 Boyden chamber 132 5-bromo-deoxyuridine 64, 195 bronchi tis 343 B-type virus 59 buffy coat leucocytes 142, 249 Burkitt's lymphoma 431 bursectomy 18 butazolidin 370
see also phenylbutazone
candida 121 carbon 427 cardiotoxin 292 carrageenan 42?, 429
- induced oedema 372, 386 cartilage
articular - 28, 183, 244, 269 degradation of polysaccharide 280 destruction 32, 169, 216, 352 energy metabolism 408
446
cartilage enzyme digestion 196 erosion 11, 198, 257 fibro - 213 fibrous structure 352 hyaline - 263 proliferating 269
cathepsin D 164, 287, 293, 377, 413 digestion of IgG by - 165 isolation of - 165
C2 - deficiency 157 cell culture 188 cell cycle
determ. of time 306 G2 -phase 317 Go-phase 330 metaphase 328 S-phase 317
cell debris 80, 264, 302 cell fusion 329 cell kinetics 328
- of chronic inflammation 329 - of macrophages 328
cell lines Chang liver - 196 D17 (Dog sarcoma -) 195 HeLa - 111, 196 HTI (Hamster transformed -) KB - 54 LLC-MK2 - 195 118 MGEH (human glioma -) SP104 - 73, 204 V3A - 80 vero - 78 XC - 195
cell-mediated immunity 17, 34, 53, 189, 249, 265, 290, 372, 376, 428
chemotaxis 133, 371, 376 chemotactic factor 100, 140, 321,
428 C5a 100 C567 100 generation of - 290 mononuclear - 282 - neutrophil granulocytes 100,
133, 376 chloramine - T method 42, 86 chloramphenicol 400 chloroquine 418 cholera toxin 396 chondrocytes 196, 257
fusion of - 196 rabbit embryo - 196
chondroitin 406 antibodies to - 284
hybrids with keratan sulfate 406 - sulfate 284, 406, 408
chondroitin sulfotransferase 408 chondrolysis 261 chorea 256 chorio-allantoic membrane 241 chromatin 303, 332 chromosome 328 clotrimazole 370 coacervates
polylysine/hyaluronate 354 resistance to enzymic digestion
360 coagulation 155
intravascular - 152 - factors 216, 230, 321 assays of - 216 - crisis 233
coagulopathy 221 fibrin-rich - 222 hyaline - 222, 224
colcemid 36 colchicine 328 colitis
arthri tic - 425 ulcerative - 392, 402
collagen 437 biosynthesis 370 degradation 123, 377, 384 distribution 407 - fibres 407 interaction with proteoglycan
409 type I 408 type II 408
collagenase 290, 292, 302, 330, 377, 428 secretion from macrophage 330
colony stimulating factor 321 complement 52, 96, 118, 155, 189,
215, 222 - activated 117, 131 - activation 156, 290 altered - 156 anaphylatoxin 100 canine - 74 chemotactic factors 100 classical pathway 128 - depletion 97 - deposition 130 - fixation 60
complement components 20, 109, 153, 192, 265, 279, 302, 321 ilIA 156 ill C 74, 153, 156, 184 CI 129, 154 Clq 153, 157, 182, 198
complement components C3 100,156,182,198,367,440 C3a 100 C3b 96 C3c 120, 129, 157 C3d 120, 157 C4 120, 182 Cs 157, 367 CS a 100 CS67 96, 440 Cs 96 Cg 96 cleavage of C3 30, 182 cleavage of Cs 30, 182
congo red 353 connective tissue 406, 429
- cells 349 composition 407 depolymerisation 279 matrix 411 metabolism 441 proliferation 349
corticosteroids 191, 193, 233, 259, 284, 288, 292, 302, 305, 315, 364, 386, 391, 415
corynebacteria 188, 269 coryza 240 C-reactive protein 118, 119, 127 Crohn's disease 82, 425 SlCr-release technique 192 cryoglobulins 123, 158 cryoprecipitates 153, 195
intravasal - 154 C-type particle
see C-type virus C-type virus 53, 59, 73, 189
activation 64 defective 61, 62 group-specific antigen 60 helper virus 61 human 66 inter species-specific antigen
60 isolation 59 latency 61, 73 persistence 65 replication 59 type-specific antigen 60
cyclic AMP (cAMP) 259, 287, 371, 395 dibutyryl - 396
cyclic GMP 371 cycloheximide 195 cyclophosphamide 233, 392, 418 cytoplasmic membrane 264 cytosine arabinoside 399 cytospectrophotometry 317
cytotoxic chemotherapy 84, 391 cytotoxicity 265, 367
~egeneration 171 bone marrow 213 fibrinoid - 119, 268
dehydration 243 delayed hypersensitivfty
447
see cell-mediated immunity density gradient analysis 80, 193 dermatan sulfate 406 dermatomyositis 82 dextran sulphate 397 diapedesis
- of blood plasma 215 diphtheria toxoid 86 disseminated lupus
see systemic lupus erythematosus DNA
content in promonocytes double stranded - 111 - precursors 192 - repair 395
317
- synthesis - synthesis
196, 366, 376, 418 time 306
- template DNAse 281
- B 259 DPNase 281 drugs
401
alkylating - 329, 418 anti-inflammatory 230, 285, 302,
315, 370, 385, 406, 441 aspirin-like - 292, 370 non-steroidal - 258, 370, 377 steroidal - 258, 315
anti-rheumatic - 441 compartmentalization of - 398
drug-induced lupus-like syndrome 431 dye exclusion 378
E. coli 233 elastase 428 electrocardiogramm 215, 222 electromicroscopy 154, 189, 192,
215, 224, 259 electrophoresis
cellulose acetate - 251 crossed - 182
encephalitis 437 experimental allergic - 387
endocardiosis 226 endocarditis 431 endogenous virus of baboons (BaEV)
66
448
endoplasmatic reticulum 216, 264 endotoxin 137, 281, 425, 439 enzymes
bacterial - 155, 437 lysosomal - 117, 131, 186,
352, 371, 376, 412, 428 proteolytic - 30, 101
spectrum of tissue - 226 enzyme inhibitors 400
inhibition of plasmin 137 epichlorhydrin 128 epimyoepithelial islands 344 epitheloid cells 195, 279, 428
280,
formation from macrophages 328 life span 329
epizootics 260 Epstein-Barr virus 77, 191, 205
- genome 204 - infection 431
erosion - articular cartilage 11, 198,
213, 244 - bone 11, 198, 245
erysipelothrix bacteria 215 agglutinating antibody 216, 238 arthritis 221, 238 arthritogenicity 238 chronic polyarthritis 216 E. insidiosa 215, 238, 422 E. rhusiopathiae 215, 265, 292 - induction of autoimmunological
processes 239 - infection 215, 238, 422
erythema 376 - multiforme 82
- nodosum 119, 137 erythrocytes
aggregation 222 human group ORIR2 167 phagocytized 339 sheep - 167, 397
Evans blue 98
!actor increasing monocytosis (FIM) 307, 318
Farr technique 153 Felty's syndrome 342 feprazone 386 a-fetoprotein 200, 397 Feulgen stain 197 fibrin 101,117,118,215,256
antibody 33, 221 auto-allergy to - 136 auto-antigen 136, 143 autologous 148 consumption 221
delayed hypersensitivity to -148
deposits of - 157, 168, 222 - exudation 221 - fibers 226
fibrin degradation products 136, 397 autoantigen 136 detection 138 fibrinopeptide B 140 Hodgkin's disease 137 immunosuppression 397 leucocyte attraction 136, 140 persistence of - 136 pregnancy 137
fibrinogen 20, 198 extravasation of - 20 determination 216 local polymerization 20 overproduction 228
fibrinoid 117 - degeneration 268 - deposits 169, 264 - foci 257 - necrosis 34, 136, 216, 263
fibrinolysis 136, 137 fibroblast 101, 352, 371, 385
granuloma - 327 human foetal - 193, 195 interaction with lymphocytes 352 proliferation 261, 327, 352 release of lysosomal enzymes 352 synovial (see also type B lining
cells) 191, 226, 256 fibrosarcoma 193 fibrosis 11, 221
- myocardial - 227 - of synovia 257 - of tendon sheaths 244
flufenamic acid 413 fluorouracil 397 Freund's adjuvant 328, 437
complete - 5, 6, 28, 141, 183, 291, 379
incomplete - 5, 6, 28, 291, 372
S-~alactosidase 358, 366, 413 galactosyl transferase 410 gamma globulin
al tered - 284 bovine - 6, DNP-bovine -
gammopa thy 203 gengrene 231
7, 242, 379 398
genetic recombination 65 giant cell 279
cell fusion 329
giant cell - formation 328 hyperdiploid nuclei 329 life span 329 multinucleated - 256, 329, 357
gibbon ape lymphoma virus (GALV) 66
glomerulonephritis 52, 59, 64, 101, 154, 424 complement and neutrophil
dependent - 101 complement and neutrophil in-
dependent - 99 chronic - 102, 109 immune complex-induced - 74, 112 membranous - 74 post-streptococcal - 256
a-glucosidase 413 6- glucuronidase 134, 293, 358
lysosomal - 366 glucuronyl transferase 410 glycoprotein 406
glycine-rich-6 - 157 inhibition of biosynthesis 419 viral - 201
glycosaminoglycan 406 - polysulfate 411 protein-polysaccharide linkage
408 glycosidases 320
endo - 414 exo - 414
gold 370 Golgi apparatus 216, 264
gonococcus 292 graft rejection 395
homograft - 64 graft-versus-host reaction 53, 64 gram stain 295 granulation tissue 222, 357 granuloma
allergic - 20 chronic - 353 experimental - 34, 427 high-turnover - 327, 428 - induction 353 leprosy 327 low-turnover - 327 mixed - 5, 18 sarcoidosis 327 subcutaneous - 19, 33
granulomagens 425
haptoglobin 198 Hashimoto's disease 428 HEL-12 virus 66
449
hemagglutination - inhibition 246 - passive hemagglutination test
164, 215 hematocrit 216 hematoxylin bodies 340 hemolysin 257, 280 hemolysis 128 hemoptysis 154 hemosiderin 342 hemostasis 215 Henoch-Schonlein purpura 152, 156,
157 hepar an sulfate 406 heparin 249, 303, 366, 412, 416 hepatitis
acute - 198 - A virus 188 - B 154 - B virus 188, 197 lupoid - 198
hepatomegaly 198 hepatosplenomegaly 198, 345 herpes viruses 191
herpes simplex - 78, 80 histamine 96, 427
hypersensitivity to - 427 histiocytes 256, 338
neoplasm of - 346 HLA
typing 432 minor systems 432
HL23V - 1 virus 66 Hodgkin's disease 137 Homeostasis 322, 429 homoreactant 164 "hot antigen suicide" model 42 human respiratory syncytial (RS)
virus 65 hyaline bodies 213 hyaluronate 353, 406
complex with polylysine 353 degradation 415 depolymerization 413 preparation 354 - protein 191 radiolabelled - 360 synthesis 191
hyaluronidase 81, 167, 182 hybridization of nucleic acids 67 hydrolases
acid - 358 leucocyte - 265 lysosomal - 265, 302
hydroxychloroquine 418 hypergammaglobulinaemia 41, 198, 345 hyperimmunisation 41
450
hypersensitivity 4 delayed - 117 (see also allergic response)
hyperviscosity 154 - syndrome 154
hypoalbuminaemia 400 hypocomplementaemia 154 hypoglobulinaemia 199 hysterectomy 222
immune adherence 122 immune complex disease 81, 94, 107,
117, 152, 182, 196 chronic - 102 experimental - 94, 152 viral 191
immune complexes 5, 28, 117, 140, 168, 182, 190, 257, 264, 290, 302, 366, 430 anaphylactic trigger for deposi
tion of - 96 circulating 95, 152 containing viral antigens 53,
114 cryoglobulins 153, 158 deposition 95, 114, 182, 197 DNA/anti-DNA 109 formation 95 IgG/lgG - 202 induction of arteritis 98 ingestion of - 195 intermediate 158 local formation 178 MuLV/anti-MuLV - 109 nucleic acid/anti-nucleic acid -
197 persistence 114 phagocytosis of - 178 preformed - 108 retention of 185 size 95 soluble - 107 tissue localization - 94 trapping of - 30, 102, 196
immune deviation 17 immune elimination 108 immune response
anamnestic - 35 - gene 432 ontogeny of - 112 self-limiting - 39
immunoadsorption 85 - column 124
immunoblasts see lymphoblasts
immunoblast-like cells 336
immunoblastic sarcoma see lymphoma
immuno-conglutinin 121, 156, 198 immunodeficiency 107 immunodiffusion 153, 212
OUchterlony - 55, 165 Mancini radial - 130, 182
immunoelectrophoresis 153, 282 immunofluorescence 60, 74, 134, 157,
167, 182, 192, 215, 238, 264 detection of
- bacterial antigen 215 complement compounds 134,
182 - CRP 134
- fibrin 157 - immunoglobulin 74, 120, 134,
167, 182, 238 indirect assay 75
immunoglobulin 109, 118, 331 aggregated 123, 124 autologous 424 canine - 74 - class 112 conjugate with peroxidase 215 fragments see immunoglobulin
fragments y-chain 55 IgA 119, 157, 173, 202
- mesangiopathy 158 IgD 119, 202 IgE 96, 97, 119, 130 IgG 112, 119, 173, 184, 191,
202, 215, 218, 424, 430 IgGl 112 IgG2a 112 IgG2b 112 IgG3 123 IgM 112, 119, 159, 191, 202, 218,
250, 340 IgY 250 insoluble 124 isolation of IgG 165 isologous - 424 Il-chain 55 membrane 48 production 431 proteolysis of secretion of -subclass 112
IgG 430
127, 164, 431
synthesis 80, 85, 419 immunoglobulin fragments
autologous IgG - 164 IgG - Fab 164 - F(ab') 2 124, 164, 165 - Fc 124, 168, 202
immunoglobulin fragments preparation 165 purification 165
immunological surveillance 65 immunostimulation 25, 64, 370 immunosuppression 25, 89
drugs 352, 370, 387, 391, 441 a-globulins 397 a-fetoprotein 397 fibrin-degradation products 397
indicator cells 90 indomethacin 233, 260, 286, 370,
377, 386, 413 infection 212, 215, 238, 240, 292,
391, 422, 430 bacterial - 82 endogenous - 436 erysipelothrix - 215, 238, 422 exogenous - 436 mixed - 65 multiplicity of - 80 natural 245, 422 persistent - 77, 423 transmission of mycoplasma - 241 viral - 109, 430, 438
infectious mononucleosis 82, 200, 334, 431 autoantibodies in - 200
inflammation acute - 314 allergic - 11 chronic - 4, 30, 64
cellular kinetics of chronic -327, 329
granulomatous - 257 immuno - 331, 391 influx of cells 328 - of joints 6, 49 local - 227 mediators of - 29, 155, 222 persistence of - 238, 366 proliferating - 221 purulen t - 240 turpentine-induced - 227
inflammatory injury cardiovascular - 94 chronic, self-perpetuating - 103 glomerular - 94
influenza 82 - virus 78, 80
innocent bystander lysis 97, 98 interferon 78, 80, 376
induction of - 84 intraarticular injection 166 5-iodo-deoxyuridine 64, 111, 195,
397 Ir-gene 432
- products 57 irradiation
whole body - 328 ionizing - 64, 328, 395
isolator 222
i Oint experimental - disease 353 - fluid 182, 366
451
- inflammation 6, 49, 212, 215, 240, 256
pathology 11, 349
~aryotype 328 keratan sulfate 406
- glycanohydrolase 413 keratoconjunctivitis sicca 156, 343 ketoprofen 386 keyhole limpethaemocyanin 42, 282 kinin 155
- system 222 Klinefelter's syndrome 433 Kupffer cell blockade 397
lactiC dehydrogenase 133 - virus 191
Langmuir plot 107 latex agglutination test 215, 242,
252 lectins 38, 79, 80, 191, 204, 430,
436 LE cells 52, 71, 198 leprosy 327 lesions
active - 376 arthritic - 238, 241 chronic inflammatory - 358 endothelial - 230 extra-articular - 19, 199 granulomatous - 265, 353 hemorrhagic - 155 indolent - 119 rheumatoid - 428 rheumatoid -, models 4 spontaneous - 118 tumor-like - 213 vascular - 19, 95
leucine-2-naphthylamidase 293 leucocyte migration inhibition test
142, 249 leucocytes
basophil 97 - degranulation 97
452
leucocytes eosinophil 123 neutrophil (polymorphnuclear)
96, 117, 122, 155, 169, 216, 244, 249, 263, 302, 312, 338, 356, 378, 428 - accumulation 100, 264 - activation of lysosomes 191 - attraction test 132 - bactericidal system 265 chemotaxis 100, 376 C3b-receptor 101 degenerate 123, 256 depletion 99, 118 exocytosis of granules 101 extracts 440 Fc-receptor 101 imma ture 244 infiltration 117, 213 proteolytic enzymes 101, 122 release of lysosomal enzymes
131, 366 leukemia 59
erythroid - 61 human - 66 lymphoblastic - 59, 67, 75,
155, 156, 203 myeloblastic - 61, 67
leukemia virus 53 avian - (ALV) 60 avian myeloblastic - (AMV) 62 endogenous 203 feline 194 murine - (MuLV) 60, 73, 109
levamisole 370 lining cells 216, 353
type A - 188, 195 - phagocytic ability 195 type B - 188, 191, 226, 256 - proliferation 192 type C - 188
lining layer 168 - hyperplasia 169
lipopolysaccharide (LP8) 64, 283, 292, 426, 440 - shock 98
lipoteichoic acids 257, 292 sensitization with - 283
liquemin 167 Listeria-like organisms 188 L-phase organisms 188 lymphadenitis
hyperplastic - 23 postvaccineal - 334
lymphadenopathy 331 benigne - 340 generalized - 345
- in lupus erythematodes 340 lymph follicles
extopic - 5, 18, 41, 213 extension into perinodal fat 332 formation 249 fusion 334 hyperplasia 332 lining layer 169 pseudolymphatic - 263 starry sky pattern 333, 334
lymph node 382, 396 - biopsy 332 - enlargement 331, 339 - hyperplasia 41, 49, 331 opliteration of sinus 340 pathology 331 retroperitoneal - 339 rheumatoid - 20, 331 - sinus 336 vascular proliferation 338
lymph node cells 35, 37, 72, 112, 383 lymphoblast 192, 346 - proliferation 48 - transformation 193
lymphochoriomeningitis 152 lymphocyte 101, 192, 216, 244, 249,
256, 312, 327, 376, 428 activation 24, 38, 381, 435 aggregations of - 354 allogenic 432 altered 424 B - 35, 52, 53, 64, 80, 190, 203,
334, 346, 391, 430 B-cell proliferation 192 blast cell proliferation blast cell transformation
376 blood - 85 competent - 190 circulating - 429 culture 91 cytoplasmic membrane 75 defective function 83 depletion 203 DNA-synthesis 376 effector 392
44, 48 193,
emigration 23, 430, 439, 440 Fc-rosetting - 48 foetal thymic - 204 helper 392, 396 homing properties 397 Ig-synthesis - 85 inappropriate activation 435,
436 infiltration 52, 349, 429, 438 lymphotoxic agents 397
lynphocyte memory - 334 migratory properties 397 - modulation 334 non-sensitized 377, 428 peripheral 193 perivascular infiltration 213 permissiveness to viral infection
84 PHA-induced activation 38, 381 production of macrophage mitogens
330 recirculatory 24, 35, 75, 398 receptor for myxo- and para-
myxov irus 81 recruitement 38 sensitized 279, 422 subpopulations 80, 92 suppressor 396 surface markers 80 surface membrane 57 susceptibility to viral infec-
tion 77 synovial membrane - 202 T- 35, 48, 49, 52, 53, 57, 80,
112, 190, 203, 391, 430 thoracic duct - 398 transformation 142, 291, 334,
371 transmural passage 19 virocidal - 84 virus particles in - 195 virus receptors on - 80
lymphocyte-macrophage axis 378 lymphocytic choriomeningitis virus
73, 107, 191 lymphocytotoxin 204 lymphoendothelial system 24 lymphoid malignancy 52 lymphoid proliferation 331 lymphoid system 35, 373 lymphoid tissue 391
hyperplasia of - 47 lymphokin 6, 17, 19, 48, 201, 279,
282, 352, 373, 376, 430 mediator of cell-mediated
immuni ty 376 properties 380 release 291 secretion 383
lymphoma 59, 67, 75, 155, 156, 203 Burki tt' s - 431 histiocytic - 346 lymphocytic - 340 malignant - 331, 340, 431 - in Sjogren's syndrome 344
lymphopenia 213, 395
lymphoproliferation benigne - 331 generalized - 344
lymphoreticular cells 77 lymphoreticular system 331 lymphosarcoma 203
453
lysosomal enzymes 117, 280, 352, 376, 412 - of polymorphnuclear leucocytes
186 - secretion 131, 371, 428
lysosome 216, 329, 413 enzymes 117, 131, 186, 280, 352,
371, 376, 412, 428 intralysosomal structures 266 labilizing toxins 280 myelin-like figures adjacent to -
269 stabilizing antibodies 281
lysozyme 413, 428 cleavage of peptidoglycan 265 secretion by macrophages 302, 330
~croglobulinemia
monoclonal - 53 Waldenstrom's - 52, 346
macrophage 57, 101, 118, 140, 249, 302, 327, 338, 366, 376, 428 activation 18, 376 activation of lysosomes 191 alveolar 309, 382 blockade of - 374 cellular kinetics 328 clearance function 109, 112 DNA synthesis 327 epitheloid cell formation 328 Go-phase - 330 granuloma 118, 327 helical tubular structures in RA -
195 inactivation 428 inflammatory 327 labelling of - 327 liver - 309 lymphokine generation 383 migration inhibition 376, 382 mitogen 330 mitotic division 327, 329 myelin figures in - 269 peritoneal - 108, 303, 309, 366,
427 perivascular infiltration 213 persistence of streptococcal com
pounds 265 phagocytosis 302, 377 pinocytosis 302
454
329 macrophage
polykaryon production
pounds of complement com-302
proliferation 328, 366, 367 prostaglandin production 381,
386 recrui tment 18 red pulp - 334 release of lysosomal enzymes
293, 302 secretion of enzymes 330 stromal - 353 synovial - 196 tissue - 176 turnover 327, 427, 428 type A lining cells 189, 195 virus infection of - 87
macrophage migration inhibition factor (MIF) 6, 282
malaria 432 tertiary - 436
Mancini radial immunodiffusion see immunodiffusion
Mantoux reaction 397 Marbrook chamber 85, 90 mast cell 97, 101 Masugi nephritis 99, 101 MAV 62 measles virus 65, 78, 84, 191 mediators 99, 221
autopharmacological - 20 - of cell mediated immunity 376 - of inflammation 29, 155, 222,
377 peptide - 30 - release 370
meningi tis 183 meniscus 28 6-mercaptopurine 392 mesangiopathy 157
IgA - 158 mesenchymal reaction 233 mesenchymoid transformation methotrexate 399 MHC gene products 57 micrococcus 121 microsomes 400 mitochondria 216 mi togen 78, 83
352
lymphocyte transformation by -334
streptococcal - 257, 282 mitomycin C 195 mitosis 328, 401
- in follicle centers 339 - of macrophages 328
mixed lymphocyte cultures 64, 434 monoarthritis
allergic - 5, 6, 18 models 5, 28
monoblast 308 monocyte 224, 302, 327, 391, 429
blood - 303, 366 bone marrow - 304 circulating 311, 313 electron microscopy 224 in inflammation 314 influx of - 314 labelling 305 migration 374 - precursor 327 - production 306 - production inhibitor (MPI) 323
monocytopenia 315 monocytopoiesis 302
- inhibiting factor 323 humoral control 318 stimulators of - 322
mononuclear cells 5, 77, 169, 366, 372, 376 accumulation 118 blood - 79 function 79 infiltration 171, 376 separation 80 susceptibility to virus infection
84 synovial exudate 193 transit 315
mouse strains A/jax 108 AKR 59, 64 Balb/c 64 CAf 1 72 CBA/H 36 CBA/H"T6T6 36 C3H 108 CRF 303 high affinity -low affinity -New Zealand 59,
- black (NZB) 203
108 108 64, 71, 434
52, 108, 191,
hybrids (NZB/W) 52, 109 - white (NZW) 52, 64, 108
non-responder - 432 responder - 432 Swiss 63, 303
mucopeptide-polysaccharide complex 269, 278
mucopolysaccharide 290 multiple sclerosis 82, 189, 433 multiplicity of infection 80
Mumps virus 191 mutagens 64 myasthenia gravis 433 Mycobacteria 269, 292, 427
M. tuberculosum 121, 379 - residues 426
Mycoplasma 188, 212, 292 aetiology of M. infection - antigen 241 - arthri tis 240 growth inhibition test 241 hemagglutination inhibition
245 infection 212, 240 metabolic inhibition test M. gallisepticum 241 M. meleagridis 240 M. orale 194 M. synoviae 214, 240 pathogenicity 245
240
241,
241
rapid slide agglutination test 241
myeloma 202 myeloperoxidase 134 myocarditis 212 myoglobin 165
~acetyl-S-glucosaminidase 293, 358, 414
N-acetyl-galactosaminyl transferase 410
Naproxen 386 nasal septal perforation 154 nasopharyngeal carcinoma 432 Neisseria meningitidis 182 neoantigens 191 neoplasma
hemopoietic - 59 - of histiocytes 346 lymphoreticular - 65 mesenchymal - 59
neoplastic cells 340 nephritis
complement"and neutrophil de-pendent - 101
immune complex - 109 lupOid - 157 nephrotoxic - 99, 101 post-streptococcal -
nephrotic syndrome 401, neuraminidase 155, 222 neuroblastoma cells 201
154, 157 402
Newcastle disease virus 192 nitrogen mustard 100, 118 nodules
rheumatoid - 19, 33, 198
secondary 426 subcutaneous - 19, 428
nonpermissiveness 62, 81 abnormal - 81 of host cells 62
nucleolus 334 nucleus membrane 334 nylon wool column 399
oedema angioneurotic - 156 carrageenan-induced 372 inflamma tory - 213, 244
oncogene 62 oncorna virus 59, 189, 204 orchi tis 437
455
osteoarthrosis 195, 291, 349, 408 osteoblast 213 osteoclast-activating factor (OAF)
290 osteo-neogenesis 245 osteoporosis 291 oxazolone 35 oxidases 400 oxyphenbutazone 413
£anniculitis 19 chronic - 137 nodular - 119
pannus 12, 32, 169, 213, 263, 293 - formation 216, 354
papain 127, 406 papova viruses group 191 parabiosis 328 paramyxovirus 191 paraprotein 202 Pasteurella 233 pathobiochemistry 408 penicillamine 370, 413 penicillin 239, 279, 304, 379 peptidoglycan 428
cleavage by lysozyme 265 - polysaccharide complex 258
pericarditis 203 peritonitis 320 permeabili ty
capillary - 29 - factors 29, 370 organ-specific - 221 vascular - 97, 99, 154, 370, 376
persistence - of antigen 4, 114, 269, 278,
291, 373, 384, 422, 423 autoimmune - 422 - of microbial remnants 269, 422
456
persistence - of synovitis 175 viral - 77, 114
phagocytosis 128, 131, 178, 302, 338, 377, 428
phagolysosomes 427 phenylbutazone 386, 411, 413 phosphatase, (acid) 122, 358, 377 phosphodiesterase 385 phosphorylation 418 phytohaemagglutinin (PHA) 38, 79,
204 125J-Iabelled 204 lymphocyte activation 381 response of RA lymphocytes 204
picric acid 129 picryl chloride 35 pinocytosis 222, 281, 302 plague assay 80 plasma cells 33, 44, 118, 124, 192,
244, 256, 327, 334, 354, 428 - accumulation in synovium 28,
169 binucleate - 338 - infiltration 34, 52, 216, 349,
356 virus particles in - 195
plasmacytoid cells 346 plasmacytosis 44
interfollicular - 332 plasmapheresis 156 plasmin 137 plasminogen 137 plasminogen activator 302 platelets 96, 98, 229
- aggregation 222, 371 platelet activating factor (PAF)
97 pleurisy 203 pleuropneumonia-like organisms
see mycoplasma pneumococcus 263, 292
- somatic C-polysaccharide 128 -, polymerised 128
type III polysaccharide 397 pokeweek mitogen (PWM) 80, 204,
436 response of RA lymphocytes to -
204 poly adenylic acid (Poly A) 54 polyanions 414 polyarteritis 77
- nodosa 82, 119, 152 polyarthalgia 198 polyarthritis 291, 372
chronic - 216, 257, 408 polyethylene glycol 153, 182
- precipitation 153, 182 polykaryocyte 195, 329, 354
macrophage - 329 polylysine 354
arthritogenicity of - 354 complexes with hyaluronate 353 hydrolysis 360 preparation 354
polymerase 190 DNA-dependent RNA - 417 DNA-dependent DNA - 417 RNA-dependent DNA - 60, 195, 417 inhibition of RNA - 416
polymorph nuclear depressing agent 189
polyphenylalanine inhibition of synthesis 417 synthesis 406
polysaccharides complexes with peptidoglycan 258 complexes with mucopeptide 269 pneumococcal C - 128 polymerisation 410 streptococcus C - 259 tissue - 261 type III pneumococcal - 397
polyoma virus 73, 109 polystyrene latex particles 305 polysynovitis 23 poly-U 406 polyvinyl-pyrrolidone 113
clearance of - 113 125J -Iabelle d 108
post streptococcal sequelae 256, 290 pregnancy 137 pressure dialysis 129 promonocytes 304
DNA content 317 DNA synthesis 317 DNA synthesis time - 306 G2-phase 312 mitotic activity - 315 S-phase 317
properdin factor B 157 propionic acid derivatives 370 prostaglandin (PG) 20, 192, 222, 259,
285, 302, 370, 376 chemotactic for PMN 291 erythema 377 generation 3H-Iabelled
258, 302 380
lymphocyte regulation 383 production by macrophage 381 suppression of - 441 vascular permeability 377
prostaglandin synthetase 259, 292, 386
prostaglandin synthetase inhibition of - 370
proteases acid - 117, 122, 131, 134, 290 activated - 281 leukocyte - 124 neutral - 290
proteochondroitin sulfate 410 biosynthesis 409 degradation 412
protein core 408 proteinuria 71, 101 proteoglycan 200, 352, 407, 413
age-dependence of composition 408
- aggregates 413 composition 408 degradation 413 heterogeneity 407 specific 407 structure 407 subunits 408
proteokeratan sulfate 410 protoplast 280 provirus 61 pseudo lymphoma 344, 345 Pseudomonas 233 puromycin 411 purpura
anaphylactic - 82 anaphylactoid - 155 Henoch-Schonlein - 152, 156,
157 hypergammaglobulinaemic 156 intermediate complex - 155 thrombocytopenic 71
pyrogen 302 pyroninophily 334
rabbits New Zealand White - 141 "Old English" - 354 White Kunath - 165
radioimmune presipitation assay 67 radioimmunoassay 55, 60, 66, 75,
85, 86, 195, 259, 380, 426 radiography 215 radioresistance 396 radiosensitivity 396 rat strains
Sprague-Dawley 215 Wistar 215, 258
Raynaudi disease 82 reactive pathology 440 receptor loss 385 Reiter's disease 221
renal tubular acidosis 156 reovirus 212 replication
viral - 62, 77 assay of viral - 80
457
reticular cells 334 reticulo-endothelial system 95, 155 reticulocytosis 52 reticulum cell sarcoma 346 reverse transcriptase 60, 195, 417 rhagocyte 171 rhesus monkey 195 rheumatic diseases
predilection sites 221 rheumatic fever 221, 256, 291 rheumatoid arthritis 4, 28, 33, 48,
77, 82, 164, 188, 216, 238, 257, 327, 331, 353, 376, 408, 422, 424, 428 viral involvement in - 189
rheumatoid factor 121, 123, 126, 153, 197, 214, 216, 243, 252, 346, 370, 422, 436 IgG-type 284, 437 IgM-type 202, 284, 437 local formation 123, 164 phagocytosis of - 164 in relatives of RA patients 23 self-associating - 423
rheumatoid-like factor 118, 164 rhino virus 438 ribonuclease 282, 320 ribosome 407 Rickettsia-like bodies 152 RNA
genomic 60 messenger - 61, 418 synthesis 196, 418 transcription 61
rosette formation 80 rubella virus 191 Russel bodies 338
~alicylate 386, 419 salivary gland 344 Salmonella 292 sarcoidosis 82, 327, 397, 428 sarcoma 59, 61
immunoblastic - 346 scleroderma 82 selectivity
- of drug action 400 interactive - 392 schedule-dependent - 393
Sephadex 165
458
septicaemia 82 meningococcal - 81 streptococcal - 261
serotonin 96 serum
- albumin see albumin anticomplementary - 158 foetal bovine - 85, 250, 304,
378 fractionation of - 54 - globulin 241 guinea pig - 378 preparation of mouse - 306
serum sickness see immune complex disease
sex hormones 57 shock
anaphylactic - 97 lipopolysaccharide-induced - 98 - phase in erysipelothrix infec-
tion 229 vascular - 221
Shwartzman reaction 152 sialic acid 155 silent gene 63 silica 7, 305, 381, 429 simian sarcoma associated virus
(SSAV) 66 sindbis virus 65 single pulse method 328 SjOgren's syndrome 52, 156, 331,
343 antisalivary gland antibodies
346 chronic bronchitis 343 histopathology 343, 344 hyperglobulinaemia 345 keratoconjunctivitis 156, 343 lymphoid proliferation 344 vaginal dryness 343 xerostomia 343
skin - reactions
- Arthus-type 5 - delayed type 5
- test 142, 250, 397 smallpox virus 196 SP 104
- virions 75 - plasmocytoma 73
spleen B-Iymphoid dependent areas 342 - cells 37, 53, 72, 112 Felty's syndrome 342 rheumatoid arthritis 342 T-dependent zones 342
splenectomy 339
splenomegaly 52, 198, 241, 331 spondylitis ankylopoetica 221 staphylococcus 227, 233, 263
- abscesses 121 - aureus 120, 240
starch 381 "starry sky" effect 334 streptococcus 233, 256, 425
- abscess 280 - antibodies 259 - antigen 119, 291
arthritis 258, 280 cell free extract 258, 278 cell wall components 257, 269 C-polysaccharide 259 degradatation 426 extracellular products 282 fragments 264 group A - 120, 256, 261, 284 group B - 437 hemolytic 155, 261 immune complexes 257 - infection 122, 256, 439 intracellular 264, 270, 272, 275 intralysosomal 271, 273 isolation from lesions 269 L-form arthritis 290 L-forms 257, 279, 291 lysins 428 mitogen 257, 282, 290 mitogenic factor of L-forms 280 M-protein 266 persistence of cell wall components
278 - pharyngitis 440 polysaccharide antigens 122 protein antigens 122 protoplasts 280 St. viridans 261 - tonsillitis 121 toxins 439
streptodornase 392 streptokinase 138, 281, 392 streptolysin 259
- 0 259, 279 - S 278, 279
streptomyces 269, 292 streptomycin 304, 379 streptozyme 259 sucrose gradient centrifugation 54 SV40 virus 195 synovectomy 349 synovia 11, 218, 355, 430 synovial cells 256, 264
cytotoxic effects on - 265 - hyperplasia 213, 244, 282 - hypertrophy 213, 244
synovial cells proliferating - 327 - receptor 190
synovial fluid 256, 363 - cells 363 rheumatoid - 366
synovial lavage 358 synovial membrane 183, 213, 241,
359, 430 capillaries 196 hyperplasia 11, 264 hypertrophy 11, 264 infiltration 11, 356 lymphocytes 202 rheuma toid - 91 villous formation 244
synovial stroma 349 synovitis 28, 164, 212, 245, 257,
290 acute - 169 auto-immune - 164, 175 chronic - 5, 169 model 19 persistence 175 subacute 169 by streptococcal mitogens 282
syphilis 340 systemic lupus erythematodes (SLE)
52, 64, 71, 77, 82, 109, 152, 203, 331, 402, 423
T cell 35, 48, 49, 52, 57, 80, 190, 203, 391, 430 - activation 48, 381 defective suppressor - 53 helper - 53, 57 mitotic response 38 - regulation 53, 112 suppressor - 49, 53, 57, 112
tendon 244 mineralisation
teno-synovitis 212 Thiotepa 418 testosterone 195 tetanus toxoid 202
245
112,
thoracic duct drainage 203, 370, 384
thrombin 138 thrombocytes
see platelets thrombosis 117, 137
aortic - 230 fibrin-rich - 221, 230 micro - 222
thymectomy 18, 54, 56 thymidin
14C-labelled - 79 3H-labelled - 305,
thymocytes 399 thymus
atrophy 395 cells 398 cortex 396 necrosis of - cortex
thyroidi tis 437 Hashimoto's - 438 viral - 438
thyroglobulin 438 tingible bodies 340 tissue injury 96 tolerance
- to DNA 424
327, 383
396
- to endogenous antigen 423 high zone - 41, 374 - induction 108, 424 loss of - 204, 425 low zone 374
tonsil cells 85 tonsillitis 121 toxins 430
cardio - 292 cholera - 396 cyto - 290 diphtheria - 86 endo - 137, 281, 425, 439 erythrogenic - 281 tetanus - 202
transfer factor 433 transferrin 107, 110, 198 transforma tion
lymphocyte - 334 mesenchymoid - 352 viral 188
transmission of infection 63 Trasylol 138 Trypan blue 303, 353, 378 tuberculosis 82, 327 twins
monozygotic -dizygotic -
433, 434 434
ulceration 122, 278 ultrafiltration 165 ultracentrifugation urate 381 urticaria 156, 221
chronic - 82
vaccinia virus 79 varicella virus 196
153, 437
459
460
vasculitis allergic - 19, 119, 152 Arthus-like - 134 chronic - 118 cryoglobulinaemic - 154 cutaneous - 118, 146, 158 extra-articular - 199 iatrogenic - 122 immune complex - 52, 290 intestinal - 154 leucocytoclastic - 117, 125 mononuclear cell - 121 necrotizing - 33, 119 neutrophil-infiltrated - 117,
121 nodular - 119, 137 rheumatoid - 19 spontaneous -subclinical -widespread -
vasoactive amines
117, 146 23
152 96
vesicular stomatitis virus 65, 78, 84, 192
vinca alkaloids 401 viral infection
inappropriate expression of -60, 429
- in neuroblastoma cells 201 mixed - 65 non-expressed - 424 permissiveness of host cells to
63 persistenct - 65, 77, 188, 200 resistance to - 77
viral interference 84, 89, 197 virus
activation of endogenous - 64 cytopathic - 188
- determinants 424 ecotropic - 64 endogenous - 63 ether-resistant RNA - 212 - genome 190 - gen products 190, 197 - glycoproteins 201 haemadsorbing - 81 heat-resistant RNA - 212 helper - 61 inappropriate expression
429 integra ted 201 non-cytopathic 188 non-replicating 424 phenotypically mixed - 65 - proteins 189
virus-coded - 189 virus-induced - 189
slow - 188 xenotropic -
virus receptor 63, 109
80
Xenon clearance 377 xerostomia 343 xylosyl transferase 410
~ellow fever virus 84 Yersinia enterocolitica 292
~ymosan 293
60,
Current Problems in Immunology
Bayer-Symposium I, held at Grosse Ledder near Cologne, W. Germany, Oct. 11-13, 1968.
Editors: O. WESTPHAL, H.-E. BOCK, E. GRUNDMANN 135 figures, XI, 349 pages. 1969. ISBN 3-540-04424-8
Lectures and discussions from an international symposium on problems of theoretical and clinical immunology and immunopathology.
New Aspects of Storage and Release Mechanisms of Catecholamines Bayer-Symposium n, held at Grosse Ledder, Oct. 9-12,1969.
Editors: H.J. SCHUMANN, H.-G. KRONEBERG 116 figures, X, 301 pages. 1970. ISBN 3-540-05051-5
International Experts - among them two Nobel Price Winners 1970 - attending an International Symposium, report latest results of this research field on sympathetic transmitting substances.
Bacterial Infections Changes in their Causative Agents. Trends and Possible Basis
Bayer-Symposium III, held at Grosse Ledder, Oct. 23-27, 1970.
Editors: M. FINLAND, W. MARGET, K.BARTMANN 53 figures. VIII, 231 pages. 1971. ISBN 3-540-05557-6
The changes which have been observed in the agents causing bacterial infection are attracting increasing clinical attention. The 19 papers given at this symposium and the discussions which followed present a good picture of the complexity of the factors involved.
Psychic Dependence Defmition, Assessment in Animals and Man; Theoretical and Clinical Implications
Bayer-Symposium IV, held at Grosse Ledder, Sept. 27-0ct. 1, 1972.
Editors: L. GOLDBERG, F. HOFFMEISTER 47 figures. X, 244 pages. 1973. ISBN 3-540-06478-8
This symposium presents the pharmacological, psychological, and social aspects of human and animal drug dependence. In addition, the book discusses the theoretical (ethical and legal) and clinical implications of such behavior.
Proteinase Inhibitors Bayer-Symposium V. Proceedings of the 2nd International Research Conference on Proteinl!Se Inhibitors, held at Grosse Ledder, Oct. 16-20, 1973.
Editors: H. FRITZ, H. TSCHESCHE, LJ. GREENE, E. TRUSCHEIT 410 figures. XVI, 751 pages. 1974. ISBN 3-540-06775-2
Contents: Plasma Proteinase Inhibitors. -Proteinases and Proteinase Inhibitors in Fertilization. - Pancreatic Proteinase Inhibitors. - Characterization and Structure of New Inhibitors. - Structure-Function Relationships. Physical-Chemical Studies of Enzyme-Inhibitor Interactions. Molecular Aspects of Enzyme-Inhibitor Interactions. - Organic Chemical Models and Low-Molecular-Weight Inhibitors. -Inhibition of Non-8erine Proteases. -Evolution of Specificity of Proteinase Inhibitors. - Proteinases and Inhibitors in Biological Systems. - Resume.
Prospektuses are on request / Bitte Prospekte anfordern
Springer-Verlag Berlin Heidelberg New York
Molecular and Cellular Mechanisms in Disease
J. VAN LANCKER, M.D., Department of Pathology, U.C.L.A. School of Medicine, Los Angeles, USA
411 figures, 68 tables. XX, 1168 pages. 1976. (In 2 parts, not available separately) ISBN 3-540-06932-1
Fields: Pathology, General Medicine, Molecular Biology. Of interest to pathologists, practicing and clinically oriented physicians of all specialities, advanced medical students.
Recent Results in Cancer Research Fortschritte der Krebsforschung Progr~s dans les recherches sur Ie cancer Editor in Chief: P. Rentchnick Vol. SS
Cancer Active Immunotherapy Immunoprophylaxis and Immunorestoration An Introduction
G. MATHE, Villejuif, France
123 figures, 87 tables. XV, 405 pages. 1976. ISBN 3-540--07601-8
Pathology of Rheumatic Diseases H.G. FASSBENDER, University ofMainz Translated from the German Edition by G. LOEWI, Harrow 444 figures. XI, 353 pages. 1975. ISBN 3-540-07289-6
Contents: History of the Rheumatic Diseases. - Components of Connective Tissue. - Reactions. - Rheumatic Fever.Rheumatoid Arthritis. - Juvenile Rheumatoid Arthritis and Still's Disease. -Sjogren's Syndrome. - Ankylosing Spondylitis. - Psoriatic Arthritis. - Gout. -Chondrocalcinosis. - Osteo-Arthritis. -
Non-Articular Rheumatism. - Experimental Arthritis. - References. - Subject Index.
Distribution rights for Japan: Igaku Shoin Ltd. Tokyo
Gram-Negative Bacterial Infections and Mode of Endotoxin Actions Pathophysiological, Immunological, and Oinical Aspects
Editors: S. URBASCHEK, R. URBASCHEK, Abteilung fur Immunologie und Serologie, Klinikum Mannheim der Universitat Heidelberg, E. NETER, State University of New York at Buffalo
155 partly colored figures. XIV, 524 pages, 1975. ISBN 3-211-81292-X
Contents: Microbiology and Epidemiology. - Immunology. - Nonspecific Resistance and Endotoxin Tolerance. - Pathophysiology. - Hemodynamics and Metabolism. - Pharmacology. - Blood Coagulation. - Clinical Aspects Including Shock. - Burn Disease.
Virology Monographs / Die Virusforschung in Einzeldarstellungen Continuing / Fortfiihrung von Handbook of Virus Research / Handbuch der Virusforschung. Editors: Gard, S., Hallauer, C., Meyer, K.F.
Vol. 13: K.E.K. ROWSON, B.W.J. MAHY Lactic Dehydrogenase Virus 54 figures, IV, 121 pages. 1975. ISBN 3-211-81270-9
Vol. 14: L.PHILIPSON, U.PETTERSSON U. LINDBERG Molecular Biology of Adenoviruses
20 figures, III, 115 pages. 1975. ISBN 3-211-81284-9
Prospectuses are on request / Bitte Prospekte anfordern
Springer-Verlag Berlin Heidelberg New York
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