<< Prev Figure 2 Next >>PMC full text: Neuron. Author manuscript; available in PMC Oct 15, 2010.Published in final edited form as:

Neuron. Oct 15, 2009; 64(1): 79–92.doi: 10.1016/j.neuron.2009.08.038

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Figure 2

Impact of proinflammatory signaling on neurogenesis in the adult

A, B. Neurogenesis naturally occurs within the dentate gyrus (DG) of the adult mouse hippocampalformation. Neural stem cells (NSCs) divide to produce progeny that differentiate into an abundantpopulation of doublecortin expressing newborn neurons (white). These immature neurons decorate a thinneurogenic lamina underlying the granular cell layer (GCL). C. As for other regions in the brain, Iba-1-

<< Prev Figure 1 Next >>PMC full text: Neuron. Author manuscript; available in PMC Oct 15, 2010.Published in final edited form as:

Neuron. Oct 15, 2009; 64(1): 79–92.doi: 10.1016/j.neuron.2009.08.038

Copyright/License ► Request permission to reuse

Figure 1

Immune response in the CNS

Immune signaling in the CNS follows a well characterized and stereotypical progression. 1. The innateimmune response is stimulated as a consequence of infection, injury or cell death, which releasesmolecules recognized by Toll-like receptors. The initial immune recognition and signaling cascade ismediated primarily by astrocytes (A) and microglia (MG), tissue resident cells that recognize and respond to