Disease Biophysics Group Will Adams 1
Sarcolemmal Displacement
Will Adams
Disease Biophysics Group Will Adams 2
Cardiac Myopathies
Physiological
Dilated Cardiomyopathy
Hypertrophy (concentric)
medlib.med.utah.edu
medic.med.uth.tmc.edu
Disease Biophysics Group Will Adams 3
Individual Myocyte Geometry
L = 80µm
R = 10µm
H = 50nm
L = 80µm
R = 16µm
H = 50nm
L = 110µm
R = 10µm
H = 50nm
PhysiologicalConcentric Hypertrophy
Dilated Cardiac Myopathy (eccentric hypertrophy)
Disease Biophysics Group Will Adams 4
Displacement
• Why displacement?– Mechanical energy
dissipated from internal viscosity will depend on displacement and velocity
– Perhaps the pathological morphology of the heart is maladaptive not only on a macroscale (ejection fraction) but on a microscale (intracellular drag)
Disease Biophysics Group Will Adams 5
Longitudinal Displacement
Stress Displacement
Disease Biophysics Group Will Adams 6
Longitudinal Displacement
Disease Biophysics Group Will Adams 7
Transverse Displacement
Disease Biophysics Group Will Adams 8
Results
SystoleDiastole Hypertension
Critical Ejection Fraction
Disease Biophysics Group Will Adams 9
Directions• Maintain cytosolic volume conservation • Intregrate a t-tubule network into ABAQUS
http://mednote.co.kr/
Disease Biophysics Group Will Adams 10
Acknowledgements
• Adrian Podpirka
Top Related