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RADIOLOGIC CONFERENCE
Gene Margaret Bernabe
Internal Medicine
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Pulmonary Function Tet
• Mild retricti!e !entilatory de"ect#it$ no igni%cant re&one tobronc$odilator'
• T$ere i mild im&airment in gae(c$ange'
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Bleomycin
• c$emot$era&eutic agent commonlyued to treat curable dieae uc$a germinati!e tumor and )odg*in+lym&$oma
• AE, pulmonary toxicity
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Bleomycin
bronc$iolitieoino&$ilicintertitial
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C$et radiogra&$ic Finding
• bilateral- bibailarin%ltrate
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)ig$.reolution com&utedtomogra&$y /)RCT0
• more eniti!e• Di1ue al!eolar
damage iaociated #it$air&aceconolidation and
ground.glao&acitie'
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• Endtage %broi – e(teni!e reticular
mar*ing- – Traction bronc$iectai-
and $oneycombing
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BrochiolitisObliteransOrgani2ing&neumonia
• mani"et a ground.gla o&acitie in abilateral but aymmetric&attern or by air&ace
conolidation #it$ aub&leural or&eribronc$ialditribution'
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Pulmonary Function Tet
• Reduced carbonmono(ide di1uionca&acity
• Retricti!e !entilator de"ect
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• Patient recei!ing Bleomycin.
containing regimen- age over 40year #a aociated #it$ a 2.3-foldhigher ri* o" &ulmonarycom&lication
• tage I3 dieae at &reentation /)R4'50
• cumulati!e doe o" 6788888 I9 /)R7':0 ;'M'O+
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• Cumulati!e doe o" 6?889 are aloaociated #it$ $ig$er rate o"&ulmonary to(icity
)'
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Treatment
• Prednione at 0.7 - !mg"#g• A"ter ?. #ee* . ta&ered o!er an
additional
?.5 mont$ in accordance #it$ t$e&atient+ condition and clinicalre&one
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T)AN O9
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