QACS Services
Complete range of micro physicochemical tests
Challenge Test – The challenge test laboratory
Safety Assessment (PIF)
Patch Test-HRIPT
Stability
Efficacy
One Stop Shop on Cosmetics Testing
QACS Time Line
2002 Laboratory creation, GLP, Micro, Challenge
2004 ISO 17025 accreditation
2006 New premises
2008 Safety Assessment, Marketability
2009 GLP on Pharmaceuticals
2010 Central Europe, Middle East, Asia, QACS Istanbul
2011 ISO 9001, Dermatological testing
2012 ERPA member, Efficacy tests
2014 Pharmaceuticals
2015 In Vitro testing
2016 Expand Efficacy tests
QACS in figures
Laboratory creation : 2002
Manpower : 40 persons
Annual production : 40000 samples
Site Athens : 1000 m2
Annex I- Cosmetic Product Safety Report
Part A. Gathering all the necessary data to prove that the product is safe
Part B. The actual assessment of the safety of the product by the assessor
Part A
1. Quantitative and qualitative composition of the cosmetic product
2. Physical/chemical characteristics and stability of the cosmetic product
3. Microbiological quality
4. Impurities, traces, information about the packaging material
5. Normal and reasonably foreseeable use
6. Exposure to the cosmetic product
7. Exposure to the substances
8. Toxicological profile of the substances
9. Undesirable effects and serious undesirable effects
10. Information on the cosmetic product
Part B
1. Assessment conclusion
2. Labeled warnings and instructions of use
3. Reasoning
4. Assessor’s credentials and approval of part B
Protocols
EP or USP 35 protocol
Challenge ISO 11930
Mixed culture test
Re-inoculation protocol
Wipe protocol
Protocols
48hrs Patch Test Non- irritant
Human Repeated Insult Patch Test(HRIPT)
Hypo-allergenic
Protocol Claim
Claims to support
Anti Wrinkle
Moisturizing
Elasticity
Sebum control
Ophthalmologically Tested
Very well tolerated to skin
Very well tolerated to eyes
Shelf life & PAO
Shelf life The period of time during which a product remains in
compliance with its specification when stored under the conditions of the market
Expiry date (EC date of minimum durability)
The date on which the product becomes no longer acceptable
The date by which it is best to use the product
The date until which the cosmetic product will continue to fulfill its initial function and remain safe
PAO (Period After Opening) Where the minimum durability is more than 30 months, the
consumer should be informed of the period of time after opening that the cosmetic product may be used without any harm to the consumer
EC/1223/2009, ANNEX IISubstances Prohibited in Cosmetics
No Chemical name CAS EC
97 Chromium; chromic acid and its salts 7440-47-3 231-157-5
89 Lead and its compounds 7439-92-1 231-100-4
43 Arsenic and its compounds 7440-38-2 231-148-6
221 Mercury and its compounds, except those special cases included in Annex V
(preservative 0,007 % (of Hg)
7439-97-6 231-106-7
68 Cadmium and its compounds 7440-43-9 231-152-8
40 Antimony and its compounds 7440-36-0 231-146-5
297Selenium and its compounds with the exception of selenium disulphide under
the conditions set out under reference No 49 in Annex III (antidandruff 1%)7782-49-2 231-957-4
No limits
EC/1223/2009, ANNEX III
Substances which cosmetics must not contain
except subject to restrictions laid down
Reference number 67 – 92
Allergens
INCI name
CAS number
Amyl cinnamal 122-40-7
alpha-Amylcinnamyl alcohol 101-85-9
Anise alcohol 105-13-5
Benzyl alcohol 100-51-6
Benzyl benzoate 120-51-4
Benzyl cinnamate 103-41-3
Benzyl salicylate 118-58-1
Butyl phenyl methyl propional 80-54-6
Cinnamal 104-55-2
Cinnamyl alcohol 104-54-1
Citral 5392-40-5
Citronellol 106-22-9
Coumarin 91-64-5
Eugenol 97-53-0
Farnesol 4602-84-0
Geraniol 106-24-1 Hexyl
Cinnamal 101-86-0
Hydroxycitronellal 107-75-5
Hydroxyisohexyl-3- cyclohexene carboxyaldehyde 31906-04-4
Isoeugenol 97-54-1
Alpha-isomethyl ionone 127-51-5
d-Limonene 5989-27-5
Linalool 78-70-6
Methyl-2-octynoate 111-12-6
Evernia prunastri/oak moss 90028-68-5
Evernia furfuracea/tree moss 90028-67-4
Need to test examples
1,4-Dioxane byproduct during the manufacturing process of certain cosmetic
ingredients (detergents, foaming agents, emulsifiers and solvents)
Nitrosamines Hair dyes
Benzopyrenes Wood Tars and Wood Tar preparations
Acrylamides Polyquaterniums, polyacrylamides
Benzene Petrolatum
QACS Competitive Advantages
One stop shop on cosmetics testing
A variety of protocols in competitive prices
ISO 17025 accredited
ISO 9001 certified
GLP compliant
Real time information on intermediate results
24hr sample collection service (EU)
QACS Accreditation
GLP accreditation by NDO
(National Drug Organization)
ISO 17025 accreditation by ESYD
(Hellenic Accreditation System)
QACS Certification
Safety Assessment of Cosmetic Products
Skin Tolerance Assessment
(patch test)
Efficacy Studies (in vitro and use tests)
Determination of Allergens
Stability Testing
Evaluation of Disinfectants and Antiseptics
QACS GMP/GLP
Medicinal Products
Pharmaceutical Starting Materials
Cosmetic Products
Microbiological Quality Control Testing of Water
Disinfectants
Food Supplements
Medical Devices
QACS @ international fairs
2008 Amsterdam
2009 Munich, Istanbul
2010 Paris, Istanbul
2011 Milan, Istanbul
2012 Barcelona, Paris, Istanbul
2013 Paris, Istanbul
2014 Paris, Istanbul, Hamburg
2015 Barcelona, Istanbul, Paris
2016 Paris, Amsterdam, Istanbul, Barcelona
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