8/13/2019 Progesterones Role in Ca2+ Influx in Spermatozoa
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Progesterones Role in Ca2+Influx in Spermatozoa
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Amal Katrib
BMP 21
8/13/2019 Progesterones Role in Ca2+ Influx in Spermatozoa
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8/13/2019 Progesterones Role in Ca2+ Influx in Spermatozoa
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on0enomi%3ffe%ts of
Progesterone
Mo$ulates t"e a%ti'it& of CatSper'oltage0gate$ permeable Ca2+ %ation
%"annels in sperm tail
Bin$s to eit"er t"e CatSper %"annel or an asso%iate$ subunit
In$u%es influx of Ca2+ into "uman sperm
Ca2+ is essential for
ultimatel& penetration of t"e egg
Capacitation Chemotaxis
Hyperactivation Acrosome Reaction
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Progesterone in Spermatozoa
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Progesterone 6 Ca 2+ Influx
Bip"asi% Signal Components
Rapi$ (ransient
Slo)er Sustaine$
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Ca2+ Inta8e . C"annel (&pe
Ion0C"annel Re%eptor
CatSper Channel
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Pro$u%tion of Ca2+ Signaling in
Spermatozoa
Ca2+ signaling in spermatozoa %an o%%ur $ue to
Progesterone. $ire%t a%ti'ation of CatSper %"annels
NH4Cl. 'ia al8alinit& ,p: ;
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Ca2+ Signaling 0 Progesterone 6
:5Cl
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Cont$
How do we determine whether or not progesterone directly
activates CatSper channels or has impact on pH?
YES/ progesterone is asso%iate$ )it" CatSper %"annels
NO/ progesterone "as no impa%t on p:
What about the joint role of progesterone and NH4Cl in
activating CatSper channels?
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Pat%"0Clamp Re%or$ings
pH !
pH "
"ttp+??)))@&outub
e@%o
m?)at%
"#'
APBP
1
'2CD4DE
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Summar&
Progesterone 6 :5Cl in$u%e CatSper %urrent/
stimulating rapi$ Ca2+ influx
("e& a%t s&nergisti%all&
CatSper %"annel/ or asso%iate$ protein/ ser'es as t"e non0
genomi% progesterone re%eptor
Progesterone is essential in fertilit&
Ca %"annel blo%8ers ,C 770>4=9 6 mibefra$il- in"ibit
Ca2+ signals $ue to progesterone 6 al8aline p:
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Clini%al Impli%ations
P"arma%ologi%all& $isrupt fertilization b& in"ibiting CatSper
%"annel )it" ne) t&pe of birt" %ontrol
e) Birt" %ontrol )ill Spe%ifi%all& target progesterones effe%t on sperm
3liminate si$e effe%ts $ue to s&nt"eti% forms of progesterone
Raise a)areness regar$ing infertilit&
asso%iate$ )it" beta0%"annel blo%8ers
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Referen%es
S@ Pubi%o'er 6 C@ Barratt@ Progesterones gate)a& into sperm@ ature
511-@ An$@ (@
Strun8er et al@ ("e CatSper %"annel me$iates progesterone0in$u%e$Ca2+ influx in "uman sperm@ ature 5
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