PATHEMA-BurkholderiaA CLADE SPECIFIC
BIOINFORMATICS RESOURCECENTER
http://pathema.jcvi.org
What is Pathema?
Pathema (http://pathema.jcvi.org)
A NIAID Bioinformatics Resource Center designed tosupport bio-defense and infectious disease research.
Pathema provides detailed curation of six target pathogens:
Category A priority pathogens:Bacillus anthracis, Clostridium botulinum
Category B priority pathogens:Burkholderia mallei, Burkholderia pseudomallei,Clostridium perfringens, Entamoeba histolytica
What is Pathema?
• An extensive library of literature and manually curated data
• A customized suite of sophisticated bioinformatics software
• Comparative analysis tools customized to retrieve, display,and compute results relevant to ongoing bio-defenseresearch
Overarching Goal: to provide core resources that willaccelerate scientific progress on understanding, detecting,diagnosing and treating Category A-C pathogens and otherpathogens involved in new and re-emerging infectiousdiseases.
All Bacillus (24)
B. anthracis (17)B. cereus (3)B. thuringiensis (2)B. subtilisB. pumilus
All Clostridium (25)
C. perfringens (9)
C. botulinum (9)C. difficileC. thermocellumC. acetobutylicumC. tetaniC. butyricumC. novyiC. phytofermentans
All Burkholderia (28)
B. mallei (11)B. pseudomallei (10)B. thailandensisB. cenocepaciaB. sp.B. phages (4)P. aeruginosaR. solanacearum
All Entamoeba (3)
E. histolyticaE. disparE. invadens
What is the future of Pathema?
We are relying on your feedback! Data exchange & integration Genome sequence analysis Custom data analysis Custom tool development
New Genome Sequences & Annotation Data
Clade-specific Pathema Workshops
! Clade-specific Annotation Jamborees ! Incorporate expert annotation & experimental references
AcknowledgementsP.I.: Granger SuttonFunding: NIAIDSubcontract: University of Maryland Baltimore, IGS
Informatics Engineers Informatics AnalystsTanja Davidsen (manager) Scott Durkin (manager)Erin Beck Ramana MadupuAlex Richter Susmita ShrivastavaKevin Galinsky Bob DodsonJay Sundarm Derek HarkinsSeth Schobel Lis Caler
Owen White (University of Maryland Baltimore)Anu Ganapathy YongMei ZhaoJosh Orvis Aaron GussmanKevin Galens Jonathon Crabtree
Jamboree OverviewDay 1: Prokaryotic Annotation Methodologies
• Gene Model & Functional Curation Introduction to ManateeDay 2:
Participant Presentations Burkholderia Training Exercises Burkholderia AnnotationDay 3: Burkholderia Annotation
Introductions Bioinformatics Project Manager
Lauren Brinkac [email protected]
Burkholderia InvestigatorBill Nierman [email protected]
Bioinformatics AnalystRamana Madupu [email protected]
Bioinformatics AnalystDerek Harkins [email protected]
Pathema-Burkholderia [email protected]
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