Copyright,LeslieE.Korn,2018
Liver
•Majordetoxificationorgan• Phase1:takesfat-solubletoxinstransformsthemintowater-solublecompounds• CytochromeP-450enzymesattachtotoxins
• Phase2:thetoxinsarethenexcretedbykidneys&duodenum.• DetoxstrategiesfocusonsupportingPhase2detox
3
Copyright,LeslieE.Korn,2018
Glymphatic system• Newlydiscovered• Clearswasteproductsfromthebrain• Glymphaticsystemismostactiveduring(slowwave)sleep
Copyright,LeslieE.Korn,2018
Detoxification Strategies for Mood & Cognition
• LiverFlushes:Ayurvedicrecipe&Gonzalezmethod• CoffeeEnemas• 1-2dayJuiceandVegetablefastsforBioindividuality
• Carrot/apple/beetforliver/GB• FiberFlushforcolonhealth• SkinBrushing
• Sodiumalginate
• Hydrotherapy• Saunas/Sweats
Copyright,LeslieE.Korn,2018
Foods
• Foods• Supporteliminationoftoxins
• Cruciferous(cabbage,broccoli&brussellesesprouts)Richinsulforaphane,aninducerofglutathioneS-transferases(GSTs)&othercellprotectiveenzymes,enhanceP-450enzymes
• Sulphur(Onions,garlic)-daily• Seaweeds(kelp)• Bindtoxinsindigestivetract:Toxicmetals&radioactiveisotopes:alginates(brownseaweeds)(EliazWeil&Wilk,2007)
• Heavymetals:sodiumalginate+modifiedcitruspectin(every3months)8
Copyright,LeslieE.Korn,2018
Detoxification & Culture
• Detoxificationispresentineveryculture’straditionalmedicine
• Alterative(Blood-purifying)plantslikeBurdock(vegetable)• Bitter:Dandelion,bitterroot,purslane(verdolagainMexico)
• Japan:Bamboocharcoal&activatedcharcoal(poisoning)
• Toxins:Fibers&barks• Nutritious:Elmbark
• Purge&cleanse:clay,animal&plantoils,sweatlodges&saunas,watertherapies,inducedregurgitationfromherbs
• Enemas(metabolicbalance)
Copyright,LeslieE.Korn,2018
Cultural Traditions
•Modernreenactmentofancientritualsthatincorporatedetoxification
10
Copyright,LeslieE.Korn,2018
Enemas
• Indigenouspeoples:enemasforhealth/religiouspurposes
•Animalskins/bladders/horns
• Substancesintorectum➡largeintestine➡intestinalwall➡bloodstream
• Directroutetoabsorbsubstances• Colonicirrigationfor“mentalconditions”
(Drs.Marshall&ThompsonNewEnglandJournalofMedicine1932)
Copyright,LeslieE.Korn,2018
Cultural Traditions•Detoxificationmethodsrootedinownculturaltraditions&religiousbeliefs
• Communitydetoxificationrevitalization:• PacificNorthwestEEUU:canoejourney(sobriety)• Thepowerofthegroupreinforcesthebehavioroftheindividual• Higherpower/purpose• Australia&PapuaNewGuinea:traditionalwalkabout•Wildernessprograms&outdoortherapies(teens)
•Movingthebody:• Releasinganxiety-producinglacticacid•Withdrawalfromaddictivetechnologies
• Restorerhythms,communitysharinghardships&triumphstogether12
Copyright,LeslieE.Korn,2018
Cultural Traditions
• Bloodimpurities/tissuehealing:Leeches/Segmentedworms• Purification:drinkingurine(Buddhist,Jains,earlyChristians)• Richinmelatonin&aminoacids
• EnhanceCircadianRhythm&slowbrainwaveactivity(Mills&Faunce,1991)
• LiverCleanse/Immunehealth:Carrotjuice(carotenoids)
Copyright,LeslieE.Korn,2018
Symptoms of Liver & Gall Bladder Congestion
• Nausea•Morningheadaches• Bloodshoteyes• Constipation• Lightcoloredorpoorlyformedstools• Painintheuppershoulders/underribcage
• Skindullwithboils&Infections
14
Copyright,LeslieE.Korn,2018
Reduce toxic substances
•Householdcleaners/mattresses&carpetsthatareneurotoxic•External(exogenous)toxicfoods&substances(pesticides&toxiccleaners)•Majordetoxificationorgans:Liver&Skin•Pharmaceuticals
15
Copyright,LeslieE.Korn,2018
Neurotoxins
•Mattressesandcarpetscontainneurotoxins
• Toxiccleaningsupplies&draincleaners•Applecidervinegar:• Anti-bacterial• Anti-mold
• Anti-fungalcleanser• Cleandishes,counters,floors,toilets,&tubs
• Addbakingsoda&salt=scrubbingpaste
16
Copyright,LeslieE.Korn,2018
Bread & Yeast
17
• Toxicityespeciallyforthosesensitivetoalcohol• Yeastfermentssugar➡alcohol&endogenousalcoholproductioniselevatedaftereatingfoodsrichincarbohydrates
(Logan&Jones,2000)• Yeast:alcohol(ethanol)➡acetaldehyde
(Nosova,Jousimies-Somer,Jokelainen,Heine,&Salaspuro,2000)• Changinglevelsofgutflora (James,2006)
• Leadingtochroniccandidiasis• Acetaldehydetoxinscancauseleakygut (Nosovaetal.,2000)•Whichisimplicatedinallergies&autoimmuneillnesses
Copyright,LeslieE.Korn,2018
Fasts
•Waterfasts/citrusjuicefasts,forexample,arecontraindicatedindiabetesoranxiety
18
Copyright,LeslieE.Korn,2018
Juice for the Liver & Gall Bladder
•Carrots,apples,&beetsasfreshjuices⬆sugar
•Greatcleanserforthegallbladder&liver.Vitamin-richdrink• 50%carrots,35%apples&15%beets• Canaddcelery/parsley(naturaldiuretics)
• Cilantro(Chineseparlsey)removesheavymetals
Cilantro/Parsley Pesto Detox• Ingredients• 2cupsoffirmlypackedorganiccilantroleavesandstems
• 2cupsoffirmlypackedorganicItalian,• flatleaf,parsleyleavesandstems• ½cupofchoppedorganicwalnuts• ½cupoforganicoliveoil• 1tsp.ofkelppowder• ¼teaspoonofseasalt• 2garliccloves• Directions:• Usingafoodprocessororblender,• mixallingredientstogetheruntilsmooth.
Copyright,LeslieE.Korn,2018
Copyright,LeslieE.Korn,2018Copyright,LeslieE.Korn,2018
Sodium Alginate: Seaweed
HeavyMetalDetox
Take2sodiumalginatecapsaday,every25daysfor3days
Copyright,LeslieE.Korn,2018
• BrownAlgae-bindswithmetalpollutants• Excessbarium• ExcessCadmium• ExcessZinc• OtherexcessheavymetalsProtectiveagainstradiation
ThomasA.DavisFranciscoLlanesBohumilVoleskyGuillermoDiaz-PulidoLaurenceMcCookAlfonsoMucci1H-NMRstudyofNaalginatesextractedfrom
Sargassumspp.inrelationtometalbiosorptionAppliedBiochemistryandBiotechnologyAugust2003,Volume110,Issue2,pp75–90.
Brown Algae
Copyright,LeslieE.Korn,2018
Bentonite Clay/Montmorillonite
• InternalUse• 1tbsp.mixedwith8ouncesofliquid
• Naturalclaymineralofvolcanicorigin• Mechanismofactionisphysical• Colloidalstructurechargedparticlesofsodium,calcium,magnesium&potassiumions,allowittobindwithunwantedsubstancesinthestomach,smallintestine&colon• Notdigested,norabsorbedintothebloodstream• Substancesareboundtothebentonite,&excretedbowel• Topicaluse:applytoskin• Combinewithactivatecharcoalincasesofpoisoning
Copyright,LeslieE.Korn,2018
Skin Brushing
• Lymphatichealth,skinhealth,&dissociation,depression,&anxiety
• Pleasurable&grounding,safeself-careactivity
•Daily:checkin&connectwithfeelingssensations&theboundariesofthebody
• Chronicstressisassociatedwithloweredimmunefunction• Stimulationoflymphaticsystemeffectiveatpreventingcolds&congestiondueallergies
Copyright,LeslieE.Korn,2018
Skin Brushing Instructions
•Alwaysindirectionoftheheart•Beginatthefeetandsweepthebrushovertheskininlongbrushes
• Coversamepathway3timeseach
•Workupfront&backofbody,feet,legs,abdomen,&armswithspecialattentiontothearmpits&breasts(avoidnipples),thebuttocks,back,&neck
Copyright,LeslieE.Korn,2018
Oil Pulling
• Lipophyllicdetox• Saponification/detergenteffectthatreducesinflammatorybacteria&plague(linksofgumdisease,heart/brain)
• Ayurvedictreatmentforguminflammation,bacterialinfections
• Coldpressedsesameoil/coconutoilorcombination
• Swishatablespooninthemouthfor10-15minutes,spitout
Copyright,LeslieE.Korn,2018
Enemas & Trauma
• Someclientswillnot/cannotdoenemas• Hxofabusewithenemas• Sexualabuse• “Analretentive”types• Theseclientsdonotdoaswell
Copyright,LeslieE.Korn,2018
Coffee Enema
• Thecoffeeenemaisusedprimarilyforliver/gallbladderdetoxification
• “Dialysisofthebloodacrossthegutwall”• Supportliverfunction,dilutebile&bloodvessels,reduceintestines’inflammation,&enhancegluthianoneStransferase,thusfacilitatingthephase2liverdetoxificationpathway
(Walker,2001,p.49)•MerckManualCoffee
(Gonzalez&Issacs,1999)• Senseofrelaxation,reducepainsignificantly,&promotewell-beingbystimulatingparasympatheticresponse
(N.Gonzalez,personalcommunication,June23,2002)
Copyright,LeslieE.Korn,2018
Liver Flush
•First,ortho-phosphoricacidhelpsremovecalcium&lipids(fats)fromarteries,&normalizescholesterolmetabolism•Orthophosphoricacidworks+malicacid(applejuice):•Dissolve&softengallstones•Removecalcium&fatsfromarteries
Copyright,LeslieE.Korn,2018
How the Liver Flush Works
•MagnesiuminEpsomsaltsrelaxesthesphincterofthegallbladder&bileducts,allowingforeasypassageofthesoftened,shrunkenstones• Thecream&theoilcauseastrongcontractionofthegallbladder&liver,forcingoutstoredwastes,bile,&stones,whicheasilypassintothesmallintestine
Copyright,LeslieE.Korn,2018
How the Liver Flush Works
•Thesewastes&stonesarethenexcreted•Theliverflushisasimplewayofremovinggallstoneswithoutsurgery,whileatthesametimeloweringcholesterollevels&improvingliverfunction
Copyright,LeslieE.Korn,2018
The Colon: Fiber Flush
•1teaspoonofpsyllium20minutesbeforeeachmeal(3/day)⬇
glucoseabsorption&⬇hunger.
•1every3monthsfor5days
Copyright,LeslieE.Korn,2018
Hydrotherapies
•Theuseofwater
•Altermood
•Decreasepain• Increaseenergy• Increaserelaxation/wellbeing• Improvebloodflow&oxygen
Copyright,LeslieE.Korn,2018
Hydrotherapies
•Hotrelaxesdrivesbloodtosurface• Coldstimulatesdrivesblooddeep• Ice/soaks/baths/footbaths•Hotandcoldalternating;stimulatesbloodflow•Herbal/salts/minerals•Mustardfootsoaks
Copyright,LeslieE.Korn,2018
Cold Water
• Contraction
• Reducesinflammation&pain
• Moodbooster!
• ApplyicetoxyphoidprocessforGERD&hiatalhernia
• IcePackbetweenshoulderbladestoenhancerespiration,anxiety,asthma
Copyright,LeslieE.Korn,2018
Hot Water
• Calming
• Relaxesmuscles
• Soaking
• Addingaromas
• Mineralsalts
Copyright,LeslieE.Korn,2018
Reducing or Eliminating Pharmaceuticals
“For every drug that benefits a patient, there is a natural substance that can achieve the same effect.”
―CarlPfeiffer.MDPioneeringorthomolecularphysician&scientist
Copyright,LeslieE.Korn,2018 42
Client Questions & Concerns
• Manyclientswantadvice&supporttoeither:• Improvetheefficacyoftheirmedications
• Reducedosage• Eliminateorstayoffmedications
Copyright,LeslieE.Korn,2018 43
Client Questions & Concerns
• Understandhowclientswanttoaddresstheirsymptoms• Knowtheirfearsandconcernsaboutmedication• Prioritizenon-pharmaceuticalapproachestoaddresstheirsymptoms
• Instillhopethattheirsymptomscanbemanagedandeveneliminatedwhencombiningpsychologyandnutritionalinterventions
Copyright,LeslieE.Korn,2018
Reduction & Elimination of Pharmaceutical Medications
• 60,000patientswithMDaged65+years•Tricyclicsincreasetherelativemortalityrateby16%•SSRIby54%,SNRIby66%
• Somepatientsmaybenefitfromacutepharmacotherapy• Butclinicalbenefitsaredebatable• Shouldbeweighedagainstadversesideeffects• Continuation&maintenancetherapyisnotrecommended• Lackofclearclinicalbenefits• Increasedvulnerabilitytochronicdepression,increasedsuiciderisk(particularinolderadults)higherall-causemortality
Hengartner,M.P.(2017).Methodologicalflaws,conflictsofinterest,andscientificfallacies:Implicationsfortheevaluationofantidepressants’efficacyandharm.FrontiersinPsychiatry,8(275).https://doi.org/10.3389/fpsyt.
2017.00275
Copyright,LeslieE.Korn,2018
Mitochondrial Function
• Multiplestudies:• Psychotropicmedicationcontributestomitochondrialdysfunction• Typicalandatypicalantipsychoticmedicationscaninhibitthemitochondrialrespiratorychain• Moodstabilizervalproicacidcaninhibitthemitochondrialrespiratorychain• Secondaryimpairmentofmitochondrialfunctionthroughtheinductionofcarnitinedeficiency
• SSRI’sinhibitmitochondrialfunctioninanimalmodelsofdepression&potentiallytoxicinhighdoses• DysfunctionofthemitochondrialrespiratorychainanddecreasedATPproduction
PsychotropicmedicationsandmitochondrialtoxicityRebeccaAnglin,PatriciaRosebush&MichaelMazurekNatureRev. Neurosci.13,293–307(2012)
Copyright,LeslieE.Korn,2018
Elements of Psychotropic Withdrawal
• Psychoeducation• SelfcarePlan• PrescribingClinician• WithdrawalSchedule• NutritionalSupplementationProtocol:
• SocialSupportTeam• TherapeuticSupports• SleepRegulation• At-HomeDetoxificationMethods
Copyright,LeslieE.Korn,2018
Coming Off Psychotropic Medications
•Workwiththeprescriber • Prescribersrarelywanttohelppeopledetoxifyfrommeds:toolaborintensive
• Nutritionaltherapyroleinpreventing,reducing/eliminatingpharmause
• Identifygoals&timeline
• Requirebasicadherencetoacomprehensiveprepprogramfor3months(diet,nutrients,exerciseselfcare) • Basicrule:1yearonthemedication=1monthtowithdraw(mayvary) •Workwithcompoundingpharmaciestoprovideliquidmedstotitratedownml.eachweek
• Identifywhatthebrain/mindiscraving&substitute
Copyright,LeslieE.Korn,2018
Case: Wilma
• 40mg.dailyofProzacfordepression75mgofTrazadoneforsleep7years
• Wantedtowithdrawfromthemedications
Copyright,LeslieE.Korn,2018
Pre-withdrawal Nutritional Plan
•Omega3fattyacids,(minimumof2000mg/day)•FullspectrumvitaminE(400-800IU/day)•BComplexincludingB-12andB-6
Copyright,LeslieE.Korn,2018
Self Care Plan
•Workwiththeclientfor4-12weekstoprepareforwithdrawal&elimination
• Self-careplaninplace:• Consistsofgoodqualityfood,nutritionalprotocol• Dailyexercise• Therapeuticsupportslikeacupuncture&massage
Copyright,LeslieE.Korn,2018
Pre-withdrawal Nutritional Plan
•Omega3fattyacids,(minimumof2000mg/day)•FullspectrumvitaminE(400-800IU/day)•BComplexincludingB-12andB-6•Skillbuildingtotoleratediscomfort
Copyright,LeslieE.Korn,2018
Prescribing Clinician
• Communicatetheplanwiththeprescriber
• Engagesupport•Workwithateamofprescribingprofessionals(MD,ARNP,ND,)• Compoundingpharmacist(R.Ph.)
Copyright,LeslieE.Korn,2018
Developing a Withdrawal Schedule
• Developacalendar&timelinefortaperingoffthemedication• Definethetherapeuticsupports&whattheyprovide&atwhatspecificintervals• Keepsharednotebook,digital/web-basedsharedcalendar
Copyright,LeslieE.Korn,2018
Developing a Withdrawal Schedule
• Thewithdrawalschedulewillbedesignedbasedon• The“half-life”ofthespecificmedication/drug• Howmanydifferentdrugspeoplearetaking&whichorderisprioritized• Howmanymonths/yearspeoplehavebeenusingthemedication(s)•Whattheclient&clinicianidentifyasoptimal&achievable
• Stresslevelsintheclient’slife,includingacuteperturbations• Socialsupportsthatareinplacetocarryouttheplan
Copyright,LeslieE.Korn,2018
The 2:1 Rule
• 2:1rule:halfaslongtowithdrawastimeonthemedication• e.g.onProzacfor6months;take3monthstotaper• Reducemg.ormicrogram/ml.stabilizeatthatlevelfor1-2weeks• Prozacfor6months,use3monthstoslowlytaperthedosage.•Onmedicationfor2yearswouldtake1yeartowithdraw
Copyright,LeslieE.Korn,2018
Social Support Team
• Holdingameetinginperson/viaconferencecalltoeducateeveryoneabouttheprocessandtoengagesupport• Shouldbeundertakenmuchlikeanydrugaddiction• Intensivestagesrequiringfulltimecare&thensupportsforrelapseprevention&care
Copyright,LeslieE.Korn,2018
Therapeutic Supports
• Formofaspalikeatmosphereofself-carebothinthehome&outsideincludingreflexology&acupuncture• Clienttaketimeoff,atleastreducetheworkloadduringtheinitialwithdrawalphasethisisadvisable• RegulateSleep
Copyright,LeslieE.Korn,2018
Effects on Nutritional Status
• Benzowithdrawal&comprehensivewithdrawalschedulesforeachspecificdrugtype• Peoplewhotakeanti-depressantswithdrawfromthebenzofirst•Melatonin(1mg)&niacinamide(400mg4-6timesaday)uptoatotal1500-2500mg/daydividedthroughouttheday
(Prousky,2005)• SeeAshtonforBenzowithdrawal(2002)https://www.benzo.org.uk/manual/
Copyright,LeslieE.Korn,2018
First Steps: Month 1
• Priortowithdrawalofmedications&drugs
• Eliminateglutenandcaseinifnecessary,• Foodadditives• InitiateOmega3and6Fattyacids,FreeAminoAcids,VitaminE,BComplex,Minerals&Probiotics• Initiatedailyskinbrushing&twiceweeklysaunabaths
Copyright,LeslieE.Korn,2018
Month 2 and 3
• Beginthewithdrawalprocesswithataperingscheduleappropriateforthespecificdrug/medication• Additionalnutrientstoincludeadditionalaminoacidstargetingtheappropriatereceptorsthatthemedicationtargets• Continuepsychotherapeuticsupportfortheemotionalups&downsofthewithdrawalprocess• Providenutritionalsupporttoeasewithdrawal• Providehope
Copyright,LeslieE.Korn,2018
Detoxification
• YerbaPrima• SkinBrushes,Bentonite,PsyilliumHuskPowder
• https://yerba.com/
Copyright,LeslieE.Korn,2018
Summary
• Identifycurrentmedications&theirsideeffects
• Identifymedicationseffectonnutritionalstatus
• Developanenhancedself-careplanwiththeclient• Planascheduleforwithdrawalincooperationwithprescribingclinician
• Conductafamily/socialsupportsessiontoidentifyspecificareasofsupportorobstacles
• Identifyin-patientorat-homewithdrawalprocesses
• Reviewcliniciancontactavailabilitytotheclient
Copyright,LeslieE.Korn,2018
Summary
• Engage(para)professionalsupportsforfoodandnutrientadministrationwherenecessary
• Beginnutritionalprotocolsatleast2-4weekspriortoinitiatingwithdrawal
• Createan“availabilitycontract”withtheclientsotheclientcanreachtheclinician
Thank you!drlesliekorn.com [email protected]
Top Related