ORBAS 20, 40 mg(Olmesartan Medoxomil INN)
Presented by
Mohammed Moshiur Rahaman
Senior Brand Executive
Brand Management Department
Strategic Brand Management Division
The ACME Laboratories Ltd.
ORBAS(Olmesartan Medoxomil INN 20, 40 mg)
Olmesartan effectively reduces blood pressure in adult patients along with 6 years old children
Price & Supply
Price: 20 mg (08 taka)
40 mg (15 taka)
Supply: 3x10 tablets
Product Group : A
IndicationFor the treatment of hypertension
Dosage & Administration 20 mg Once daily OR
may be increased after 2 weeks to 40 mg
Children (10 mg for weigh <35 kg & 20 mg for weigh >35 kg)
Endothelial Cell:The endothelium is the thin layer of cells that lines the interior surface of blood vessels and lymphatic vessels, forming an interface between circulating blood in the lumen and the rest of the vessel wall. The cells that form the endothelium are called endothelial cells.
Major function of Endothelial Cell:Vasoconstriction and vasodilation, and hence the control of blood pressure.
Dysfunction of Endothelial Cell:Endothelial dysfunction can result from and/or contribute to several disease processes, as occurs in hypertension, hypercholesterolemia, diabetes.
Product information of Losart, Valtin & Orbas
Losart Valtin Orbas
Generic Losartan Valsartan Olmesartan
Dosage form Tablet Tablet Tablet
Strength 25, 50, 100 mg 80, 160 mg 20, 40 mg
Indication Hypertension, Congestive Heart failure
Hypertension, Heart failure, Myocardial infarction
Hypertension
AT1 affinity 10000 fold 20000 fold 12500 fold
tmax (h), on set of action
3-4 hrs 2 hrs 1.4-2.8 hrs
IMS market size
105 crore with 8% positive growth
9.7 crore with 6.21% negative growth
15.56 crore with 65% positive growth
Positioning Shows better control on blood pressure
Provides prompt & sustained blood pressure
More potent ARB Ensures double digit BP reduction
Economic ARB Significantly reduces mortality and morbidity in patients with HF
Shows 24 hrs BP control, even final 4 hrs
Also effective in CHF Shows early onset of action compared to other ARBs
Improves endothelial dependent coronary dilation in hypertensive patients
Mechanism of action
Blocks AT1 receptor, as a result Angiotensin II is unable to participate further reaction
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