Opportunities for Biomedical Computing and Informatics Research
Funding at NIH
Zohara Cohen, PhDProgram Director
NIBIB, NIH, DHHS
KOrean Computer Scientists and Engineers Association in America (KOCSEA) Technical Symposium
October 26, 2008
National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS
NIH Mission and StructureNIH Mission and StructureNIH is the steward of medical and behavioral research for the Nation. Its mission is science in pursuit of fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to extend healthy life and reduce the burdens of illness and disability.
National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS
NIH StructureNIH Structure
NIA
OD
NIAAA NIAID NIAMS
NCI
NICHD
NIDCD NIDCR NIDDK NIDA
NEI
NIEHS NIGMS
NHLBINHGRI
NIMH NINDS NINR NCCAM
FICNCRR NLMNCMHD
CC CSR CIT
NIBIB
National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS
NIBIB MissionThe mission of the National Institute of Biomedical Imaging and Bioengineering is to improve health by leading the development and accelerating the application of biomedical technologies.
NIBIB is committed to integrating the physical and engineering sciences with the life sciences to advance basic research and medical care.
National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS
www.nibib.nih.gov
National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS
Current NIBIB Portfolio Areas• Biomaterials• Biomedical Informatics• Biosensors• Drug & Gene Delivery Systems• Image-Guided Interventions• Image Processing and Display• Magnetic Resonance Imaging
and Spectroscopy• Mathematical Modeling,
Simulation, and Analysis• Medical Devices and Implant
Science• Micro-Biomechanics• Micro- and Nano-Systems;
Platform Technologies
• Molecular Imaging• Nanotechnology• Nuclear Medicine• Optical Imaging and
Spectroscopy• Rehabilitation Engineering• Sensors• Surgical Tools, Techniques,
and Systems• Telehealth• Tissue Engineering• Ultrasound: Diagnostic and
Interventional• X-ray, Electron, and Ion
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Biomedical Information Science and Technology Initiative (BISTI)
• established in May 2000 to serve as the focus of biomedical computing issues at the NIH
• a consortium of representatives from each of the NIH institutes and centers
• mission: – make optimal use of computer science and technology
to address problems in biology and medicine– foster new basic understandings, collaborations, and
transdisciplinary initiatives between the computational and biomedical sciences
• coordinates research grants, training opportunities, and scientific symposia associated with biomedical computing
http://bisti.nih.gov/
National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS
BISTI FOA’s• Innovations in Biomedical Computational Science and
Technology (R01) - PAR-07-344• Exploratory Innovations in Biomedical Computational
Science and Technology (R21) - PAR-06-411• Innovations in Biomedical Computational Science and
Technology Initiative (SBIR [R43/R44]) - PAR-07-160 • Innovations in Biomedical Computational Science and
Technology Initiative (STTR [R41/R42]) - PAR-07-161• Continued Development and Maintenance of Software
(R01) - PAR-08-010http://bisti.nih.gov/
National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS
• BISTI
• Roadmap NCBC’s
• Blueprint for Neuroscience
• IMAG
• CTSA Informatics Coordinating Committee
• NanoHealth Enterprise
• PhysioNet Resource
• Osteoarthritis Initiative
• caBIG Imaging Informatics Workspace
National Centers for Biomedical Computing (NCBCs)
www.ncbcs.org
National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS
National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS
NCBC-Related FOA’s• Collaborations with National Centers for Biomedical
Computing (R01) - PAR-07-249
• Exploratory Collaborations with National Centers for Biomedical Computing (R21) - PAR-07-250
Interagency Modeling and Analysis Group
Multiscale Modeling• spans scales from molecular to population• encompasses concepts of space, time and state space• expected to impact the understanding of biological
processes• further the predictive capability in biomedical systems
Genes Cellstructure-function
Tissue structure-function
Clinicalmedicine
Organ structure-function
ProteinsLipids
Carbohydrates
mRNA
…
30,000+genes
100,000+proteins
12 organsystems
1body
200+ celltypes
4 tissuetypes
Courtesy of Peter Hunter
National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS
www.nibib.nih.gov/Research/MultiScaleModeling
National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS
IMAG Wikihttp://www.imagwiki.org/mediawiki
10 Working Groups
IMAG Multiscale Modeling (MSM) Consortium Working Groups
• WG1 - Filament Dynamics and Simulation (FDS)• WG2 - Cardiac and Skeletal Muscle Physiology• WG3 - Macro-To-Micro Scale Imaging and Transport in Human
Systems• WG4 - Cell Level Modeling• WG5 - High Performance Computing, Computational Issues and
Algorithms• WG6 - Tissue Mechanics• WG7 - Multiscale Imaging• WG8 – Theoretical Methods• WG9 – Nano-modeling• WG10 – Model Sharing
Multiscale Modeling of the Physiome and the NIH vision for
the 21st Century
Grace C.Y. Peng, PhDApril 10-11, 2008
International Physiome Symposium 2008 Toward Holistic Medicine:
Physiome and Oriental MedicineSeoul, Korea
National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS
Promoting Global Cooperation and Awarenesshttp://www.imagwiki.org/mediawiki
Please Populate Korea Page
12 NIH participatinginstitutes
3 years, 9 receipt dates
IMAG-Related FOA
PAR 08-023 Objectives• To develop multiscale models that link at least two biological scales
of modeling and accurately predict biomedical and behavioral processes in health and disease states
• To develop predictive, multiscale models that link to higher levels of the physiome. Models must link to at least one scale beyond molecular interactions at the cellular level (e.g. to cell-cell, cell-environment interactions, as listed above)
• To develop predictive, multiscale models that are physiologically mechanistic and have translational potential or clinical applicability
• To bring together modeling and biomedical expertise to collaborate on building multiscale model(s)
• To validate and test models with standard datasets• To develop models that can be explicitly shared with other modelers
National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS
NIH Blueprint for Neuroscience Research
National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS
Goal: Provide an independent clearinghouse for neuroimaging tools, vocabularies and datasets that promotes adoption and evolution of these resources by providing access, advice, and forums for input and discussion for both developers and the widespread user community.
Neuroimaging Tools and Resources Clearinghouse (NITRC)
National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS
www.nitrc.org
National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS
NITRC-Related FOAsNIH Blueprint provides supplemental funding to support enhancement of existing neuroimaging informatics tools and resources to improve interoperability, adoptability, dissemination, and usability.
• Neuroimaging Informatics Software Enhancement for Improved Interoperability and Dissemination (R03) – PAR-07-417
• Notice of Availability of Administrative Supplements for Neuroimaging Informatics Software Enhancement for Improved Interoperability and Dissemination - NOT-EB-08-002
National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS
BIRN: Biomedical Informatics Research Network
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National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS
BIRN and caBIG-Related FOA’s
• Sharing Data and Tools: Federation using the BIRN and caBIG Infrastructures (R01) – PAR-07-426
• Data Ontologies for Biomedical Research (R01) – PAR-07-425
Biotechnology Resource Centers:a NCRR and NIBIB Program
National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS
Other Active NIH FOA’s with Relevance to Biomedical Computing and
Informatics• Bioengineering Research Partnerships (R01)
- PAR-07-352• Bioengineering Research Grants (R01)
- PA-07-279 • NLM Express Research Grants in Biomedical
Informatics (R01) - PAR-08-080
http://grants.nih.gov/grants/guide/
National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS
Thank You!
Zohara [email protected]
The Future Paradigm: The 4 P’sTransform Medicine from Curative to
Preemptive
PreemptivePersonalizedPredictive
Participatory
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