Neuroscience Paris Seine Director H. Chneiweiss

UPMC Institut de Biologie Paris Seine

Gathers 15 research teams in Neurosciences

100 permanent position (Researchers, Assistant Professors, Professors, Engineers and Technicians)

More than 70 students (Masters, Thesis, Post-doctorants)

CdF

ENS

UPMC

IFM

IdV

ICM

Institute of Biology Neuroscience Paris Seine

Neuroscience Paris Seine Director H. Chneiweiss

Embedded into a rich Neuroscience environment in Paris

2700 m2 available space, 1500m2 already refurbished, 70 m2 minimal space per team

Neuroscience Paris Seine

To understand the brain, to treat its diseases and to improve its abilities.

Neuroscience Paris Seine

Complementarity of scientific questions, skills and technological approaches among teams

An integrated approach: From molecular & cellular networks to physiology & pathology

Continuum from fundamental research to preclinical models

Transversal axis 1 (5 teams) Neural Development, Plasticity and Regeneration

Neuroscience Paris Seine

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Plasticity of Neural networks Stem cell niche CNS/PNS microenvironment Spinal Cord

Transversal axis 2 (7 teams) Dynamics of Neuronal Networks and Cognitive Processes

Neuroscience Paris Seine

Neurotransmitters Sensory processing Neurovascular coupling Energy supply Sleep – Decision making Depression - Anxiety Autism - Schizophrenia Drug abuse - Absence Epilepsy Alzheimer’s disease

Transversal axis 3 (3 teams) Cellular and molecular basis of Neuroadaptation

Neuroscience Paris Seine

Long-term adaptation Epigenetics Nuclear receptors Reproduction Addiction Stress

Examples of shared methodological approaches

• Molecular and cellular biology – epigenetics – proteomics – metabolism

• Cell cultures neurons – glial cells - human neural stem cells and glioma stem cells

• Imaging at cell and whole brain levels - two-photon Ca2+ imaging - in vivo functional imaging

Shared methodological approaches

• In vitro electrophysiology unitary and multiunitary in brain slices

• In vivo electrophysiology Anesthetized or freely moving mice in enriched environments – optogenetics

• Animal models

• Behavioral tests and phenotyping platforms

Development of micro-patterning of substrate molecules for cell culture

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Nano-eNablerTM System

FRM & biotech

Virtual reality treadmill for mouse

Labex Biologie Psychiatrique

Bioluminescence

Examples of technological developments :

Neuroscience Paris Seine

Complementarity of scientific questions, skills and technological approaches :

Common facilities of the Neuroscience Paris Seine unit:

Culture rooms (P2/L2 – 100 m2)

A2/L2 (B6 25m2)

Rooms for deep freezers and machines – 48 m2

Histology (cryostat) – 28 m2

Microscopy – 28 m2

Behavioral platforms - 250 m2

Stabulation rooms for animals under experimentation – 28 m2

Neuroscience Paris Seine scientific animation

Weekly data club

Weekly seminar on Epistemology, History and Ethics in Neurosciences: Jean-Gael Barbara

Weekly scientific seminars of distinguished visitors

General rehearsals: Prior competitions or diploma defences.

Strong training support: Internal and external Workshops opened to scientists, technicians, engineers & administrative staff

Science and Society: Brain Awareness week Ecole des neurosciences de Paris (ENP) Neuroethics

National/International positioning of Neuroscience Paris Seine

2 groups with teams both at UPMC and McGill University, Montreal CANADA

2 coop with University of British Columbia, Vancouver CANADA

University of Rio de Janeiro (CAPES/COFECUB program) BRAZIL

ANR International University Hong-Kong, CHINA

Paris Excellence Network : ENP (9)

Labex (10)

European associated laboratory Cardiff university, CNRS UNITED KINGDOM

University of Hässelt Tournesol program BELGIUM

More than 130 papers published from sept 2013 to sept 2014 12 papers co-authored by 2 or more teams 2 registered patents (+ 1 pending) 1 start-up (Melkin-Pharmaceuticals) (+ on-going projects)

Neuroscience Paris Seine Metrics

IF> 12 : Science (2), Neuron (3), Molecular Psychiatry (5), PLoS Genet (3), Nat. Neurosci., Nat. Genet., Nat. Medicine, Nat. Commun., Blood, Biomaterials, Faseb J., Am. J. Hum. Genet. IF>7 : J. Neurosci. (9), Biol. Psy (4), Cereb Cortex (3), Embo Rep. (2), PNAS, Cell Death. Diff., Stem Cells….

Neuroscience Paris Seine Unit

Thank you for your attention Hervé Chneiweiss

DEPARTEMENT OF NEUROSCIENCES Head : CHNEIWEISS Hervé 15 Research Groups

Group 1 Genetics of Autism BETANCUR Catalina (DR2, INSERM) DELABY Elsa (DOC) PILORGE Marion (DOC) XXX (MCF, UPMC)

Group 2 Neuronal Signaling and Gene Regulation CABOCHE Jocelyne (DR1, CNRS) VANHOUTTE Peter (CR1, CNRS) BETUING Sandrine (MCF, Chaire UPMC) CAHILL Emma (DOC) HECK Nicolas (MCF, UPMC) KAPPES Vincent (TCH, CNRS) MOUMNE Lara (POST-DOC) PAGES Christiane (TCH, UPMC) SALERY Marine (DOC)

Group 3 Cortical Networks & Neurovascular Coupling LAMBOLEZ Bertrand (DR2, INSERM) CAULI Bruno (CR1, CNRS) BERGEL Antoine (DOC) BONNOT Agnès (MCF, UPMC) COHEN Ivan (CR1 INSERM) HAY Audrey (DOC) HEPP Régine (MCF, UPMC) LACROIX Alexandre (DOC) NOMURA Shinobu (DOC) SIEU Lim Anna (DOC) TRICOIRE Ludovic (CR2, CNRS)

Group 4 Glial Plasticity CHNEIWEISS Hervé (DR1, CNRS) JUNIER Marie-Pierre (DR2, INSERM) DEVAUX Bertrand (PUPH, UPD) DIAS-MORAIS Amélie (TCH, INSERM) LIPECKA Joana (AI, INSERM) El-HABR Elias (POST-DOC) BOGEAS Alexandra (DOC) DiUBOIS Gustavo (DOC)

Group 5 Normal and Pathologic Glutamatergic Systems EL MESTIKAWY Salah (DR1, CNRS) BERNARD Véronique (CR1, INSERM) DAUMAS Stéphanie (MCF, UPMC) FABRE Véronique (CR1, INSERM) LAMBERT Lisa (DOC) MIOT Stéphanie (DOC) POIREL Odile (TCH, INSERM) RAMET Lauriane (DOC) SAKAE Diana Yae (DOC)

Group 6 Neurophysiology and Behavior FAURE Philippe (DR2, CNRS) DIDIENNE Steve (DOC) MOREL Carole (DOC) MOUROT Alexandre (CR1, INSERM) NAUDE Jerémie (POST-DOC) TOLU Stéfania (POST-DOC) VALVERDE Sébastien (DOC)

Group 7 Pathophysiology of Psychiatric Disorders GIROS Bruno (DR1, CNRS) BECKER Christel (MCF) BENOLIEL Jean-Jacques (MCUPHHC, UPMC) CAMUS Françoise (AI, UPMC) COUROUSSE Thomas (DOC) DE GOIS Stéphanie (IR2, CNRS) ERDOZAIN Amaia Maite (POST-DOC) FARLEY Séverine (POST-DOC) GAUTRON Sophie (CR1, INSERM) GRANNEC Gael (TCH, UPMC) LOUIS Franck (TCH, INSERM) MORICE Elise (MCF) SEVOZ-COUCHE Caroline (CR1 INSERM) TZAVARA Eleni (DR2, INSERM) VIALOU Vincent (CR2, INSERM)

Group 8 Development and Degeneration of Spinal Motor Neurons HAZAN Jamilé (CR1, CNRS) FASSIER Coralie (CR2 INSERM) JARDIN Nicolas (DOC) TEN MARTIN Daniel (DOC)

Group 9 Neuronal Networks and Physiophatological Rhythms LERESCHE Nathalie (DR1, CNRS) LAMBERT Régis (PR1, UPMC) BESSAIH Thomas (MCF, UPMC) BOUTOURLINSKY Katia (IE2, CNRS) CHAUSSON Patrick (DOC) PIGEAT Romain (DOC)

Group 10 Development of the Spinal Cord Organization LEGENDRE Pascal (DR2, INSERM) MANGIN Jean-Marie (CR1, INSERM) BULLIER Erika (AI, UPMC) CZARNECKI Antony (MCF, UPMC) LE BRAS Barbara (MCF, UPMC) LE CORRONC Hervé (MCF, U Angers) MOUFFLE Christine (TCH, CNRS) RIGATO Chiara (DOC) SWINNEN Nina (DOC)

Group 11 Neuroplasticity of Reproductive Behaviors MHAOUTY-KODJA Sakina (DR2, CNRS) ALBAC Christelle (AI, CDD/CNRS) CLARISSE Marie-Luce (DOC) HARDIN-POUZET Hélène (PR1, UPMC) MESSENT Valérie (MCF, UPMC) NAULÉ Lydie (DOC, CDD/CNRS) PARMENTIER Caroline (TCH, UPMC) PICOT Marie (POST-DOC)

Group 12 Axonal Growth and Regeneration NOTHIAS Fathia (DR2, CNRS) BENASSY Marie-Noëlle (AI, UPMC) CHEDLY Jamila (DOC) MILBRETA Ulla (DOC) SOARES Sylvia (MCF, UPMC) VINCENSINI Laetitia (MCF, UPMC) VON BOXBERG Ysander (CR1, CNRS)

Group 15 Gene Expression, Neurophysiology and Behavior TRONCHE François (DR2, CNRS) BARIK Jacques (MCF, UPMC) BENECKE Arndt (CR1, CNRS) KARAKI Samah (POST-DOC) MAATOUK Layal (DOC) TASSIN Jean-Pol (DR Emerite, INSERM) VYAS Sheela (CR1, INSERM) WONG Alana (DOC)

Group 14 Development & Plasticity of Neural Networks TREMBLEAU Alain (PRCE, UPMC) CAILLE Isabelle (MCF UPMC) DAROLES Laura (DOC) DUBACQ Caroline (MCF UPMC) DUSART Isabelle (DR2, CNRS, join in 2014) FOUQUET Coralie (AI, CNRS) GRIBAUDO Simona (POST-DOC) MAUCUER Alexandre (CR1 INSERM, join in 2014) MOREL Marie-Pierre (TCH, INSERM, join in 2014) SMIT Daniel (DOC) VILLALPANDO Sabrina (POST-DOC)

Group 13 Memory, Navigation and Aging RONDI-REIG Laure (DR2, CNRS) BABAYAN Bénédicte (DOC) DE LAVILLEON Gaëtan (DOC) LEFORT Julie (DOC) OBIANG Pauline (POST-DOC) PARADIS Anne-Lise (CR1, CNRS) ROCHEFORT Christelle (MCF, UPMC) WATILLIAUX Aurélie (IE2, CNRS) ZHANG Lu (POST-DOC)

Mis à jour le, 20/09/2012

ADMINISTRATION COMMON SERVICE DEJANCOURT Catherine (TCN, CNRS) CANNYA Vidji (AGT, UPMC) DIAMANT-CABARUS Joanna (AJT, UPMC) COULIBALY Mariatou (AJT UPMC) FAIVRE- WEBER Sylvie (IE, CNRS) HANNESSE Bernadette (AGT, UPMC) GÉRARD Catherine (TCE, CNRS) HANOUEL Marie-Jo (AJT, UPMC) HOAREAU Sonia (AI, UPMC) KHYAR Najat (TN, Inserm) REBECCHI Barbara (TS, Inserm) MARIE Jean-Luc (AJT, UPMC) PONTIFICE Maria (AJT, UPMC) TURQUET Maryse (AJT, CNRS)

ATTACHES A LA DIRECTION

Directeur de l'UFR 927 Daniel VERGE (PR, UPMC)

Epistémologue BARBARA Jean-Gaël (CR, CNRS)

Neural development, plasticity and regeneration

Plasticity of Neural networks Stem cell niche CNS/PNS microenvironment Spinal Cord

E14 Trembleau Development and Plasticity of Neural networks

E4 Chneiweiss/Junier Glial Plasticity

Plasticity of Neural networks Stem cell niche CNS/PNS microenvironment Spinal Cord

Neural development, plasticity and regeneration

E10 Legendre-Mangin Development of the Spinal Cord Organization

E12 Nothias Axonal Regeneration and Growth

E8 Hazan Development and Degeneration of Spinal Motor Neurons

Neurotransmitters Sensory processing Neurovascular coupling Energy supply Sleep – Decision making Depression - Anxiety Autism - Schizophrenia Drug abuse - Absence Epilepsy Alzheimer’s disease

Dynamics of neuronal networks and cognitive processes

E7 Giros Pathophysiology of Psychiatric disorders

E1 Betancur Genetics of Autism

Dynamics of neuronal networks and cognitive processes E5 El-Mestikawy

Normal and Pathologic Glutamatergic Systems

Neurotransmitters Sensory processing Neurovascular coupling Energy supply Sleep – Decision making Depression - Anxiety Autism - Schizophrenia Drug abuse - Absence Epilepsy Alzheimer’s disease

E6 Faure Neurophysiology and Behavior

Dynamics of neuronal networks and cognitive processes

E9 Lambert/Leresche Neuronal networks & Physiopathological Rythms

E13 Rondi-Reig Memory, Navigation & Aging

Neurotransmitters Sensory processing Neurovascular coupling Energy supply Sleep – Decision making Depression - Anxiety Autism - Schizophrenia Drug abuse - Absence Epilepsy Alzheimer’s disease

E3 Cauli/Lambolez Cortical Networks & neurovascular coupling

Long-term adaptation Epigenetics Nuclear receptors Reproduction Addiction Stress

Cellular and molecular basis of neuroadaptation

E11 Mhaouty-Kodja Neuroplasticity of Reproductive Behaviors

E15 Tronche Gene regulation & Adaptative Behaviors

E2 Caboche/vanHoutte Neuronal Signaling & Gene Regulation

Neuroscience Paris Seine

2014-2018 Catalina Betancur E01 Jocelyne Caboche/ Peter Vanhoutte E02 Bruno Cauli / Bertrand Lambolez E03 Hervé Chneiweiss / Marie-Pierre Junier E04 Salah El-Mestikawy E05 Philippe Faure E06 Bruno Giros E07 Jamilé Hazan E08 Regis Lambert / Nathalie Leresche E09 Pascal Legendre/ Jean-Marie Mangin E10 Sakina Mhaouty-Kodja E11 Fatiha Nothias E12 Laure Rondi-Reig E13 Alain Trembleau E14 François Tronche E15