NATIONAL RESEARCH AND
DEVELOPMENT INSTITUTE
FOR NON-FERROUS AND
R A R E M E TA L S – I M N R
Medical applications
April 2018
102 Biruintei Blvd., Pantelimon, Ilfov County, Romania
(T) +4021.352.20.46; (F) +4021.352 20 49
[email protected]; www.imnr.ro
WH
O W
E A
RE
01 July 1966
IMNR is established from:• ICEM research team
• ICECHIM research team
• IPRAN design team
1990-2004
IMNR S.A. is a state-owned company
24 December 2004
IMNR becomes National R&D Institute
RESEARCH• technologies for obtaining metals from
Romanian primary resources:
Cu, Zn–Pb, Al, TR, Mg, Li
• technologies for capitalizing on secondary
resources:
In, Bi, Cd, Au, Ag, Sb, Se, Mo, W
• technologies for new materials for other
industries: nuclear, aeronautics, chemistry,
medicine
DESIGN• technological installations for the
recovery of: Cd, Se, In, Au, Ag, Sb
• application of licenses: Outokumpu (Cu),
ISP (Zn-Pb), Pechiney (Al), Kowa Seiko
(pyrite ashes)
SMALL SCALE MANUFACTURE• non-ferrous alloys
• Mo salts from elctro-technical waste for
the chemical industry
• other custom made products
BA
CK
GR
OU
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GE
NE
RA
L A
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IVIT
Y (
196
6-2
004)
WH
AT
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IMNR aims to be a competitive institute recognized
for the quality of R&D services at national and
European level in the field of materials science
and engineering based on non-ferrous and rare
metals, meeting the needs of governmental and
industry partners, as well as innovative SMEs.
• generating new knowledge: competitive, top-
level scientific results
• raising the competitiveness of the Romanian
economy: innovation and transfer of
knowledge to economic agents
• improving quality of life: technological
solutions with societal and environmental
impact (recycling, recovery, re-use,
biomaterials for regenerative medicine)
MIS
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IMS
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IN D
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&D
AN
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HN
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Y T
RA
NS
FE
R technologies for advanced metal-basedmaterials and their compounds’ synthesis
new chemical processes for raw and
secondary materials: autoclave
solubilization in controlled atmosphere,
microwave processing
mild chemistry methods for advanced
nanomaterials synthesis (oxides,
composites, hybrids): hydrothermal /
solvothermal, high pressure, spray
drying, encapsulation and core-shell
materials
new technologies for capitalizing advanced
materials: - thin film coatings and deposition (EB-PVD)
- electro-deposition in aqueous solutions and
molten salts
- hydrothermal-electrochemical deposition with
on-line monitoring via RAMAN
R&
D P
RO
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CT
S
EU projects: H2020, ERA-NET, COST, RSRP, LIFE+, FP7
Structural funds
projects: POSCCE, POSDRU,
POC
National Core Program
(12 projects)
National R&D
projects
12
51
23
41 R&D PROJECTS2013-2017
2 NATIONAL CLUSTERS
3 EU NETWORKS (COST)2016-2020
4 EU PLATFORMS• ETP Raw Materials
• EIP Raw Nanovalue
• ETP Nanomedicine
• JTI Nanofutures
• ROHEALTH – Medicine
• MHTC Magurele – Physics & Engineering
• HERALD: Hooking together European
Research in Atomic Layer Deposition
(MP14102)
• CRM EXTREME: Replacement of Critical
Raw Materials for Extreme Environmental
Conditions (CA15012)
• BIONECA: Biomaterials and Advanced
Physical Techniques for Regenerative
Cardiology and Neurology (CA16122)
EX
PE
RT
ISE • nano-bio-materials (ceramics, composites, hybrid
inorganic-organic systems) for regenerative medicine
and tissue engineering.
• thin films and advanced coatings by hydrothermal
– electrochemical processes for sensors;
• functionally graded materials for non-conventional
energy
• new materials and functionalities for creative
manufacturing
• thermodynamic and kinetic modelling and
simulation
NA
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EQ
UIP
ME
NT
freeze dryer
DSC Maya F3 Netzschautoclave with in-situ
RAMAN monitoringscratch test / AFM
computer-controlled
hydrothermal /
electrochemical system spin coater + UV cure
FT-IR spectrometer Zetasizer ZS90
3D Bioscaffolder SEM Quanta 250
drop shape analyzer
high T chamber and tubular
furnaces
Zortrax M-200
spray-dryer
ME
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AP
PL
ICA
TIO
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ORBIMPLANT ProjectPN II – PCCA Type 2 (2014-2016)
Grant no. 114/01.10.2014
NANOPOWDERS & 3D-STRUCTURES
FOR REGENERATIVE MEDICINE
The project aimed to
design a new type of
orbital implant made of
nanocomposite material
based on hydroxyapatite
and polyurethane: a
composite scaffold with a
higher rate of vascular
proliferation within the
implant that allows
shortening of the waiting
time for final prosthesis
and preserving the
integrity of the eyelid.
HYBRID NANOPOWDERShydrothermal synthesis at high pressures from synthetic
raw materials (calcium and phosphorus salts;
polyurethane), followed by spray-drying of the hybrid
organic-inorganic nanocomposites
PASTES FOR 3D-PRINTINGpreparation of controlled-composition pastes for
deposition of 3D structures based on hybrid
nanopowders and non-cytotoxic crosslinking agents
(commercial organic polymers)
3D STRUCTURES FOR ORBITAL IMPLANTS3D printing of structures with controlled properties, using
a BioScaffolder; the implants have undergone successful
animal testingCO
NT
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ION
ME
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ICA
TIO
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NANOVIBER ProjectEURONANOMED II ERA-NET
Grant no. 1/2017 (2017-2019)
MAGNETIC NANOPARTICLES FOR
VIBRATIONAL ANTI-TUMOR THERAPY
The project aims to
translate – at patient level –
a tumour vibrational therapy
for glioblastoma, involving
spintronic particles and a
low-cost device.
The translational
nanomedicine approach
also aims to boost
nanotechnology innovation
at a faster and safer pace
towards patients. CO
NT
RIB
UT
ION
NANOPOWDER
CHARACTERIZATIONcharacterization methodology
for functionalized nanoparticles,
using:• particle size distribution and
zetapotential measurements
• quantitative chemical analysis
• inductively coupled plasma
optical emission spectrometry
(ICP-OES)
• X-ray diffraction (XRD)
• UV-VIS spectrophotometry
• FT-IR spectroscopy
• optical microscopy (MO)
• scanning electron microscopy
(SEM)
• complex thermal analysis
(DSC-TG)
NV6
NV5
NV4
Inte
ns
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CP
S)
0
100
200
300
400
500
600
700
2-Theta - Scale
14 20 30 40 50 60 70 80
NV4
NV5
NV6
4000 3500 3000 2500 2000 1500 1000
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G
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NV4
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NV7
T [
%]
[cm-1]
G
XRD analysis
FT-IR analysis
ME
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PL
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NANOCAGE ProjectRSRP JRP IZERZO
Grant no. 142141 (2012-2016)
The project aimed to
develop iron oxide
nanoparticles decorated
with PPI/PEI dendrimers
having attached folic acid
as a way to achieve active
targeting of tumour cells
and carrying antisense
survivin oligonucleotides
as an imaging contrast
agent. CO
NT
RIB
UT
ION
IRON OXIDE BASED NANOMATERIALSAS CONTRAST AGENTS FOR CANCER DETECTION
MAGNETIC HYBRID NANOMATERIALS• development of new magnetic hybrid nanomaterials that display controlled
composition, morphology, structure, magnetic properties and bioactivity
• biological interaction of these hybrid nanomaterials with MSC cells in vitro showed no
cytotoxic effect and preservation of the cells morphology
• the cells proliferated in the presence of hybrid nanostructures.
HRTEM images for iron oxide: dendrimer ratio=0.5
ME
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PL
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RETE-β-DENT ProjectCEEX (2005-2008)
Grant no. 46
The project aimed to
develop advanced
biocompatible
structures for dental
implants based on new
Ti alloys and new
methods for thin film
deposition, multilayer
structure deposition,
analysis and
characterization of
nanostructured hybrid
films. CO
NT
RIB
UT
ION
ADVANCED BIOCOMPATIBLE
STRUCTURES FOR DENTAL IMPLANTS
THIN FILM DEPOSITION ON 3D SUBSTRATEShydrothermal-electrochemical deposition of hybrid organic
-inorganic nanopowders on cylindrical Ti alloy.
ANIMAL TESTINGinsertion of implant in rabbit bone
macroscopic image of a
cylindrical implant made of
hybrid organic-inorganic
nanopowders deposited
on TiAlNb alloy, inserted in
rabbit’s bone
HYBRID NANOPOWDERShydrothermal synthesis at high pressures of hydroxyapatite – maleic copolymer
hybrid nanopowders
ME
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PL
ICA
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TROPSENSE ProjectMSCA RISE HORIZON 2020
Grant no. 645758 (2016-2019)
BIOSENSORS FOR TROPICAL AND
RARE DISEASES’ DETECTION
The project aims to
demonstrate the feasibility
of a non-invasive, safe and
patient-friendly methodology
for on-site rapid diagnosis of
tropical diseases
(Hydatidosis, Leishmaniasis
and Dengue), based on
breath samples analyses,
which are easy to obtain
and present no discomfort
or risk for patients’ health.
CO
NT
RIB
UT
ION THIN FILM DEPOSITION
hydrothermal – electrochemical deposition
of gold functionalized with carbon
nanotubes (MWCNT), polymers or CNT-
functionalized with polymers.
THIN FILMS CHARACTERIZATIONmicroscopy (AFM, SEM), FT-IR spectroscopy
SUBSTRATES FOR DEPOSITIONcommercial interdigitated DROPSENS
electrodes (Au/glass, Au/alumina) or
specially designed gold electrodes
hydrothermal-electrochemical
deposition system: CORTEST
autoclave and VOLTALAB /
potentiostat / HVB booster
cyclic voltammetry of gold-
cysteine hybrid deposited on
commercial Au-glass electrode
AFM analysis:
surface topography SEM analysis:
film thickness
ME
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SENSGAS ProjectPNII – PCCA 2 (2012-2016)
Grant no. 198/2012
The project aimed to to
develop new multi-
functional materials
based on doped BST for
sensors with specific
sensitivity in detecting
each of the following
gases: NH3, SO2 and
H2S, as close to room
temperature as possible,
with a detection range
between 0-100 ppm.
CO
NT
RIB
UT
ION
SENSORS FOR TOXIC GAS
DETECTION (NH3, SO2, H2S)
Cu-DOPED BST NANOPOWDERShydrothermal synthesis of nanostructured
perovskite materials: Cu-doped BST nanopowders
with high specific surface area (low temperature
<200⁰C, high pressure >100 atm)
NANOPOWDER CHARACTERIZATIONchemical analysis (ICP-OES), structural analysis
(XRD), morphological analysis (SEM), thermal
analysis (DSC/TG), DLS analysis (Zetasizer)
DEPOSITED SENSORserigraphic deposition of the
sensitive layer on a
commercial sensor
Berghoff autoclave
deposited sensor
INTEGRATED SENSORintegrated sensors with a
0-100 ppm detection range
for NH3, SO2 and H2S in air
integrated sensor
CO
NTA
CT
National R&D Institute for Non-
ferrous and Rare Metals – IMNR
102 Biruintei Blvd.
Pantelimon, Ilfov
077145 - Romania
phone +4021 3522048
fax +4021 3522049
e-mail: [email protected]
website: www.imnr.ro
General Manager
Roxana Mioara Piticescu, PhD
e-mail: [email protected]
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