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i
Guidelies or te
rogrammatic maagemeto drug-resistat
tuberculosis
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WHO Library Cataloguing-in-Publication Data
Guidelines or the programmatic management o drug-resistant tuberculosis. WHO/HTM/TB/2008.402 .
1.Tuberculosis, Multidrug-resistant drug therapy. 2.Tuberculosis, Multidrug-resistant prevention and control. 3.Antitubercular agents administration anddosage. 4.HIV inections drug therapy. 5.Antiretroviral therapy, Highly active.6.Guidelines. I.World Health Organization.
ISBN 978 92 4 154758 1 (NLM classication: WF 310)
The 2006 edition was unded by the Bill & Melinda Gates Foundation and the Unit-ed States Agency or International Development to the Green Light Committee sub-
group o the Stop TB Partnership Working Group on MDR-TB.The 2008 emergency update was unded by the UK Department or International
Development and the United States Agency or International Development. Theirnancial contribution was essential or WHO and partners to produce and analysemost o the evidence supporting these guidelines.
Emergency update, 2008
Expiry date: 2010
World Health Organization 2008
All rights reserved. Publications o the World Health Organization can be obtained rom WHO
Press, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland (tel.: +41 22 791
3264; ax: +41 22 791 4857; e-mail: [email protected]). Requests or permission to reproduce or
translate WHO publications whether or sale or or noncommercial distribution should be ad-
dressed to WHO Press, at the above address (ax: +41 22 791 4806; e-mail: [email protected]).
The designations employed and the presentation o the material in this publication do not imply theexpression o any opinion whatsoever on the part o the World Health Organization concerning the
legal status o any country, territory, city or area or o its authorities, or concerning the delimitation
o its rontiers or boundaries. Dotted lines on maps represent approximate border lines or which
there may not yet be ull agreement.
The mention o specic companies or o certain manuacturers products does not imply that they
are endorsed or recommended by the World Health Organization in preerence to others o a similar
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All reasonable precautions have been taken by the World Health Organization to veriy the inor-
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o the material lies with the reader. In no event shall the World Health Organization be liable or
damages arising rom its use.
Designed by minimum graphics
Printed in Switzerland
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iii
Cotets
Acknowledgements v
Abbreviations viii
Executive summary xi
Foreword to the 2008 emergency updated edition xvii
Chapter 1 Background inormation on DR-TB 1
Chapter 2 Framework or eective control o DR-TB 8
Chapter 3 Political commitment and coordination 14
Chapter 4 Denitions: case registration, bacteriology and
treatment outcomes 19
Chapter 5 Case-nding strategies 26
Chapter 6 Laboratory aspects 36
Chapter 7 Treatment strategies or MDR-TB and XDR-TB 50
Chapter 8 Mono-resistant and poly-resistant strains 75
Chapter 9 Treatment o DR-TB in special conditions and situations 79
Chapter 10 DR-TB and HIV inection 89
Chapter 11 Initial evaluation, monitoring o treatment and
management o adverse eects 107Chapter 12 Treatment delivery and community-based DR-TB support 120
Chapter 13 Management o patients ater MDR-TB treatment ailure 130
Chapter 14 Management o contacts o MDR-TB patients 135
Chapter 15 Drug resistance and inection control 140
Chapter 16 Human resources: training and stang 145
Chapter 17 Management o second-line antituberculosis drugs 150
Chapter 18 Category IV recording and reporting system 154Chapter 19 Managing DR-TB through patient-centred care 165
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iv
GUIDELINES FOR THE PROGRAMMATIC MANAGEMENT OF DRUG-RESISTANT TUBERCULOSIS
Aees
Annex 1 Drug inormation sheets 173
Annex 2 Weight-based dosing o drugs or adults 193
Annex 3 Suggestions or urther reading 195
Annex 4 Legislation, human rights and patients rights in
tuberculosis prevention and control 198
Annex 5 Use o experimental drugs outside o clinical trials
(compassionate use) 208
Annex 6 Methodology 213
Forms 217Index 237
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v
Ackoledgemets
WHO grateully acknowledges the contributions o the ollowing individuals
to the 2006 edition and the 2008 emergency edition.
2006 editio
Writing Committee
Jaime Bayona
Karin Bergstrm
Kai Blndal
Jos Caminero
Peter Cegielski
Manred Danilovits
Jennier Furin
Victoria Gammino
Malgorzata Grzemska
Einar Heldal
Myriam Henkens
Vahur Hollo
Ernesto Jaramillo
Fabienne Jouberton
Boris Kazenniy
Michael Kimerling
Hans Kluge
Kitty Lambregts
Kayla Laserson
Vaira Leimane
Andrey Mariandyshev
Fuad Mirzayev
Carole Mitnick
Joia Mukherjee
Edward Nardell
Eva Nathanson
Lisa Nelson
Paul Nunn
Michael Rich
Kwonjune Seung
Alexander Sloutsky
Tamara Tonkel
Arnaud Trbucq
Thelma Tupasi
Francis Varaine
Irina Vasilieva
Fraser Wares
Karin Weyer
Abigail Wright
Matteo Zignol
Expert Reiew Committee
Marcos Espinal
Paul Farmer
Mario Raviglione
Wang Xie Xiu
2008 emergec udate
Steering Group
Chie EditorMichael Rich
Editors-in-chieErnesto Jaramillo
Salmaan Keshavjee
Kitty Lambregts
Karen Weyer
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vi
GUIDELINES FOR THE PROGRAMMATIC MANAGEMENT OF DRUG-RESISTANT TUBERCULOSIS
Guidelines Reference Group
Jaime Bayona, Socios En Salud, Sucursal Peru, Lima, Peru
Jose Caminero, International Union Against Tuberculosis and Lung Disease,
Paris, FranceRichard Coker, London School o Hygiene and Tropical Medicine, London,
UK
Charles Daley, National Jewish Medical and Research Center, Denver, CO,
USA
Hamish Fraser, Partners In Health, USA
Jennier Furin, Partners In Health, Boston, MA, USA
Giuliano Gargioni, WHO Stop TB Department, Geneva, Switzerland
Haileyesus Getahun, WHO Stop TB Department, Geneva, Switzerland
Charles Gilks, WHO HIV Department, Geneva, Switzerland
Case Gordon, World Care Council, Geneva, Switzerland
Reuben Granich, WHO HIV Department, Geneva, Switzerland
Diane Havlir, University o Caliornia, San Francisco, CA, USA
Einar Heldal, Independent consultant
Tim Holtz, United States Centers or Disease Control and Prevention, At-
lanta, GA, USA
Phil Hopewell, University o Caliornia, San Francisco, CA, USA
Roco Hurtado, Massachusetts General Hsopital, Harvard Medical School,Boston, MA, USA and Socios en Salud, Peru
Ernesto Jaramillo, WHO Stop TB Department, Geneva, Switzerland
Salmaan Keshavjee, Partners In Health, Harvard Medical School, Boston,
MA, USA
Catharina (Kitty) Lambregts van Weezenbeek, KNCV Tuberculosis Founda-
tion, Netherlands
Vaira Leimane, State Agency o Tuberculosis and Lung Diseases, Latvia
Refloe Matji, University Research Corporation, South Arica
Fuad Mirzayev, WHO Stop TB Department, Geneva, SwitzerlandCarole Mitnick, Harvard Medical School, Boston, MA, USA
Christo van Niekerk, Global Alliance or TB Drug Development
Domingo Palmero, Hospital Muniz, Buenos Aires, Argentina
Genevive Pinet, WHO Legal Department, Geneva, Switzerland
Mamel Quelapio, Tropical Disease Foundation, Philippines
Michael Rich, Partners In Health/Division o Social Medicine and Health
Inequalities, Brigham and Womens Hospital, Boston, MA, USA
Vija Riekstina, State Agency o Tuberculosis and Lung Diseases, Latvia
Irina Sahakyan, WHO Stop TB Department, Geneva, SwitzerlandFabio Scano, WHO Stop TB Department, Geneva, Switzerland
Adrienne Socci, Partners In Health, Boston, MA, USA
Kathrin Thomas, WHO Stop TB Department, Geneva, Switzerland
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vii
Arnaud Trbucq, International Union Against Tuberculosis and Lung Dis-
ease, Paris, France
Francis Varaine, Mdecins Sans Frontires, France
Marco Vitoria, WHO HIV Department, Geneva, SwitzerlandFraser Wares, WHO Regional Ofce or South-East Asia, New Delhi
Karin Weyer, WHO Stop TB Department, Geneva, Switzerland
Abigail Wright, WHO Stop TB Department, Geneva, Switzerland
Matteo Zignol, WHO Stop TB Department, Geneva, Switzerland
Declaration of interests
All o the above contributors completed a WHO Declaration o Interest orm.
The ollowing interests were declared:
Case Gordon declared that he is an unpaid advocate or patients with anti-
TB drug resistance and or improved access to high-quality care. He
declared that he has himsel survived XDR-TB.
Tim Holtz declared that he is an unpaid technical adviser and member o
the Scientifc Advisory Board o a manuacturer o anti-TB products, to
advise on the development o a new anti-TB compound that will be tested
in clinical trials o MDR-TB regimens.
Salmaan Keshavjee declared that his employer received unding rom a oun-
dation associated with a manuacturer o anti-TB products to support theresearch and training unit that he is heading.
Carole Mitnick declared that she is serving as a paid member o the
Scientifc Advisory Board o a manuacturer o anti-TB products, to ad-
vise on the development o a new anti-TB compound that will be tested in
clinical trials o MDR-TB regimens.
Michael Rich declared that his employer received unding rom a manuac-
turer o anti-TB products, in support o his salary.
ACkNOwLEDGEMENTS
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ix
PI protease inhibitor
PIH Partners In Health
PPD puried protein derivative
PPM publicprivate mixR&R recording and reporting
SCC short-course chemotherapy
SMX sulamethoxazole
SRL supranational reerence laboratory
STB WHO Stop TB Department
TB tuberculosis
TB/HIV HIV-related TB
TMP trimethroprim
TSH thyroid-stimulating hormone
UNAIDS Joint United Nations Programme on HIV/AIDS
Union International Union Against Tuberculosis and Lung Disease
UVGI ultraviolet germicidal irradiation
WHO World Health Organization
XDR-TB extensively drug-resistant tuberculosis
Antituberculosis drug abbreiations
Group Description DruG AbbreviAtion
1 First-line oral isoniazid H
antituberculosis drugs riampicin R
ethambutol E
prazinamide Z
riabutin Rb
2 Injectable antituberculosis anamcin km
drugs amiacin Am
capreomcin Cm
streptomcin S
3 Fluoroquinolones leooxacin Lx
moxioxacin Mx
ooxacin Ox
4 Oral bacteriostatic second-line ethionamide Eto
antituberculosis drugs protionamide Pto
ccloserine Cs
terizidone Trd
p-aminosaliclic acid PAS
5 Antituberculosis drugs with cloazimine Cz
unclear efcac or unclear role linezolid Lzd
in MDR-TB treatment (not amoxicillin/claulanate Amx/Cl
recommended b WHO or thioacetazone Thz
routine use in MDR-TB patients) clarithromcin Clr
imipenem Ipm
ABBREvIATIONS
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xi
Eecutie summar
Multidrug-resistant tuberculosis (MDR-TB), dened as TB caused by
organisms that are resistant to isoniazid and riampicin, two rst-line anti-
TB drugs, continues to threaten the progress made in controlling the dis-ease. The emergence o extensively drug-resistant TB (XDR-TB), dened
as MDR-TB that is resistant as well to any one o the fuoroquinolones and
to at least one o three injectable second-line drugs (amikacin, capreomycin
or kanamycin), has heightened this threat. XDR-TB has been identied in
all regions o the world since 2006. Treatment outcomes are signicantly
worse in XDR-TB patients than in MDR-TB patients. Outbreaks o XDR-
TB in populations with high prevalence o HIV have caused alarmingly high
mortality rates. The emergence o XDR-TB as a new threat to global public
health demands that health ocials and health-care providers respond with
a coordinated strategy drawing on the Stop TB Strategy.1
Guidelines or the programmatic management o drug-resistant tuberculosis:emergency update 2008provides updated guidelines and recommendationson how to manage drug-resistant TB (DR-TB) based on a rapid assessment o
the best available evidence by a group o experts. A ully revised second edi-
tion will be published in 2010, ollowing WHO guidance on retrieval, syn-
thesis and grading o evidence. Until that time, the emergency update serves
as interim guidance or TB control programmes and medical practitionerson all aspects o the management o DR-TB, including XDR-TB. It contains
19 chapters based on the original 18 chapters rom the rst edition published
by the World Health Organization in 20062 plus an additional chapter on
patient-centered care.
1 The Stop TB Strategy launched by the World Health Organization in 2006 describes the recom-mended interventions that should be implemented to achieve the targets or global TB controlthat have been established within the context o the Millennium Development Goals. See Rav-iglione MC, Uplekar MW. WHOs new Stop TB Strategy. Lancet, 2006, 367:952955.
2 Guidelines or the programmatic management o drug-resistant tuberculosis. Geneva, World HealthOrganization, 2006 (WHO/HTM/TB/2006.361).
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xii
GUIDELINES FOR THE PROGRAMMATIC MANAGEMENT OF DRUG-RESISTANT TUBERCULOSIS
The key changes or the emergency update 2008 are summarized below.
chApter Key recommenDAtions Key chAnGes(* da dad da)
Cater 1 Not applicable Target audience is defned.
Bacground Deelopment o guidelines is
inormation on described.
drug-resistant Stop TB Strateg is
tuberculosis summarized.
New data are proided rom
the WHO/IUATLD Global
Project on Antituberculosis
Drug Resistance
Sureillance.
Updated inormation isproided rom a sure o the
networ o supranational
reerence laboratories to
determine the prealence o
XDR-TB among strains sent
or drug susceptibilit testing
(DST).
Cater 4 Not applicable Defnition o XDR-TB is
Defnitions: case introduced.
registration, Concise instructions or
bacteriolog and registration o new cases otreatment XDR-TB are proided.
outcomes
Cater 5 All patients at increased ris Stronger emphasis is placed
Case-fnding or MDR-TB should be screened on the recommendation that
strategies or drug resistance.* all patients at increased ris
Patients inected with HIv or MDR-TB should receie
should receie DST at the start DST, with the goal o
o anti-TB therap to aoid uniersal access to DST or
mortalit caused b all that need it.
unrecognized MDR-TB.* The use o rapid DST in all
Rapid DST should be used or HIv-inected patients who arethe initial screening o MDR-TB smear-positie is highl
wheneer possible. encouraged, and it is
Patients at increased ris or recommended that all
XDR-TB should receie DST o HIv-inected patients at
isoniazid, riampicin, second- moderate to high ris be
line injectable agents and a screened or resistance in
uoroquinolone.* order to aoid the high
mortalit associated with
unrecognized MDR-TB.
An algorithm or the use o
rapid drug-resistance testing
is introduced.
The use o DST or second-
line drugs in case-fnding or
XDR-TB is introduced, and
ris actors or XDR-TB are
described.
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xiii
EXECUTIvE SUMMARy
chApter Key recommenDAtions Key chAnGes(* da dad da)
Cater 6 All patients with suspected Defnitions o common terms
Laborator MDR-TB or XDR-TB need access used in laborator issues areaspects to laborator serices or proided at the start o the
adequate and timel diagnosis. chapter.
Laboratories should be tested New recommendations or
or profcienc and qualit DST to second-line drugs are
assured externall to perorm proposed based on recent
DST.* WHO polic guidance;
Laboratories should perorm Reerences or regulations on
DST or the uoroquinolones how to transport inectious
and second-line injectable specimens internationall are
agents where adequate capacit proided.
and expertise exists.* DR-TB strains can be
transported sael across
international borders i inter-
national procedures and guide-
lines are ollowed.*
Laboratories must ollow all
standardized protocols or
inection control and biosaet.
Qualit control and qualit
assurance should be in place
or microscop, culture and DST.
Lins with supranational
reerence laboratories are
strongl encouraged.
Cater 7 Design regimens with a The fe groups o anti-TB
Treatment consistent approach based on drugs are re-defned.
strategies or the hierarch o the fe groups Thioacetazone is placed in
MDR-TB o anti-TB drugs. Group 5. High-dose isoniazid
Promptl diagnose MDR-TB and and imipenem are added to
initiate appropriate therap. Group 5.
Use at least our drugs with Ciprooxacin is remoed as
either certain, or almost certain, an anti-TB agent because o
eectieness. its wea efcac compared
DST should generall be used to with other uoroquinolones.
guide therap; howeer, do not Strong caution is warranted
depend on DST o ethambutol or an programme that uses
or prazinamide in indiidual gatioxacin gien the rare but
regimen design, prazinamide, dangerous aderse eects o
Group 4 and 5 drugs. dsglcaemia associated
Do not use ciprooxacin as an with this drug.
anti-TB agent in management A new reiew o DST o
o DR-TB.** second-line drugs has
Design a programme strateg resulted in strong caution
that taes into consideration against basing the design oaccess to qualit-assured DST, indiidual regimens on
rates o DR-TB, HIv prealence, results o DST o ethambutol,
technical capacit and fnancial prazinamide, or Group 4 and
resources. 5 drugs.
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xiv
GUIDELINES FOR THE PROGRAMMATIC MANAGEMENT OF DRUG-RESISTANT TUBERCULOSIS
chApter Key recommenDAtions Key chAnGes(* da dad da)
Cater 7 Treat MDR-TB patients or Table 7.2 is new and
(continued) 18 months past the date o summarizes programmeculture conersion. strategies accepted b the
Use adjunct therapies including Green Light Committee that
surger and nutritional or social tae into consideration
support. qualit o DST, rates o
Treat XDR-TB aggressiel DR-TB, technical capacit
wheneer possible. and fnancial resources.
Treat aderse eects The management o XDR-TB
immediatel and adequatel. is introduced.
Cater 10 Perorm proider-initiated HIv Stronger emphasis is placed
HIv inection testing and counselling in all on perorming DST o
and MDR-TB TB suspects.* HIv-inected indiiduals at Use standard algorithms to the start o anti-TB therap in
diagnose pulmonar and extra- areas o moderate or high
pulmonar TB. MDR-TB prealence. This
Use mcobacterial cultures and, subject is also introduced in
where aailable, newer more Chapter 5 as a e change.
rapid methods o diagnosis. Greater detail is proided on
Determine the extent (or the concomitant treatment o
prealence) o anti-TB drug HIv and MDR-TB, including
resistance in patients with HIv. discussion o immune
Introduce antiretroiral therap reconstitution inammator
(ART) promptl in MDR-TB or sndrome.XDR-TB /HIv patients. Table 10.3 proides a list o
Consider empirical therap with potential oerlapping and
second-line anti-TB drugs.* additie toxicities o ART and
Proide co-trimoxazole anti-TB therap.
preentie therap (CPT) as part
o a comprehensie pacage o
HIv care to patients with actie
TB and HIv.*
Arrange treatment ollow-up b
a specialized team.
Implement additional nutritional
and socioeconomic support.
Ensure eectie inection
control.
Inole e staeholders in
MDR-TB/HIv actiities.
Monitor oerling toxicit with
ART and DR-TB therap.
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xv
chApter Key recommenDAtions Key chAnGes(* da dad da)
Cater 11 Standard monitoring should be New recommendations or
Initial ealuation, implemented or all patients on monitoring the response tomonitoring o MDR-TB treatment. treatment are described.
treatment and Results both o sputum smear Laborator monitoring or
management o and culture should be monitored patients receiing both ART
aderse eects monthl to ealuate treatment and MDR-TB therap is added
response.* to Table 11.1.
Increased monitoring is
required in HIv cases and or
patients on ART.*
Health-care worers in MDR-TB
control programmes should be
amiliar with the managemento common aderse eects o
MDR-TB therap.
Ancillar drugs or the manage-
ment o aderse eects should
be aailable to the patient.
Cater 12 Use disease education, DOT, A section on communit-
Treatment socioeconomic support, based care and support is
delier and emotional support, manage- added to this chapter. NTPs
adherence ment o aderse eects and are encouraged to add
monitoring sstems to improe communit -based care and
adherence to treatment. support into their national National TB control programmes strategies and plans.
(NTPs) are encouraged to
incorporate communit-based
care and support into their
national plans.*
Cater 14 MDR-TB contact inestigation NTPs should consider
Management o should be gien high priorit, contact inestigation o
contacts o and NTPs should consider XDR-TB as an emergenc
MDR-TB patients contact inestigation o XDR-TB situation.
as an emergenc situation.*
Cater 15 Inection control, including Inection control measures
Drug resistance administratie and engineering are proposed, with special
and inection controls as well as personal attention to XDR-TB and the
control protection, should be made a high mortalit o patients
high priorit in all MDR-TB coinected with HIv and
control programmes. DR-TB.
XDR-TB patients should be XDR-TB patients should be
placed isolated ollowing a placed in ward isolation until
patient-centred approach and no longer inectious.
WHO ethical and legal guidance MDR-TB patients should
until no longer inectious.* receie routine care outside
o normal HIv care settings.
EXECUTIvE SUMMARy
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xvi
GUIDELINES FOR THE PROGRAMMATIC MANAGEMENT OF DRUG-RESISTANT TUBERCULOSIS
chApter Key recommenDAtions Key chAnGes(* da dad da)
Cater 18 A standardized method o Chapter 18 has been
Categor Iv recording and reporting should rewritten to be simpler andrecording and be implemented in DR-TB more consistent with the
reporting sstem control programmes. DOTS recording and
DR-TB treatment cards should reporting sstem.
hae an expanded section or The treatment card described
inormation on patients with in Chapter 18 has an
HIv.* expanded section or
The International Health inormation on patients with
Regulations (IHR2005) should HIv.
be ollowed.* Box 18.1 proides additional
recording and reporting
components, which areoptional or programmes.
The International Health
Regulations 2005 should be
ollowed.
Cater 19 Not applicable Chapter 19 is the onl
Managing DR-TB completel new chapter in
through patient- this reision.
centered care
An patient in whom MDR-TB or
XDR-TB is suspected or
diagnosed should be proidedwith high-qualit patient-
centered care, as outlined in
both the International
Standards or Tuberculosis
Care, the Patients Charter or
Tuberculosis Care and in the
WHO Good Practice in
Legislation and Regulations or
TB Control.
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xvii
Foreord to te 2008emergec udated editio
The emergence o resistance to antituberculosis drugs, and particularly o multi-
drug-resistant TB (MDR-TB),1 has become a major public health problem in a
number o countries and an obstacle to eective global TB control. Nearly hala million cases o MDR-TB emerge every year as a result o under-investment
in basic activities to control TB, poor management o the supply and quality o
antituberculosis drugs, improper treatment o TB patients and transmission o
the disease in congregate settings. However, in many areas such as Arica, the
extent o drug resistance is unknown and in most resource-constrained coun-
tries the treatment o patients with MDR-TB is absent or inadequate.
As with other inectious diseases, rom staphylococcal inections to ma-
laria, pathogens have almost invariably developed resistance to the drugs used
to treat them. Tuberculosis is no exception: strains resistant to streptomycin
were identied within months o the start o use, in the mid 1940s, o this
rst antituberculosis drug. Indeed, the emergence o drug resistance was the
primary reason that therapy or TB evolved to include treatment with more
than one drug or up to 18 to 24 months the standard o care or over two
decades. The advent o riampicin in the early 1970s permitted a drastic reduc-
tion in the duration o therapy to six months while the ecacy o treatment
improved. But those amiliar with drug resistance in general would have pre-
dicted the emergence o resistance to what are now termed these rst-linedrugs, and by the mid-1990s, most countries participating in a global survey
o anti-TB drug resistance registered cases o MDR-TB. The worse was yet to
come: in 2006, extensively drug-resistant TB (XDR-TB) emerged. This is de-
ned as resistance to rst- and second-line drugs2 and was rapidly announced
by the World Health Organization (WHO) as a serious emerging threat to
global public health, especially in countries with a high prevalence o human
immunodeciency virus (HIV). In act, reports have identied XDR-TB in
all regions o the world and, to date, treatment outcomes have been shown to
1 MDR-TB is dened as TB caused byMycobacterium tuberculosisresistant in vitro to the eects oisoniazid and riampicin, with or without resistance to any other drugs. Resistance is dened byspecic laboratory criteria (see Chapter 6).
2 XDR-TB is dened as TB resistant to multiple rst-line drugs as well as to any one o the fuo-roquinolones and to at least one o three injectable second-line drugs (amikacin, capreomycin orkanamycin).
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GUIDELINES FOR THE PROGRAMMATIC MANAGEMENT OF DRUG-RESISTANT TUBERCULOSIS
be extremely poor (14). In one cohort rom KwaZulu-Natal, South Arica,98% o XDR-TB patients coinected with HIV died, with a median time o
death o only 16 days rom the time o specimen collection.
This rapidly changing terrain requires health ocials and providers torespond with novel and eective responses. These guidelines oer updated
recommendations or TB control programmes and medical workers in mid-
dle- and low-income countries aced with MDR-TB and other drug-resistant
orms o TB. They replace previous publications by WHO on drug-resistant
TB (DR-TB) and are a direct update to the 2006 rst edition oGuidelinesor the programmatic management o drug-resistant tuberculosis(5). Taking ac-count o important developments and recent evidence, the new guidelines aim
to disseminate consistent, up-to-date recommendations or the diagnosis and
management o MDR-TB in a variety o geographical, political, economic
and social settings. The guidelines are designed to be o use to both TB con-
trol programmes and medical practitioners. The updated guidelines take into
particular account a number o considerations and developments. First, access
to culture and drug susceptibility testing should be available to all patients in
whom DR-TB is considered likely. Secondly, there is a larger experience in
treating DR-TB, and this experience can guide ormal therapeutic recommen-
dations. Thirdly, the 2006 edition insuciently addressed DR-TB and HIV,
and new knowledge can now guide revised policies. Finally, there now existnovel strategies to prevent and treat XDR-TB.
These updated guidelines expand upon the most recent general WHO
guidelines or national TB control programmes (6), which are currently beingupdated to ensure ull consistency with recent advances in our understanding
o the programmatic management o MDR-TB.
In addition, these guidelines provide standards or registering, monitoring
and reporting the treatment outcomes o patients with DR-TB. This uniorm
inormation management system will allow systematic, consistent data collec-
tion and analysis, which will play an important role in shaping uture policiesand recommendations.
The guidelines can be adapted to suit diverse local circumstances because
they are structured around a fexible ramework, combining a consistent core
o principles and requirements with various alternatives that can be tailored to
the specic local situation.
The guidelines also detail the recommended management protocols to en-
able national TB control programmes to access concessionally-priced, quality-
assured second-line antituberculosis drugs through a mechanism known as
the Green Light Committee (GLC), hosted by WHO.1 The GLC was estab-
1 For more inormation about the services and how to contact the Green Light Committee or tech-nical support or apply or access to concessionally-priced, quality-assured second-line antituber-culosis drugs, see the GLC web page at: http://www.who.int/tb/challenges/mdr/greenlightcom-mittee/en/index.html
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xix
lished in June 2000 as a partnership among ve categories o participants:
governments o resource-limited countries; academic institutions; civil-society
organizations; bilateral donors; and WHO. The GLC has successully negoti-
ated prices o drugs with producers; solicited creation o, and adopted soundpolicies or, proper management o DR-TB; established strict criteria to review
proposals or DR-TB management programmes; assisted countries in develop-
ing such proposals and ensured their proper implementation; and, nally, has
provided access to quality-assured second-line drugs at concessionary prices
to those management programmes considered technically and scientically
sound and not at risk o producing additional drug resistance. In brie, the
GLC rapidly became a model o good practice which, by providing access to
previously unaordable drugs, ensured that their use was as sae and ratio-
nal as possible. Demand or technical assistance rom the GLC grew rapidly
and in 2002, the GLC was adopted by the newly established Global Fund to
Fight AIDS, Tuberculosis and Malaria (the Global Fund) as its mechanism or
screening proposals or DR-TB programme nancing. This was a major his-
toric milestone, and today the Global Fund is the leading nancial mechanism
supporting the management o MDR-TB in resource-constrained settings.
Today, a new threat that linked to XDR-TB now requires even more in-
novative thinking (7). In October 2006, the WHO Stop TB and HIV depart-
ments organized a meeting o the Global Task Force on XDR-TB at WHOheadquarters in Geneva, Switzerland, in response to the XDR-TB emergency.
During this meeting, eight recommendations were put orward to the inter-
national TB community, outlining key areas o response, beginning with
strengthening o basic TB and HIV/AIDS control and proper management o
MDR-TB (8). The eight recommendations are:
strengthening basic activities to control TB and HIV/AIDS, as detailed in
the Stop TB Strategy and the Global Plan, to avoid additional emergence
o MDR-TB and XDR-TB;
scaling-up the programmatic management o MDR-TB and XDR-TB to
reach the targets set orth in the Global Plan;
strengthening laboratory services or adequate and timely diagnosis o
MDR-TB and XDR-TB;
expanding surveillance o MDR-TB and XDR-TB to better understand the
magnitude and trends o drug resistance and the links with HIV;
ostering sound inection-control measures to avoid MDR-TB and XDR-
TB transmission to protect patients, health workers, others working in
congregate settings and the broader community, especially in high HIVprevalence settings;
strengthening advocacy, communication and social mobilization or sus-
tained political commitment and a patient-centered approach to treat-
ment;
FOREWORD TO THE 2008 EMERGENCy UPDATED EDITION
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xxi
Reereces
1. Gandhi NR et al. Extensively drug-resistant tuberculosis as a cause o
death in patients co-inected with tuberculosis and HIV in a rural area
o South Arica. Lancet, 2006, 368(9547):15751580.2. Shah NS et al. Worldwide emergence o extensively drug-resistant tuber-
culosis. Emerging Inectious Diseases, 2007, 13(3):380387.3. Migliori GB et al. Extensively drug-resistant tuberculosis, Italy and Ger-
many. Emerging Inectious Diseases, 2007, 13(5):780782.4. Kim HR et al. Impact o extensive drug resistance on treatment outcomes
in non-HIV-inected patients with multidrug-resistant tuberculosis. Clin-ical Inectious Diseases, 2007, 45(10):12901295.
5. Guidelines or the programmatic management o drug-resistant tuberculo-sis. Geneva, World Health Organization, 2006 (WHO/HTM/TB/2006.361).
6. Treatment o tuberculosis: guidelines or national programmes, 3rd ed. Ge-neva, World Health Organization, 2003 (WHO/CDS/TB/2003.313).
7. Raviglione MC, Smith IM. XDR tuberculosis Implications or global
public health. New England Journal o Medicine, 2007, 356(7):656659.8. The Global MDR-TB & XDR-TB Response Plan 20072008. Geneva,
World Health Organization, 2007 (WHO/HTM/TB/2007.387).
FOREWORD TO THE 2008 EMERGENCy UPDATED EDITION
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1
CHAPTER 1
Backgroud iormatioo DR-TB
1.1 Chapter objecties 1
1.2 The Stop TB Strateg 1
1.2.1 Pursuing high-qualit DOTS expansion and enhancement 2
1.2.2 MDR-TB, XDR-TB and other challenges 2
1.2.3 Contributing to health sstem strengthening 2
1.2.4 Engaging all care proiders 2
1.2.5 Empowering people with TB, and communities 2
1.2.6 Enabling and promoting research 2
1.3 Integration o diagnostic and treatment serices to control TB 2
1.4 Causes o DR-TB 3
1.5 Addressing the sources o DR-TB 3
1.6 Magnitude o the DR-TB problem 4
1.7 Management o DR-TB, the Green Light Committee and
the global response to DR-TB 6
Table 1.1 Causes o inadequate antituberculosis treatment 3
1.1 Cater objecties
This chapter summarizes key inormation on the emergence o drug-resistantTB (DR-TB), its public health impact, experience gained in the management
o patients and strategies or addressing drug resistance within national TB
control programmes (NTPs).
1.2 Te Sto TB Strateg
The goals o the Stop TB Strategy are to reduce dramatically the burden o
TB by 2015 in line with the Millennium Development Goals and the Stop TB
Partnership targets and to achieve major progress in the research and devel-
opment needed or TB elimination. The Stop TB Strategy continues to em-phasize the basic components o the DOTS strategy (See Chapter 2 or how
the basic DOTS strategy applies to DR-TB) while addressing additional con-
straints and challenges to TB control. The Stop TB Strategy has six principal
components:
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GUIDELINES FOR THE PROGRAMMATIC MANAGEMENT OF DRUG-RESISTANT TUBERCULOSIS
1.2.1 Pursuing high-qualit DOTS expansion and enhancement
a. Political commitment with increased and sustained nancing
b. Case detection through quality-assured bacteriology
c. Standardized treatment with supervision and patient supportd. Eective drug supply and management system
e. Monitoring and evaluation system and impact measurement
1.2.2 Addressing TB/HIv, MDR-TB, XDR-TB and other challenges by
implementing collaborative TB/HIV activities, preventing and controlling
DR-TB, including XDR-TB, and addressing prisoners, reugees and other
high-risk groups and situations.
1.2.3 Contributing to health sstem strengthening by collaboratingwith other health-care programmes and general services, e.g. by mobilizing
the necessary human and nancial resources or implementation and im-
pact evaluation, and by sharing and applying achievements o TB control
as well as innovations rom other elds.
1.2.4 Engaging all care proiders, including public, nongovernmental
and private providers, by scaling up publicprivate mix (PPM) approaches
to ensure adherence to international standards o TB care, with a ocus on
providers or the poorest and most vulnerable groups.
1.2.5 Empowering people with TB, and communities by scaling up
community TB care and creating demand through context-specic advo-
cacy, communication and social mobilization.
1.2.6 Enabling and promoting research to improve programme per-
ormance and to develop new drugs, diagnostics and vaccines.
Emphasis on expanding laboratory capacity (sputum smear microscopy rst,then culture and drug susceptibility testing (DST)) and the use o quality-
assured drugs across all programmes are important aspects o this comprehen-
sive approach to TB control.
1.3 Itegratio o diagostic ad treatmet serices to
cotrol TB
Detection and treatment o all orms o TB, including drug-resistant orms,
should be integrated within NTPs. In the past, many public health authorities
reasoned that scarce resources should be used or new patients with drug-sus-ceptible TB because the cost o detecting and treating the disease was 10- to
100-old lower than or MDR-TB. However, it has now proved easible and
cost eective to treat all orms o TB, even in middle- and low-income coun-
tries. Untreated or improperly treated patients with DR-TB are a source o
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1. BACkGROUND INFORMATION ON DR-TB
ongoing transmission o resistant strains, resulting in uture added costs and
mortality. The ramework or the management o DR-TB presented in these
guidelines can be adapted to all NTPs and integrated within the basic DOTS
strategy.
1.4 Causes o DR-TB
Although its causes are microbial, clinical and programmatic, DR-TB is essen-
tially a man-made phenomenon. From a microbiological perspective, resist-
ance is caused by a genetic mutation that makes a drug ineective against the
mutant bacilli. From a clinical and programmatic perspective, it is an inad-
equate or poorly administered treatment regimen that allows a drug-resistant
strain to become the dominant strain in a patient inected with TB. Table 1.1
summarizes the common causes o inadequate treatment.Short-course chemotherapy (SCC) or patients inected with drug-resistant
strains may create even more resistance to the drugs in use. This has been
termed the amplier eect o SCC.
Ongoing transmission o established drug-resistant strains in a population
is also a signicant source o new drug-resistant cases.
TABLE 1.1 Causes o iadequate atituberculosis treatmet (1)
heAlth-cAre proviDers: DruGs: inADequAte supply pAtients: inADequAteinADequAte reGimens or quAlity DruG intAKe
Inappropriate guidelines Poor qualit Poor adherence (or poor
Noncompliance with Unaailabilit o certain DOT)
guidelines drugs (stoc-outs or Lac o inormation
Absence o guidelines delier disruptions) Lac o mone (no treatment
Poor training Poor storage conditions aailable ree o charge)
No monitoring o Wrong dose or Lac o transportation
treatment combination Aderse eects
Poorl organized or unded Social barriers
TB control programmes Malabsorption
Substance dependenc
disorders
1.5 Addressig te sources o DR-TB
Any ongoing production o DR-TB should be addressed urgently beore em-
barking on any programme designed or its control. The ramework approach
described in these guidelines can help to identiy and curtail possible sources
o DR-TB. Recent outbreaks o highly resistant TB underscore the impor-
tance o preventing the development o resistance, as mortality or patientsinected with highly resistant strains is alarmingly high.
The possible contributing actors to the development o new drug-resistant
cases should be reviewed (see Table 1.1 or a list o possible actors). Well-
administered rst-line treatment or susceptible cases is the best way to pre-
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GUIDELINES FOR THE PROGRAMMATIC MANAGEMENT OF DRUG-RESISTANT TUBERCULOSIS
vent acquisition o resistance. Timely identication o DR-TB and adequate
treatment regimens (Category IV regimens) administered early in the course
o the disease are essential to stop primary transmission. Integration o DOTS
with treatment o DR-TB works synergistically to eliminate all the potentialsources o TB transmission.
1.6 Magitude o te DR-TB roblem
The incidence o drug resistance has increased since the rst drug treatment or
TB was introduced in 1943. The emergence o MDR-TB ollowing the wide-
spread use o riampicin beginning in the 1970s led to the use o second-line
drugs. Improper use o these drugs has uelled the generation and subsequent
transmission o highly resistant strains o TB termed extensively DR-TB, or
XDR-TB. These strains are resistant to at least one o the fuoroquinolonedrugs and an injectable agent in addition to isoniazid and riampicin.
The WHO/IUATLD Global Project on Antituberculosis Drug Resistance
Surveillance gathers data on drug resistance using a standard methodology in
order to determine the global magnitude o resistance to our rst-line antitu-
berculosis drugs: isoniazid, riampicin, ethambutol and streptomycin (2). Thestandard methodology includes representative sampling o patients with ad-
equate sample sizes, standardized data collection distinguishing between new
and previously treated patients and quality-assured laboratory DST supported
by a network o supranational TB reerence laboratories (SRLs).
Based on available inormation rom the duration o the Global Project (3),the most recent data available rom 116 countries and settings were weighted
by the population in areas surveyed, representing 2 509 545 TB cases, with the
ollowing results: global population weighted proportion o resistance among
new cases: any resistance 17.0% (95% condence limits (CLs), 13.620.4),
isoniazid resistance 10.3% (95% CLs, 8.412.1) and MDR-TB 2.9% (95%
CLs, 2.23.6). Global population weighted proportion o resistance among
previously treated cases: any resistance 35.0% (95% CLs, 24.145.8), isoni-azid resistance 27.7% (95% CLs, 18.736.7), MDR-TB 15.3% (95% CLs,
9.621.1). Global population weighted proportion o resistance among all TB
cases: any resistance 20.0% (95% CLs, 16.123.9), isoniazid resistance 13.3%
(95% CLs, 10.915.8) and MDR-TB 5.3% (95% CLs, 3.96.6). Based on
drug resistance inormation rom these 116 countries and settings reporting
to this project, as well as nine other epidemiological actors, it is estimated
that 489 139 (95% CLs, 455 093614 215) cases emerged in 2006. China and
India carry approximately 50% o the global burden o MDR-TB and the
Russian Federation a urther 7%.Data rom the most recent collection period showed ar greater proportions
o resistance among new cases than ound in previous reports, ranging all the
way to 16% MDR-TB among new cases in Donetsk, Ukraine, 19.4% in the
Republic o Moldova and 22.3% in Baku, Azerbaijan. Trends in MDR-TB
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5
among new cases in the Baltic countries appear to have stabilized, but there
were signicant increases reported rom the two oblasts o the Russian Federa-
tion that reported data.
Prevalent cases worldwide could be two or three times higher than thenumber o incident cases (4), as MDR-TB patients oten live or several yearsbeore succumbing to the disease (5).
Drug resistance is strongly associated with previous treatment. In previ-
ously treated patients, the probability o any resistance was over 4-old higher,
and o MDR-TB over 10-old higher, than or untreated patients. The overall
prevalence o drug resistance was oten related to the number o previously
treated cases in the country. Among countries with a high burden o TB, pre-
viously treated cases ranged rom 4.4% to 26.9% o all patients registered in
DOTS programmes. In the two largest high-TB burden countries (China and
India), re-treatment cases accounted or up to 20% o sputum smear-positive
cases (6).In 2006, the United States Centers or Disease Control and Prevention
(CDC) and WHO conducted a drug resistance survey to determine the extent
o resistance to second-line drugs. Surveying the WHO/IUATLD network o
SRLs, over 17 000 isolates rom 49 countries were included, all o which had
been tested or resistance to at least three classes o second- line drugs. These
are not population-based data, as second-line drug testing is not routinely car-ried out in most countries. The survey ound that o the isolates tested against
second-line drugs in the 49 contributing countries, 20% were MDR-TB and
2% were XDR-TB (7). Strains o XDR-TB have been reported in every regiono the world, with as many as 19% o MDR-TB strains ound to be XDR-TB,
a proportion that has more than tripled in some areas since 2000 (8). Whencapacity allows, these guidelines recommend testing all MDR-TB isolates or
resistance to a fuoroquinolone and the second-line injectable agents to dene
the proportion XDR-TB among MDR-TB (see Chapter 5 and 6).
Despite the association with previous treatment, drug-resistant strains in-cluding XDR-TB are readily transmissible and outbreaks have been reported,
oten in populations with high HIV prevalence. In one outbreak o XDR-TB
in KwaZulu-Natal, hal o the patients had never received antituberculosis
treatment (9). The overlapping epidemics o HIV and TB are signicantlyworsened by XDR-TB, as outbreaks o these strains appear to cause higher
and more rapid mortality in HIV-inected patients. Such strains pose a serious
threat to global TB control, as detection is challenging in settings where labo-
ratory resources and treatment options are severely limited.
1.7 Maagemet o DR-TB, te Gree Ligt Committee ad
te global resose to DR-TB
The Working Group on DOTS-Plus or MDR-TB (currently the Work-
ing Group on MDR-TB) was established in 1999 to lead the global eort to
1. BACkGROUND INFORMATION ON DR-TB
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GUIDELINES FOR THE PROGRAMMATIC MANAGEMENT OF DRUG-RESISTANT TUBERCULOSIS
control MDR-TB. This working group, part o the Stop TB Partnership,
ormed the Green Light Committee (GLC) in 2000 to provide technical assist-
ance to DOTS programmes, promote rational use o second-line drugs world-
wide and improve access to concessionally-priced quality-assured second-linedrugs. As DR-TB has emerged as a growing threat to DOTS programmes, new
recommendations described in these updated guidelines must become a part o
routine national TB control activities.
The GLC has developed a mechanism to assist countries in adapting the
ramework described in these guidelines to country-specic contexts. Coun-
tries that meet the ramework requirements, with a strong DOTS oundation
and a solid plan to manage DR-TB, can benet rom quality-assured second-
line drugs at reduced prices. The GLC also oers technical assistance beore
implementation o programmes or control o DR-TB and monitors approved
projects.1
A well-unctioning DOTS programme is a prerequisite or GLC endorse-
ment and or continuation o GLC support. Experience has shown that im-
plementing a DR-TB control programme substantially strengthens overall TB
control or both drug-susceptible and drug-resistant cases (10).For control o DR-TB worldwide, WHO and its partners recommend inte-
grating management o the disease into essential services or TB control and
expanding treatment or DR-TB as rapidly as human, nancial and technicalresources will allow.
Reereces
1. Lambregts-van Wezenbeek CSB, Veen J. Control o drug-resistant tuber-
culosis. Tubercle and Lung Disease, 1995, 76:455459.2. Interim recommendations or the surveillance o drug resistance in tuber-
culosis. Geneva, World Health Organization, 2007 (WHO/CDS/TB/2007.385).
3. Anti-tuberculosis drug resistance in the world. Fourth global report. TheWHO/IUATLD global project on anti-tuberculosis drug resistance surveil-lance, 20022007. Geneva, World Health Organization, 2008 (WHO/HTM/TB/2008.394).
4. Blower SM, Chou T. Modeling the emergence o the hot zones: tuber-
culosis and the amplication dynamics o drug resistance. Nature Medi-cine, 2004, 10(10):11111116.
5. Migliori GB et al. Frequency o recurrence among MDR-TB cases
successully treated with standardized short-course chemotherapy. Inter-
national Journal o Tuberculosis and Lung Disease, 2002, 6(10):858864.
1 For more inormation about the services o the GLC and or technical support or to apply or ac-cess to concessionally-priced quality-assured second-line antituberculosis drugs, see the GLC webpage at: http://www.who.int/tb/challenges/mdr/greenlightcommittee/en/index.html
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7
6. Global tuberculosis control: surveillance, planning, fnancing. WHOreport 2008. Geneva, World Health Organization, 2008 (WHO/HTM/TB/2008.393).
7. The Global MDR-TB and XDR-TB Response Plan 20072008. Geneva,World Health Organization, 2007 (WHO/HTM/TB/2007.387).
8. Emergence o Mycobacterium tuberculosis with extensive resistance to
second-line drugs worldwide, 20002004. Morbidity and MortalityWeekly Report, 2006, 55(11):301305.
9. Gandhi NR et al. Extensively drug-resistant tuberculosis as a cause o
death in patients co-inected with tuberculosis and HIV in a rural area o
South Arica. Lancet, 2006, 368(9547):15751580.10. Kim JY et al. From multidrug-resistant tuberculosis to DOTS expansion
and beyond: making the most o a paradigm shit. Tuberculosis, 2003,83:5965.
1. BACkGROUND INFORMATION ON DR-TB
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CHAPTER 2
Frameork or eectiecotrol o DR-TB
2.1 Chapter objecties 8
2.2 DOTS ramewor applied to the management o DR-TB 8
2.2.1 Sustained political commitment 9
2.2.2 A rational case-fnding strateg including accurate, timel
diagnosis through qualit-assured culture and DST 9
2.2.3 Appropriate treatment strategies that use second-line
drugs under proper case management conditions 9
2.2.4 Uninterrupted suppl o qualit-assured antituberculosis drugs 10
2.2.5 Standardized recording and reporting sstem 10
2.3 A plan or tailored integration o management o DR-TB into
national programmes 112.4 Summar 11
Box 2.1 ke steps or integrating management o DR-TB into
national TB control programmes 12
Box 2.2 List o ariables to consider when assessing needs or
integrating management o DR-TB into national TB control
programmes 12
Box 2.3 Fie components o DOTS as applied to DR-TB 13
2.1 Cater objecties
This chapter describes the ve essential components o the DOTS ramework
as they apply to the management o DR-TB. It also introduces a systematic ap-
proach or tailoring these components to the local situation, with integration
into a DOTS-based NTP.
2.2 DOTS rameork as alied to te maagemet o DR-TB
The ramework or DR-TB is organized around the ve components o the
DOTS strategy because the underlying principles are the same (12):a. Sustained political commitment
b. A rational case-nding strategy including accurate, timely diagnosis
through quality-assured culture and DST
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2. FRAMEWORk FOR EFFECTIvE CONTROL OF DR-TB
c. Appropriate treatment strategies that use second-line drugs under proper
case management conditions
d. Uninterrupted supply o quality-assured antituberculosis drugs
e. Standardized recording and reporting system
Each o these components involves more complex and costly operations than
those or controlling drug-susceptible TB. However, addressing DR-TB usu-
ally strengthens the NTP.
2.2.1 Sustained political commitment
Sustained political commitment is essential to establish and maintain the
other our components. It requires both long-term investment and leader-
ship to ensure an appropriate environment or integrating the managemento DR-TB into NTPs. An appropriate environment includes adequate inra-
structure, development and retention o human resources, interagency cooper-
ation, enactment o necessary legislation, TB control policies enabling rational
implementation o the programme and acilitation o the procurement o qual-
ity-assured second-line drugs. In addition, the NTP must be strengthened to
prevent the emergence o more MDR-TB and XDR-TB cases.
2.2.2 A rational case-fnding strateg including accurate, timel
diagnosis through qualit-assured culture and DSTAccurate, timely diagnosis is the backbone o a sound NTP. DR-TB must be
diagnosed correctly beore it can be treated eectively. Case-nding strate-
gies may vary depending on the epidemiological situation and local capacity.
In some settings, all TB patients are tested with culture and DST. However,
in most settings, only patients with an increased risk o DR-TB are tested
(strategies on which risk groups to test are discussed in Chapter 5). In areas
where XDR-TB threatens TB control, laboratories should develop the capac-
ity or DST to second-line injectable agents and the fuoroquinolones in order
to diagnose XDR-TB.Quality-assured culture and DST are indispensable. Non-viable cultures,
culture contamination and unreliable DST results have major consequences
or both individual patients and the NTP as a whole. Internal quality control
and external quality assurance should thereore be in place, including a link
or prociency testing with a recognized reerence laboratory such as one o
the WHO-recognized SRLs.
2.2.3 Appropriate treatment strategies that use second-line drugs
under proper case management conditions
An appropriate treatment strategy consists o a rational method or designing
the optimal treatment regimen, a patient-centered approach or delivering this
regimen with direct observation, and a plan or monitoring and managing
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GUIDELINES FOR THE PROGRAMMATIC MANAGEMENT OF DRUG-RESISTANT TUBERCULOSIS
adverse drug reactions. Designing an optimal regimen requires proessional
expertise to consider several actors together, including:
representative data on drug resistance surveillance (DRS) o well-dened
local groups o TB patients, distinguishing new cases and dierent types o
re-treatment cases;
history o drug use in the country and in the individual;
specic array o available second-line drugs;
availability o DST to rst- and selected second-line drugs;
reliable options or delivering directly observed therapy (DOT) or up to
two years;
addressing patients coinected with HIV;
proper inection control policies implemented.A standardized regimen or certain groups o patients may be more appropri-
ate than an individualized regimen in some countries, while in others the con-
verse may be best.
The choice between hospitalization and ambulatory treatment depends on
several actors in addition to the severity o the disease. Such actors include
the availability o hospital beds with adequate inection control measures to
prevent nosocomial transmission; the availability o trained personnel at hos-
pitals and clinics to administer treatment and manage adverse drug reactions;
the availability o a social support network to acilitate adherence to ambu-
latory treatment; and the presence o other clinical or social conditions in
patients.
2.2.4 Uninterrupted suppl o qualit-assured
antituberculosis drugs
Management o second-line drugs is complex, especially when individualized
treatment regimens are used. Drugs are requently changed as a result o ad-
verse eects, delayed DST results and poor response to treatment. In addition,most second-line drugs have a short shel-lie, global production o quality-
assured drugs is limited, and drug registration may be a lengthy and costly
process that is not always attractive to drug manuacturers. Steps to ensure an
uninterrupted drug supply must begin six months or more in advance o the
anticipated need, and drug needs must be estimated as accurately as possible.
Countries should use only drugs that have been quality-assured by a stringent
drug regulatory authority recognized by WHO, a WHO prequalication pro-
gramme or that meet WHO GMP standards.
2.2.5 Standardized recording and reporting sstem
The specic characteristics o a DR-TB control programme include a record-
ing system with dierently dened categories or patient registration, culture
and DST results, and monitoring o treatment delivery and response or 24
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months. Cohort analysis includes interim indicators and treatment outcomes
ater two or more years, as well as treatment outcomes by treatment regimen
and DST results. The set o case registration groups and treatment outcome
denitions or MDR-TB used in these guidelines (Chapter 4) were developedthrough a process that involved the Stop TB Working Group on DOTS-Plus
or MDR-TB (3). They can be used or conducting cohort analyses in DR-TB control programmes. The redesigned recording and reporting system (see
Chapter 18) is essential or evaluating programme perormance and treatment
eectiveness.
2.3 A la or tailored itegratio o maagemet o DR-TB
ito atioal rogrammes
Management o DR-TB should be ully integrated into the NTP. The chal-lenge involved in this integration should not be underestimated. However, the
complexity o the process should not deter programmes rom taking the steps
necessary to allow all patients with DR-TB access to lie-saving treatment. I
many o the patients with DR-TB are treated in the private sector, integra-
tion can be acilitated through PPM approaches. Box 2.1 depicts the three key
steps o a plan or integrating the management o DR-TB into NTPs.
The most important consideration is the political will to deliver rational
treatment to patients with DR-TB as part o a sound NTP. Following conr-
mation o political will, a needs assessment should be carried out. Box 2.2 lists
the most relevant variables to consider.
The needs assessment will acilitate the design and implementation o a
plan to meet the gaps identied, in terms o both inrastructure and unction-
ing o the health-care system. Once the inrastructure is in place and the key
unctions such as a quality-assured TB laboratory are operating, a stepwise
integration o activities to control DR-TB can proceed within the NTP. Step-
wise integration means that those districts or administrative areas where the
integration is more likely to succeed should be prioritized.The design and implementation o a DR-TB control programme may vary
between and within countries, depending on the local needs and resources
available. Despite a wide range o acceptable strategies, essential requirements
such as quality-assured laboratories or diagnosis and monitoring o treat-
ment response, delivery o DOT and use o quality-assured second-line drugs
should be met under all conditions to ensure proper case management and
prevent the emergence o resistance to second-line drugs.
2.4 SummarThe DOTS ramework approach to management o DR-TB, summarized in
Box 2.3, includes ve essential components that orm the basis or every NTP
that includes detection and treatment o DR-TB.
2. FRAMEWORk FOR EFFECTIvE CONTROL OF DR-TB
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GUIDELINES FOR THE PROGRAMMATIC MANAGEMENT OF DRUG-RESISTANT TUBERCULOSIS
Reereces
1. Treatment o tuberculosis: guidelines or national programmes, 3rd ed.Geneva, World Health Organization, 2003 (WHO/CDS/TB/2003.
313).
2. An expanded DOTS ramework or eective tuberculosis control. Geneva,World Health Organization, 2002 (WHO/CDS/TB/2002.297).
3. Laserson KF et al. Speaking the same language: treatment outcome
denitions or multidrug-resistant tuberculosis. International Journal o Tuberculosis and Lung Disease, 2005, 9(6):640645.
BOx 2.1
Ke stes or itegratig maagemet o DR-TB ito atioal TB
cotrol rogrammes
1. Assessment o political will to delier rational treatment to patients with
drug-resistant TB.
2. Needs assessment or drug-resistant TB control actiities.
3. Design and implementation o a plan or management o drug-resistant TB
and its stepwise integration into the national TB control programme.
BOx 2.2
List o ariables to cosider e assessig eeds or itegratig
maagemet o DR-TB ito atioal TB cotrol rogrammes
Magnitude and distribution o DR-TB
Magnitude o HIv
Preailing patterns o drug resistance
Options or case-fnding
Existing inrastructure o the health-care sstem
Aailable laborator capacit
Resources aailable or DOT oer a prolonged period
Inection control polic in place and adequate unding aailable or control
measures
Qualit standards o the laborator networ
Aailabilit o human resources
Training needs Existing legal ramewor or management o second-line drugs
Needs or external technical assistance
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2. FRAMEWORk FOR EFFECTIvE CONTROL OF DR-TB
BOx 2.3 FIvE COMpOnEnTS OF DOTS AS AppLIED TO DR-TB
1. Sustaied olitical commitmet
Addressing the actors leading to the emergence o MDR-TB
Long-term inestment o sta and resources
Coordination o eorts between communities, local goernments and inter-
national agencies
A well-unctioning DOTS programme
2. Aroriate case-dig strateg icludig qualit-assured culture
ad DST
Rational triage o patients into DST and the DR-TB control programme
Relationship with supranational TB reerence laborator
3. Aroriate treatmet strategies tat use secod-lie drugs uder
roer case maagemet coditios Rational treatment design (eidence-based)
DOT
Monitoring and management o aderse eects
Properl trained human resources
4. Uiterruted sul o qualit-assured secod-lie atituberculosis
drugs
5. Recordig ad reortig sstem desiged or DR-TB cotrol
rogrammes tat eables moitorig o erormace ad ealuatio o
treatmet outcomes
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14
CHAPTER 3
political commitmet adcoordiatio
3.1 Chapter objecties 14
3.2 General considerations 14
3.3 Political commitment 14
3.3.1 Sufcient economic support 15
3.3.2 Regulator and operational documents 15
3.4 Coordination 16
3.5 Proposed checlist 17
Box 3.1 Proposed elements o the DR-TB control programme manual 16
Box 3.2 Summar checlist or DR-TB control programme managers 18
3.1 Cater objecties
Sustained political commitment is a prerequisite or control o DR-TB. This
chapter considers how political commitment can be translated into practical
measures to support all aspects o the ramework or control o DR-TB, and
the practical implications or NTPs. The main elements are described and a
checklist or programme managers is provided.
3.2 Geeral cosideratios
Sustained political commitment and leadership are the oundation or any
sound programme to control TB. The legal and regulatory context denes
the potential as well as the structure and policies o NTPs and DR-TB control
programmes. Political commitment is expressed through adequate nancial
support and appropriate inrastructure, including acilities and trained sta.
Coordination among the dierent components o public and private health-
care programmes and organizations is essential or successul programme im-
plementation. Sucient training and retention o medical and public health
personnel depend on long-term government planning and support.
3.3 political commitmet
Political commitment must be expressed at all stages o the health intervention
process, rom planning and implementation to monitoring and evaluation.
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3. POLITICAL COMMITMENT AND COORDINATION
Political support needs to be garnered rom sources including government
ministries and regional departments responsible or TB control, nongovern-
mental organizations and the private sector, the pharmaceutical industry,
academic and research institutions, proessional medical societies and thedonor community. This commitment takes the orm o nancial and human
resources, training, legal and regulatory documents, inrastructure and coor-
dination o all stakeholders involved in all aspects o the ramework or control
o DR-TB.
3.3.1 Sufcient economic support
The NTP budget must be sucient to develop and retain an adequate work-
orce with interest and expertise in DR-TB without weakening the workorce
o the national programme as a whole. The nancial resources needed to sup-
port the ramework should be provided. There should be no nancial barriers
to patients accessing appropriate care or DR-TB. Human resource needs are
discussed in Chapter 16.
3.3.2 Regulator and operational documents
Beore embarking on a DR-TB control programme, national and regional au-
thorities need to develop policies as a oundation or any subsequent legal,
administrative and technical support necessary or the initiation, implementa-tion and monitoring o the programme. Regulatory document(s) should con-
sider how the programme will be integrated into the NTP. The ollowing are
examples o the use o regulatory and operational documents:
Legislation can be drated to ensure proper registration, availability, qual-
ity, saety and distribution o second-line drugs. (Oten, strict control o
second-line drugs is possible only ater establishment o the programme to
provide quality-assured drugs ree o charge to patients.)
A local steering committee or expert committee can be ormed to meetperiodically to consult on individual patients and to address programmatic
problems.
A memorandum o understanding delineating responsibilities and unding
is oten necessary i multiple organizations are involved. In settings where
programmes involve dierent ministries or departments (including, or ex-
ample, the prison system or the social security system), an interministerial
or interdepartmental agreement should be signed that codies the mecha-
nism or coordinating services or diagnosis o TB and treatment o patients
between all authorities.
A programme manual can be the vehicle or disseminating operational and
clinical protocols to ensure consistency. It should be ocially endorsed by
the relevant authorities. The manual describes treatment protocols, denes
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GUIDELINES FOR THE PROGRAMMATIC MANAGEMENT OF DRUG-RESISTANT TUBERCULOSIS
responsibilities or dierent health-care providers and delineates the hu-
man resources that will be needed. It specically denes how disease will be
diagnosed and how patients will be registered, reported, treated and ol-
lowed up, in addition to programme monitoring and evaluation. Items tobe included in the programme manual are proposed in Box 3.1.
BOx 3.1 pROpOSED ELEMEnTS OF ThE DR-TB COnTROL
pROGRAMME MAnUAL
Bacground inormation on the DOTS programme and its integration with
treatment o patients with DR-TB
Organization and management o the DR-TB control programme
Case detection, diagnosis, classifcation o and reporting requirements or
drug-resistant TB
Organization o the laborator networ, including qualit control proceduresor laboratories proiding culture and DST
Treatment regimens or drug-resistant TB
Management o aderse eects caused b antituberculosis drugs
Management o drug-resistant TB in special populations and situations (in-
cluding children; pregnant or lactating women; diabetes mellitus; HIv; renal
or hepatic insufcienc; the elderl; alcohol and drug-dependent patients;
prisoners)
Case management sstem including DOT, transition to ambulator care,
patient assistance and deaulter tracing
Standards or ealuation and monitoring o treatment and o oerall project
perormance Plan or inection control in health acilities and other methods to preent
drug-resistant TB
3.4 Coordiatio
Coordination needs to include the contributions o all the key stakeholders,
organizations and external partners, as considered below.
National TB control programme. The NTP is the central coordinating
body or the activities described in the strategic ramework. Commitmento the necessary resources, particularly or a strong central management
team, ensures that all elements are in place, rom the procurement o sec-
ond-line drugs to the appropriate implementation and monitoring o the
DR-TB control programme. As needed, the national programme may build
partnerships with all relevant health-care providers.
Local health system. DR-TB control programmes should be tailored to
t the local inrastructure. The precise organizational structure o the pro-
gramme may vary greatly between dierent settings depending on how
the local health care is provided. Transer rom hospitals to outpatient set-
tings or between DOT centres requires care, advance planning and good
communication. Given the type o care required during the treatment o
DR-TB patients, a team o health workers including physicians, nurses and
social workers is oten used.
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Community level. Community involvement and communication with
community leaders can greatly acilitate implementation o treatment and
respond to needs that cannot be met by medical services alone. Commu-
nity education, involvement and organization around TB issues can ostercommunity ownership o control programmes and reduce stigma. In some
circumstances, communities have helped to address the interim needs o
patients, including the provision o DOT, ood and/or housing. Commu-
nity health workers oten play a critical role in ambulatory care o DR-TB
patients.
Coordination with prisons (1). Transmission in prisons is an importantsource o spread o DR-TB in some countries, and inection control meas-
ures can reduce incidence substantially. In many cases, inmates are releasedrom prison beore they nish treatment. Close coordination and commu-
nication with the civilian TB control programme, advance planning, tar-
geted social support and specic procedures or transerring care will help
ensure that patients complete treatment ater release rom prison.
All health-care providers (both public and private) (2). In some coun-tries, private practitioners manage most cases o DR-TB. In these settings,
it is important to involve the private sector in the design and technical as-
pects o the programme. Many PPM programmes have demonstrated eec-
tive and mutually benecial cooperation (3). In PPM systems, patients andinormation move in both directions. For example, private providers can be
compensated airly through negotiated systems o reimbursement, and the
public health system may provide clinic- or community-based DOT as well
as registering patients and their treatment outcomes. Similar PPM mixes
can be established or treatment o patients with DR-TB, but they require
exceptional coordination. The public health system may also get involved
in training on national guidelines or DR-TB.
International level. International technical support through WHO, theGLC, SRLs and other technical agencies is recommended. The NTP
should set up and lead an interagency body that ensures clear division o
tasks and responsibilities.
3.5 proosed cecklist
From the earliest planning phase, the ull range o issues encompassed in po-
litical commitment needs to be addressed. These include adequate nancial
support, an enabling regulatory environment, sucient human resources, ad-
equate physical inrastructure and good coordination. In addition, a communi-
cation strategy should be established to ensure that inormation is disseminated
eectively rom the central level to the periphery and that reports rom the peri-
pheral level are received centrally. Box 3.2 provides a checklist or programme
managers, summarizing the key aspects o a DR-TB control programme.
3. POLITICAL COMMITMENT AND COORDINATION
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GUIDELINES FOR THE PROGRAMMATIC MANAGEMENT OF DRUG-RESISTANT TUBERCULOSIS
Reereces
1. Bone A et al. Tuberculosis control in prisons: a manual or programmemanagers. Geneva, World Health Organization, 2000 (WHO/CDS/TB/2000.281).
2. Involving private practitioners in tuberculosis control: issues, interventions
and emerging policy ramework. Geneva, World Health Organization,2001 (WHO/CDS/TB/2001.285).
3. Towards scaling up. Report o the Third Meeting o the PPM Subgroup orDOTS Expansion. Geneva, World Health Organization, 2005 (WHO/CDS/TB/2005.356).
BOx 3.2 SUMMARy ChECKLIST FOR DR-TB COnTROL pROGRAMME MAnAGERS
preetio Sound implementation o DOTS programme
Inection control measures taen where all DR-TB patients will be treated
Contact tracing or MDR-TB cases in place
Laborator
Testing and maintenance o equipment
Biosaet measures in place
Reagents suppl
Superision and qualit assurance sstem (relationship with SRL estab-
lished)
Sstem or reporting laborator results to the treatment centre
Laborator or monitoring o electroltes, creatinine, lipase, throid unc-
tion, lier enzmes, and hematocrit in place Point-o-care HIv testing, with counselling and reerral aailable
Pregnanc testing
patiet care Council o experts or steering committee set up
Adequate capacit and trained sta at the health centre or DOT and
patient support
DOT in place and plan to ensure case holding
Sstem to detect and treat aderse eects, including suppl o appropriate
medications
Patient and amil support to increase adherence to treatment, such as
support group, pschological counselling, transportation subsid, ood bas-ets
Patient, amil and communit health education, including stigma reduc-
tion
programme strateg Integration with DOTS programme
Sources o DR-TB identifed and corrected
Legislation or treatment protocols accepted
Project manual published and disseminated
Agreement o criteria or prioritization o patient waiting lists
Location o care defned and unctional (ambulator s hospitalization)
Integration o MDR-TB serices with HIv care Integration o all health-care proiders into the DR-TB control programme
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CHAPTER 4
Deitios:case registratio, bacteriolog
ad treatmet outcomes
4.1 Chapter objecties 19
4.2 Defnitions o drug resistance and diagnostic Categor Iv 20
4.3 Site o DR-TB disease (pulmonar and extrapulmonar) 20
4.4 Bacteriolog and sputum conersion 21
4.5 Categor Iv patient registration group based on preious
antituberculosis treatment 21
4.6 Defnitions or diagnostic Categor Iv treatment outcomes 23
Box 4.1 Helpul hints on registrations and defnitions 25
4.1 Cater objectiesThis chapter establishes case denitions, patient registration categories, bac-
teriological terms, treatment outcome denitions and cohort analysis proce-
dures or patients who meet WHO Category IV diagnostic criteria.1 It is an
extension o the basic DOTS inormation system (1,2).The categories, denitions and procedures dened in this chapter will
acilitate the ollowing:
standardized patient registration and case notication;
assignment to appropriate treatment regimens; case evaluation according to disease site, bacteriology and history o treat-
ment;
cohort analysis o registered Category IV patients and Category IV treat-
ment outcomes.
1 Treatment o tuberculosis: guidelines or national programmes(1) recommends treatment regimensbased on dierent TB diagnostic categories. The diagnostic categories are:
Category I New smear-positive patients; new smear-negative pulmonary TB (PTB) with exten-sive parenchymal involvement; severe concomitant HIV disease or severe orms o extrapulmo-
nary TB.Category II Previously treated sputum smear-positive PTB: relapse; treatment ater interrup-tion; ailures.Category III New smear-negative PTB (other than in Cat I) and less severe orms o extra-pulmonary TB.Category IV Chronic cases (still sputum-positive ater supervised re-treatment) and MDR-TB.
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GUIDELINES FOR THE PROGRAMMATIC MANAGEMENT OF DRUG-RESISTANT TUBERCULOSIS
4.2 Deitios o drug resistace ad diagostic Categor Iv
DR-TB is conrmedthrough laboratory tests that show that the inecting
isolates oMycobacterium tuberculosisgrow in vitro in the presence o one or
more antituberculosis drugs (see Chapter 6 or urther inormation on labo-ratory requirements). Four dierent categories o drug resistance have been
established:
Mono-resistance: resistance to one antituberculosis drug.
Poly-resistance: resistance to more than one antituberculosis drug, other
than both isoniazid and riampicin.
Multidrug-resistance : resistance to at least isoniazid and riampicin.
Extensive drug-resistance: resistance to any fuoroquinolone, and at least
one o three injectable second-line drugs (capreomycin, kanamycin and
amikacin), in addition to multidrug-resistance.
Diagnostic Category IVincludes patients with:
Conrmed MDR-TB.
Suspected MDR-TB. This requires that the relevant health authority (such
as a review panel) recommends that the patient should receive Category IV
treatment. Patients may be entered in the Category IV register and started
on Category IV treatment beore MDR-TB is conrmed onlyi representa-
tive DST surveys or other epidemiologic data indicate a very high probabil-
ity o MDR-TB (see Chapter 5).
Poly-resistant TB. Some cases o poly-resistant TB will require Category
IV treatments. These patients require prolonged treatment (18 months or
more) with rst-line drugs combined with two or more second-line drugs
(see Chapter 8, Table 8.1) and should be entered into the Category IV reg-
ister. (Most programmes choose to keep cases o mono- and poly-resistancethat do not require second-line drugs or require only one second-line drug,
in the District TB Register).
4.3 Site o drug-resistat TB disease
(ulmoar ad etraulmoar)
In general, recommended treatment regimens or drug-resistant orms o TB
are similar, irrespective o site. The importance o dening site is primarily or
recording and reporting purposes.
Pulmonary TB. Tuberculosis involving only the lung parenchyma.
Extrapulmonary TB. Tuberculosis o organs other than the lungs, e.g.
pleura, lymph nodes, abdomen, genitourinary tract, skin, joints and bones,
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4. DEFINITIONS: CASE REGISTRATION, BACTERIOLOGy AND TREATMENT OUTCOMES
meninges. Tuberculous intrathoracic lymphadenopathy (mediastinal and/
or hilar) or tuberculous pleural eusion, without radiographic abnormali-
ties in the lungs, thereore constitutes a case o extrapulmonary TB. The
denition o an extrapulmonary case with several sites aected depends onthe site representing the most severe orm o disease.
Patients with both pulmonary and extrapulmonary TB should be classied as
a case o pulmonary TB.
4.4 Bacteriolog ad sutum coersio
Bacteriological examinations used in patients with DR-TB include sputum
smear microscopy and culture. Sputum smear microscopy and culture should
be perormed and results reported according to international standards (3).These examinations should be done at the start o treatment to conrm TBdisease and to group the patients according to inectiousness, sputum smear-
positive being most inectious.
At least one sputum sample or smear and culture should always be taken
at the time o Category IV treatment start. In order or a patient to be consid-
ered culture- or sputum smear-positive at the start o Category IV treatment,
the ollowing criteria must be met: at least one pre-treatment culture or smear
was positive; the collection date o the sample on which the culture or smear
was perormed was less than 30 days beore, or 7 days ater, initiation o Cat-egory IV treatment.
Sputum conversion is dened as two sets o consecutive negative smears
and cultures, rom samples collected at least 30 days apart. Both bacterio-
logical techniques (smear and culture) should be used to monitor patients
throughout therapy (see Chapter 11). The date o the rst set o negative cul-
tures and smears is used as the date o conversion (and the date to determine
the length o the initial phase and treatment).
The recording and reporting system assesses the smear- and culture-status
6 months ater the start o treatment as an interim outcome. Programmesoten use the smear and culture conversion rate at 6 months to assess pro-
gramme perormance (see Chapter 18).
4.5 Categor Iv atiet registratio grou based o istor o
reious atituberculosis treatmet
Category IV patients should be assigned a registration group based on their
treatment history, which is useul in assessing the risk or MDR-TB. Since
DST is targeted at certain risk groups or MDR-TB (see Chapter 5), the treat-
ment history should be assessed at the time o collecting the sputum sam-
ple, which is ultimately used to conrm MDR-TB. Patients registered as
Category IV without laboratory conrmation o MDR-TB should be grouped
by their status when registered as diagnostic Category IV.
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GUIDELINES FOR THE PROGRAMMATIC MANAGEMENT OF DRUG-RESISTANT TUBERCULOSIS
The registration groups describe the history o previous treatment and do
not purport to explain the reason(s) or drug resistance.1
Each Category IV patient should be classied in two dierent ways:
I. Classication according to history o previous drug use, mainly to as-
sign the appropriate treatment regimen.
New. A patient who has received no or less than one month o antitubercu-
losis treatment. Patients are placed in this group i they had sputum collect-
ed or DST at the start o a Category I regimen and were then switched to a
Category IV regimen because MDR-TB was later conrmed. They should
be considered new i DST was perormed within one month o the start
o treatment (even i they had received more than one month o Category I
treatment by the time the results o DST returned and they were registeredas Category IV).
Previously treated with rst-line drugs only. A patient who has been
treated or one month or more or TB with only rst-line drugs.
Previously treated with second-line drugs. A patient who has been treat-
ed or one month o
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