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For 25 years, Cisbio Bioassays has been committed to
offering innovative solutions and kits to speed up research
into new medicines.
From oncology and CNS to metabolic disorders,
rare diseases, and more, Cisbio helps you reach your drug discovery objectives with trusted solutions that streamline your research
efforts
With its headquarters in France and 3 subsidiaries around the world, Cisbio has never been closer to you, working with your
team in a true partnership day after day.
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Click on the interested product and be redirected
to the associated product on Cisbio website.
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SUMMARY
GPCRs
Cell signaling Phospho-assays
Cell signaling Cytokines
Biomarkers
Biotherapeutic development tools
Cisbio drug discovery services
Biochemical & cell-based epigenetics
KinEASE™
Protein-protein interaction tools
HTRF® compatible readers
Therapeutic areas
Kits and reagents to speed up your projects
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GPCRs
cAMP IP1
p-ERKp-AKT
Tag-lite®
Cell-based kits for GPCR investigation
• Second messengers (cAMP, IP-One)
• Ready-to-use binding assays: Tag-lite®
• Downstream phospho-markers: p-AKT, p-ERK
www.cisbio.com/gpcr
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Explore the cell function
• Up to 20 times more sensitive than WB
• Validated on 2D and 3D cell cultures, cell tissues and tumor xenografts
• High species cross-reactivity
• A single, simple add-and-read protocol for all kits
* Phospho & Total
Listen toyour cellular
pathway
Cell signaling
Phospho-assays
p-VASP*
p-LRRK2*p-Tau*
p-SMAD1*p-SMAD3
p-IKKβp-NFκB
p-ACCp-AMPK*
p-AKT* p-mTor
p-STAT3* p-STAT5
p-p38MAPK p-JNK p-cJun
p-YAP
p-H2AXp-Histone H3*
p-β-catenin* p-GSK3 α* p-GSK3 β*
Advanced pERK p-ERK* p-MEK1
p-MEK1/2* P-CREB
p-EGFR* p-HER2* p-HER3*
p-IR beta*p-VEGFR2
p-S6RP p-EIF4E p-70S6K p4-EBP1
p-Badp-BTK
www.cisbio.com/cell-signaling
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Cell-based assays made simple
• Strong correlation with ELISA
• Single protocol for all kits
• Low sample consumption: 10 µL
• Easily combined with other detection types (HCS, phospho, label-free)
CCL20 (h)
G-CSF (h)
GROα (h) CXCL1
IFNα (h)
IFNγ (h & m)
IL1α (h & m)
IL1β (h & m)
IL2 (h & m)
IL4 (h)
IL5 (h)
IL6 (h & m)
IL8 (h)
IL10 (h)
IL12 (h)
IL17 (h & m)
IL18 (h)
IL23 (h)
IL31 (h)
MCP1 (h)
MIP-1 β (h)
TNFα (CyPV)
TNFα (h & m)
Cell signaling
Cytokines
www.cisbio.com/cytokines
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From ready-to-use kits to custom assay development:
• A cost-effective alternative to ELISA
• Simple add-and-read protocol
• Reproducible, highly sensitive assays
Histamine
LTB4 / LTC4Prostaglandin E2
Amyloid beta 1-40 (h)alpha-SynucleinAPP substrate
Biotin-APP substrate-KGAD67
MANF (h)MAP-Tau
Tau aggregation
Active GLP1Glucagon
IGF1 (r)Insulin
Apo A1/B/C3/E (h)
c-Myc cell-based (h)
FMRP (h)Frataxin (h)MBNL1 (h)
SMN (h)Utrophin (h & m)
AldosteroneCortisolEstradiol
ProgesteroneTestosterone
cGMP
Heme Oxygenase (h)PCSK-9 (h)Pro-collagen Type 1 (h)cleaved PARP
alpha Tubulin acetyl K40alpha Tubulin
Biomarkers
www.cisbio.com/biomarkers
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Tools for biotherapeutic characterization
• CD16 and variant assays for ADCC prediction
• Human and mouse IgG quantification kits
• CHO host cell protein kit for contaminant quantification
• Tag-lite® for Ab screening on cell surface targets
• Cell-signaling assays: cytokines, P-proteins, 2nd messengers
Biotherapeutic
development tools
www.cisbio.com/biotherapeutics
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Fast, reliable services provided by HTRF experts
• Protein/antibody labeling in 3 days
• Antibody pair for immunoassays in 2 weeks
• Full HTRF assay development
• Early ADCC prediction for MAb optimization
• Compound profiling
Cisbio
drug discovery
services
www.cisbio.com/htrf-services
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Explore epigenetic modifications
• Specific cell-based assays
• Specific and universal biochemical assays
• Extensive enzyme validation
• Downstream signaling assays
Binding domain assays
Universal SAH detection formethyltransferases
Epigenetic cell-basedmethyltransferase
assay
Epigenetic markspecific assays
Biochemical
&
cell-based
epigenetics
www.cisbio.com/epigenetics
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Kits for Serine/Threonine and Tyrosine kinases
• Over 107 Ser/Thr and 58 Tyr kinases validated
• Complete kit for simplified kinase assay development
• Compatible with a broad range of [ATP]
• Low enzyme comsumption
KinEASE™
www.cisbio.com/kinease
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Benefit from unlimited flexibility for your assay development
• Validated on numerous target configurations
• Anti-tag: 6His, c-myc, FLAG, GST, MBP, HA, DNP
• Anti-species: human, rabbit, mouse, prot A
• Affinity: streptavidin
• Custom labeling services for coupling untagged proteins
Protein-protein
interaction tools
www.cisbio.com/toolbox
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HTRF® compatible
readers
www.cisbio.com/htrf-compatible-readers
More than 30 validated readers across 7 brands
• High standards for reader certification to serve you more effectively
• Freedom to choose equipment that matches your exact needs
• Your guarantee for top quality HTRF readouts
Can’t find your microplate reader? Check its compatibility by contacting your local Cisbio Bioassays sales and application support team.
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HTRF Solutions for Therapeutic Areas
From oncology and CNS to metabolic disorders, rare diseases, and more, Cisbio helps you reach your drug discovery objectives with trusted solutions that streamline your research efforts.
Therapeutic areas
Oncology Infectious diseases
Inflammation / Immunology
Rare diseases
Neurosciences
Metabolism / Diabetes
Cardiovascular
www.cisbio.com/therapeutic-areas
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* Homogeneous Time-Resolved Fluorescence
Europe and other countries +33(0)466 796 705
U.S. and Canada 1-888-963-4567
China +86 21 5018 9880
Japan +81-(0)43-306-812
Kits and reagents
to speed up
your projects
www.cisbio.com
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