7/27/2019 Introduction to Surgical Pathology
1/29
7/27/2019 Introduction to Surgical Pathology
2/29
1853 Velpeau , Paris
Ewing, Stout, Willis, AFIP-Fascicles , USA
1950 Lauren Ackerman ,
USA
7/27/2019 Introduction to Surgical Pathology
3/29
7/27/2019 Introduction to Surgical Pathology
4/29
Excisional Biopsy
Incisional Biopsy
Core Needle Biopsy
Breast, lung, soft tissue
tumor
7/27/2019 Introduction to Surgical Pathology
5/29
7/27/2019 Introduction to Surgical Pathology
6/29
FINE Needle Biopsy (FNAB)
A. Non-image guided:
Thyroid gland, breast, salivary gland,
lymph nodes, soft tissue tumor
B.Image guided:
Lungs, paraaortic tumor, retroperitonealmasses, liver
7/27/2019 Introduction to Surgical Pathology
7/29
Thyroid - Benign
7/27/2019 Introduction to Surgical Pathology
8/29
Lung adenocarcinoma
7/27/2019 Introduction to Surgical Pathology
9/29
Paps smear benign
7/27/2019 Introduction to Surgical Pathology
10/29
Paps smear squamous cell carcinoma
7/27/2019 Introduction to Surgical Pathology
11/29
Endoscopic Biopsy
Esophagus, stomach, colon
Stereotactic Biopsy
Brain
7/27/2019 Introduction to Surgical Pathology
12/29
98.58% accuracy
Intra-operative decision-
making
7/27/2019 Introduction to Surgical Pathology
13/29
Gynecological
Paps Smear
Non-gynecological
Other body fluids
Cell Block
7/27/2019 Introduction to Surgical Pathology
14/29
PAS Glycogen(Gastric signet ring adenocarcinoma)
7/27/2019 Introduction to Surgical Pathology
15/29
Mucicarmine Mucin
Reticulin Stain Reticulin Fiber
Bone marrow - AML
7/27/2019 Introduction to Surgical Pathology
16/29
Silver Stain Helicobacter Pylori, Pneumocystis
Carinii
7/27/2019 Introduction to Surgical Pathology
17/29
demonstration of
molecules present on
the surface of specific
cells that allow their
identification
7/27/2019 Introduction to Surgical Pathology
18/29
Substances produced by
tumor cells and released
to the blood
7/27/2019 Introduction to Surgical Pathology
19/29
Cytokeratin epithelial
tumors
CD45 lymphocytic tumorsCD3 T-cell tumors
CD20 B-cell tumorsCD30 Reed Stenberg cell
7/27/2019 Introduction to Surgical Pathology
20/29
Vimentin fibrosarcoma
Desmin Leiomyosarcoma
Actin RhabdomyosracomaChromogranin and
Synaptophysin neuroendocrine
tumor eg. Small cell carcinomaof the lung, medulloblastoma
7/27/2019 Introduction to Surgical Pathology
21/29
Chromogranin
(neuroendocrine tumor)
-only letter B picture
7/27/2019 Introduction to Surgical Pathology
22/29
Glial Fibrillary Acidic Protein
glial cells eg. Astrocytoma
CD117 gastrointestinal stromaltumor
Cadherin lobular carcinoma of
the breast
7/27/2019 Introduction to Surgical Pathology
23/29
ERA, PRA, Her-2-Neu breast Ca
Her-2-Neu gastric Ca
7/27/2019 Introduction to Surgical Pathology
24/29
CEA adenocarcinoma of thecolon
AFP liver
CA 19-9 - tumor of the pancreasand bile duct
PSA prostate cancer
CA-125 mucinouscystadenocarcinoma of theovary
7/27/2019 Introduction to Surgical Pathology
25/29
7/27/2019 Introduction to Surgical Pathology
26/29
7/27/2019 Introduction to Surgical Pathology
27/29
Diploid versus aneuploid
versus polyploid cells are
identified to predict therapidity of the tumor
growth
7/27/2019 Introduction to Surgical Pathology
28/29
Uses cameras attached to
microscope and hooked tothe internet
7/27/2019 Introduction to Surgical Pathology
29/29
Top Related