I IIIII

A

B

0 50 100 150 200 250 300

pGL3b -+

TgRelative luciferase activity

ALG12-+-361/+11

-+-361/+11 m4

-+-361/+11 m5

-+-361/+11 m6

-+-361/+11 m7

pGL3b -+

0 5 10 15 20 25 30Tg Relative luciferase activity

I IIIII

-209/+396

pGL3b -+

-+

0 5 10 15 20 25 30 35Tg Relative luciferase activity

-209/+396 m1-+

-209/+396 m2-+

C

+11-361 ALG12

-+-361/+11 m75’-ACCAATTGAGGCTCGCCACGAGAAGCCACCAATG-3’

-361/+11 m8 -+AgactaTGAGGCTCGCCACGAGAAGCCACCAATG

-361/+11 m9 -+ACCAATTGAGGCTCGCCACGAGAAGCCAgactaG

-209-396 CRELD2

3’-TGGTTAACTCCGAGCGGTGCTCTTCGGTGGTTAC-5’

TctgatACTCCGAGCGGTGCTCTTCGGTGGTTAC

TGGTTAACTCCGAGCGGTGCTCTTCGGTctgatC