HYPERSENSITIVITY IoriO

NORMAL immune Nhs DONTHURTthe host o o o o o oit EXCESSIVE ANTIGENS o

diseasecausing a p p p p p a

normal immuneresponse sensitized BugsEnvironment

excessive response hypersensitive self

PROCESS x i RXN TYPESimmuneresponse triggered maintained inappropriately type l ALLERGYhardtoeliminatestimulus immediatehardtoSTOPoncestarting antigenbindsto IgEantibodiSO hypersensitivity diseases Chronic onmastcell

DebilitatingHardtotreat STEPS releasemediator

allergeninhaledleatent RESULTadtyfpI ANTIBODIES injected dilation

antibodiesbindtoantigens allergenSlims 112prod SMcontractiononcellsurface THIsecretecytokines inflam persists

STEPS macrophageseat mastcellbindsIgEAbbindtocell complementactivated allergenbridgesIgEonmastcellsurfaceantigens inflamoccurs mastcelldegranulatesThesehappen RESULT cellsdieinflamharmsopsonizationlphagoc t

ShytREtAgfEainme

contentsORinflammation histamine

OR chemotacticfactorcellular dysfunction gyrqnyile.fi temnetmsjL.mem.bprPoYfIhgf'ainiadmmetabolites

phosphmetabolites leukotrienes

jtijp 3 im OMPfxE.actonBrs.sm cytokinesAbbindtoAg complexes WBCs PT RESPONSE4 complexescirca te immediateresponseminTWOTYPES egetstuck vasodibrasleak LOCAL7

SMspasm skin it.ch hivesSystemic IC inflammation granulecontentsprostag Gl diarrheadisease necrotizingvasculitis leukotrienes lung bronohoconst

complexesformedinciro laterXh hrs ANAPHYLAXIS7depositedin inserieralorgans inflamltissuedestruct itchhives redEX scrumsickness I Inoffeeisgernupnffeiinniect cytokines bronchoconstwheezin

Abmade AbAgcomplex laryngealedemalocal1C listAll complexeslodgeinkidneyjointssmallvessels Manthecomplexesformedantigeninjectsite inflamfeverpainproteinuria vomitcrampsdiarrhe

P g I l t i l iprecipitated injectionsite shockEXArthusNn ji i i localizedareaofskinNECROSIS DEATH

from1Cvasculitis

oinfoiiiin reiminaman

mn i.IEIt.i.ainEicomplexesprecipitate RELEASEcytokines macroph

INFLAMMATION inflameedemahemhurrageulceration useful ORagainst1C adorganisms kill directly

1CactivatecomplementattractIactivateneutrophilslmonocytes UpHERE inflamcelldestrucleakyvessels granulomaform

neutrophilstmonocytesreleasebadstuff TWOTYPES1CactivateclottingOUTCOMES vasoulitis glomerulonephritisarthritis Delayed Hypersensitivity TBtest

µ 1ft secretecytokines macrophagecome killE DirectcytotoxicityII Exposure atupgresainftfetfenfiD4afeInffl D8 kill targetcells

effector THImemorycellsto

fdExposure TAIcells toAgexposure CD8tcellsseeAgoncellsurf

releasecytokines activate Tcellsdiff cytotoxicTeemacrophages inflammation whichkill things like

RESULT macrophageseatAg organtransplantcellYAYNAYlotsof inflamedamage pancreaticisletcells