Pre-survey
Hemoglobin is an allosteric protein.
What does the prefix “allo” mean?
A. In B. Out C. Same D. Different E. Soothing
Pre-survey
Hemoglobin is an allosteric protein.
What does the suffix “steric” mean?
A. repulsion B. geometry/shape C. clean D. regulator E. inhibitor
Pre-survey Hemoglobin is an allosteric protein.
Put together, allosteric means that a hemoglobin changes its activity based on a
“difference in shape”
The pO2 in the lungs is 100 torr. Which would be better at picking up oxygen in the lungs?
A
Hemoglobin
B
Myoglobin has a much greater affinity for O2 at the tissues
Myoglobin picks up O2 from
hemoglobin at the capillaries and
transfers the O2 to the tissues that
need it.
Proximal Histidine
A histidine ring is attached to the iron ion. As the iron moves into the protoporphyrin ring, the histidine as well as the attached α-helix shift. This changes the 4º structure of hemoglobin.
Allosteric Regulator How does BPG affect the
affinity of hemoglobin for O2?
A) Increases O2 affinity in the lungs
B) Decreases O2 affinity in the lungs
C) Increases O2 affinity in the tissue
D) Decreases O2 affinity in the tissue
When pH drops, what happens
to hemoglobin’s
affinity for oxygen?
A) It increases
B) It decreases
C) Stays the same
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