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Genealogy
Using DNAAnalytics
GRP 7: ASUNCION, MAGLANQUE, MAS, VELASCO
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GENEALOG
Int!o to
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"
Genealogy
$a#ily %is St&'y o$ an' t!acit%ei! line%isto!y
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"esting
A (ay $o! )eo)le inte!efamily historyto go *t%ey can lea!n $!o# !ela$!o# %isto!ical 'oce
Tests of comparison
in'i+i'&als DNA to ot%et%e sa#e lineage o! to %isto!ic et%nic g!o&)s
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To know more about a persons histofamilies
P!o+i'e cl&es a*o&t a )e!sons ancesto!s an'
!elations%i)s *et(een $a#ilies
A combination of these tests from mapeople can be used to track historiespopulation
Mig!ation-#i.ing o$ )eo)le g!o&)s
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in+ol+e'P!oce'&
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S"EP /: Submission of DNA S
C%ee0sc!a)ing
1*&ccals(a*2
S)it
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S"EP 3: Sa#)le is t%en #aile' toTesting Lab
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Genealogical
"est
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"y)es o$ Genealogical "ests
/4 A&toso#al (atDNA)
34 Mitoc%on'!ial DNA (mtDNA)
64 C%!o#oso#e (Y-DNA)
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/4 A&toso#al"est (atDNA)Autosomes
- 33 #atc%e' )ai!s o$c%!o#oso#es
Autosomal DNA
-in%e!ite' $!o# *ot%)a!ents !an'o#cont!i*&tions $!o# t%ei!)a!ents, g!an')a!ents,an' so on
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#ay *e ta0en *yeit%e! a maleo! afemale
/4 A&toso#al "est (atDNA)
Used for:
!elati+e connalong any *!yo&! $a#ily t
X connection *ac0
X (%ic% *!anc$a#ily t%e #
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A&toso#al "est 1atDNA2: 8o( 'oes
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The smaller the fragment of shared autoDNA, generally the further back the conyour family tree
Relation Percentage of
aDNA Sharing()
Pa!ents an'Si*lings
;
G!an')a!ents,A&nts-Uncles,8al$si*lings
3
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"lose #s$
Distant
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Data*ases o$ Co#)anies O?e!A&toso#al DNA "ests
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Ancestr& DNA
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Relati#e %in!er
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34 Mitoc%on'!ial"est (mtDNA)'itochon!ria-
8as its o(n DNAmaternal DNA
'itochon!rial DNAin%e!ite' e.cl&si+ely$!o# o&! #ot%e!s$ollo(s an &n*!o0en#ate!nal line
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#ay *e ta0en *yeit%e! a maleo! a
female
Used for:
'i!ect #ate!n
+e!i$ying t%e o$ a co##on
ancesto! only &se$&l $o
'ete!#ining
#ate!nal anc
34 Mitoc%on'!ial"est (mtDNA)
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34 Mitoc%on'!ial"est (mtDNA)#tDNA lineages
can *e g!o&)e'toget%e! in ala!ge mtDNAtree
Eac% *!anc% o$t%is t!ee #ay
%a+e a specifcgeographicdistribution t%at%el)s in location
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Mitoc%on'!ial "est 1#tDNA2: 8o( '(o!09
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/4 o&! #tDNA !es<s
!e$e!ence se@&ence Cambridge Reerence (CRS)
34 o&! s)ecic%a)loty)ea set o$ closely lin0e' alleles t%in%e!ite' as a &nit
People with the same haplotype shacommon ancestor somewhere in the ma
line
Compared to
Determine
Lie this
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Alice
Betty
Cecily
Dotty
Erica
CRS
Beulah
Carol
Dorcas
Elizabeth
16519C 263G
315.1C
Ancestral 'tDNA PatternSample
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!mtDNA(*R+), *asic #ate!nal ancest!y*ac0 %&n'!e's o$ t%o&san's o$ yea!s
"!mtDNAPlus (*R+.), #o!e !ene' geoo!igins 'ata $o! #ate!nal line in t%e last 3,;
0$mtDNA #ull $enomic %e&uence, &n'e!st%e genealogy, %isto!ic, an' ancient ancest'i!ect #ate!nal line
0 le#els of mtDNAtests,
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ample mtDNA result
0 Y DNA T t
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0$ Y-DNA Test
Y-chromosome- Se. c%!o#oso#e t%at
is !es)onsi*le $o!#aleness 1all #ales%a+e one c%!o#oso#e2
- co)ies a!e )asse''o(n 1+i!t&ally2&nc%ange' $!o#
$at%e! to son eac%
0 Y DNA T t
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0$ Y-DNA Test
'#or (ales )nly!
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1DNA "est2: 8o( 'oes it (o!09
/ DNA t t lt
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/4 o&! DNA test !es<s
n*e!s !e)!esent t%e !e)eats 1st&tte!s2 $eac% o$ t%e teste' #a!0e!s on t%e c%!o#
34 o&! s)ecic DNA%a)loty)e
$o! )ate!nal line%ame as, or e*tremely similar to, all o
males who ha+e come before you on y
Contains a gene!al %a)log!st!ing o$ n*e!s
Determine
Lie this
%amil&Tree, Y DNA
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%amil&Tree, Y-DNATest
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A&'ience
'aternal origin tests
-e.act #atc%ing on t%e #tDNA $&ll se@&enc
1eographical origin tests-atte#)t to #eas&!e an in'i+i'&alBs #i.e' g
%e!itage *y i'enti$ying )a!tic&la! #a!0e!s
i$e$US, Nati+e A#e!ican, A$!ican, Mel&ngeoCo%ani#, E&!o)ean, 8in'& Ancest!y
raphical origin tests (1enographic Pro2ect
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raphical origin tests (1enographic Pro2ect
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enets
I#)o!tance
an'
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+e!i$y e.isting !esea!c%es
Esta*lis% t%e !elation o$ t(o s&!na#e +a!iants
P!o+i'e locations $o! $&!t%e! genealogical
!esea!c%es
8el) 'ete!#ine t%e ancest!al %o#elan'
8el) 'isco+e! li+ing !elati+es
Positi#e results ma& ,
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Positi#e results ma&, Con!# o! 'eny s&s)ecte' connections
*et(een $a#ilies P!o+e o! 'is)!o+e t%eo!ies !ega!'ing anc
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Do(nsi'e9
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"%e ne(e! genetic admi*ture tests
t%e c%ance o$ #isi'enti$ying ancest!al gt%ese genealogy tests #ay *e )e!cent
SNPS t%at 'isting&is% nationalities $!o# eac%
a!ent t%at (ell esta*lis%e' $o! so#e nationalClai# to i'enti$y t%e ancest!al co#)onents'i?e!ent )o)&lations4
Disa!#antages
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Po(ell, 4 13;/24 A&toso#al DNA "esting $o! Genealo
$!o#%tt):--genealogy4a*o&t4co#-o'-'naFgenetics-)-a&t
Genetic Genealogy, 8isto!y an' P!e%isto!y, an' DNAAncest!y "!acing
Donal' N4 ates, P%4D4%at Can I Lea!n
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