Emerald Health Pharmaceuticals
P.2
Important NoticeEmerald Health Pharmaceuticals Inc. (the Company) is currently engaged in an ongoing offering under Regulation A+ (Regulation A+) under theSecurities Act of 1933, as amended. The offering will be made only by means of an offering circular. This presentation shall not constitute an offerto sell or the solicitation of an offer to buy, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitationor sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction. No money or otherconsideration is being solicited at this time, and if sent in response to these materials, it will not be accepted. No securities may be sold, and nooffer to buy securities can be accepted and no part of the purchase price can be received for an offering under Regulation A+ except pursuant toan Offering Circular qualified by the U. S. Securities and Exchange Commission, and any such offer may be withdrawn or revoked, withoutobligation or commitment of any kind, at any time before notice of its acceptance given after the qualification date. A person's indication ofinterest in a Regulation A+ offering is non-binding and involves no obligation or commitment of any kind. Our most recent Offering Circular andperiodic reports are available via this URL: https://emeraldpharma.life/sec-filings-2019/
Cautionary Note Regarding Forward-Looking StatementsTO THE EXTENT STATEMENTS CONTAINED IN THE FOLLOWING PRESENTATION ARE NOT DESCRIPTIONS OF HISTORICAL FACTS REGARDING THECOMPANY, THEY SHOULD BE CONSIDERED “FORWARD-LOOKING STATEMENTS,” AS DESCRIBED IN THE PRIVATE SECURITIES LITIGATION REFORM ACTOF 1995, THAT REFLECT MANAGEMENT’S CURRENT BELIEFS AND EXPECTATIONS. YOU CAN IDENTIFY FORWARD-LOOKING STATEMENTS BY WORDSSUCHAS “ANTICIPATE,” “BELIEVE,” “COULD,” “ESTIMATE,” “EXPECT,” “FORECAST,” “GOAL,” “HOPE,” “HYPOTHESIS,” “INTEND,” “MAY,” “PLAN,” “POTENTIAL,”“PREDICT,” “PROJECT,” “SHOULD,” “STRATEGY,” “WILL,” “WOULD,” OR THE NEGATIVE OF THOSE TERMS, AND SIMILAR EXPRESSIONS THAT CONVEYUNCERTAINTY OF FUTURE EVENTS OR OUTCOMES. FORWARD-LOOKING STATEMENTS CONTAINED IN THESE PRESENTATIONS INCLUDE, BUT ARE NOTLIMITED TO, STATEMENTS REGARDING: (I) THE SUCCESS AND TIMING OF OUR PRODUCT DEVELOPMENT ACTIVITIES AND CLINICAL TRIALS; (II) OURABILITY TO DEVELOP OUR PRODUCT CANDIDATES; (III) OUR PLANS TO RESEARCH, DISCOVER, EVALUATE AND DEVELOP ADDITIONAL POTENTIALPRODUCT, TECHNOLOGY AND BUSINESS CANDIDATES AND OPPORTUNITIES; (IV) OUR ABILITY TO DEVELOP AND MANUFACTURE OUR PRODUCTCANDIDATES AND TO IMPROVE THE MANUFACTURING PROCESS; (V) OUR ABILITY TO ATTRACT AND RETAIN KEY SCIENTIFIC OR MANAGEMENTPERSONNEL; (VI) THE ANTICIPATED TIMING OF CLINICAL DATA AVAILABILITY; (VII) OUR ABILITY TO MEET OUR MILESTONES; (VIII) OUR EXPECTATIONSREGARDING OUR ABILITY TO OBTAIN AND MAINTAIN INTELLECTUAL PROPERTY PROTECTION; AND (IX) THE IMPACT OF CAPITAL MARKET CONDITIONSON US. FORWARD-LOOKING STATEMENTS ARE SUBJECT TO KNOWN AND UNKNOWN FACTORS, RISKS AND UNCERTAINTIES THAT MAY CAUSE ACTUALRESULTS TO DIFFER MATERIALLY FROM THOSE EXPRESSED OR IMPLIED BY SUCH FORWARD LOOKING STATEMENTS. UNDUE RELIANCE SHOULD NOT BEPLACED ON FORWARD-LOOKING STATEMENTS. WE UNDERTAKE NO OBLIGATION TO PUBLICLY UPDATE ANY FORWARD-LOOKING STATEMENTS. THECOMPANY’S INVESTIGATIONAL DRUG PRODUCTS HAVE NOT BEEN APPROVED OR CLEARED BY THE FDA.
Emerald Health Pharmaceuticals
• A clinical-stage biotechnology company developing first-in-class new chemical entities to treat diseases with unmet medical need
• Our technology has a unique multi-pronged mechanism of action, addressing validated targetsfor neurodegenerative, autoimmune, fibrotic & inflammatory diseases
• Preclinical studies demonstrate disease modificationwith the potential to reverse the progression of diseases which currently have no cure and cause significant morbidity and mortality
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• Phase I completed successfully on our lead product candidate - Phase II initiation underway
Emerald Health Pharmaceuticals
Status: Private Headquarters: San Diego, CA, USAR&D: Córdoba, Spain
Focused on developing patented synthetic cannabinoid-derived drug candidates to treat diseases with unmet medical need
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Emerald Health Pharmaceuticals: Key Highlights
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Broad patent protection with a US$39B market
opportunity in the first 4 targeted
diseases
New Chemical Entities (NCEs)
with the potential for disease
modification in diseases with no
current cure
Experienced biotech/pharma executives and
globally-recognized clinical
and scientific advisors
Unique Mechanism of
ActionClinical StageDevelopment
StrongTeam
Phase 1 completed on lead product
candidate demonstrating
tolerability, safety, and dosing
flexibility
Strong IP & Significant Market
Not for Distribution
NOTE: In the scientific literature:EHP-101 = VCE-004.8EHP-102 = VCE-003.2
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Development Roadmap
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Market Opportunity: ~$39B in the First Four Target Diseases
1Global Multiple Sclerosis Drugs Market Size, Market Share, Application Analysis, Regional Outlook, Growth Trends, Key Players, Competitive Strategies and Forecasts, 2017 To 2025 Research and Markets Report 2Parkinson's Disease Therapeutics Market Global Industry Analysis Size, Share, Growth ,Trends, and Forecasts, 2017 To 2025 Transparency Market Research Report 3Scleroderma Diagnostics and Therapeutics Market Global Industry Analysis, Size, Share, Growth, Trends, and Forecast 2017 - 2024 Transparency Market Research Report4Opportunity Analyzer: Huntington's Disease Opportunity Analysis and Forecast to 2024 Research and Markets Report
• Cannabidiol (CBD) & Cannabigerol (CBG)have multiple positive physiologic effects through interaction with the endocannabinoid system (ECS)
• Research indicates they are: - Anti-inflammatory- Antioxidative- Neuroprotective- Analgesic- Anti-infective- Non-psychoactive
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The Technology: Patented NCEs Derived from CBD & CBG
Source: https://carebydoctors.com/ailments-corresponding-cannabinoids/
CB1
Receptors
CB2 TRPV1
GPR55 FAAH
PPARs MALG
TRPA1
Distribution of CB1 Receptors
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The ECS Exists Throughout the Body
Health benefits;Psychoactive effects
Health benefits;No psychoactive effects
• EXPANDED receptor targeting
• FOCUSED on receptors that can treat diseases with unmet medical need
• DEVELOP composition of matter patented new chemical entities (NCEs)
• CREATE a strong IP portfolio
To improve on the positive health effects of CBD and CBG by modifying them to create enhanced new chemical entities
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Our Scientific and Pharmaceutical Approach
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Cannabinoid Science: Rational Drug Design
New, patented molecules
The Result:
• Totally synthetic NCEs• Non-psychotropic• Targeted receptor activity• Potential for disease modification• Composition of matter patents
Synthetic
CB2 TRPV1
GPR55 FAAH
PPARs MALGTRPA1
• The goal: to affect targets validated for various diseases with unmet medical need
• Our drug discovery platform focuses on targets related to the ECS without binding to CB1 receptors
Chemical modifications of the CBD molecule create new
targets and receptor binding
14 patented CBD derivatives
11 patented CBG derivatives
Molecules in our NCE Library
• Composition of matter and method of use patents
• Broad protection in the US, EU and many countries worldwide
• Protection to 2039
• Potential for multiple products and indications
16 granted, 22 pending, covering 25 molecules
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Patents
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The Unique Convergence of Cannabinoids, Science & Biology
Science
Biology
Patented CBD Derivatives (“4-series”)
EHP-101
Patented CBG Derivatives (“3-series”)
EHP-102
Cannabinoids
CBG
14 patented CBD derivatives
11 patented CBG derivatives
EHP-101(VCE-004.8)
EHP-102(VCE-003.2)
TheEHP
Platform
New ProprietaryMolecules
OtherCannabinoids
Parkinson’s disease Huntington’s disease
Neurodegenerative
Fibrotic
Ulcerative Colitis / Crohn’s
Inflammatory
Metabolic
Auto-Immune
CancerDiabetes
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Provides Many Therapeutics Opportunities
Lupus
Systemic Sclerosis (Scleroderma)
A patented CBD derivative (NCE)
• Oral formulation
• Unique multi-pronged mechanism of action
• Preclinical proof-of-concept established
• IND-enabling studies completed
• Phase I completed
• Phase II initiation underway
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Lead Product Candidate: EHP-101CBD
EHP-101
The U.S. Drug Enforcement Administration (DEA) has determined that:
• VCE-004.8 (the active ingredient in EHP-101) is not a controlled substance
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A Cannabinoid that is Not a Controlled Substance
Chronic, systemic autoimmune disease causing fibrosis of skin and internal organs
• Life-threatening orphan disease
• No SSc-specific approved drugs
• Current drugs are not effective and have toxicities
• Lung fibrosis is a common cause of death (~60% mortality in 10 years)
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EHP-101: Systemic Sclerosis (SSc) – a Form of Scleroderma
• PPARγ and CB2: extensively studied molecular targets for the treatment of scleroderma*
• Combined effect on PPARγ, CB2 and HIF have not been described for other types of marketed drugs
• Pre-clinical proof-of-concept has been established in relevant animal models
*Minghua et al, Tavarares et al, Akhmetshina et al, Del Rio et al
EHP 101 PPARγ
CB2
Inhibition of collagen synthesis
Inhibition of ERK activation
Fibroblast migrationdecrease
Myofibroblastdifferentiation
Anti-inflammatoryactivity in vivo
Anti-fibrotic activity in vivo
Vascular protection and regeneration
HIF
EHP-101 MoA targets scleroderma
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EHP-101: Why Systemic Sclerosis/Scleroderma?
Demonstrated efficacy in 2 validated SSc/fibrosis models
• Exerts potent antifibrotic effects and prevents dermal thickening
• Prevents collagen accumulation around blood vessels
• Reduces inflammation
• Prevents lung, cardiac and kidney fibrosis
• Prevents vascular damageWWW . E M E R A L D P H A RM A . L I F E
EHP-101: Efficacy Demonstrated in Systemic Sclerosis (SSc)
NATURE
MS is a chronic, degenerative, demyelinating CNS disorder
• Our molecule targets the receptors associated with MS
• Current medications provide mainly symptomatic relief (pain and spasticity) mostly during the inflammatory (early) phase of the disease
• No effective disease-modifying drugs for progressive MS
• No therapies currently can remyelinate damaged neurons
Main symptoms ofMultiple Sclerosis
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EHP-101: Why Multiple Sclerosis?
Multiple SclerosisNormal
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Damaged Myelin (Demyelination) in MS is Irreversible
Our strategy:
To improve on CBD’s known positive effectsby creating a unique new molecule that affectsvalidated targets in MS:
- PPARγ- CB2- HIF
EHP-101
PPARγ
CB2
PPARγ: Peroxisome proliferator-activated receptor gammaCB2: Cannabinoid receptor Type 2HIF: Hypoxia inducible factor
Increases Neuroprotection
Improves neuron survival
and repair
Promotes Remyelination
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EHP-101: Designed for Targeted Mechanism of Action
Reducesneuroinflammation
HIF
Demonstrated efficacy in 4 validated MS models
• Significant improvement in clinical signs
• Stops neuroinflammation and demyelination
• Remyelinates neuronal axons
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EHP-101: Efficacy Demonstrated in Multiple Sclerosis
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EHP-101: Other Demyelinating Disease Opportunities
Inflammatory/ Immune
Disorders
Infectious diseases
• Human Immunodeficiency Virus• Progressive multifocal
leukoencephalopathy• Lyme disease• Neurosyphilis• Human T-cell leukemia virus-1
Granulomatous diseases
• Sarcoidosis• Wegener granulomatosis• Lymphoid granulomatosis
Demyelinating Disorders (CNS)
Neonatal intracranial hemorrhage
Demyelination associated to ischemic or
Traumatic Brain injury
Toxic/ metabolic disorders
• B12 deficiency• Central pontine
myelinolysis• Carbon monoxide• Radiation• Posterior reversible
encephalopathy syndrome
Myelin disorders
• Metachromatic leukodystrophy• Adrenoleukodystrophy• Adrenomyeloneuropathy• Globoid cell (Krabbe)
leukodystrophy• Alexander’s disease• Canavan disease
• Multiple sclerosis• Optic neuritis • Acute disseminated encephalomyelitis • Paraneoplastic• Rheumatoid arthritis • Systemic lupus erythematosus• Behcet’s disease• Sjorgen’s disease
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Developed an oral formulation and initiated manufacturing for Phase I
Applied and got US FDA and EMA grant of Orphan Drug Designation for systemic scleroderma
H1
H2
Completed final clinical-enabling studies
Completed a Pre-IND meeting with US FDA (for MS)
Initiated Phase I human study in Australia
Completed a Pre-IND meeting with US FDA (for SSc)
Completed Phase I study
SSc IND submission MS Phase II initiation
MS US IND submission
SSc Phase IIa initiation Initial SSc Phase IIa data
2017 2018 2019 2020
Received DEA determination that our NCE is not a Controlled Substance
Initiated 6- and 9-month rat and dog tox studies
Completion of 6- & 9-mth rat and dog tox studiesDesigned Phase I
protocol based on FDA feedback to be applicable for Phase II in both MS and SSc
Formed MS and SSc KOL Clinical Advisory Boards
Completed non-clinical proof-of-concept for MS and SSc
EHP-101: Our Path to the Clinic
Initiated GLP toxicity studies
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SSc IND clearance
MS IND clearance
First patient in - AUS
First patient in - US
Canada SSc CTA submission
HD EMA Orphan Designation
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EHP-101: Phase I Completed
A Phase 1, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Pharmacodynamics, Pharmacokinetics, and Food Effect of Single Ascending Doses and Multiple Ascending Doses* of EHP-101 in Healthy Subjects.
• 104 healthy volunteers
• Doses tested: 0.91mg to 185mg (anticipated therapeutic dose = 25mg-50mg/day)
• No clinically relevant laboratory, cardiac, or other abnormalities • PK data support intended dosage and administration regimen for Phase II
• Biomarker analysis underway for support of mechanism of action
• All doses tested were well tolerated with only mild to moderate adverse events - No maximum tolerated dose reached- Adverse reactions included mild to moderate paresthesia, headache, blurred vision
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EHP-101: Phase I Pharmacokinetics Summary
Phase I: PK supports dosage and administration
• Maximum VCE-004.8 plasma levels (Cmax) occurred within 4 hours of dosing in all cohorts
• A proportional increase in Cmax and drug exposure (area under the curve, AUC) observed with increasing dose
• No drug accumulation observed after repeated dosing
• Anticipated therapeutic dose between 25 and 50 mg per day based on Cmax and AUC
• Daily doses in Phase II study not expected to exceed 100 mg per day
Blue: 185 mgPink: 100 mgGreen: 50 mgBrown line: 20 mgPurple line: 9 mgDark Green line: 3 mgRed line: 0.91 mg
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EHP-101: Phase I Biomarker Analysis
Drug-related biomarkers being evaluated to possibly support mechanism of action (MoA)
• Exploratory: potential to show changes related to the HIF pathway (vascular endothelial cell function; angiogenesis) and PPARγand CB2 receptor activity (inflammation & immunomodulation)
• Preliminary analysis supports EHP-101 MoA: - 19 proteins up-regulated* 6 hours post administration (Tmax 2-4h)
o 7 related to vascular endothelial cell function (HIF pathway activation), such as VCAM1, NCAM1 and ECM1
o 4 related to lipid metabolism and control of inflammation (PPARγ activation), such as APO1, APOA4, APOE and APOM
- 39 proteins down-regulated** at 6 hours post administrationo Several related to CB2 and PPARγ activation (e.g., FGB, LDHB, PCOLCE)
(inflammation and immunomodulation)
NCAM1
p = 0.0009
p = 0.009
APOA4
* Up regulation is increased expression of a gene or protein that increases a target action (e.g., activation of HIF, leading to vasculogenesis and others positive physiologic processes) ** Down regulation is reduced expression of a gene or protein associated with a process (e.g., reduction of markers mediated by PPARg/CB2 activation – anti-inflammatory/immunomodulatory)
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EHP-101: Phase II Plan (Based on Pre-IND Discussions with FDA)
SSc: Phase II, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Preliminary Efficacy in Patients with Diffuse Cutaneous Systemic Sclerosis (36 patients)Primary Objective: Safety and tolerability of various doses over 12 weeksSecondary Objective: Treatment effect by Composite Response Index in dcSSc (CRISS) over 12 weeksExploratory Objectives: Treatment effect on patient-reported outcomes; treatment effect based on potential biomarkers related to the mechanism of action; molecular skin score
MS: Phase II Study in Patients with Relapsing Forms of Multiple Sclerosis (RMS) to Evaluate Safety, Tolerability, and Preliminary Efficacy (60-120 patients)Co-Primary Objectives: Safety and tolerability and treatment effect based on MRI at 6 monthsSecondary Objectives: Disease progression and disability status; MS Functional Composite and Expanded Disability Status Scale; time to first study relapse; annual relapse rate Exploratory Objectives: Treatment effect based on changes from baseline for: serum neurofilament light chain, diffusivity by Diffusion Tensor Imaging, patient reported outcome by multiple sclerosis impact scale-29, biomarkers
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EHP-101: Planned Phase II Biomarker Analysis
In addition to clinical efficacy endpoints, biomarkers will be assessed in Phase II to possibly provide further evidence of efficacy
• Examples:- Neurofilament light chain in MS patients and gene expression in skin biopsies of SSc patients
• Preclinical evidence supports the relevant biomarkers and endpoints:Ø MS: Neurofilament expression in spinal cord shows EHP-101 prevents axonal damage
and preserves myelinationØ SSc: EHP-101 reduces the expression of genes associated with fibrosis and inflammation
• As in Phase I, drug-related biomarkers will also be tested in the diseased populations (higher probability of effect with longer treatment in Phase II)
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A patented CBG derivative (NCE)
• Being developed for oral delivery
• Preclinical proof-of-concept established
• Designed to target receptors and pathways involved in neurodegenerative diseases
• Clinical-enabling studies initiated
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EHP-102: Second Product Candidate
CBG
EHP-102
O
OHO
O
OHO
NHAir
VCE-003.2
EtNH2EtOH
t.a., 1.2 h71%
VCE-003
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PD is a chronic, progressive neurodegenerative disorder with no current cure
• More than 10 million people worldwide have Parkinson's disease
• A disease where damaged neurons do not produce sufficient dopamine (dopamine helps transmit impulses from the brain to the muscles)
• EHP-102 provides neuroprotection, partially through PPARγ activity and reduction in proinflammatory mediators
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EHP-102: Why Parkinson’s Disease?
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Demonstrated efficacy in 2 validated PD models
• Improves clinical symptoms and recovers movement parameters (motor coordination and activity)
• Reduces inflammatory marker expression
• Prevents the loss of dopaminergic neurons
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EHP-102: Efficacy Demonstrated in Parkinson’s Disease
HD causes progressive breakdown of nerve cells
• An orphan disease
• EHP-102 targets PPARγ with improved activity
• Also targets other pathways involved in neuronal survival
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EHP-102: Why Huntington’s Disease?
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Demonstrated efficacy in 3 validated HD models:
• Improved motor function & clinical scores
• Provides neuroprotection
• Prevents neuroinflammation
• Promotes the regeneration of subventricular neuronal cells (neurogenesis)
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EHP-102: Efficacy Demonstrated in Huntington’s Disease
1Scientific RepoRtsȁͼǣͿͽ;ͿȁǣͷͶǤͷͶ;ȀͿͽ;Ϳ
ǤǤȀ
ǦͶͶǤǡǡǯ ÀǦͷǡǡǡ*ǡ ÀǦͷǡǡǡ*ǡͺǡ*ǡÀͻǡͻǡ±ͻǡ ±ͷǡǡǡ ǦͷǡǡͼǡÀͺǡͽǡͽǡǤͻǡǦͷǡǡƬÓͻ
ơγǤǦͶͶǡȋȌǡǦƪγǤǦǦͶͶǦͶͶǤγǤơǡγǡơǤǡǦͶͶǤȋȌǦǦǤƤǦͶͶǤin vivoǦȋȌǤǦͶͶǤ+ǯǦƤǡǤǦͶͶǤƪǤǦͶͶǤǯȋȌƪǤ
Cannabinoids the main active compounds of marijuana (Cannabis sativa), and its endogenous counterparts anandamide and 2-arachidonoyl glycerol have attracted the interest of the scientific community in the last decade owing to their prominent effects on neurodegenerative and neuroinflammatory conditions1 . Cannabinoids exert neuroprotective actions in various experimental models of neurodegenerative diseases, and most of their effects are mediated via the presynaptic CB1 receptor. CB1 receptor levels notably diminish at early stages of Huntington’s
ͷ××ȋȌǡǡǡǤͿͷͶͶǡǡǤÀÀǡǡǡǤCentro de ×±ȋȌǡǡǤͺVivaCell Óǡ×ǡǤͻ××±×ǡÀǡÀǡÀÀǡ×ǡǤͼ×ÀǡÀÀǡǡǡǤͽǡǡǡǤ*ǤǤǤǦǤȋǣǤǤȌǤǤȋǣǤǤȌ
rǣͿ Ͷͷͼ
aǣͺ Ͷͷͼ
ǣͷͿ Ͷͷͼ
OPEN
NATURE
Experienced Pharma & Biotech Management
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Jim DeMesa, MD, MBAChief Executive Officer
30 years in pharma product development and management, including preclinical and clinical trial management, and partnering with pharma companies. 15 years as CEO of public biotech companies.
Nancy Coulson, MBASVP, Regulatory & Quality Affairs
>30 years in global pharma and biotech regulatory mgmt with J&J, BMS, and others.
Eduardo Muñoz, MD, PhDChief Scientific Officer, SAB Chairman
>30 years in biomedical research,Professor of Immunology, author of 200 articles, patents and book chapters with nearly 5,000 citations
Giovanni Appendino, PhDScientific Advisor, SAB
One of the world's thought leadersin cannabinoid research; Professor ofPharmaceutical Chemistry at the University of Eastern Piedmont; Author of 250 articles and 10 book chapters.
Alain Rolland, PharmD, PhDChief Operating Officer
>30 years of leadership experience inbiotech/pharma R&D, product, strategic and business development
Clinical Advisory Boards:MS: Emmanuelle Waubant, MD, PhD
Juan Antonio Garcia-Merino, MD, PhDSSc: John Varga, MD
Janet Pope, MD Patricia Carreira, MD
Joachim Schupp, MD, Dr. medChief Medical Officer
>30 years in clinical drug development, medical monitoring and clinical trial mgmtwith Ciba-Geigy, Novartis, & others
Rao Movva, PhDScientific Advisor, SAB
30 years in drug discovery and development; Novartis Distinguished Scientist; pioneered chemical biology efforts that led to the discovery and the understanding of TOR pathways
Lisa Sanford, CPAChief Financial Officer
>30 years of diversified finance and accounting experience in life sciences, pharmaceuticals and biotechnology.
TO LEARN MORE PLEASE CONTACT :
Jim DeMesa, MDCHIEF EXECUTIVE OFFICER
EMERALD HEALTH PHARMACEUTICALS
Bernie HertelVP FINANCE & COMMUNICATIONS
EMERALD HEALTH SCIENCES
T. 1 604 727 0106
T. 1 858 352 0622
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Thank you
Developing medicines based on cannabinoid science
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