Dosage and SolutionsDosage and Solutions
Gerardo I. Lirag, RNGerardo I. Lirag, RN
Lung Center of the PhilippinesLung Center of the Philippines
I.V. Therapy Training Program for NursesI.V. Therapy Training Program for Nurses
Commonly Used UnitsCommonly Used Units
cc (cubic centimeter) or (cmcc (cubic centimeter) or (cm33) centimeter ) centimeter cubecube
ml (milliliter) ml (milliliter) mg (milligram)mg (milligram) ų (micro) ų (micro) g (gram)g (gram) qtts (drops) qtts (drops) kg (kilogram)kg (kilogram) G (gauge) G (gauge) meq (milli-equivalent) meq (milli-equivalent) u (unit)u (unit)
1 ml = 1 cc1 ml = 1 cc 1 liter = 1000 ml1 liter = 1000 ml 1 kg = 1000 g1 kg = 1000 g 1 g = 1000 mg1 g = 1000 mg 1 mg = 1000 ųg1 mg = 1000 ųg 1 hr. = 60 min.1 hr. = 60 min. 1 min. = 60 sec. 1 min. = 60 sec. 1 ųqtts/min = 1 ml/hr1 ųqtts/min = 1 ml/hr
Review of ConversionReview of Conversion
Commonly Used Drop FactorCommonly Used Drop Factor
Macroset Abbot (15 qtts/ml)Macroset Abbot (15 qtts/ml)
BlBraun (20 qtts/ml)BlBraun (20 qtts/ml) BT Set Abbot (10 qtts/ml)BT Set Abbot (10 qtts/ml)
Microset (60 qtts/ml)Microset (60 qtts/ml)
Commonly Used Emergency Drugs Commonly Used Emergency Drugs and its Stocksand its Stocks
Epinephrine 1mg/mlEpinephrine 1mg/ml Atropine Sulfate 1 mg/mlAtropine Sulfate 1 mg/ml Aminophylline 25mg/ml in 10 mlAminophylline 25mg/ml in 10 ml Paracetamol (Aeknil) 150mg/ml in 2mlParacetamol (Aeknil) 150mg/ml in 2ml Diphenhydramine HCL (Benadryl) 50mg/ml in 1mlDiphenhydramine HCL (Benadryl) 50mg/ml in 1ml Hyoscine Butylbromide (Buscopan) 20mg/1mlHyoscine Butylbromide (Buscopan) 20mg/1ml Terbutaline Sulfate (Bricanyl) 500ųg/ml in 1mlTerbutaline Sulfate (Bricanyl) 500ųg/ml in 1ml
Isosorbide dinitrate (Isoket) 1mg/ml in 10mlIsosorbide dinitrate (Isoket) 1mg/ml in 10ml Tranexamic Acid (Hemostan) 100mg/ml in 5mlTranexamic Acid (Hemostan) 100mg/ml in 5ml Diazepam (Valium) 5mg/ml in 2mlDiazepam (Valium) 5mg/ml in 2ml Phenytoin Na (Dilantin) 50mg/ml in 2mlPhenytoin Na (Dilantin) 50mg/ml in 2ml Dopamine 40mg/ml in 5mlDopamine 40mg/ml in 5ml Dobutamine 50mg/ml in 5mlDobutamine 50mg/ml in 5ml Furosemide (Lasix) 10mg/ml in 2mlFurosemide (Lasix) 10mg/ml in 2ml
Verapamil (Isoptin) 5mg/2mlVerapamil (Isoptin) 5mg/2ml Digoxin (Lanoxin) 0.5 mg/2mlDigoxin (Lanoxin) 0.5 mg/2ml Magnesium Sulfate 250mg/ml in 10mlMagnesium Sulfate 250mg/ml in 10ml Metoclopramide (Plasil) 5mg/2mlMetoclopramide (Plasil) 5mg/2ml Ranitidine (Zantac) 25mg/mlRanitidine (Zantac) 25mg/ml Phytomenadione (Hema-K) 10mg/ml in 1mlPhytomenadione (Hema-K) 10mg/ml in 1ml Nalbuphine (Nubain) 10mg/ml in 1mlNalbuphine (Nubain) 10mg/ml in 1ml
Tramadol (Tramal) 50mg/ml in 1mlTramadol (Tramal) 50mg/ml in 1ml Midazolam (Dormicum) available in Midazolam (Dormicum) available in
5mg/5ml, 15mg/3ml, 5mg/1ml5mg/5ml, 15mg/3ml, 5mg/1ml Dexamethasone 4mg/ml in 2mlDexamethasone 4mg/ml in 2ml Sodium bicarbonate 1meq/ml in 50mlSodium bicarbonate 1meq/ml in 50ml Hydrocortisone (Solu Cortef) 100mgHydrocortisone (Solu Cortef) 100mg Lidocaine (Xylocaine 2%) 20mg/ml in 5mlLidocaine (Xylocaine 2%) 20mg/ml in 5ml
FormulaFormula
D = dose desired (in mg)D = dose desired (in mg)
H = Dose on Hand (total dose in mg)H = Dose on Hand (total dose in mg)
Q = Quantity (total volume in ml)Q = Quantity (total volume in ml)
R = Required or amount to be administeredR = Required or amount to be administered
R =(Q)(D)
H
FormulaFormula
R = Rate in qtts/minR = Rate in qtts/min
V = Volume in ml or ccV = Volume in ml or cc
DF = Drop Factor in qtts/mlDF = Drop Factor in qtts/ml
T = Time in minutesT = Time in minutes
R =(V)(DF)
T
FormulaFormula
R = Rate to be administeredR = Rate to be administered
D = Desired dose in mg/hrD = Desired dose in mg/hr
S = Total solutions in mg/mlS = Total solutions in mg/ml
R =D
S
S =Solute (mg)
Solvent (ml)
FormulaFormula
Dopamine = Dopamine = [Wt[Wt(kg)(kg)] [D] [D(ųg/kg/min)(ųg/kg/min)][60][60min/hrmin/hr]]
800 ųg/ml800 ųg/ml
Dopamine = Dopamine = 1600 ųg/ml1600 ųg/ml
Single dose Single dose
Double dose Double dose
[Wt[Wt(kg)(kg)] [D] [D(ųg/kg/min)(ųg/kg/min)][60][60min/hrmin/hr]]
FormulaFormula
Dobutamine = Dobutamine = 1000 ųg/ml1000 ųg/ml
2000 ųg/ml2000 ųg/ml
Single dose Single dose
Double dose Double dose
Dobutamine = Dobutamine =
[Wt[Wt(kg)(kg)] [D] [D(ųg/kg/min)(ųg/kg/min)][60][60min/hrmin/hr]]
[Wt[Wt(kg)(kg)] [D] [D(ųg/kg/min)(ųg/kg/min)][60][60min/hrmin/hr]]
Computation of DrugsComputation of Drugs
Problem 1Problem 1
Please administer 40mg of gentamicin thru Please administer 40mg of gentamicin thru IV every 12 hours. How much volume will IV every 12 hours. How much volume will your aspirate if the stock dose of your aspirate if the stock dose of gentamicin is 80mg/2ml?gentamicin is 80mg/2ml?
Problem No. 1
Given: D = 40 mg
H = 80 mg
Q = 2 ml
R = ?
Formula: R = (D)(Q)
H
Solution: R = (40mg)(2ml)
80mg
R = 1ml
R = 80ml
80
Answer
Problem 2Problem 2
Start DStart D55NSS 1 liter using a DF of 15 and NSS 1 liter using a DF of 15 and
regulate it for 16 hours. Calculate for the regulate it for 16 hours. Calculate for the qtts/min.qtts/min.
Computation of DrugsComputation of Drugs
Problem No. 2
Given:
DF = 15 qtts/ml
T = 16 hours or 960 mins
R = ?
Formula: R = (V)(DF)
T
Solution: R = (1000ml)(15qtts/ml)
960 mins
R = 16 qtts/min
R = 15000qtts
960 mins
Answer
V = 1 liter or 1000ml of D5NSS
Problem 3Problem 3
Start DStart D55NSS 500ml using a DF of 20 and NSS 500ml using a DF of 20 and
regulate at 125ml/hr. Calculate for the regulate at 125ml/hr. Calculate for the qtts/min.qtts/min.
Computation of DrugsComputation of Drugs
Problem No. 3
Given: V = 125 ml
DF = 20 qtts/ml
T = 1 hour or 60 mins
R = ?
Formula: R = (V)(DF)
T
Solution: R = (125ml)(20qtts/ml)
60 mins
R = 42 qtts/min
R = 2500qtts
60 mins
Answer
Computation of DrugsComputation of Drugs
Problem 4Problem 4
Please prepare diazepam drip by Please prepare diazepam drip by dissolving 30mg of diazepam in Ddissolving 30mg of diazepam in D55W 100 W 100
ml by soluset and regulate it at 5mg/hr. ml by soluset and regulate it at 5mg/hr. Calculate for the qtts/min.Calculate for the qtts/min.
Note: Always use a microset everytime we sidedrip a dopamine, Note: Always use a microset everytime we sidedrip a dopamine, dobutamine, cardiac drugs, and sedatives.dobutamine, cardiac drugs, and sedatives.
Problem No. 4
Given:
Solvent = 100 ml of D5Water
D = 5 mg/hr
R = ? in µqtts/min
Formulas: S = Solute
Solvent
Solution:
R = 17 ml/hr ≈ 17 µqtts/min
R = 5mg/hr
0.3 mg/ml
Answer
R = D
S
S = 30mg
100ml S = 0.3mg/ml
Solute = 30 mg of Diazepam
Computation of DrugsComputation of Drugs
Problem 5Problem 5
Please start lidocaine drip by dissolving 5 g. Please start lidocaine drip by dissolving 5 g. of lidocaine in Dof lidocaine in D55W 500ml and regulate it at W 500ml and regulate it at
5mg/min. Calculate for the ml/hr.5mg/min. Calculate for the ml/hr.
Note: Always use a microset everytime we sidedrip a dopamine, Note: Always use a microset everytime we sidedrip a dopamine, dobutamine, cardiac drugs, and sedatives.dobutamine, cardiac drugs, and sedatives.
Problem No. 5
Given:
Solvent = 500 ml of D5Water
D = 5 mg/min
R = ? in ml/hr
Formulas: S = Solute
Solvent
Solution:
R = 30 ml/hr
R = 5 mg/min
10 mg/ml
Answer
R = D
S
S = 5,000mg
500ml S = 10 mg/ml
R =
5 mg
10 mg/ml
( 1 hr
60 min 1 min )
R =
5 mg
0.01666 hr 10 mg/ml
R = 300 mg/hr
10 mg/ml
Solute = 5 grams or 5,000 mg of Lidocaine
Problem 6Problem 6
Start dopamine drip double dose in Start dopamine drip double dose in DD55W250ml, assuming weight of patient is W250ml, assuming weight of patient is
50 kg. Regulate drip at 5ųg/kg/min. 50 kg. Regulate drip at 5ųg/kg/min. Calculate for the qtts/min.Calculate for the qtts/min.
Note: Always use a microset everytime we sidedrip a dopamine, Note: Always use a microset everytime we sidedrip a dopamine, dobutamine, cardiac drugs, and sedatives.dobutamine, cardiac drugs, and sedatives.
Computation of DrugsComputation of Drugs
Problem No. 6
Given:
D = 5 µg/kg/min
Concentration = double dose
Formula: R = (Wtkg)(D)(60)
1,600 µg/ml
Solution: R = (50 kg)(5 µg/kg/min)(60min/hr)
1,600 µg/ml
R = 9 ml/hr ≈ 9 µqtts/min
R = 15,000kg- µg/kg/min-min/hr
1,600 µg/ml
Answer
R = ?
Wtkg = 50 kg
Problem 7Problem 7
Start dobutamine drip double dose in Start dobutamine drip double dose in DD55W250ml, assuming weight of patient is W250ml, assuming weight of patient is
55 kg. Regulate drip at 5ųg/kg/min. 55 kg. Regulate drip at 5ųg/kg/min. Calculate for the qtts/min.Calculate for the qtts/min.
Note: Always use a microset everytime we sidedrip a dopamine, Note: Always use a microset everytime we sidedrip a dopamine, dobutamine, cardiac drugs, and sedatives.dobutamine, cardiac drugs, and sedatives.
Computation of DrugsComputation of Drugs
Problem No. 7
Given:
D = 5 µg/kg/min
Concentration = double dose
Formula: R = (Wtkg)(D)(60)
2,000 µg/ml
Solution: R = (55 kg)(5 µg/kg/min)(60min/hr)
2,000 µg/ml
R = 8 ml/hr ≈ 8 µqtts/min
R = 16,500kg- µg/kg/min-min/hr
2,000 µg/ml
Answer
R = ?
Wtkg = 55 kg
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