Data Virtualization Modernizes Biobanking
Speakers
Lori Ball
COO & President, Integrated Solutions
William Barnett
Chief Research Informatics Officer
Suresh Chandrasekaran
Senior Vice President
Ravi Shankar
CMO
Comprehensive Sample Management
Data Virtualization in Healthcare
Integrated Biobank Visual Analytics
Solution Development
Lori A. BallCOO & President,
Integrated Solutions
Comprehensive Sample Management Solutions
www.biostorage.com
Biorepository and Biobanking Sample Storage –Onsite and Offsite
Supply Chain Services – Logistics and Relocation
Technology Solutions - ISIDOR®
Business Continuity / Disaster Recovery
Bioprocessing Solutions – Sample Preparation /Genomics/Cell Services
Project Management Services
Millions SamplesStored around world
>200 sample types
>275 Clients 18 of the top 20 global biopharma companies
4 global site locations(US, Europe, Singapore, China)
+27ºC to -190ºC storage temperatures
Thousands ft² facility space
TechnologyUS FDA 21 CFR Part 11 compliant
QualityCAP, GxP, NRC,IATA, CCSF
5
Healthcare Industry Trends Impacting Biobanking
Industry focus on precision medicine1
Bioscience research budget challenges2
Expansion in global clinical trials3
Growing industry and research collaborations
4
Increasing need for more transparent and standardized informed consent tracking
5
Growing demand for integrated sample and research data
6
Research organizations are beginning to intelligently apply data integration and visual analytics tools in ways that enable researchers to both explore and interact with aggregate data. 1
Source: 1 2020 Vision: Fulfilling the Future of Clinical Research, Applied Clinical Trials, Feb 2015.
Development of effective data management systems is the #1 challenge facing individuals managing biobanks today.1
Source: 1 PharmaVoice, “The Internet of Things”, March 2015
Data Integration(physical & virtual)
Virtualization
Valorization
Visualization
Cloud Storage: SAS, SQL, Oracle, ERP
ConsolidatedData Center / Logical Data Warehouse
Biobanking Industry Data Integration Challenges
ISIDOR® Technology Solutions
A transformational and scalable informatics platform
which integrates research and sample data to advance
bioscience discoveries.
How Data Virtualization Works and the Value it Delivers in Healthcare
Suresh Chandrasekaran | Senior Vice President, Denodo
Denodo at a Glance
© Copyright Denodo 2015 9
Denodo offers unified access to corporate data assets, flexible integration and management of data of all kinds, and real time data delivery for applications and analytics in a single solution that doesn't need to move data from their original physical repositories.
Headquarters
Palo Alto, CA
Denodo Offices, Customers, Partners
Global presence throughout North America, EMEA, APAC and Latin America
Leadership
Longest continuous focus on data virtualization and data services. Product leadership. Solutions expertise.
Customers
250+ customers,
including many F500 and G2000 companies across healthcare, life sciences, technology, media, telecommunications, insurance, financial services, consumer/retail, energy and public sector.
What is Data Virtualization?
© Copyright Denodo 2015 10
Data Virtualization combines disparate data sources into a single “virtual” data abstraction
layer (aka information fabric) that provides unified access and integrated data services to
consuming applications in real-time (right-time).
Connect &
Virtualize
Combine &
Integrate
Publishas a Data Service
Local Database XML Documents
Name | Description | Price Name | Description | Price
U
∞
Name | Manufacturer | Score
Name | Description | Manufacturer | Price | Score
Application
Browser
ResultsSQL Query
Base ViewBase View
Base View
Derived ViewData Service
(SQL, SOAP, REST, Widgets…)
DV Enables Agile Info ArchitectureMany to Many
Agile BI &Agile Apps
Data Services
Any Data, Anywhere
IntegrateNew Sources
OptimizedPerformance
© Copyright Denodo 2015 11
DV Has Several Uses in Life Sciences
© Copyright Denodo 2015 12
Disparate DataAny SourceAny Format
Data VirtualizationRight Informationat the Right Time
Business SolutionsAccess Information-as-a-Service
Research
Scientific Knowledge BaseCompetitive Intelligence Portal
Drug Development
Clinical Data CollectionCompliance Reporting
Commercial
Sales & Marketing AutomationSingle View of Physician
Scientific Clinical
Intellectual Property
BusinessData
Pharma Relationship Map
Research, Trial
Bioinformatics,Clinical
Internal
External
Patent Data Financial Data
Patent Issues Competitive Info
Drug
CEME
Company
Disease
Biosample and Research Intelligence Example
© Copyright Denodo 2015 13
Access heterogeneous data sources
Create logical abstraction layer
Deliver canonical business views
Data services – access anywhere
Agile data integration and quality
Minimize replication (cost, time)
Enterprise to cloud scalable, secure
TrialCRO
Samples
Clients
Consent
Data Virtualization Layer
Bu
sin
ess N
eed
(Canonic
al Vie
ws)
Real W
orld
(Sourc
e D
ata
Vie
ws)
Clinical Trial Data
CTMS
Biorepository Data
SMS
Researcher Data
Laboratory Data
SDMS
LIMS
Biobank Data
SMS
Hospital / Clinic Data
SDMS
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
Indiana CTSI Integrated Biobank
Visual Analytics
William K. Barnett
Chief Research Informatics Officer
Indiana CTSI and
Regenstrief Institute
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
The Indiana CTSI:To transform the participating institutions to create an environment that facilitates the
conduct of clinical and translational science research.
• One of 62 national translational institutes, funded by the NIH
• A Statewide collaboration among Indiana U., Purdue, and Notre Dame to
advance translational research
• Partnerships with healthcare providers to improve care
• Partnerships with industry to speed discovery to market
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
Goals of the Indiana CTSI
• Accelerate translational research
• Train a new cadre of translational researchers
• Foster robust community engagement
• Build facile research resources and technologies
• Leverage the Indiana and national partnerships
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
Informatics Programs
• Community portals such as IndianaCTSI.org
• Research systems such as our clinical research and trials
management systems
• Data collection and management systems, including biobanks
and registries
• Systems Integration – instruments, research process
• Data integration and analytics
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
Biobank Integration and Analytics
• Biospecimens and their affiliated
demographic, phenotypic, and
genotypic data are a critical research
assets
• We collect biospecimen data through
the Indiana Biobank, research biobanks
at IU, and biospecimen registries at IU
and elsewhere.
• As we move to precision medicine,
comparing and integrating these data
will be a key element in improving care.
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
Towards Integrated Visual Analytics
• Many biorepositories on different platforms.
• Goal to eliminate redundancies and identify opportunities
for research.
• BioStorage already provides redundant specimen storage
for many of our biorepositories.
• This ISIDOR® project is a proof of concept to visualize
aggregate specimen data.
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
informatics platform integrates research and sample data
Enhance
Sample & Data Optimization
Accelerate
Medical Research
Improve
Sample & Data Sharing
• Project Vision: To create an environment where sample assets and data sharing
across the enterprise enhances opportunities to support and accelerate research
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
Use Case 1: Visualizing Tissue Availability
for Research
• Background: IU Simon Cancer Center (IUSCC) Tissue Procurement
and Distribution Facility has the responsibility to collect and distribute
biospecimens to support cancer research. As such, the IUSCC would
like to make biospecimen data available to as widely as possible to
the IU research community.
• Problem solved: Enabling researchers to visualize the availability of
specific subsets of samples and publicizing this within a shared
database enables improved sample asset sharing across the
research enterprise.
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
Use Case: Visualizing Tissue Availability for Research
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
Use Case 2: Enabling Research Study
Feasibility
• Background: An investigator with a research idea must first determine
if the study is feasible based upon availability of viable samples which
meet the study requirements.
• Problem solved: The researcher’s ability to isolate data about the
availability of different types of tissue and matching bio-
macromolecules is crucial for planning the types of experiments that
can be performed.
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
Use Case: Enabling Research Study Feasibility
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
Use Case 3: Tracking Multi-Center Study
Collections
• Background: In a multi-center clinical study, research labs from
multiple research or clinical institutions will be accruing participants
and collecting specimens to meet research goals. One challenge is
the need to accurately track the number and source of samples from
each participating center.
• Problem solved: The development of a centralized dashboard for
querying and reporting sample collections within a multi-center study
will enable researchers to identify if the overall study collection goals
are being met, and whether each study center is contributing as
planned.
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
Use Case: Tracking Multi-Center Study Collections
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
Use Case 4: Disease Sample Collections
• Background: Researchers often need access to biological research
samples and data that may not exist within their internal biobanks or
databases that are managed by research foundations, government
agencies and epidemiological biobanks that relate to specific medical
conditions, diseases and populations.
• Problem solved: A visual dashboard for querying and reporting the
demographics of samples collected within a research foundation,
demographic and phenotypic data on these normal volunteer samples
support research programs.
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
Use Case: Disease Sample Collections
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
Business Benefits
• Optimized operations with better data management tools
• Acceleration of research by rapid, user-defined querying
• Increase grant competitiveness and sponsor partnerships
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
Roadmap
The Indiana CTSI sees data integration as a key component
to the next wave of research that will move discoveries to
healthcare improvements, particularly in areas such as:
– Precision Medicine
– Epidemiology and Population Health
– Heath Services Research
– Quality Studies
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
Reflections
A journey of many steps and many partners
Careful planning leads to responsive and useful analytics
The tools are only as good as the data
Speakers
Lori Ball
COO & President, Integrated Solutions
William Barnett
Chief Research Informatics Officer
Suresh Chandrasekaran
Senior Vice President
Ravi Shankar
CMO
Panel
Next Steps
To learn more about ISIDOR Technology solutions, visit http://www.biostorage.com/isidor/
To learn about agile data solutions for life science organizations, download http://bit.ly/1QKCdyZ
To learn more about Indiana CTSI and their translational research, visit http://www.indianactsi.org
© Copyright Denodo Technologies. All rights reservedUnless otherwise specified, no part of this PDF file may be reproduced or utilized in any for or by any means, electronic or mechanical, including photocopying and microfilm, without prior the written authorization from Denodo Technologies.
Thanks!
Lori Ball William Barnett Suresh Chandrasekaran
[email protected] [email protected] [email protected]
www.biostorage.com www.indianactsi.org www.denodo.com
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