CONVENTIONAL CANCER THERAPIES
Halsted’s Radical Mastectomy vs ‘Lumpectomy’
3-D structure & schematic of p-glycoprotein
Examples: Methotrexate Eg. Doxorubicin Eg. Cyclophosphoramide, Melphalan
Eg. Vinblastine, paclitaxel
Newer Approaches to Cancer Therapy
Incorporate Predictive Diagnosis
Are Mechanism Based
Designed for Selectivity
Figure 16.2 The Biology of Cancer (© Garland Science 2007)
Figure 16.4a The Biology of Cancer (© Garland Science 2007)
Figure 16.4b The Biology of Cancer (© Garland Science 2007)
Figure 16.5a The Biology of Cancer (© Garland Science 2007)
Figure 16.5b The Biology of Cancer (© Garland Science 2007)
Figure 16.5c The Biology of Cancer (© Garland Science 2007)
Figure 16.5d The Biology of Cancer (© Garland Science 2007)
Therapies Targeting nonTumor Cells
Table 13.3 The Biology of Cancer (© Garland Science 2007)
Targeting the Angiogenic Switch
Tsp-1 Expression Induced by p53
Tsp-1 Expression Inhibited by Ras
An Intrinsic Negative Regulator of Endothelial Cell Populations
VEGF-
R
Inhib
.
PDGF-R
Inhib
.
Synergistic Inhibition of Angiogenesis by the Combination of a Pericyte Inhibitor and an Endothelial Cell Inhibitor
Figure 13.48a, b The Biology of Cancer (© Garland Science 2007)
Radiation Can Have a Greater Effect on Cells of the Microvasculature Than on Tumor Cells
Bone marrow origin of microvasculature cells
Figure 13.49 The Biology of Cancer (© Garland Science 2007)
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