Download - CompiledandProducedbytheNjardarsonGroup(CornellUniversity ...€¦ · O N OH H N HN S Cl SO2NH2 O O 71 Hyzaar Company: 2008Sales: $0.53Billion 2007Rank: 82 Profile: AnangiotensinIIreceptorblockeranda

O

N

OH

HN

HNS

Cl

SO2NH2OO

71 Hyzaar

Company: 2008 Sales:$0.53 Billion

2007 Rank:82

Profile:An angiotensin II receptor blocker and adiuretic used to treat hypertension.

N

N

Cl

OHN

N N

NH

72 ProAir HFA


2007 Rank:91

Profile:Inhaler used to treat obstructive airwaydisease and prevent bronchiospasms .

HO

HN

OH OH

73 Reyataz


2007 Rank:87

Profile:A protease inhibitor used to treat HIV.

O NH

HN N

NH

O

O

OH OHN O

O

N

HN

HNS

Cl

SO2NH2OO

74 Benicar HCT


2007 Rank:93


N

N

N

NN

HN

HO

O

O

OO

O

CO2H

75 Synthroid


2007 Rank:69

Profile:A thyroid hormone used to treat hypo-thyroidism and to suppress goiters.

H2N

O

OH

I

I

I

I

76 Avandia


2007 Rank:29

Profile:A thiazolidinedione used to treat type 2diabetes.

N NO

SNH

O

O

77 Boniva


2007 Rank:96

Profile:A bisphosphonate used to treat andprevent osteoporosis.

NP

OH

P

OHO

HOO

OH

OH

78 Strattera


2007 Rank:73

Profile:A selective norepinephrine reuptakeinhibitor used to treat ADHD.

NH

O

79 Polymagma Plain


2007 Rank:N/A

Profile:A fluid absorbent used to controldiarrhea.

80 Skelaxin


2007 Rank:78

Profile:A muscle relaxant used to treatmusculoskeletal discomfort.

O

O

NH

O

HO

81 Evista


2007 Rank:81

Profile:A selective estrogen receptor modulatorused to prevent and treat osteoporosis.

S

O

ON

OH

82 Asacol


2007 Rank:92

Profile:An anti-inflammatory agent used totreat inflammation of the colon.

CO2H

OH

H2N

83 Depakote


2007 Rank:67

Profile:An anticonvulsant used to controlseizures in patients with epilepsy.

OHO

O O

84 Xalatan


2007 Rank:88

Profile:A prostaglandin analogue used totreat ocular hypertension or glaucoma.

HO

HO

O

O

HO

Ph

85 Humira


2007 Rank:85

Profile:A tumor necrosis factor-blocker used totreat rheumatoid arthritis.

86 Benicar


2007 Rank:102

Profile:An angiotensin II receptor blocker usedto treat hypertension.

N

N

N

NN

HN

HO

O

O

OO

O

87 Gleevec


2007 Rank:99

Profile:A protein-tyrosine kinase inhibitor usedto treat chronic myeloid leukemia.

N

N

NHN

HN

O

N

N

88 AndroGel


2007 Rank:103

Profile:A testosterone gel used to treat menwith testosterone deficiencies.

O

OH

H

H

H

O

O

O

OHN

OH

HN

c

93 RenaGel


2007 Rank:113

Profile:A prosphate binder used for patientswith chronic kidney disease on dialysis.

H2N

H2N

a

bm

94 Avapro


2007 Rank:98


N

HN N

NN

N

O

95 Humira Pen


2007 Rank:162

Profile:A tumor necrosis factor-blocker used totreat rheumatoid arthritis.

96 Vyvanse


2007 Rank:N/A

Profile:A central nervous system stimulant fortreatment of ADHD.

NH

O

NH2

H2N

97 Kaletra


2007 Rank:100

Profile:Two protease inhibitors used to treatHIV.

HN

O

NHN

O

NH

OH

O

O

HN

O

NH

NH

OH

O

O

SN

N

O

SN

98 Xopenex


2007 Rank:104

Profile:A bronchodilator used to treat andprevent asthma attacks.

OH

HO

OHHN

CO2H

99 Copaxone


2007 Rank:112

Profile:A polypeptide mixture used to treatrelapsing-remitting multiple sclerosis.

H2N O

HN

NH2

O

NH O

HN

OH

O

OH

5n

3n

1.5n

nNH

O

H

H

H

H

O HN

CF3

F3C

100 Avodart


2007 Rank:121

Profile:A 5-alpha-reductase inhibitor used totreat enlarged prostates.

101 Femara


2007 Rank:114

Profile:An aromatase inhibitor used to treatbreast cancer.

N

N

N

CNNC

102 Avalide


2007 Rank:107


N

NO

NHN

N N

HN

NHS

O O

Cl

H2NO2S

103 Ortho TriCyclen Lo


2007 Rank:101

Profile:An estrogen and progestin combinationused as birth control.

NHO

H H

O

O

H H

HO

H H

H

OH

104 Sensipar


2007 Rank:127

Profile:A calcimimetic agent used to treathyperparathyroidism in dialysis patients.

HN

CF3

105 Aldara


2007 Rank:118

Profile:An immune response modifier used totreat skin cancer and genital warts.

N

N

NH2

106 NovoLog Mix70/30


2007 Rank:116

Profile:A mixture of insulin analogs used totreat diabetes.

107 Restasis


2007 Rank:125

Profile:An immunomodulator used to treatchronic dry eyes.

MeLeu-MeVal

Me-Leu-D-Ala-Ala-MeLeu-Val-MeGlu

Abu-MeGly

NO

OH

N

SNH2

HN

108 Mirapex


2007 Rank:132

Profile:A dopamine agonist used to treatParkinson's disease.

O

O

O

H

HHOH

H

HHHO

109 Yasmin 28


2007 Rank:76


110 Solodyn


2007 Rank:143

Profile:A semi synthetic tracycline derivativeused to treat severe acne vulagirs.

H

OH

HN(CH3)2

CONH2

OH

OHOH

N(CH3)2

O O

111Lantus SoloSTAR


2007 Rank:N/A

Profile:A long-acting insulin analog used totreat diabetes.

112 Norvir


2007 Rank:123

Profile:A protease inhibitor used to treat HIV.

S

NN

O

HN

ONH

HO HN

O

O

S N

113 Focalin XR


2007 Rank:133

Profile:A central nervous system stimulantused to treat ADHD.

HN O

O

114 Actoplus Met


2007 Rank:140

Profile:Combination of two antihyperglycemicsused to treat type II diabetes.

NH3C O

NH

S

O

O

NHN NH2

NH NH

115 Vesicare


2007 Rank:152

Profile:A muscarinic receptor antagonist usedto treat overactive bladder.

N O

NO

OHHO

O

O

116 Forteo


2007 Rank:119

Profile:A synthetic parathyroid hormone usedto treat osteoporosis.

OH

NH

117 Allegra-D12 Hour


2007 Rank:110

Profile:An antihistamine and a decongestantused to treat seasonal allergies.

NHO

HO

CO2H

118 Procrit


2007 Rank:105

Profile:A glycoprotein used to treat anemia inpatients with kidney failure or cancer.

119 Nasacort AQ


2007 Rank:108

Profile:An adrenocortical steroid used totreat nasal allergy symptoms.

O

HO O

O

O OH

F

H

H

120 Tarceva


2007 Rank:128

Profile:A tyrosine kinase inhibitor used to treatlung cancer.

N

N

HN

O

O

O

O

121 Combivir


2007 Rank:109

Profile:Two reverse transcriptase inhibitorsused to treat HIV.

N

NH2

O N

S

O

OH

O

N3

HON

NH

O

O

122 Tamiflu


2007 Rank:N/A

Profile:A viral neuraminidase inhibitor used totreat influenza types A and B.

O

O

O

NH

NH2

O

123 Avonex


2007 Rank:126

Profile:An interferon used to treat relapsingforms of multiple sclerosis.

O

OH

HO

OH

H

H H

H H

H H

124 NuvaRing


2007 Rank:137


125 Coreg CR


2007 Rank:199

Profile:A ß-adrenergic blocking agent used totreat mild to severe heart failure.

NH

O

NH

O

OH

H3CO

HO

NN

N N

NH

NH2

126 Epzicom


2007 Rank:136


127 Levemir


2007 Rank:N/A


128 Duragesic


2007 Rank:111

Profile:An opioid analgesic used to managechronic pain.

N

O N

129 RisperdalConsta


2007 Rank:160

Profile:An antipsychotic used to treatschizophrenia and bipolar mania.

NO

NF

N

N

O

130 Zyvox


2007 Rank:135

Profile:An oxizolidinone antibiotic used to treatserious bacterial infections.

N

F

NO

HN

O

O

O

NN

Cl

131 Tussionex


2007 Rank:167

Profile:A cough-suppressant and antihistamineused to treat colds and allergies.

O

N

OO

132 Invega


2007 Rank:N/A

Profile:An antipsychotic used to treatschizophrenia

N

N

ON

ON

F

133 Fosamax


2007 Rank:24

Profile:A bisphosphonate used to treat Paget'sdisease and osteoporosis.

HO P

O

OH

P

O

OH

H2N

HO OH

134 Kadian


2007 Rank:163

Profile:An opiate analgesic used to treatmoderate to severe pain.

O

HO

HO

H

N

O

O

N N

HN

N

O

135 Levitra


2007 Rank:158

Profile:A phosphodiesterase inhibitor usedto treat erectile dysfunction.

N

NS

O

136 Differin


2007 Rank:164

Profile:A retinoid used to treat acne.

O

CO2H

N

N

O

N

Cl

137 Astelin


2007 Rank:146

Profile:An antihistamine used to treat nasalallergy symptoms.

138 Lumigan


2007 Rank:141

Profile:A prostaglandin analog used to treatglaucoma and ocular hypertension.

OH

HO

HO

O

NH

139 Symbicort


2007 Rank:N/A

Profile:Combination of bronchodialator andanti-inflammatory used for asthma.

HOO

O

H

HH H

O

OH

O

O

HN

OH

OH

NHO

140 Janumet


2007 Rank:N/A

Profile:A combination of two complementaryantihyperglycemic agents for diabetes.

89 Enbrel Sureclick


2007 Rank:115

Profile:A tumor necrosis factor inhibitor used totreat arthritis and psoriasis.

CO2H

N

O

O

N

F

HN

H

H

90 Avelox


2007 Rank:90

Profile:A fluoroquinolone antibiotic used to treatbacterial infections.

91 Fantanyl Oral Citra


2007 Rank:94

Profile:An opioid analgesic used to managebreakthrough cancer pain.

N

NO

92 Lovaza


2007 Rank:131

Profile:Ethyl esters from omega-3 fatty acidsused to lower high triglyceride levels.

F

FF

H2N

O N

NN

N

CF3

HNN

NH

NH2

NH

NHN

141 Xeloda


2007 Rank:156

Profile:An antimetabolite used to treat breastand colon cancers.

N

O

F

O

HO OH

OO

142 Clarinex


2007 Rank:117

Profile:An antihistamine used to treat thesymptoms of allergies.

N

Cl

HN

143 Proventil HFA


2007 Rank:N/A

Profile:A bronchodilator used to treat asthmaand obstructive pulmonary disease

HO

HO

OHHN

144 Humalog Mix75/25 Pn


2007 Rank:153

Profile:A mixture of insulin analogs used totreat diabetes.

O

O O

O

145 BenzaClin


2007 Rank:147

Profile:An antibiotic and a drying agent usedto treat acne.

N

O

NH

Cl

O

OH

OH

S

O

P OH

OH

O

N

O

O

F

NHNH

H

HO2C

146 Vigamox


2007 Rank:151

Profile:A fluoroquinolone antibiotic used to treateye infections.

147 Foxamax Plus D


2007 Rank:139

Profile:A bisphosphonate and vitamin D usedto treat and prevent osteoporosis.

OHP

OH

O

OH

P

O

OH

HO

NH2H

H

OH

148 Maxalt


2007 Rank:169

Profile:A serotonin receptor agonist used totreat migranes.

NH

N

NN

N

149 Cosopt


2007 Rank:134

Profile:A carbonic anhydrase inhibitor and abeta blocker used to treat glaucoma.

S S

NH

OO

S NH2

O

O

NNS

ON

O

HNHO

150 Requip


2007 Rank:95

Profile:A dopamine agonist used to treatParkinson’s disease and RLS.

NH

N

O

151 Relpax


2007 Rank:148


S

O

O

HN

N

152 Patanol


2007 Rank:129

Profile:An antihistamine used to relieve watery,red, or itchy eyes caused by allergies.

O HO

O

N

F3C

NH

O

HO S

O

O

F

NC

153 Casodex


2007 Rank:150

Profile:A nonsteroidal antiandrogen used totreat prostate cancer.

154 Welchol


2007 Rank:176

Profile:A non-absorbed polymeric LDL-C andglucose-lowering agent.

**

NH2

**

NH2

NH2

**

NH2

**

NH2

N

OH

ClCl

Cl

Cl Cl

Cl

...... ...... ...... ............a b c d

m

155 Ciprodex Otic


2007 Rank:172

Profile:An antibiotic and a corticosteroid usedto treat ear infections.

N

HO2C

N

NH

O

F

O

O OH

OHHO

F

H

H

156 Viread


2007 Rank:149

Profile:A reverse transcriptase inhibitor used totreat HIV.

N

NN

N

NH2

O P O

O

O

O O

O

O O

O

157 Catapres-TTS


2007 Rank:165

Profile:An alpha agonist used to treathypertension.

Cl

Cl

HN

HN

N

158 Loestrin 24 Fe


2007 Rank:N/A

Profile:An estrogen and progestin combinationused as an oral contraceptive.

H

H H

HO

H H

H H

O

O

O

OH

159 Thalomid


2007 Rank:144

Profile:An immunomodulator used to treat skininflammation and multiple myeloma.

N

O

O

NH

O

O

160 Alphagan P


2007 Rank:166

Profile:An adrenergic agonist used to treatglaucoma and ocular hypertension.

N

NN

BrHN

NH

O

NH

HO

161 Endocet


2007 Rank:159

Profile:A narcotic and an analgesic/antipyreticused to treat moderate pain.

O

OH

N

OO

162 Revlimid


2007 Rank:N/A

Profile:An immomodulatory compound to treatmultiple myeloma.

N

NH

NH2

O

O

O

163 Avandamet


2007 Rank:124

Profile:An insulin resistance reducer and abiguanide used to treat type 2 diabetes.

N NO

SNH

O

O

NHN NH2

NH NH

164 Maxalt MLT


2007 Rank:177


NH

N

NN

N

165 Altace


2007 Rank:56

Profile:An ACE inhibitor used to treathypertension and heart disease.

N

HO2C

O

HN

OO

166 Budeprion SR


2007 Rank:155

Profile:A norepinephrine and dopamine reuptakeinhibitor used to treat depression.

Cl

O

NH

167 Pegasys


2007 Rank:183

Profile:An interferon used to treat chronichepatitis C infection.

169 Fentora


2007 Rank:194

Profile:An opeoid analgesic intended for opeoidtolerant cancer patients..

N N

O

170 Asmanex


2007 Rank:178

Profile:A corticosteroid inhaler used to treatasthma.

OHO

Cl

O

O

OClH2C

H

171 Rhinocort Aqua


2007 Rank:142

Profile:A corticosteroid used to treat nasalallergy symptoms.

O

HO

H

O

O

O OH

H

N

NN

N

O

NNH2

O

172 Temodar


2007 Rank:173

Profile:An antineoplastic agent used to treatrecurrent malignant brain tumors.

173 Micardis HCT


2007 Rank:191

Profile:An orally active angiotensin II antagonistused to treat hypertension.

NN

N

N

OOH

NH

NHS

O OH2NO2S

Cl

174 Sotret


2007 Rank:N/A

Profile:A retinoid that inhibits sebaceous glandfunction used to treat nodular acne

O OH

N3

175 Trizivir


2007 Rank:154

Profile:Three reverse transcriptase inhibitorsused to treat HIV.

N

N N

N

H2N

HN

OH

S

OOH

N

N

NH2

O ONHO

NH

O

O

176 Enablex


2007 Rank:195

Profile:A muscarinic receptor antagonist usedto treat overactive bladder.

O

N

O NH2

177 Isentress


2007 Rank:N/A

Profile:An antiviral that inhibits HIV-1 integraseused to treat HIV.

N

N

O

HN

O

NN

O

OH

O

NH

F

180 Sustiva


2007 Rank:157

Profile:A non-nucleoside reverse transcriptaseinhibitor used to treat HIV.

NH

OCl

O

F3C

179 Trileptal


2007 Rank:75

Profile:An anticonvulsant used to treat seizuresin patients with epilepsy.

N

O NH2

O

O

OHO

HO

F

H

H

OH

178 TobraDex


2007 Rank:174

Profile:An antibiotic and a glucocorticoid usedto treat eye infections.

O

O

OOH

H2N

O

HO

H2N OH

NH2

OHNH2

NH2

OH

168 Ultram ER


2007 Rank:184

Profile:An analgesic used to treat severe tomoderate chronic pain.

HO

NCH3

CH3

H3CO

181 Amitiza


2007 Rank:N/A

Profile:A chloride channel activator that is usedto for chronic constipation.

O

O

F F

OH

O

OH

H

H

182 Micardis


2007 Rank:N/A

Profile:An orally active angiotensin II antagonistused to treat hypertension.

NN

N

N

OOH

183 Zovirax Topical


2007 Rank:186

Profile:An antiviral used to treat the symptomsof herpes simplex virus infections.

HN

N N

N

OOH

H2N

O

184 Ocella


2007 Rank:N/A

Profile:An ethinyl estradiol and drospirenonemix used as an oral contraceptive.

H

H

H

O

O

O

H

H H

HO

OH

185 Propecia


2007 Rank:N/A

Profile:An azasteroid used for the treatment ofmale pattern hair loss.

NH

H

H

H H

O

OHN

186 Taclonex


2007 Rank:N/A

Profile:Combination of a corticosteroid and avitamin D analogue used for psoriasis.

H

F H

O

O

OH

HH

O

HOO

O

O

187 Actiq


2007 Rank:138

Profile:An opioid analgesic used to managecontinual breakthrough cancer pain.

N

O N

188 Valcyte


2007 Rank:N/A

Profile:An inhibitor viral DNA synthesis used totreat cytomegalovirus retinitis.

N

NH

N

N

O

H2N

O

HO

O

O

NH2

189 Klor-Con


2007 Rank:182

Profile:Potassium chloride used as potassiumsupplementation.

190 Atacand


2007 Rank:179

Profile:An angiotensin II receptor blocker usedto treat hypertension and heart failure.

N

HN

N

N

NN

HO2C

O

191 Doryx


2007 Rank:N/A

Profile:A tetracycline broad-spectrum antibioticused to treat a variety of infections.

OH O HOHO

O O

NH2

OH

NH

OHH

192 Veramyst


2007 Rank:N/A

Profile:An anti-inflammitory corticosteroid usedto treat nasal symptoms and allergies.

H

F H

O

O

F

O

O

S

O

F

193 Avinza


2007 Rank:197

Profile:An opioid analgesic used to treatmoderate to severe pain.

O

HO

HO

H

N

194 Allegra-D 24 Hour


2007 Rank:N/A

Profile:An antihistamine and a decongestantused to treat seasonal allergies.

OH

NH

NHO

HO

CO2H

195 Opana ER


2007 Rank:N/A

Profile:An opiate analgesic used to treatmoderate to severe pain.

O

HO

O

OH

N

196 Zomig


2007 Rank:N/A


HN

N

NHO

O

197 Humulin 70/30


2007 Rank:N/A

Profile:An insulin analog used to treat diabetes.

198 Prempro


2007 Rank:198

Profile:A combination of hormones used to treatmenopausal symptoms.

O3SO

H H

H

O

O3SO

H H

O

O

H

H

H

OO

O

199 Humulin N


2007 Rank:190

Profile:An insulin analog used to treat diabetes.

200 Xopenex HFA


2007 Rank:N/A

Profile:A bronchodilator used to treat andprevent asthma attacks.

HO

HO

OHHN

Profile:An HMG-CoA reductase inhibitor usedto lower LDL cholesterol levels.

1 Lipitor


2007 Rank:1

HN

O

NHO

HO

HO2C

F

7 Singulair


2007 Rank:6

Profile:A leukotriene receptor antagonist usedto treat asthma and allergies.

NCl

OH

S

CO2H

8 Effexor XR


2007 Rank:8

Profile:A serotonin and norepinephrine reuptakeinhibitor used to treat depression.

O

N

OH

Profile:A proton pump inhibitor used to treatheartburn and esophagitis.

2 Nexium


2007 Rank:2

N

O

S

O

HN

N

O

3 Plavix


2007 Rank:5

Profile:A platelet aggregation inhibitor used toreduce stroke and heart attack risk.

S

N

OOCl

4 Advair Diskus


2007 Rank:3

Profile:A corticosteroid and a bronchodilatorused to treat and prevent asthma.

O

HO

F

H

H

SO

F

O

F

O

HO

HO

OH HN

OPh

Profile:A proton pump inhibitor used to treatgastric reflux disease.

5 Prevacid


2007 Rank:4

N

HN

SO

N

OCF3

6 Seroquel


2007 Rank:7


S

NN

N OOH

9 OxyContin


2007 Rank:33

Profile:An opioid analgesic used to treatmoderate to severe pain.

10 Actos


2007 Rank:10

Profile:A thiazolidinedione used to treat type 2diabetes.

N

O

S

NH

O

O

11 Lexapro


2007 Rank:9

Profile:A selective serotonin reuptake inhibitorused to treat depression and anxiety.

O

NF

NC

12 Abilify


2007 Rank:15


HN

O

O

N N

Cl Cl

13 Topamax


2007 Rank:13

Profile:A carbonic anhydrase inhibitor used totreat seizures and prevent migranes.

O

OO

O O

S OO

O

NH2

14 Cymbalta


2007 Rank:16

Profile:A serotonin and norepinephrine reuptakeinhibitor used to treat depression.

O

NH

S

15 Zyprexa


2007 Rank:18

Profile:A thienobenzodiazepine used to treatschizophrenia and bipolar mania.

NH

N

S

N

N

16 Valtrex


2007 Rank:22

Profile:An antiviral agent for treating shingles,cold sores, and genital herpes.

HN

N N

N

O

H2N

O

OO

H2N

17 Crestor


2007 Rank:23

Profile:An HMG-CoA reductase inhibitor usedto lower LDL cholesterol levels.

N

N

CO2H

NSO

O

F

OH OH

18 Vytorin


2007 Rank:12

Profile:A statin and a cholesterol absorptionblocker used to treat high cholesterol.

FN

O

OH

F

OH

H

O

O

O

HO O

19 Lamictal


2007 Rank:17

Profile:An anticonvulsant used to treatseizures and bipolar disorder.

N

N N

H2N

NH2

Cl Cl

20 Celebrex


2007 Rank:20

Profile:A COX-2 inhibitor NSAID used to treatarthritis pain.

S

O

H2NO

NN

CF3

21 Lantus


2007 Rank:26


22 Levaquin


2007 Rank:19

Profile:A fluoroquinolone antibiotic used to treatbacterial infections.

F

N

N

N

O

O

CO2H

23 Adderall XR


2007 Rank:27

Profile:An amphetamine used to treat ADHDand narcolepsy.

NH2

24 Lyrica


2007 Rank:37

Profile:An anticonvulsant used to treat nervepain and seizures.

CO2H

H2N

25 Diovan


2007 Rank:28

Profile:An angiotensin II receptor blocker usedto treat hypertension and heart failure.

N

HNNN

N

CO2HO

26 Tricor


2007 Rank:30

Profile:A lipid-lowering agent used to treat highcholesterol and triglyceride levels.

Cl

O

O

OO

O O

NH2

27 Flomax


2007 Rank:36

Profile:An alpha blocker used to treat enlargedprostates.

S

O

NH

O

O

28 Risperdal


2007 Rank:14


N

N

ON

ON

F

HN

HNS

Cl

SO2NH2OO

29 Diovan HCT


2007 Rank:32


N

HNNN

NCO2HO

30 Zetia


2007 Rank:21

Profile:An antihyperlipidemic agent used tolower cholesterol levels.

NO

OH

F

FOH

31 Aricept


2007 Rank:39

Profile:A cholinesterase inhibitor used to treatAlzheimer's disease.

N

O

OO

32 Spiriva

Company: 2008 Sales:$1.14Billion

2007 Rank:47

Profile:An anticholineric agent used to treatchronic obstructive pulmonary disease.

N

O

O

O

OH

S

S

33 Concerta


2007 Rank:34

Profile:A central nervous system stimulantused to treat ADHD.

O

O

HN

34 Aciphex


2007 Rank:31

Profile:A proton pump inhibitor used to treatduodenal ulcers and acid reflux.

HN

NSO

N

O O

35 Imitrex Oral


2007 Rank:40


NH

N

S OO

NH

36 Lidoderm


2007 Rank:49

Profile:A local anesthetic used to relieve painassociated with shingles.

NH N

O

37 Keppra


2007 Rank:57

Profile:An anticonvulsant used to treat seizuresin patients with epilepsy.

N O

NH2

O

38 Viagra

Company: 2008 Sales:$0.92Billion

2007 Rank:48

Profile:A phosphodiesterase inhibitor used totreat erectile dysfunction.

NH

NS

N

N

O

O

NN O

O

39 Atripla


2007 Rank:61

Profile:Efavirenz, Emtricitabine, and TenofovirDF combination used to treat HIV.

N

NN

N

PO

OO

O

O

OO

O

O

NH2

NH

O

F3CCl

O

S

O

OH

N

NH2N

F

O

O

O

O

O

OH

HO3SO

OH

OSO3H

OOSO3H

O

HO3SHN

O OSO3H

O

HN

HOO

HO

OH

O

HO

O

40 Lovenox


2007 Rank:53

Profile:An antithrombotic used to prevent bloodclots.

41 Januvia


2007 Rank:84

Profile:A DPP-4 enzyme inhibitor used to treattype II diabetes.

N

NN

N

O

F

F

F

CF3

NH2

42 Nasonex


2007 Rank:43

Profile:A corticosteroid used to treat allergicand nonallergic nasal symptoms.

O

O

OCl

H

HO

Cl

HO

O

43 Ambien CR


2007 Rank:45

Profile:A sedative-hypnotic used to treatinsomnia.

N

N

N

O

44 Provigil


2007 Rank:54

Profile:A wakefullness-promoting agent used totreat narcolepsy.

S

O

NH2

O

45 Geodon Oral


2007 Rank:58

Profile:An antipsychotic used to treat acuteagitation in patients with schizophrenia.

N

N

NS

Cl NH

O

46 Truvada


2007 Rank:62


NN

N

NH2N

O PHO

OH

O

S

OHON

NO

NH2

F

47 Lunesta


2007 Rank:55

Profile:A hypnotic agent used to treat insomnia.

N

N

N

N

O

N

O

N

O

Cl

48 Enbrel


2007 Rank:46

Profile:A tumor necrosis factor inhibitor used totreat arthritis and psoriasis.

49 Actonel


2007 Rank:50

Profile:A bisphosphonate used to treat andprevent osteoporosis.

N

OH

P P

OH

O

OH

O

HO

HO

50 CellCept


2007 Rank:63

Profile:An immunosuppressant used to preventorgan transplant rejection.

O

O

CO2H

OH

OCH3

51 Humalog


2007 Rank:65

Profile:A rapid acing insulin analog used totreat diabetes.

52 Detrol LA


2007 Rank:60

Profile:An antimuscarinic agent used to treatoveractive bladders.

OH

N

53 Depakote ER


2007 Rank:66

Profile:An anticonvulsant used to controlseizures in patients with epilepsy.

OHO

O O

54 Cozaar


2007 Rank:59


N

N

N

NHN

N

Cl

OH

55 PulmicortRespules


2007 Rank:64

Profile:An inhaled corticosteroid used to treatand prevent asthma.

O

O

O

OHO

H

HO

H

H

56 Niaspan


2007 Rank:70

Profile:A vitamin used to lower LDL and raiseHDL cholesterol levels.

N

CO2H

57 Wellbutrin XL


2007 Rank:38

Profile:A norepinephrine and dopaminereuptake inhibitor that treats depression.

O

NH

Cl

58 Chantix


2007 Rank:51

Profile:An oral tablet taken to aid in smokingcessation.

N

N

NH

59 Budeprion XL


2007 Rank:72

Profile:A norepinephrine and dopamine reuptakeinhibitor used to treat depression.

Cl

O

NH

60 Byetta


2007 Rank:71

Profile:An incretin mimetic used to treat type 2diabetes.

61 Yaz


2007 Rank:130

Profile:An Ethinyl Estradiol and Drospirenonemix used as an oral contraceptive.

O

H

HH

H

HH

H

O

O

OH

H

H

HO

H

OHO

O

HOO

NO

O

O

OH

OO

H

O

62 Prograf


2007 Rank:79

Profile:An immunosuppressant used to preventliver or kidney transplant rejection.

63 Namenda


2007 Rank:83

Profile:An NMDA-receptor antagonist used totreat Alzheimer-type dementia.

NH2

64 Arimidex


2007 Rank:80

Profile:An aromatase inhibitor used to treatbreast cancer.

CNNN

N

NC

65 Combivent


2007 Rank:74

Profile:A bronchodilator and beta-receptorstimulant used to treat COPD.

N

O

OHOOH

NH

HO

OH

66 Cialis


2007 Rank:86

Profile:A phosphodiesterase inhibitor used totreat erectile dysfunction.

OO

N

N

NH

O

OH

67 Flovent HFA


2007 Rank:77

Profile:A corticosteroid used to prevent and toreduce the frequency of asthma attacks.

O

F

F

O

S O

F

O

HO

H

68 Protonix


2007 Rank:11

Profile:A proton pump inhibitor used to treatesophagus inflammation and erosion.

N

O

O

S

O

NH

N

O

F

FO

HH

O3S

69 Premarin Tabs


2007 Rank:68

Profile:Estrogen mixture used to treat breastcancer and menopausal symptoms.

O

H

HH

O3S

70 Suboxone


2007 Rank:120

Profile:An opioid agonist/antagonist and an ant-agonist used to treat opioid dependence.

O

HO

O

HO

N

O

HO

OH

OH

HO

Compiled and Produced by the Njardarson Group (Cornell University): Matthew Brichacek, Nicholas McGrath, Dan Mack, Jón T. Njarðarson

http://drugtopics.modernmedicine.com/drugtopics/data/articlestandard//drugtopics/192009/597083/article.pdf

S

OOH

N

N

NH2

O

O

O

O

OH

N

Administrator

矩形

Administrator

矩形

Administrator

矩形

Administrator

矩形

Administrator

矩形

Administrator

矩形

Administrator

矩形

Administrator

矩形

Administrator

矩形

Administrator

矩形

Administrator

矩形

Administrator

矩形

Administrator

矩形

Administrator

矩形

Administrator

矩形

Administrator

矩形

Administrator

矩形

Administrator

矩形

Administrator

矩形

Administrator

矩形

Administrator

矩形

Administrator

矩形