CNESH Horizon Scanning:
Challenges and Alternative Approaches.
John Soloninka, PEng MBAPresident and CEO, HTX
• Private non-profit corporation.
• Leading Canadian supporter of medtech.– Project financing – Support, ecosystem information broker and network.
Connectivity.
• De-risking technologies and business plans.
• Multiple foreign market access initiatives.
• $21.4M HTCP fund – 38 financings – $86M total project value
• NEW REACH Innovation Procurement Fund
33 Portfolio Companies
Thoughts…
• Quick observations on Horizon Scanning• Value Proposition?• How HTX-led Initiatives might support
CNESH– National RISE Medtech Ecosystem Registry– REACH Innovative Technology Registry
23 International Scanning Organizations:Are there complementarities or collaboration potentials?
• EuroScan (20 government-funded members) • AHRQ• U.S. Centers for Medicare & Medicaid Services (CMS) • U.S. Food and Drug Administration (FDA)• U.S. Center for Disease Control and Prevention (CDC)• Private organizations: ECRI Institute, Frost and
Sullivan, Hayes, Ingenix, and Thomson Reuters.
EuroScan includes the following: • Agencia de Evaluación de Tecnologías Sanitarias
(AETS). Instituto de Salud Carlos III, Spain • Agencia de Evaluación de Tecnologías Sanitarias de
Andalucía, Spain (AETSA) • Agenzia nationale per i servizi sanitari regionali, Italy
(Age.na.s) • Australia and New Zealand Horizon Scanning
Network, Australia and New Zealand (ANZHSN, including Adelaide Health Technology Assessment [AHTA])
• Basque Office for Health Technology Assessment, Basque Country (OSTEBA)
• Canadian Agency for Drugs and Technologies in Health, Canada (CADTH)
EuroScan - continued: • Committee for Evaluation & Diffusion of Innovative
Technologies, France (CEDIT) • Council of the Netherlands, The Netherlands (GR) • Danish Centre for Evaluation and Health Technology
Assessment, Denmark (DACEHTA) • Division of Medical Technology Policy, Ministry of
Health, Israel (DMTP) • German Institute for Medical Documentation and
Information, Germany (DIMDI) • Haute Autorité de Santé, France (HAS) • Health Information & Quality Authority, Ireland
(HIQA) • Italian Horizon Scanning Project, Servizio
Farmaceutico Territoriale, Italy (IHSP) • Ludwig Boltzmann Institute for Health Technology
Assessment, Austria (LBI-HTA) • Managed Uptake of Medical Methods programme,
Finnish Office for Health Technology Assessment, Finland (Finohta [MUMM])
• National Horizon Scanning Centre, England (NHSC) • Norwegian Knowledge Centre for the Health
Services, Norway (NOKC) • Swedish Council on Technology Assessment in Health
Care, Sweden (SBU) • Swiss Federal Office of Public Health, Switzerland
(SFOPH)
Horizon Scanning Examples Show Wide DivergenceHealth System Priorities and Local Innovation Sector Influences Results
All of the lists are unique….no overlap?!Could be due to criteria, health systems, local technologies…
NHSC Evaluation:
Sensitivity, specificity, and predictive values of NHSC’s prediction methods.Estimated wrt expert opinion of the impact 3 to 5 years after prediction.
• Sensitivity 71% (95% CI, 0.36–0.92), • Specificity 73% (95% CI, 0.64–0.8), • NPV 98% (95% CI, 0.92–0.99), and • PPV 14% (95% CI, 0.06–0.3).
The authors concluded that NHSC methods were ..“reasonably good at identifying lower priority developments, but tended to assign significance to more topics than the experts considered significant in their later practice.”
Challenges…
• Increasing relevance?• Getting more nominations?• HTX-led Initiatives might support CNESH
– National RISE Medtech Ecosystem Registry– REACH Innovative Technology Registry
Possible Directions…• For Regulators
– Focus on new science discoveries and capabilities introducing new risks or requiring new reg. science.
• Eg. BYOD mobile diagnostics; radical material properties; new imaging modalities; implantable sensors; closed loop artificial organs; self appendectomy iPhone apps.
– Focus less on cool devices that are not new from a regulatory science or clinical trial perspective.
• For HTA bodies– Focus on “cross silo” or “lean” technologies that show dramatic
potentially to increase quality at reduced cost.– Focus on technologies that could fundamentally alter existing
treatment pathways for dramatic effect.
• For Procurement and Providers– Focus on technologies showing realized value, not potential.– Focus on 10x, 5x, 2x benefits actually achieved!– Allow industry to self report…based on demonstrated evidence.
RISE – Medtech Ecosystem DatabaseRegistry of Innovators, Suppliers and Exporters
Vancouver
Toronto Montreal
Alberta6%
British Columbia
11%Manitoba
4%New
Brunswick1%
Newfound-land0%
Nova Scotia2%
Nunavut0%
Ontario56%
PEI0%
Quebec19%
Saskatchewan1%
Yukon0%
Total Provincial Aggregate
MedTech RISERegistry of Canadian Medtech Innovators, Suppliers and Exporters
WHAT IS RISE?
A SUSTAINABLE ONLINE REGISTRY OF
MEDTECH ENTITIES2,700+MEDTECH RISE PLAYERS
MANUFACTURERS
GOVERNMENT ORGANIZATIONS/NPO
DISTRIBUTORS
INVESTORS
SERVICE PROVIDERS/CONSULTANTS
MEDIA
R&D SERVICES 20863
929594
382545
16
BENEFITS TO REGISTERING?
Improves LOCAL &INTERNATIONAL VISIBLITY for your
COMPANY
IDENTIFIEScompetition and relevant players in Medtech space enable
s
opportunitiesADVANTAGEOUS
partnership
COST-FREE & EASY REGISTRATION!
~3,000
REACH: A New Innovation Procurement Program.(Highlighted in the “Evidence is Not Enough” Panel)
Technology/Product Development/
Validation
Maturing/ Evidence
Generation
Scale: Diffusion/ Export - Local,
Global
Intake(Pipeline)
OntarioSales
$ MNEs
SMEs
AcademicSpinoffs
USEU
ROCChina
Ont
US
EU
Rest of Canada
China
Ontario
HTX REACHTraditional InnovationSupport
Pre-MarketDevelopment Post-Market Evaluation
and AdoptionForeign Market Access
REACH Planned Registries• Innovative Technology Registry
– To support procurement and providers– “What innovative technologies are out there?”– ‘What has worked well?”– Pre/Post market technologies – so less speculative– Can be linked to the Problem Registry below.
• Health System Problem Registry– To inform innovators of H/S Needs & Priorities– Three possible classes
• Generic (e.g. Deskilling, setting of care change, lean etc.)• Reform driven e.g. (5% focus, QBPs, etc.)• Clinical Priorities (eg. Re-admits on CHF, Dx Apnea, ALCs, etc.)
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