Clinical Pharmacyand TherapeuticsEDITED BY
Roger Walker BPharm PhD FRPharmS FFPH
Professor of Pharmacy Practice,Welsh School of Pharmacy, Cardiff University;Consultant in Pharmaceutical Public Health, National Public Health Service for Wales, Wales, UK
Cote Whittlesea BSc MSc PhD MRPharmS
Senior Lecturer, Pharmacy Practice Department, Pharmacy School of Biomedical and Health Sciences,King's College London, London, UK
FOURTH EDITION
CHURCHILLLIVINGSTONE
ELSEVIER
EDINBURGH LONDON NEW YORK OXFORD PHILADELPHIA ST LOUIS SYDNEY TORONTO 2007
Contents
Section 1 General
1. Clinical pharmacy process 3D. Webb, J. G. Davies, D. McRobbie
2. Prescribing 14B. Strickland-Hodge
3. Practical pharmacokinetics 24R. Fitzpatrick
4. Drug interactions 40A. Lee, I. H. Stockley
5. Adverse drug reactionsA. Lee, S. H. L. Thomas
51
6. Laboratory data 64H. Wynne, C. Edwards
7. Parenteral nutrition 82S. J. Dunnert
8. Pharmacoeconomics 101J. Cooke
Section 2 Life stages
9. Neonates 111M. P. Ward Platt
10. Paediatrics 119C. Barker, A. J. Nunn, S. Turner
11. Geriatrics 135H. G. M. Shetty, K. Woodhouse
Section 3 Therapeutics
Gastrointestinal disorders
12. Peptic ulcer disease 149S. Ghosh, M. Kinnear
13. Inflammatory bowel disease 169S. E. Cripps, S. Beresford
14. Constipation and diarrhoea 187P. Rutter
Hepatic disorders
15. Adverse effects of drugs on the liver 199B. E. Cadman, B. Featherstone
16. Liver disease 215P. Kennedy, J. O'Grady
Renal disorders
17. Chronic kidney disease and end-stage renalfailure 232S. Smith, J. Marriott
18. Acute renal failure 250
J. Marriott, S. Smith
Cardiovascular disorders
19. Hypertension 265S. H. L. Thomas
20. Coronary heart disease 280D. Scott, J. Dwight
21. Chronic heart failure 298J. McAnaw, S. A. Hudson
22. Cardiac arrhythmiasD. Scott
319
23. Thrombosis 334P. A. Routledge, H. G. M. Shetty
24. Dyslipidaemia 346
R. Walker
Respiratory disorders
25. Asthma 367K. P. Gibbs, D. Cripps
26. Chronic obstructive pulmonary disease 386K. P. Gibbs, D. Cripps
27. Drug-induced lung disease 401
N. P. Keaney
Neurological and psychological disorders
28. Insomnia and anxiety 409C. H. Ashton
29. Affective disorders 424J. P. Pratt
30. Schizophrenia 438D. Branford
31. Epilepsy 447S. Dhillon, J W Sander
32. Parkinson's disease 463D. J. Burn
33. Pain 474S. Woolfrey, D. Kapur
34. Nausea and vomiting 487
E. Mason, P. A Routledge
Infections
35. Respiratory infections 496K. Saeed, A. Berrington
36. Urinary tract infections 510N J B Carbarns
37. Gastrointestinal infections 521J W Gray
38. Infective meningitis 531J W Gray
39. Surgical antibiotic prophylaxis 543J C Graham
40. Tuberculosis 555I K Nehaul
41. HIV infection 568H Leake Date. M Fisher
42. Fungal infections 599S J Pedler
Endocrine disorders
43. Thyroid and parathyroid disorders 614M D Page
44. Diabetes meffitus 629E A Hackett, S M Thomas
Obstetric and gynaecological disorders
45. Menstrual cycle disorders 656K Marshall. S Calverf
46. Menopause 669K Marshal. S CoJverf
47. Drugs in pregnancy and lactation 68)S J Gardiner. 0 J Woods
Urological disorders
48. Benign prostatic hyperplasia 691
R. L. Gower
Haematopoietic disorders
49. Anaemia 699
C. Acomb, J. Holden
Malignant disorders
50. Leukaemia 715G. Jackson, G. Jones
51. Lymphomas 731L Cameron, C. Loughran
52. Solid tumours 746
J.So
Rheumatic disorders
53. Rheumatoid arthritis and osteoarthritis 759D. M Bryant, A Alldred
54. Gout ond hyperuricoemia 777
A. Alldred, T. Capstick
Eye disorders
55. Glaucoma 789
L. C. Titcomb, S D Andrew
Skin disorders
56. Drug-induced skin disorders 807P. Magee
57. Eczema and psoriasis 818M. M. Carr
58. Pressure sores and leg ulcers 836R Anderson
Section 4 Appendices
Appendix 1 Medical abbreviations 853
Appendix 2 Glossary 861
Index 865
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