Chapter 18 Discussion
With multiple substitutents there can be antagonistic or reinforcing effects
Antagonistic or Non-Cooperative
D = Electron Donating Group (ortho/para-directing)W = Electron Withdrawing Group (meta-directing)
Reinforcing or Cooperative
Important tools for synthesis
ortho-para director
6
Diazonium chemistry
Mechanism for formation of Diazonium Salts from Anilines
Reduce reactivity with acetyl groups
Weak step here
A
B
C
D
A
B
D
From benzene
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