© Siemens AG 2012. All rights reserved.
Biograph mMRThe first two years of the world's only simultaneous, whole-body PET / MR
Siemens AGDr. Minne van der HaakBusiness Manager Biograph mMREurope, Middle East and Africa
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© Siemens AG 2012. All rights reserved.
What happened in the first two years?Biograph mMR raised immense positive feedback
Launch and Show at RSNA 2010FDA & CE Label in 2011Since 2011: more than 30 systems worldwide
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© Siemens AG 2012. All rights reserved.
Biograph mMR – PET/MRMarket Share Development
> 70% market sharein the integrated PET/MR segment
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© Siemens AG 2012. All rights reserved.
sequential is now simultaneous.
two is now one.
potential is now reality.
With Biograph mMR…
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© Siemens AG 2012. All rights reserved.
sequential is now simultaneous.Covering a large spectrum of imaging.
Morphology Physiology Biochemistry
MR
PET
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© Siemens AG 2012. All rights reserved.
sequential is now simultaneous.
Simultaneous imaging precisely aligns a large spectrum of medical imaging including...
Exquisite details of an object’s structureOrgan and tissue function in high resolution Activity and changes at the metabolic level
... at a single point in time.
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© Siemens AG 2012. All rights reserved.
sequential is now simultaneous.
Aid healthcare professional in:
Early detection and staging of diseasesTherapy selectionTreatment PlanningMonitoring of therapyFollow-up
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© Siemens AG 2012. All rights reserved.
Aid healthcare professional in:
Early detection and staging of diseasesTherapy selectionTreatment PlanningMonitoring of therapyFollow-up
sequential is now simultaneous.
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© Siemens AG 2012. All rights reserved.
sequential is now simultaneous.Clinical benefit of simultaneous imaging
“Simultaneous acquisition of MRI and PET data opens the opportunity for performance of a comprehensive cardiac stress examination. Under identical conditions we can measure perfusion and viability of the myocardium in one exam.”
Professor Pamela K. Woodard, MDHead – Advanced Cardiac ImagingMallinckrodt Institute of RadiologyWashington University, St. Louis, MO, USA
The statements by Siemens’ customers described herein are based on results that were achieved in the customer's unique setting. Since there is no "typical" setting and many variables exist there can be no guarantee that other customers will achieve the same results
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© Siemens AG 2012. All rights reserved.
sequential is now simultaneous.Simultaneous imaging improves spatial correlation
Understanding the patient's symptoms requires detailed knowledge about anatomy and functional impairment
Exact spatial registration of PET and highly-detailed anatomy offers the full picture
Institute of Medical Physics (IMP) and University Hospital Erlangen, Erlangen, Germany
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© Siemens AG 2012. All rights reserved.
sequential is now simultaneous.Simultaneous imaging allows temporal co-registration
The full spectrum of anatomy, function, and metabolism captured in one point in time*
Precise and accurate assessment of disease for a more confident diagnosis
*N. Schwenzer et al.: Whole-body MR/PET: applications in abdominal imaging; AbdomImaging (2011)
dwMRI
Overlay:Fludedoxyglucose F 18 PET + T2 fat sat
CT
T2 fat sat
University Hospital, Tuebingen, Germany
Stomach Lymphoma
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© Siemens AG 2012. All rights reserved.
sequential is now simultaneous.MR data can be used to reduce motion effects in PET
Thoracic, abdominal, and pelvic structures are in constant motion (e.g. respiration, peristalsis)
Motion information collected by MR may help to minimize motion effects in both MR and PET data
Precise alignment may enable evaluation of smaller lesions
mMR Munich (TUM/LMU), funded by the DFG
Primary liver cancer
FDG PET overlayed on arterial phase
T1w DCEDWI Fludedoxyglucose F 18 PET
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© Siemens AG 2012. All rights reserved.
With Biograph mMR…
sequential is now simultaneous.
two is now one.
potential is now reality.
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© Siemens AG 2012. All rights reserved.
two is now one.Resulting in …
One examOne roomOne whole-body solution
Only Siemens can bring it alltogether
For shorter examsEasier schedulingAnd faster results
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© Siemens AG 2012. All rights reserved.
two is now one.Shorter exams and faster results
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© Siemens AG 2012. All rights reserved.
two is now one.Shorter exams and faster results
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© Siemens AG 2012. All rights reserved.
two is now one.One streamlined exam boosts productivity.
• 1 instead of 2 examinations• Potentially >50% faster!
Sequential MR and PET images
1. Attenuation correction 2. PET exam 3. Processing 4. MR exam 5. Post processing
MR-PET exams including AC further advanced MR exams within examination
Biograph mMR
Separate system design
transport between systems
TIME
TIME
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© Siemens AG 2012. All rights reserved.
two is now one.More patient comfort
A single exam could mean happier patients and higher productivity
Acquiring two exams in one improves workflow and speeds exam times
Patients only endure a single exam
Excellent image quality and fusion accuracy through less motion or interruptions
Only one sedation in pediatric patients
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© Siemens AG 2012. All rights reserved.
“Dose reduction is a major concern of ours - and this can be quite considerable.This is particularly critical in the examination of children and young adults, especially in cases of frequent follow-up examinations in therapy monitoring.”
Markus Lentschig, MDRadiologist and partner at the CEMODI practiceBremen, GermanyFirst purely private Biograph mMR user
two is now one.Dose reduction
MR scanning has not been established as safe for imaging fetuses and infants under two years of age. The responsible physician must evaluate the benefit of the MRI examination in comparison to other imaging procedures.
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© Siemens AG 2012. All rights reserved.
two is now one.The inside story on mMR technology
The mMR technology includes:
The first whole-body MR-friendly PET architecture
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© Siemens AG 2012. All rights reserved.
two is now one.The first whole-body MR-friendly PET architecture
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© Siemens AG 2012. All rights reserved.
two is now one.The first whole-body MR-friendly PET architecture
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© Siemens AG 2012. All rights reserved.
two is now one.TrueForm Magnet and Gradient design
Same magnetic field homogeneity as our high end 3T MR systems
Cylindrical magnet and gradient homogeneity volume
Excellent MR image quality even at the edges of the field of view
Improved spectral fat saturation due to TrueForm
Less overlap needed for multi-station (multiple bed) exams
Over 1000 TrueForm MRI systems installed!*
* Data on file
Conventional magnet design
TrueFormmagnet design
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© Siemens AG 2012. All rights reserved.
two is now one.The first whole-body MR-friendly PET architecture
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© Siemens AG 2012. All rights reserved.
two is now one.MQ gradients designed to deliver outstanding performance.
45 mT/m with 200 T/m/s capabilities
50 cm MR Field of View (45cm in Z)
Specially designed for Biograph mMR
Fully integrated with PET architecture
Enables a full spectrum of mMRimaging from clinical to research
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© Siemens AG 2012. All rights reserved.
two is now one.The first whole-body MR-friendly PET architecture
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© Siemens AG 2012. All rights reserved.
two is now one.The first whole-body MR-friendly PET architecture
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© Siemens AG 2012. All rights reserved.
two is now one.The first whole-body MR-friendly PET architecture
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© Siemens AG 2012. All rights reserved.
two is now one.NEMA 2007 PET specifications
4 x 4 x 20 mm³ LSO crystals
4.4 mm transverse spatial resolution (FWHM @ 1 cm)
13.2 cps/kBq sensitivity
175 kcps peak NEC rate 22 kBq/cc)
25.8 cm axial FoV
58.8 cm transaxial FoV
mMR Munich (TUM/LMU), funded by the DFG
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© Siemens AG 2012. All rights reserved.
two is now one.The first whole-body MR-friendly PET architecture
Avalanche Photo Diodes (APDs)
Solid state electronics with secure supplyEstablished technology and well known physicsthe only currently available approach for
simultaneous MR and PET imagingAffordable technology for clinical utilizationProven high reliability and stability up to 9.4TTemperature regulation and shielding incorporated
into a compact design40% sensitivity boost (relative to Siemens’ high
end Biograph mCT) via large FOV (26cm) improves contrast and S/N
PMT
APD
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© Siemens AG 2012. All rights reserved.
two is now one.The first whole-body MR-friendly PET architecture
Biograph mMR detector integration enables the industries’ largest PET field of view*
Eight detectors aligned axially to form one detector headUp to 25.8 cm axial (z) field of view!
* Based on Competitive Literature available at time of Publication. Data on file.
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© Siemens AG 2012. All rights reserved.
two is now one.The first whole-body MR-friendly PET architecture
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© Siemens AG 2012. All rights reserved.
two is now one.TimTX TrueForm – Overview
TimTX TrueForm is Siemens’ solution for B1 homogenization.
B1 shimming with 2-channel TX array functionality.
Anatomy-specific settings save time, enhancing productivity.
More than 750 TimTX TrueForminstallations.*
* Data on file
TimTX TrueForm supports good image quality in challenging cases as shown:Good B1 homogeneity in the presence of large fluid collection.
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© Siemens AG 2012. All rights reserved.
two is now one.Best of the world PET and MR image quality
Best MR image quality
Latest 3T Siemens magnet technology
Same gradient performance and magnet homogeneity as our high-end MR scanners
Tim technology
Best PET image quality
Largest PET FoV in industry (~26cm vs ~16cm in PET/CT)
Highest sensitivity in industry (+40% compared to mCT)
Same spatial resolution asBiograph mCT best in industry
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© Siemens AG 2012. All rights reserved.
two is now one.The inside story on mMR technology.
The mMR technology includes:
The first whole-body MR-friendly PET architectureAttenuation correction for high-quality PET images
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© Siemens AG 2012. All rights reserved.
two is now one.Fully optimized for a strong signal
Attenuation Correction
µ maps are derived from MRI data –no additional acquisitions necessary
MR-based four compartment segmentation and truncation correction methods
Attenuation correction of the whole human body
User customized µ maps are possible
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© Siemens AG 2012. All rights reserved.Institute of Medical Physics (IMP) and University Hospital Erlangen, Erlangen, Germany
Uncorrected PET
Fat
two is now one.MR-based attenuation correction of PET
Corrected PET
-Map
Water
Opp PhaseIn Phase
Dixon VIBE Sequence
Attenuationcorrection
Fused
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© Siemens AG 2012. All rights reserved.
two is now one.Attenuation correction for rigid stationary hardware
CT-based AC for table, head/neck and spine coils
µ-map is part of PET reconstruction process
Relevant part of µ-map is automatically selected for each table position
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© Siemens AG 2012. All rights reserved.
two is now one.The inside story on mMR technology
The mMR technology includes:
The first whole-body MR-friendly PET architectureAttenuation correction for high quality PET imagesTim, the Total imaging matrix.
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© Siemens AG 2012. All rights reserved.
two is now one.Tim delivers state of the art 3T.
Biograph mMR is built on state-of-the-art 3T technology
Tim coils have been enhanced to improve PET attenuation correction
Tim is a major differentiator
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© Siemens AG 2012. All rights reserved.
Two is now one.
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© Siemens AG 2012. All rights reserved.
two is now one.Biograph mMR coil portfolio
Biograph mMR coils for simultaneousexams
mMR Head/Neck, A Tim coilmMR Spine, A Tim coilmMR Body, A Tim coil4-channel flex coil, large and small
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© Siemens AG 2012. All rights reserved.
two is now one.Biograph mMR coil portfolio
Coils for MR specific examsAll Biograph mMR coils
Plus:32-Ch Body coil4-Ch Shoulder Array coils Tx / Rx CP Extremity coilTx / Rx 15-Ch Knee coil 16-Ch AI Breast coil 4-Ch Breast Array coil4-Ch BI Breast coilEndorectal coil and interface36-Ch Peripheral Angio coilLoop coils
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© Siemens AG 2012. All rights reserved.
two is now one.Biograph mMR and syngo.via are one
For the first time, Biograph mMRprovides MR and PET images as one dataset - molecular MR acquisition data
Only syngo.via can
fully utilize this one dataset toenable molecular MR evaluationwith one standardized report
bring this information into yourclinical environment
University Hospital, Tuebingen, Germany
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© Siemens AG 2012. All rights reserved.
two is now one.Biograph mMR and syngo.via
syngo.mMR General takes full advantage of identical Frames of Reference:
Data preparation reduced Markings correlated automatically between the two modalitiesFindings linked exactly in the Findings Navigator
Find the MR and PET tools you need where you need them.
My cases, ready
University Hospital, Tuebingen, Germany
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© Siemens AG 2012. All rights reserved.
two is now one.Biograph mMR and syngo.via
Enables simultaneous MR and PET evaluation with standardized reporting
Comprehensive set of evaluation tools and easy creation of findings
Network wide access for viewing, reading and collaboration
Every Biograph mMR includes syngo.via in the form of syngo.mMR General
syngo.via formolecular MR
University Hospital, Tuebingen, Germany
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© Siemens AG 2012. All rights reserved.
two is now one.Biograph mMR siting
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© Siemens AG 2012. All rights reserved.
sequential is now simultaneous.
two is now one.
potential is now reality.
With Biograph mMR…
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© Siemens AG 2012. All rights reserved.
potential is now reality.A large range of clinical applications – ready to go.
Neuro-oncologyNeurodegenerative diseaseHead & Neck tumorsCardiac one-stop-shop stress studiesSecondary liver malignancies and colorectal carcinomaLymphomaFemale pelvic oncology (ovaries, cervix)Pediatric* oncologyProstateBone metastases
Based on our early users’ experience and feedback the following key clinical applications have been identified
* MR scanning has not been established as safe for imaging fetuses and infants under two years of age. The responsible physician must evaluate the benefit of the MRI examination in comparison to other imaging procedures.
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© Siemens AG 2012. All rights reserved.
sequential is now simultaneous.A revolution in patient management
“I've been really impressed by the Biograph mMR. The combination of a fully integrated PET and MRI is something that is going to revolutionize how we actually look at and treat patients today.
In terms of personalized medicine, imaging has to be at the center: we feel that with technologies that combine molecular imaging with MRI, you really now have the best of the two worlds.”
Zahi A. Fayad, PhDProfessor, Radiology & CardiologyDirector, Translational Imaging InstituteMount Sinai Medical Center
The statements by Siemens’ customers described herein are based on results that were achieved in the customer's unique setting. Since there is no "typical" hospital and many variables exist (e.g., hospital size, case mix, level of IT adoption) there can be no guarantee that other customers will achieve the same results.
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© Siemens AG 2012. All rights reserved.
Clinical proof provided by first scientific publications from Munich and Tübingen:
Schwenzer et al.: Whole-body MR/PET: Applications in abdominal imaging; Abdom Imaging (2012), Vol. 37, No. 1, 20-28.Delso et al.: Performance Measurements of the Siemens mMR Integrated Whole-Body PET/MR Scanner. J Nucl Med (2011), Vol. 52, No. 12, 1914-1922.Drzezga et al.: First clinical experience of integrated whole-body PET/MR. Comparison to PET/CT in patients with oncological diagnoses; J Nucl Med(2012), Vol. 53, No. 6
potential is now reality.First scientific publications coming out…
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© Siemens AG 2012. All rights reserved.
potential is now reality.Clinical experience at University Hospital Tübingen
Combining perfusion and receptor status for estimation of total tumor load and evaluation of therapy regime
A) arterial CT B) arterial mMRC) somatostatin receptor status D) combined mMR data
AimReview articleTechnical summaryAddress clinical applications and research interests
Schwenzer et al.: Whole-body MR/PET: Applications in abdominal imaging; AbdomImaging (2012), Vol. 37, No. 1, 20-28.
ConclusionSimultaneous measurement of PET and MRI datasets allows for insights in metabolic and functional processes, particularly in oncologic demands, but also in cardiovascular and cerebral imaging.
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© Siemens AG 2012. All rights reserved.
AimPerformance evaluation of the Biograph mMR
Delso et al.: Performance Measurements of the Siemens mMR Integrated Whole-Body PET/MR Scanner. J Nucl Med (2011), Vol. 52, No. 12, 1914-1922.
potential is now reality.Technical evaluation at Klinikum rechts der Isar, Munich
MethodPET: NEMA NU 2-2007 protocolMRI: quality control manual of the American College of Radiology
ResultThe results compare favorably with other state-of-the-art PET/CT and MR scanners.The integration of the PET detectors in the MR and their operation within the magnet do not have a perceivable impact on the overall performance.
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© Siemens AG 2012. All rights reserved.
Aim“…to evaluate comparability of the clinical performance between conventional PET/CT and PET/MR in patients with oncologicaldiseases.“
Drzezga et al.: First clinical experience of integrated whole-body PET/MR. Comparison to PET/CT in patients with oncological diagnoses;J Nucl Med (2012), Vol. 53, No. 6
potential is now reality.Clinical experience at Klinikum rechts der Isar, Munich
Method32 patientsOncological diagnosesSingle-injection exam
PET/CT followed by molecular MR
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© Siemens AG 2012. All rights reserved.
ResultsAnatomical localization was comparable using Dixon-MR versus low-dose CTMolecular MR lesion detection had good correspondence with PET/CT“Very high correlation ( =0.93) between mean SUV in suspicious lesions with MR/PET and PET/CT.“
potential is now reality.Clinical experience at Klinikum rechts der Isar, Munich
ConclusionMolecular MR is "feasible in a clinical setting with high quality and in a short examination time."
Drzezga et al.: First clinical experience of integrated whole-body PET/MR. Comparison to PET/CT in patients with oncological diagnoses; J Nucl Med (2012), Vol. 53, No. 6
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© Siemens AG 2012. All rights reserved.
Early adopters >30
EuropeIMP Erlangen, Germany
Klinikum r. d. Isar, Munich, Germany
Univ. Hospital Tübingen, Germany
Univ. Hospital Leipzig, Germany
CEMODI Bremen, Germany
Univ. Hospital Essen, Germany
Univ. College London Hospitals, UK
SDN, Naples, Italy
DKFZ, Heidelberg, Germany
Rigshospitalet, Copenhagen, Denmark
St. Olav Hospital, Trondheim, Norway
DLRZ, Bonn, Germany
University of Padua, Italy
CERMEP/University of Lyon, France
North AmericaMGH, Boston, USA
NIH, Bethesda, USA
Washington Univ., St. Louis, USA
Univ. of N. Carolina, Chapel Hill, USA
Mt. Sinai Medical Center, New York, USA
Indiana University, Indianapolis, USA
Lawson Health Research Institute,London, Canada
UPMC, Pittsburgh, USA
NYU, New York, USA
Cleveland Clinic Foundation, Cleveland, USA
Stony Brook University, Stony Brook, USA
Weill Cornell Imaging, New York Presbyterian, NY, USA
AsiaPLA 301 Hospital, Beijing, China
Parkway Mt. Elizabeth Novena Hospital, Singapore
CIRC/NUS/A*Star, Singapore
Yeungnam Univ. Hospital, Korea
SNUH, Seoul, Korea
Apollo Hospitals, Delhi, India
Fukushima Medical Univ, Fukushima, Japan
74% global market share!
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© Siemens AG 2012. All rights reserved.
Biograph mMRThe world’s only simultaneous, whole-body molecular MR.
Biograph mMR:
Simultaneous acquisition of MR and PET
Fully integrated PET detector architecture
Largest PET field of view in the industry*
Powerful 3T MRI with TrueForm Design
Potentially faster exams through simultaneous acquisition
Easy siting, easy workflow
For the first time, MR and PET are one.
* Based on Competitive Literature available at time of Publication. Data on file.
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© Siemens AG 2012. All rights reserved
Potential is now reality.
Biograph mMRClinical Highlights
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© Siemens AG 2012. All rights reserved
Clinical view
Acquisition parameters
Case images
Overview
Ewing SarcomamMR Munich (TUM/LMU), funded by the DFG
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AcquisitionAcquisition
Soft tissue tumors
MR: soft tissue contrast in high resolutionPET: metabolic information
Combining this information offers potential for improved detection and therapy monitoring in sarcoma cases.
Biograph mMRClinical view
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ImagesImages
Biograph mMRAcquisition parameters
Courtesy of mMR Munich (TUM/LMU),funded by the DFG
Clinical case Ewing Sarcoma
Tracer Fludedoxyglucose F 18 Injection
PETtotal acquistion time 12 min (4 min per bed)
PETtotal scan range 70 cm (3 beds)*
* FOV per bed 25.8 cm
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More imagesMore images
T1w ce TSE with fat saturation
Overlay of metabolic information
Biograph mMRCase images
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Overview
Corresponding T2w TSE
Corresponding native T1w TSEWater and opposed-phase T1w Dixon VIBE acquired for attenuation correction of PET mMR data
Biograph mMRCase images
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Clinical view
Acquisition parameters
Case images
Overview
University Hospital, Tübingen, Germany
Anaplastic Thyroid Carcinoma
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Biograph mMRClinical view
AcquisitionAcquisition
Imaging soft tissue with CT often requires contrast media application.
However, a number patients do not tolerate contrast media (e.g. iodine-based CM in thyroid carcinoma).
mMR is an alternative for these patients, especially for evaluation of complex anatomical structures.
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Biograph mMRAcquisition parameters
Courtesy of University Hospital, Tübingen, Germany
Clinical case Anaplastic Thyroid Carcinoma
Patient weight 69 kg
Tracer Fludedoxyglucose F 18 Injection
Activity 347 MBq iv
Uptake time 140 min
PETtotal acquistion time 18 min (6 min per bed)
PETtotal scan range 70 cm (3 beds)*
* FOV per bed 25.8 cm
ImagesImages
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Overview
attenuation corrected PET overlay of metabolic information T2w TIRM
Biograph mMRCase images
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Clinical view
Case images
Overview
Metastatic Spread of Head/Neck CancerMallinckrodt Institute of Radiology, Washington University, St. Louis, USA
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Biograph mMRClinical view
Case of patient with head/neck cancer and advanced disease
Key benefits of mMR in head/neck cancer
detailed information about soft tissue
outstanding degree of spatial co-registration due to the simultaneously acquired PET
With fast and detailed imaging techniques like HASTE and VIBE, efficient mMR scanning is made available.
ImagesImages
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Overview
+
original PET of mMR attenuation corrected PET
CorrespondingPET of mMR
MPR
coronal T2w HASTE
Biograph mMRCase images
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Clinical view
Acquisition parameters
Case images
Overview
Institute of Medical Physics (IMP) and University Hospital, Erlangen, Germany
Bronchial Carcinoma
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Biograph mMRClinical view
For best results in staging exams the most valuable information from medical imaging has to be combined.In this case, the real nature of changes of lung tissue and mediastinum as visualized by MRI is only understandable by adding the metabolic information from PET.Gating information from the MR helps to reduce motion effects in the PET.
AcquisitionAcquisition
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Biograph mMRAcquisition parameters
Courtesy of Institute of Medical Physics (IMP) and University Hospital Erlangen, Erlangen, Germany
Clinical case Bronchial Carcinoma
Patient weight 77 kg
Tracer Fludedoxyglucose F 18 Injection
Activity 221 MBq iv
Uptake time 167 min
PETtotal acquistion time 40 min (10 min per bed)
PETtotal scan range 92 cm (4 beds)** FOV per bed 25.8 cm
ImagesImages
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More imagesT2w TSE with PACE navigator overlay of metabolic information
Biograph mMRCase images
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Overview
T2w TSE with PACE navigator overlay of metabolic information
Biograph mMRCase images
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Clinical view
Acquisition parameters
Case images
Overview
Hepatocellular CarcinomamMR Munich (TUM/LMU), funded by the DFG
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Biograph mMRClinical view
Tumor biology is defined by various parameters, e.g. vessel supply including perfusion, glucose turn-over, or cellularity.
Tumors do adapt to their environment and to therapy.
These factors may have an impact on selecting patient-individualized therapeutic approaches.
Providing the right biomarkers will be a key for these decisions.
Acquisition
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Biograph mMRAcquisition parameters
Courtesy of mMR Munich (TUM/LMU), funded by the DFG
Clinical case Hepatocellular Carcinoma
Tracer Fludedoxyglucose F 18 Injection
PETtotal acquistion time 12 min (4 min per bed)
PETtotal scan range 70 cm (3 beds)*
* FOV per bed 25.8 cm
Images
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Cellularity derived from diffusion weighted imaging (syngo REVEAL)
High-resolution morphologyT2w TSE with navigator (syngo PACE)
Perfusion derived from3D T1w DCE (syngo VIBE)
Overviewoverlay metabolic informationacquired simultaneously with MRI
Biograph mMRCase images
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Clinical view
Acquisition parameters
Case images
Overview
Institute of Medical Physics (IMP) and University Hospital, Erlangen, Germany
Pheochromocytoma
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Biograph mMRClinical view
X-ray and CT visualize bone structures in high detail. However, changes of bone marrow and developing bone lesions can be missed, especially at early stages, when changes of bone density have not yet occurred.
Combining MRI (detection of bone marrow changes) and PET (metabolic information) may provide better diagnostic information.
High soft tissue contrast is also relevant to evaluate involvement of adjacent structures e.g. infiltration of the spinal canal.
AcquisitionAcquisition
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Biograph mMRAcquisition parameters
Courtesy of IMP and University Hospital Erlangen, Erlangen, Germany
Clinical case Pheochromocytoma
Patient weight 115 kg
Tracer Fludedoxyglucose F 18 Injection
Activity 328 MBq iv
Uptake time 184 min
PETtotal acquistion time 50 min (10 min per bed)
PETtotal scan range 114 cm (5 beds)** FOV per bed 25.8 cm
ImagesImages
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More images
low-dose CT for attenuation correctionsoft-tissue kernel / window
corresponding PET/CT image
T2w TSE simultaneous mMR
Biograph mMRCase images
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Overview
simultaneous mMR
low-dose CT for attenuation correctionbone kernel / window
corresponding PET/CT image
T1w TSE
Biograph mMRCase images
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Clinical view
Acquisition parameters
Case images
Overview
CEMODI, Bremen, Germany
Breast Cancer
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Biograph mMRClinical view
PET enables the visualization of mineralization processes of the bone.
The following case of a 91 year old patient with bone metastases demonstrates the potential of mMR to help in the diagnosis of bone processes either osteoplastic, osteolytic or infiltrative.
Acq. parametersAcq. parameters
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Biograph mMRAcquisition parameters
ImagesImages
Courtesy of Center of Modern Diagnostics (CEMODI), Bremen, Germany
Clinical case 91 yrs old with breast cancer and history of ovarian cancer
Tracer Sodium Fluoride F 18 Injection
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More images
T2w TIRM overlay of metabolic datasodium fluoride F 18 PET of mMR scan
Biograph mMRCase images
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© Siemens AG 2012. All rights reserved
Overview
T1w TSE T2w TIRM overlay of metabolic data
Biograph mMRCase images
sodium fluoride F 18 PET of mMR scan
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© Siemens AG 2012. All rights reserved
Thank you foryour attention!
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