Advanced Preservative Free
aptar.com/pharma Delivering solutions, shaping the future.
Actuator
Closure
State of the art production
Dose volume: 50�µl to 140���µl
Snap-onSize: 20�mm
– 100�% in process control of all critical interfaces
– 100�% in process control of tip-seal integrity
– 100�% in process control of fi lter integrity
Advanced Preservative FreeGold standard for unpreserved nasal sprays
Benefi ts
– Soft and gentle mist
– Metal free fl uid path
– Sterile according to ISO11137
– Purely mechanical barrier, no additives
– Supporting sucessful brands globally – Spring loaded Tip-Seal mechanism
– Filter membrane in ventilation channel
– Unvented preservative free system
– Pouch system allows for 360° use
– Convenient and intuitive handling
TSIT (Tip Seal Integrity Test)
Submersed actuation in Pseudomonas aeruginosa suspension
Qualifi ed with challenging microbiological tests
Full 360° Functionality
CVIT(Closure Ventilation Integrity Test)
Closure and fi lter challenge with Bacillus atrophaeus spores
360°
Outstanding priming performance
APF advantages – Fast priming – Constant dose volume
APF advantages – Very low loss of weight – No re-priming necessary
100%
85%
0%
Priming strokes Days after last actuation
Do
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in %
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100%
80%
60%
40%
20%
0%
% o
f n
om
inal
do
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0 1 2 3 4 5 6 7 8 9 10
APF Standard pump
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