Kumar Organic Products Limited

Product InformationAntidandruff Active Ingredient

Contents

• Introduction• Product Data• Anti-microbial properties• Clinical Study• Benefits of Zinc Pyrithione• Our Export Destinations• Product Specification

Kumar Organic Products LimitedUsha Krishan Centre, No.819/C, 13th Cross, 7th Block (West)J.S.S. College Circle, Jayanagar, Bangalore 560082, Karnataka, India.Ph : 00 91 80 – 41525960, 080-41425832 Fax : 91 80 -26715688Email : sales_india1@kumarorganic.net

Zinc Pyrithione 50% FPS

INTRODUCTION

The first antidandruff shampoo containing Zinc Pyrithione was launched

almost four decades ago. Since then Zinc Pyrithione bactericide-fungicide has

become the worlds leading antidandruff agent. It also used as an antibacterial

agent in Dermatological creams and ointments.

Combination of efficacy and safety has made it most effective antidandruff

agent for several decades.

It effectively does the job any antidandruff agent is expected to do i.e.

relieving the flaking and itching symptoms of dandruff. Its lasting

properties make Zinc Pyrithione a superior one, meaning it sticks and

remains active on the scalp, so it’s effectiveness lasts from one use to the

next.

PRODUCT DATA

Structural Formula

N S

Zn

N

O

S

O

Zinc-2-Pyridinethiol-1-Oxide

Zinc Pyrithione is actually Zinc complex of Pyrithione which

is 2-Pyridine thiol-1-oxide. Under chemical abstracts

registry it is named as bis[1-hydroxy-2(1H)-

Pyridinethionato-O,S]-(T-4)Zinc (CAS No: 13463-41-7). The

molecular and structural formulae are C10H8N2O2S2Zn and

Physical Properties

Description : Off – White color, stable aqueous dispersion free from sign of impurities

Odor : Mild, Characteristic odor

Assay ( % ZPT ) : 48% - 50%

Zinc Content : 09.3 to 11.3 %

pH ( 5% Slurry in pH 7 water ) : 6.5 to 9.0

Particle size : 90% < 1 Micron

Solubility Properties

Water : 0.01% Max

Ethanol : 0.02% Max

Methanol : 0.03% Max

Chloroform : 0.10% Max Ether : 0.01% Max

Heat Stability : It is stable at 100c for at least 120hrs. Around 240c it undergoes decomposition.

pH : Stability :Zinc Pyrithione is quite stable over the pH range from 4 – 10. Below 4.5 the Zinc complex starts dissociating, forming free Pyrithione. Above pH 9.5 the Zinc complex undergoes hydrolysis to give ionized Pyrithione

Light Stability :Zinc Pyrithione undergoes gradual decomposition when exposed to light

Stability Study

Minimum Inhibitory Concentration(mcg/gm)

Staphylococcus aureus 6.3Escherichia Coli 12.6Bacillus Subtillus 6.3Pytyrosporum Ovale 6.3Trichophyton 12.5M

icro

orga

nism

s

Anti-microbial properties of ZPT:

Data shows very low concentrates of Zinc Pyrithione inhibits the growth of many micro-organisms

Zinc Pyrithione, an effective biocide with anti Pityrosporum activity, eliminates P.ovale the causative organism of dandruff and maintains good personal hygiene.

In – House Clinical Study

Clinical trial to study the efficacy and safety of Anti-dandruff shampoo containing 1.0% of Zinc Pyrithione was conducted on 20 male volunteers with moderate to severe dandruff for 04 weeks

S.no No.of people Percentage Reduction in dandruff in %1 16 80 902 2 10 803 1 5 754 1 5 60

Results of Clinical Trials

S.No

Isolation of P.ovale in culture before

treatment%

Isolation of P.ovale in culture after

treatment%

1 20 100 NIL 0

After 04 weeks of product usage it was not possible to isolate P.ovale in culture from all the volunteers.

Non of them complained of any adverse effects like pruritus, erythema, hair fall or local discomfort there was definite reduction in dandruff (White powder / flakes in the scalp) in all the volunteers

World wide Clinical Study

This graphic shows the clinical studies success rates of SKIN CARE in the treatment of severe skin disorders

This therapy represents one of the best advances in the treatment of psoriasis.

- Abbott Northwestern Hospital, USA

Positive effects in 95.5% of the treated cases. Good anti-inflammatory effect. No side effects. Disappearance of itches. No irritations. Very good results in dermatitis and neurodermatitis.

- State University of Medicine of Siberia

Positive effects were observed, with decrease of inflammation, itching and flaking. ZINC PYRITHIONE spray can be recommended for the treatment of psoriasis, dermatitis, seborrhea rosacea and eczema.

Centre for the Medical and Social Rehabilitation of Children Affected by Allergodermatitis, RUSSIA,

ZINC PYRITHIONE spray is a very effective and safe treatment, specially reducing flaking and plate erythema in patients affected by common psoriasis

- University of Buenos Aires

Good and very good results from the 6th day of treatment. Very good results, above all with spray and shampoo. Good absorption. Absence of side effects.

Effective alternative for the treatment of psoriasis.University Hospital of Dermatology

- University Hospital of Dermatology

Conclusion of different Clinical Research of ZPT Formulation

Benefits of Zinc Pyrithione

An effective, practically nontoxic antidandruff active ingredient

Suitable for the manufacture of antidandruff shampoos and hair care products such as hair tonics and cream rinses with an antidandruff action

Low concentration is required.

No side effects : Safe and effective antidandruff agent

It produced dramatic healing effects on skin lesions produced by psoriasis, dandruff, eczema, ringworm, fungus, athletes foot, dry skin, atypical dermatitis, tinea etc.

End Use / Formulations

• As an antidandruff agent in Shampoo

• Effective antibacterial – Anti fungal agent in derma – Cream Spray and Soap.

• Highly effective in Dandruff control, Psoriasis, Seborrheic Dermatitis, Other Dermatitis and Eczema

Our Export Destinations

Asia

-China-Philippines-Indonesia-Thailand-Taiwan-U.A.E.-Iran-Vietnam

Europe-United Kingdom-France

Latin America

-Brazil-Argentina-Venezuela-Columbia -Guatemala

Africa-South Africa-Kenya

America-USA-Canada

Sl.No. Properties Limits

1 Description Off - White colour, Stable Aqueous dispersion free from signs of impurity.2 Identity Confirms3 Odour Mild, Characteristic odour.4 Assay 48-50%5 Zinc content 9.3 –11.3%6 PH ( 5% Slurry in pH 7 water ) 6.5-9.07 Particle size by Malvern 90% < 1 Microns8 Iron 10ppm max as Fe9 Arsenic 5 ppm max as As

10 Lead 5 ppm max as Pb11 Chromium 3 ppm max as Cr12 Cobalt 3 ppm max as Co13 Nickel 5 ppm max as Ni14 Mercury 1 ppm max as Hg

Microbiological Test1.    Total plate count/g Less than 100(Including yeast and mold)2.    E.coli/g Negative3.    S.Aureaus/g Negative4.    Pseudomonas/g Negative

5. Enterobacteria/g Negative

15

Product Specification - Zinc Pyrithione

Kumar Organic Products Limited

Kumar Organic Products Limited

Usha Krishan Centre, No.819/C, 13th Cross, 7th Block (West)J.S.S. College Circle, Jayanagar, Bangalore 560082,

Karnataka, India.Ph : 00 91 80 – 41525960, 080-41425832 Fax : 91 80 -

26715688Email : sales@kumarorganic.net