Zika Capture igM · 2017-04-20 · liaison® Xl Zika Capture igM a new standard for Zika infection...
2
FOR OUTSIDE US AND CANADA ONLY Infectious Disease The only fully automated solution for specific and accurate diagnosis of Zika virus infection Zika Capture IgM
Transcript of Zika Capture igM · 2017-04-20 · liaison® Xl Zika Capture igM a new standard for Zika infection...
for outside us and Canada only
infectious disease
the only fully automated solution for specificand accurate diagnosis of Zika virus infection
Zika Capture igM
infectious disease
Product availability subject to required regulatory approval
aVailaBle on only
LIAISON® XL Zika Capture IgM code 317130LIAISON® XL Zika Capture IgM Control Set code 317131
ordering information
diasorin s.p.a.Via Crescentino
13040 Saluggia (VC) - ItalyTel. +39.0161.487526Fax: +39.0161.487670
www.diasorin.comE-mail: [email protected]
liaison® Xl Zika Capture igMa new standard for Zika infection diagnosis on a fully automated platform Zika virus is a mosquito-borne flavivirus and is closely related to dengue, yellow fever, Japanese encephalitis, and West nile viruses. Zika virus was first identified in 1947 in a sentinel monkey in the Zika forest of Uganda but did not begin spreading widely throughout the Americas until 2015. Zika virus is a disease which is spread to people primarily through the bite of an infected mosquito (Aedes aegypti and Aedes albopictus). Most people infected with Zika virus do not have symptoms, but when present they are usually mild. Zika virus infection during pregnancy has been linked to adverse pregnancy and birth outcomes, most notably microcephaly and other serious brain anomalies. this association has resulted in an ongoing public-health emergency.
M08
7000
4327
04/
17Main features of LIAISON® XL Zika Capture IgMSample Type: Serum Assay format: CLIA qualitative capture assayConjugate: Recombinant Zika virus NS1 antigenCross reactivity: absent with other Arboviruses
•the first fully automated solution with high sensitivity, evaluated in pregnant women from endemic areas
•the kit has been designed to accurately diagnose Zika virus infection without cross reactivity to other arboviruses
Arbovirus infections/ Yellow fever vaccination
N° positivesamples
LIAISON® XL Zika Capture IgM N° positive samples
Dengue virus 10 0West Nile Virus 14 0
Yellow fever virus post-immunization 10 0Chikungunya virus 5 0
Sample Volume: 25 μL Integral on board stability: 3 weeksNumber of tests: 100
Days after onset of symptoms (adapted from CDC)
0 8 14 35 49 63 84
Zika virus detection in serum Zika virus detection in urine
Zika IgM antibody determination in serum
LIAISON® XL Zika Capture IgM Competitor A
Population % Agreement
vs. PCR N° positive
samples% Agreement
vs. PCR N° positive
samples
Non- pregnant 100% 43/43 23% 10/43Pregnant 100% 15/15 60% 9/15TOTAL 100% 58/58 33% 19/58
The capture assay and the use of recombinant specific antigen assure superior specificity without cross reactions with other Arboviruses.
Samples collected from 58 symptomatic subjects, including 15 pregnant women initially, PCR positive for Zika virus, were confirmed positive by the LIAISON® XL Zika Capture IgM assay by the first sample collected following 8 days post symptom onset.
