ZEISS AngioPlex OCT Angiography Overview

California, 2015-09-02

ZEISS OCT Angiography

2 2015-09-02 Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

ZEISS AngioPlex

Ultra-clear visualization of

microvascular blood flow

using non-invasive

OCT angiography

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3 2015-09-02 Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

AngioPlex OCT Angiography from ZEISS

new

non-invasive

microvasculature

imaging technology

AngioPlex OCT Angiography allows visualization of both perfused

vasculature and vascular abnormalities of the retina without the need

of contrast. US_31_150_0016I_REVB

4 2015-09-02 Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

AngioPlex OCT Angiography from ZEISS

AngioPlex Technology detects motion of scattering

particles such as red-blood cells within sequential OCT

B-scans performed repeatedly at the same location of

the retina.

B-scan

y0

y2

y3

y1

y

Fast axis x

AngioPlex Technology

AngioPlex Maps consist of

reconstruction of the perfused

microvasculature within the retina

and choroid.

AngioPlex Maps

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5 2015-09-02 Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

AngioPlex Maps

Superficial Retina Map

Visualization of blood flow

in superficial retina.

Deep Retina Map

Visualization of blood flow

in deep retina.

Avascular Retina Map

Avascular region of the

retina in healthy eyes.

Allows for detection of

abnormal vascular growth.

AngioPlex Maps consists of a 2D representation of retinal the

vasculature of a particular region of interest.

1

2

3

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6 2015-09-02 Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

AngioPlex Color Depth Map

Superficial Retina Deep Retina Avascular Retina

Color Depth Retina Map

The color depth map combines superficial, deep and avascular retina

maps and allows for depth visualization of retinal blood flow.

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7 2015-09-02 Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

AngioPlex OCT Angiography from ZEISS Potential clinical applications

AngioPlex can potentially be used to

detect vascular structures, such as:

Areas of CNV in AMD

Neovascularization in Mactel

Micro-aneurysms and ischemia in DR

Occlusions and abnormalities in CRVO

and BRVO cases

Abnormalities of optic nerve vasculature

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8 2015-09-02 Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

OCT enface (3x3)

OCT Fundus LSO

Clinical case #1: Wet AMD with CNV 64y Male, OS

Courtesy of Prof. Philip Rosenfeld, Bascom Palmer Eye Institute, Miami, FL

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9 2015-09-02 Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

OCT Enface

Superficial Retina

AngioPlex - CIRRUS

OCT Angiography

Superficial Retina

Clinical case #1: Wet AMD with CNV 64y Male, OS

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Courtesy of Prof. Philip Rosenfeld, Bascom Palmer Eye Institute, Miami, FL

10 2015-09-02 Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

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esio

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Su

perf

icia

l R

eti

na

Clinical case #1: Wet AMD with CNV 64y Male, OS

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Courtesy of Prof. Philip Rosenfeld, Bascom Palmer Eye Institute, Miami, FL

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CNV

lesion

Courtesy of Prof. Philip Rosenfeld, BPEI, Miami

Zeiss SD-OCT prototype (investigational device, 510k pending)

CIRRUS OCT Angiography

Superficial Retina

CIRRUS OCT Angiography

Map through CNV Lesion

Clinical case #1: Wet AMD with CNV 64y Male, OS

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Courtesy of Prof. Philip Rosenfeld, Bascom Palmer Eye Institute, Miami, FL

12 2015-09-02 Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

Clinical case #2: MacTel Type 2 56y Female, OD

Fluorescein

Angiogram

00:37

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Courtesy of Prof. Philip Rosenfeld, Bascom Palmer Eye Institute, Miami, FL

13 2015-09-02 Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

Fluorescein Angiogram

00:37 AngioPlex Map

Color Depth Retina

Clinical case #2: MacTel Type 2 56y Female, OD

Comparison between Fluorescein Angiography and AngioPlex

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Courtesy of Prof. Philip Rosenfeld, Bascom Palmer Eye Institute, Miami, FL

14 2015-09-02 Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

Clinical case #2: MacTel Type 2 56y Female, OD

AngioPlex Maps

Superficial Retina Avascular Retina Deep Retina

AngioPlex maps highlight regions of

abnormal vasculature within the retina Color depth Retina

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Courtesy of Prof. Philip Rosenfeld, Bascom Palmer Eye Institute, Miami, FL

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Superficial Retina Avascular Retina Retina

Superficial Retina Avascular Retina Retina

=

=

Deep Retina

Deep Retina

OS

O

D

AngioPlex Maps

Clinical case #2: MacTel Type 2 56y Female, OU

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Courtesy of Prof. Philip Rosenfeld, Bascom Palmer Eye Institute, Miami, FL

16 2015-09-02 Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

Fluorescein Angiogram Early phase

Clinical case #3: PDR 57y Male, OS

Courtesy of Dr. Scott Lee, East Bay Retina Consultants, Oakland, CA

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17 2015-09-02 Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

Courtesy of Dr. Scott Lee, East Bay Retina Consultants, Oakland, CA

Clinical case #3: PDR 57y Male, OS

Comparison between Fluorescein Angiography and AngioPlex

Fluorescein Angiogram

00:37 AngioPlex Map

Color Depth Retina

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18 2015-09-02 Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

Superficial Retina Avascular Retina Deep Retina

Courtesy of Dr. Scott Lee, East Bay Retina Consultants, Oakland, CA

Clinical case #3: PDR 57y Male, OS

AngioPlex maps highlight regions of

abnormal vasculature (micro-aneurysm,

ischemia) within the retina

AngioPlex Maps

Color depth Retina

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19 2015-09-02 Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

Clinical case #4: DR with NVE 37y Male, OD

Fluorescein Angiogram Early phase

Courtesy of Dr. Soraya Rofagha, East Bay Retina Consultants, Oakland, CA

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20 2015-09-02 Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

Clinical case #4: DR with NVE 37y Male, OD

Comparison between Fluorescein Angiography and AngioPlex

Fluorescein Angiogram

34s AngioPlex Map overlay on OCT Fundus LSO

Full Retina

Courtesy of Dr. Soraya Rofagha, East Bay Retina Consultants, Oakland, CA

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21 2015-09-02 Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

Clinical case #4: DR with NVE 37y Male, OD

Courtesy of Dr. Soraya Rofagha, East Bay Retina Consultants, Oakland, CA

AngioPlex Maps

AngioPlex maps highlight regions of

abnormal vasculature in the vitreous

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22 2015-09-02 Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

Courtesy of Dr. Soraya Rofagha, East Bay Retina Consultants, Oakland, CA

Clinical case #5: BRVO 44y Female, OS

Fluorescein Angiogram Late phase

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23 2015-09-02 Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

Comparison between Fluorescein Angiography and AngioPlex

Fluorescein Angiogram

10 mins AngioPlex Map

Color Depth Retina

Clinical case #5: BRVO 44y Female, OS

Courtesy of Dr. Soraya Rofagha, East Bay Retina Consultants, Oakland, CA

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24 2015-09-02 Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

Superficial Retina Avascular Retina Deep Retina

Clinical case #5: BRVO 44y Female, OS

AngioPlex maps identify regions of

abnormal vasculature (micro-aneurysm,

ischemia) within the retina

AngioPlex Maps

Color depth Retina

Courtesy of Dr. Soraya Rofagha, East Bay Retina Consultants, Oakland, CA

US_31_150_0016I_REVB

25 2015-09-02 Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector

AngioPlex OCT Angiography from ZEISS

new

non-invasive

microvasculature

imaging technology

CIRRUS AngioPlex OCT Angiography allows visualization of both

perfused vasculature and vascular abnormalities of the retina without

the need of contrast. US_31_150_0016I_REVB

26 2015-09-02 Carl Zeiss Meditec, AngioPlex from Zeiss, Retina Business Sector US_31_150_0016I REVB