Youseph Yazdi, Ph.D. Corporate Director, Science and Technology
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Transcript of Youseph Yazdi, Ph.D. Corporate Director, Science and Technology
Corporate Office of Science and Technology
© Copyright Johnson & Johnson 2004
Nanotechnology Applications in Health CareWorld Environment Center Nanotech RoundtableNew York, NYMarch 11, 2005
Youseph Yazdi, Ph.D.
Corporate Director, Science and Technology
WEC Nanotech Rountable NY | March 11, 2005 | Y. Yazdi, Ph.D.2
Health Care Applications of Nanotechnology
World’s Largest Comprehensive Health Care Company…
Medical Device and Diagnostics
Consumer Products
Pharmaceutical
$8.3($0.31)
$16.9($2.2)
$22.1($3.5) AVEENO
WEC Nanotech Rountable NY | March 11, 2005 | Y. Yazdi, Ph.D.3
Health Care Applications of Nanotechnology
Corporate Office of Science & Technology: Collaboration Hub
Medical Device and Diagnostics
Consumer Products
Pharmaceutical
AVEENO
Promote CollaborationPromote Innovation
Develop New Businesses
WEC Nanotech Rountable NY | March 11, 2005 | Y. Yazdi, Ph.D.4
Health Care Applications of Nanotechnology
Nanotechnology in Nature: Our Design and Proof-of-Principle Lab
Spider silk is 100 times stronger than steel per unit weight
Bacterial flagellar motors convert energy with near 100% efficiency. Typical auto engine is ~30% efficient
trillion neurons self-assemble to form 1016 contacts, ten orders of magnitude greater contact density than on a Pentium chip
Source: Larry Bock, Nanosys, Inc.
Nature is not biased to what humans can see and manipulate -- it is optimized on all scales
WEC Nanotech Rountable NY | March 11, 2005 | Y. Yazdi, Ph.D.5
Health Care Applications of Nanotechnology
From nature to nanotech: now we are in the game…
“nano is the scale of light, the scale of life”
WEC Nanotech Rountable NY | March 11, 2005 | Y. Yazdi, Ph.D.6
Health Care Applications of Nanotechnology
Most significant development: nanotech “picks & shovels”
Nanoscale imaging, characterization, modeling, simulation, prototyping tools
“you can’t go where to can’t see…”
- Microscope --> Lister theory of microbial basis of disease --> J&J’s first products,
antiseptic bandages
- How will aM and zM detection of PSA, HIV, effect clinical disease management --> we
can’t know until we can see it!
WEC Nanotech Rountable NY | March 11, 2005 | Y. Yazdi, Ph.D.7
Health Care Applications of Nanotechnology
Biggest Hurdle: Hype (negative or positive)
1988: Drexler “Engines of Creation”
Negative: ‘grey goo’, M. Creighton, MD, HRH Prof Prince Charles, Bill Joy…
‘Positive’: Fantastic Voyage…
?!
1985: Smalley, Curl, Rice U. (go Owls!) discover shape of C-60
WEC Nanotech Rountable NY | March 11, 2005 | Y. Yazdi, Ph.D.8
Health Care Applications of Nanotechnology
Not just the lay press…Reading past the nano
“A nanomolecular approach to the nanofabrication of nanoparticles using a nanooptical nanochemical nanobioreactor”
[ref: Bogus Journal, October 2004]
WEC Nanotech Rountable NY | March 11, 2005 | Y. Yazdi, Ph.D.9
Health Care Applications of Nanotechnology
Tissue Engineering:- scaffolds to promote tissue growth- tissue engineering of bone, cartilage, skin, arteries, nerves
Nanocomposites:- improved mechanical properties for orthopedic and other implants
Coatings for Implants:- improve osteointegration, faster fixation
Diagnostics:- identifying and quantifying rare events- evaluating the impact of anti-cancer agents in treatment and clinical
trials Tissue Ablation:
- technologies for localized tumor ablation- targeting for minimal collateral damage
Current
Some Key Opportunity Spaces for Medical Device Apps of Nanotech
WEC Nanotech Rountable NY | March 11, 2005 | Y. Yazdi, Ph.D.10
Health Care Applications of Nanotechnology
Some Key Opportunity Spaces for Pharma Apps of Nanotech
Drug Delivery- nanocapsules, liposomes, targeted delivery
Tools for Drug Discovery and Drug Development- micro and nano fluidics- biomarkers & bar codes- nano-milling for solubility/stabilization
Multifunctional Therapeutics: Combining…- targeting- recognition- drug release- monitoring
Supramolecular Drug Design- self-assembly in targeted manner- synthetic peptides
WEC Nanotech Rountable NY | March 11, 2005 | Y. Yazdi, Ph.D.11
Health Care Applications of Nanotechnology
Key Opportunity Spaces in Nanotech for Consumer Products
Improved Materials- responsive to physical or chemical changes- improved moisture and thermal handling properties
Improved Adhesives- based on physical (vs chemical) properties of materials- self-cleaning, more versatile
Nanodispersives- for delivery of therapeutic agents- increased bioavailability of active ingredients
Cosmetics- improved wear-resistance- change in response to environment
Consumer Diagnostics
WEC Nanotech Rountable NY | March 11, 2005 | Y. Yazdi, Ph.D.12
Health Care Applications of Nanotechnology
ALZA- broad range of expertise and capabilities in key areas of nanotechnology- product interests: drug delivery, drug formulation
Center Biomaterials and Adv Tech (CBAT)- Implantable biomaterials- Drug-device combinations- Tissue Engineering Scaffolds- Drug Delivery technologies- Microspheres and Microdispersives
JJ Medical Microsystems- newly formed center for MEMS R&D- focus on select product development efforts
The Stealth Liposome. ALZA
Internal Johnson & Johnson Nanotech and MEMS Expertise
Cells Scaffold
Scaffold to promote tissue growth for tissue
engineering
image courtesy of MEMS Clearinghouse
WEC Nanotech Rountable NY | March 11, 2005 | Y. Yazdi, Ph.D.13
Health Care Applications of Nanotechnology
Summary: An Industry View of ‘Nanotechnology’
not a platform or a specific field of technology, rather, the natural
progression of all fields of science and technology in understanding
and manipulating matter on a smaller and smaller scale.
not just smaller -- enables development of new materials and systems
with novel properties, features
expected to have a substantial impact on almost every field of
science, industry, health care
today, most activity still in the realm of science not tech
manage like other technologies: surveillance, relationships, organic
entry, avoid hype, focus on real impact on health care
WEC Nanotech Rountable NY | March 11, 2005 | Y. Yazdi, Ph.D.14
Health Care Applications of Nanotechnology
Nanotechnology: a test of industry’s ability to manage new science
"Wherever this field leads, it is likely to
follow the well-known pathway of
incredible results leading to unrealistic
expectations followed by sobering
complications and disappointments - and
ultimately, cautious optimism."
- Drs Roger Latham and Peter Oettgen, Harvard Medical School
WEC Nanotech Rountable NY | March 11, 2005 | Y. Yazdi, Ph.D.15
Health Care Applications of Nanotechnology
a few thoughts on environmental issues…
Nanotech is not fundamentally new, rather a stage in a continuum of human
control over matter
Modern ‘Nanotech’ can reduce risk by enabling us to measure, model,
understand and control what people and nature have been doing all along, and
better assess the impact of new products
NYT, February 22, 2005 “Tiny Is Beautiful: Translating 'Nano' Into Practical”, KENNETH CHANG
WEC Nanotech Rountable NY | March 11, 2005 | Y. Yazdi, Ph.D.16
Health Care Applications of Nanotechnology
Our Credo
…We must maintain in good orderthe property we are privileged to use,
protecting the environment and natural resources…
General Robert Wood Johnson, 1943