Yizhou Jiang, Yi Wang, Zijie Su, Ling Yang, Weiwei Guo, Ji Zuo
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Transcript of Yizhou Jiang, Yi Wang, Zijie Su, Ling Yang, Weiwei Guo, Ji Zuo
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Synergistic Induction of Apoptosis in HeLa CellSynergistic Induction of Apoptosis in HeLa Cell
s by the Proteasome Inhibitor Bortezomib and s by the Proteasome Inhibitor Bortezomib and
Histone Deacetylase Inhibitor SAHAHistone Deacetylase Inhibitor SAHA
Yizhou Jiang, Yi Wang, Zijie Su, Ling Yang, Weiwei Guo, Ji Zuo Yizhou Jiang, Yi Wang, Zijie Su, Ling Yang, Weiwei Guo, Ji Zuo
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INTRODUCTIONINTRODUCTION
• Bortezomib: Proteasome inhibitor
• Suberoylanilide hydroxamic, SAHA: His
tone deacetylase inhibitor
• HeLa cells
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Combination of Bortezomib and SAHA Inhibits HeLa Cell GrowthCombination of Bortezomib and SAHA Inhibits HeLa Cell Growth
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Combination of Bortezomib and SAHA Induces HeLa Cell ApoptosisCombination of Bortezomib and SAHA Induces HeLa Cell Apoptosis
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Combination of Bortezomib and SAHA Enhances Bax/bcl-2 RatioCombination of Bortezomib and SAHA Enhances Bax/bcl-2 Ratio
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a
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Combination of Bortezomib and SAHA Inhibits NFCombination of Bortezomib and SAHA Inhibits NFB Nuclear TrB Nuclear Translocation and Downregulates Akt/p-Aktanslocation and Downregulates Akt/p-Akt
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Akt and NF-Akt and NF-B Signaling PathwaysB Signaling Pathways
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CONCLUSIONCONCLUSION
Bortezomib + SAHA
Synergistic Induction of Apoptosis In HeLa
Promising Rationale for Treating Cervical Cancer
Akt, p-Akt, NF-B↓; bax/bcl-2↑; caspase-3↑
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THANK YOU