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Yeast - why it simply has a lot to say about human disease.
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Transcript of Yeast - why it simply has a lot to say about human disease.
![Page 1: Yeast - why it simply has a lot to say about human disease.](https://reader030.fdocuments.in/reader030/viewer/2022032723/56649d0c5503460f949e0a0f/html5/thumbnails/1.jpg)
Yeast - why it simply has a lot to say about human disease
![Page 2: Yeast - why it simply has a lot to say about human disease.](https://reader030.fdocuments.in/reader030/viewer/2022032723/56649d0c5503460f949e0a0f/html5/thumbnails/2.jpg)
Genetic mutations identified in human disorders
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A richness of data allows yeast to tell a multi-dimensional story
Zhu, et al. (2012), Stitching together multiple data dimensions reveals interacting metabolomic and transcriptomic networks that modulate cell regulation. PLoS Biology
metabolites
genes
genes w/cis-eQTLs
Leu3p binding sites
![Page 4: Yeast - why it simply has a lot to say about human disease.](https://reader030.fdocuments.in/reader030/viewer/2022032723/56649d0c5503460f949e0a0f/html5/thumbnails/4.jpg)
Human connections into SGD
Homology& Disease
X
FunctionalComplementation
Phenotypes & Orthology
Literature
DrugInteractions
![Page 5: Yeast - why it simply has a lot to say about human disease.](https://reader030.fdocuments.in/reader030/viewer/2022032723/56649d0c5503460f949e0a0f/html5/thumbnails/5.jpg)
Searchable Connectionsgene name
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Searchable Connectionsyeast gene
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Searchable Connectionshuman gene
![Page 8: Yeast - why it simply has a lot to say about human disease.](https://reader030.fdocuments.in/reader030/viewer/2022032723/56649d0c5503460f949e0a0f/html5/thumbnails/8.jpg)
disorder
Searchable Connections
![Page 9: Yeast - why it simply has a lot to say about human disease.](https://reader030.fdocuments.in/reader030/viewer/2022032723/56649d0c5503460f949e0a0f/html5/thumbnails/9.jpg)
A real and present connection
![Page 10: Yeast - why it simply has a lot to say about human disease.](https://reader030.fdocuments.in/reader030/viewer/2022032723/56649d0c5503460f949e0a0f/html5/thumbnails/10.jpg)
A real and present connection
NGLY1
SGD’s Advanced Search
![Page 11: Yeast - why it simply has a lot to say about human disease.](https://reader030.fdocuments.in/reader030/viewer/2022032723/56649d0c5503460f949e0a0f/html5/thumbnails/11.jpg)
A real and present connection
yeastPNG1
phenotypes
function
pathways
literature
protein properties
genetic interactions
NGLY1
SGD’s Advanced Search
![Page 12: Yeast - why it simply has a lot to say about human disease.](https://reader030.fdocuments.in/reader030/viewer/2022032723/56649d0c5503460f949e0a0f/html5/thumbnails/12.jpg)
Connection start points
Human genes
Yeast homologs
Function known,human homologs
Yeast genes
4500 genes1340 diseases
2750genes
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SGD: Powering Connections