YahyaAlzahrany-5min-2012 - University of Waterloo · 2013. 10. 24. · ‐Synthetic polymers can be...
Transcript of YahyaAlzahrany-5min-2012 - University of Waterloo · 2013. 10. 24. · ‐Synthetic polymers can be...
-
Yahya Alzahrany, Mario GauthierIPR Symposium, Wednesday, May 2, 2012
1
IPR
2012
-
‐ Synthetic polymers can be categorized by their molecular architecturetheir molecular architecture
‐ Dendrigraft polymers belong to the dendriticl f ilpolymers family
-DONALD A TOMALIA 1 JEAN M J FRE´CHET2 2726 J POLYM SCI PART A:
2
DONALD A. TOMALIA,1 JEAN M. J. FRE CHET2, 2726 J. POLYM. SCI. PART A: POLYM. CHEM.: VOL. 40 (2002).
IPR
2012
-
• “Arborescent” refers to a tree like architecture• Arborescent refers to a tree‐like architecture• Synthesis by a generation‐based scheme with cycles of substrate functionalization and graftinggrafting
G21) Functionalization 1) Functionalization
Li
G2)
2) Grafting*
2) Grafting
*LinearG0 G1
*
3
IPR
2012
-
= side chains (1)_
OHOH
styrene
+ (1)
OH
OH
OH OH
OH
OH
OH1-deprotection by
TBAF2 deprotonation
OHOH
OHOH
OH
OH
OHOH OHOH
OHG0PS
2- deprotonationMePh2CHK
OHOH
O-K+O-K+
O-K+O-K+O-K+
G0PSG1PS-OH
O-K+O-K+
O-K+O-K+ O-K+
glycidol acetal
4O-K+
O-K+
O-K+O-K+ O
-K+O-K+ O-K+core-shell copolymerafter deprotection alcoholate functionalities
IPR
2012
-
• Synthesis of linear and arborescent polystyreneSynthesis of linear and arborescent polystyrene substrates by cycles of acetylation and grafting
S th i f h d h bi h d l f ti li d• Synthesis of hydrophobic hydroxyl‐functionalized arborescent G0‐G3 cores using a bifunctionalinitiator
• Synthesis of glycidol acetalSynthesis of glycidol acetal• Growth of poly(glycidol acetal) chains from hydroxyl‐functionalized cores to form a shell
• Deprotection of the acetal to obtain a shell ofDeprotection of the acetal to obtain a shell of hydrophilic polyglycidol segments
5
IPR
2012