XN OV Knoxville3 15 [Read-Only] - WebEdCafe.com · 1 © 2015 Sysmex America, Inc. All rights...
Transcript of XN OV Knoxville3 15 [Read-Only] - WebEdCafe.com · 1 © 2015 Sysmex America, Inc. All rights...
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© 2015 Sysmex America, Inc. All rights reserved.
XN Series Overview
Krista Curcio
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AGENDA
XN Series Product Overview
A system to fit every lab’s needs
Features and Functionality
Built for YOU!
Technology
Making your life easier
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LABS TODAY…..
Healthcare Reform
Staffing
Workload
SpaceMergers
Acquisitions
Knowledge BaseInstitution‐wide Initiatives
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LABS TODAY…..
Healthcare Reform
Staffing
Workload
SpaceMergers
Acquisitions
Knowledge BaseInstitution‐wide Initiatives
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BEYOND TECHNOLOGY BEYOND EXPECTATIONS
Quality
Dependability
Accuracy
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THE SYSMEX® XN-SERIES brings greater accuracy and efficiency throughout the entire testing chain
S Y S M E X X N - S E R I E S
X N - 1 0 0 0 ™X N - 2 0 0 0 ™
X N - 3 0 0 0 ™
X N - 9 0 0 0 ™
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XN-1000
XN-2000
XN-3000
XN-9000
N. AMERICA XN-SERIES SALES: FEBRUARY 2015
0
50
100
150
200
250
300
350
400
XN‐1000 XN‐2000 XN‐3000 XN‐9000
391
315
182
121
1690+ XN‐10 Modules!
233 RU-20 with Compact Automation salesXN-9000 includes 30 TS, 10 A1c73 DI-60 units
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BEYOND TECHNOLOGY BEYOND EXPECTATIONS
Quality
Dependability
Accuracy
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XN-SERIES
Same Analytical Module
XN-1000 XN-2000 XN-3000 XN-9000
Up to 100 /hr /module
Common Reagent System
Common QC System
Common Software System
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COMPACT AUTOMATION SOLUTIONS
XN-2000XN-1000
XN-1000 R
XN-1000 BR
XN-1000 PR
XN-3000
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SPACE-SAVING POWERHOUSE
Taking up more space or taking up less
space?
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COMPACT FOOTPRINT – VERSATILE FUNCTIONALITY
Available with ALL the parameters and functionality
Available with configurable options to meet your needs
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THE “NORM”
Primary & “Backup”:
+
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THE CO-PRIMARY SOLUTION
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Less Space - XN-2000
2 x XT: 41.8” (+11%)
2 x XN-1000: 50.8” (+34%)
2 x XE: 55.6” (+47%)
XN-2000: 37.8”
2 x LH 500: 50.2” (+25%)
2 x DxH 800: 60” (+37%)
2 x LH 750: 78” (+52%)
XN-2000: 37.8”+1 IPU
+ 2 IPU
+ 2 IPU
+ 2 IPU
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CO-PRIMARY SYSTEM
Fully Automated Workload Balancing
Automatic re-run/reflex testing
XN-2000 and XN-3000
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COMPACT AUTOMATIONXN-3000
Best in Class Performance
XN-3000: 78.7”
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AUTOMATED SLIDE MAKING
4th generation, integrated product
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SLIDEMAKER / STAINER
Improves smear TATRules to define specific slide types
Non-batch staining
Consistent smear quality
Re-cycled reagent system
Provides positive patient ID:3 slide print options available
Low sample volume requirements:Micro-sample port
Blood aspirated and slide made when indicated
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FLEXIBLE SAMPLE PRESENTATION
Single Aspiration PathwaySampler Analysis (Rack)
Manual Analysis (Open or Closed)
No mode-to-mode QC, Comparison, Documentation
Manual - back position
Open tube
Sampler(rack)Closed tube
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SCALABLE AUTOMATION SOLUTIONS
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XN-9000-402-BPR
HEMATOLOGY TESTING SCALABILITY
XN9000-301-BPR XN9000-SP-10XN9000-XN-10-BPR
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SOFTWARE…..
Easy to use or hard to use?
What’s Better?
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INTUITIVE SOFTWARE
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INTUITIVE SOFTWARE
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FLEXIBLE AND EASY TO USE
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WORK FLOW MADE SIMPLE……
Repeat Hgb if…….
Repeat WBC when……
Make a slide if you see the _____ flag…..
All samples from the ED need a smear…….
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XN-SERIES ON-BOARD RULES
Enhanced Walk-Away Capabilities
Automated Reflex or Rerun testing
No Need To Search For Tube
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XN-SERIES ON-BOARD RULES
1st Level XN Decision Rules Incorporates ISLH Consensus Rules and more
Rules pre-loaded with operator actions
Follow-up sample handling
Critical and moderate actions color coded
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QC AND MAINTENANCEWhat’s Better?
Time consuming, complicated
maintenance and QC or simple, easy maintenance and
QC?
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MAINTENANCE
CELLCLEAN Auto
Automatic shutdown/daily maintenance for the instruments
One tube per XN Module or SP‐10
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WALK AWAY MAINTENANCE
Automated maintenance / QC rack system:
Cleaning rack for shutdown
QC rack for QC
Automated QC rack
Single button conveyor power switch
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SIMPLE, EASY, ALL INCLUSIVE QUALITY CONTROL
All inclusive QC material Three levels: CBC, Diff, NRBC, IG, Retic, IPF, Ret He, PLT-F
84 day expiration dating
Consolidated QC Reporting
Single sample pathwayNo mode to mode comparison and associated documentation
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EFFICIENT QC MANAGEMENT
Fewer files to manageTri-level QC for all reportable hematology tests
2-level BFQC for all reportable parameters
Multi-module overlay
Automated IQAP systemAutomatic transmission of data after analysis
Prompt access to peer data via internet
Documentation of out-of-range pointsWithin IQAP system
On-board XN software
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© 2015 Sysmex America, Inc. All rights reserved.© 2015 Sysmex America, Inc. All rights reserved.
SMART REAGENT MANAGEMENT SYSTEM
Color coded Reagents
Easy to identify and change
Clean, neat, easy storage
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SMART REAGENT MANAGEMENT SYSTEM
RU-20 Reagent Management System
25x concentrate
Reduces reagent changes and instrument idle time
Increases free space in the lab.
CELLPACK DCL compared with RU-20 and CELLPACK DST
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WHY IT MATTERS……
Elephants are the largest living terrestrial animals
Female African elephants can reach a weight of 7,900 lbs.
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WHY IT MATTERS……
1 cube of diluent weighs~50lbs
At 300 samples/day you move about 156 cubes/year
RU-20 = 1 cube/50 days
~7.2 cubes/year
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XN SYSTEM SUMMARY SLIDE
Easy to use
Designed with the operator’s needs in mind
Improved workflow
Automation for every lab
Minimal maintenance
Easy QC with more information at your fingertips
Improved reagent management
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RELIABLE SYSTEMS
Building On Core Strength
Minimal User MaintenanceMeasured in seconds – not minutes
Increased System AvailabilityXN-10 & XN-20 Design Intent:
2 x MTBF of XE-5000 (>~ 150 days)
SP-10 Design Intent:1.5 x MTBF of SP-1000i
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RELIABLE SYSTEMS
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XN TECHNOLOGY
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greater accuracy, specificity, productivity
NEXT GENERATION
DIAGNOSTICSsuperior insight and control, enhancing speed to treatment
ADVANCED TOOLS & TECHNOLOGIES
automatically balances work-flow and routine tasks
PROCESS OPTIMIZATION
driving improvement,supporting your staff,
helping you plan for the future
HARMONIZED SUPPORT
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SINGLE MODULE – FULLY LOADED
Every XN Configuration can include:
All the parameters
All the features
All the capabilities
N E X T G E N E R AT I O N D I A G N O S T I C S
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THE MOST ADVANCED HEMATOLOGY DIAGNOSTICS ON THE MARKET
N E X T G E N E R AT I O N D I A G N O S T I C S
Fluorescent Platelet
Rerun/Reflex Testing
Body Fluid Differentials
Advanced Clinical
Parameters
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SYSMEX XE VS. XN TECHNOLOGY
RBC, PLT, Hgb
WBC / BASO
NRBC DIFFRET / PLT‐O
RBC, PLT, Hgb
WNR WDF RET PLT‐F
NEW NEW NEW
N E X T G E N E R AT I O N D I A G N O S T I C S
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SYSMEX FOUNDATIONAL TECHNOLOGY
RBC & PlateletDC Detection / Hydrodynamic Focusing
HemoglobinAbsorbance / Sulfolyser
N E X T G E N E R AT I O N D I A G N O S T I C S
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FLUORESCENT FLOW CYTOMETRY
WNR channel WDF channel PLT-F channel RET channel
N E X T G E N E R AT I O N D I A G N O S T I C S
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WNR CHANNEL
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WNR CHANNEL
Reagent Reaction
BASO LYMPH MONO Granulocyte
NRBC RBC
N E X T G E N E R AT I O N D I A G N O S T I C S
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WNR CHANNEL Scattergram - Normal Pattern
NRBC
WBC
BASO
Debris SFL
FS
C
N E X T G E N E R AT I O N D I A G N O S T I C S
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FS
C
SFLSFL
ADVANTAGE OF FLUOROCELL WNR
N E X T G E N E R AT I O N D I A G N O S T I C S
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NRBC CORRELATION DATA
Correlation Coefficient (R) = 0.9179 N = 171
Correlation Coefficient (R) = 0.9219 N = 171
Data from the University of Iowa / Dec 2011
N E X T G E N E R AT I O N D I A G N O S T I C S
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WNR / NRBC ABSTRACT
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WNR CHANNEL
Fluorescent Flow Cytometry Technology
Maximized Efficiency
NRBC the first time – all the timeNo additional steps
Accurate WBC Counts in the presence of NRBCs
No additional reagent needed
Virtually eliminates interference from:Lyse resistant RBCs
Lipids
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WDF CHANNEL
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WDF CHANNELReagent Reaction
LYMPH MONO NEUT EO
Atypical LYMPH Immature WBC
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WDF CHANNELScattergram - Normal Pattern
LYMPH NEUT+BASO
EO
MONO
Debris
IG
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IG – XN DIFF ABSTRACT
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ENHANCED FLAGGING ALGORITHMS
(Sysmex Adaptive Flagging Algorithm based
on Shape-recognition)
LDA (Linear Discriminant Analysis)
Detects abnormal cells - (with high sensitivity)
SAFLAS method
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Normal Abnormal (Blasts?) Abnormal (Abn Lympho?)
WDF SAFLAS METHOD
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WDF CHANNEL
Enhanced Flagging
Better separation between lymphs and monos(SAFLAS)
Better identification of platelet clumps (multiple channel detection)
Auto-correction of lymphs when NRBCs are present
6-part differential (including IG)
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LOW WBC ANALYSIS MODE
WB (Whole Blood) mode LW (Low WBC) mode
Dilution Rate :Analysis Volume :Whole Counts *2 :
Dilution Rate :Analysis Volume :Whole Counts *2 :
x 61.158.2µL9,530
x 61.1174.6µL28,600
Analysis Time extended to 3 times the Whole Blood WBC count time
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LOW WBC ANALYSIS MODE
Analysis time extended to 3 times WB WBC count time
Better accuracy and precision on counts < 0.50 x 103
No Vote Outs – Differential results on all counts
Increased reportable differentials
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PLT-F CHANNEL
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PLT-F CHANNEL
Reagent Reaction
RBC PLT IPF
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PLT-F CHANNEL
Impedance platelet analysis (size) has limitations in the identification and discrimination of platelets from interfering particles with the same size.
Possible interferences
RBC fragments counted as platelets: falsely high
Microcytic RBCs counted as platelets: falsely high
Large platelets counted as RBC: falsely low
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PLT-F SEPARATES PLATELETS FROM RBC FRAGMENT BY THE DIFFERENCES IN STAINING
• CD41/CD61 positive = Platelets
• Staining by PLT-F dedicated reagent
– Platelets - Strong, especially within the cell
– RBC fragments - Weak, only cell membrane
RBC Fragment
Platelet
Transmitted light
CD61/PLT-F
Transmitted light
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PLT-F CHANNEL
Reportable Parameters
PLT-FIPF
.
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PLT-F CHANNEL
Second method of platelet
Fluorescent Dye specific for platelet organelle
Extended count time (6 times) for accurate platelet enumeration, especially in low platelet counts
Good comparison with CD41/CD61
Minimizes interference from RBC fragments, microcytic RBC’s and WBC fragments
Automated Action message and reflex with on board rules
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RETICULOCYTE CHANNEL
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RET CHANNEL
Reagent Reaction
RET RBCWBC PLT
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RET CHANNEL
Scattergram on Normal Pattern
PLT
RET
HFRRBC
MFRLFR
IRF
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RETICULOCYTE PARAMETERS
Reticulocytes # and % of immature RBC’s
Immature Reticulocyte FractionNewly released from the marrow, a direct cellular measurement of erythropoiesis
Reticulocyte HemoglobinDirect cellular measure of iron availability
© 2015 Sysmex America, Inc. All rights reserved.© 2015 Sysmex America, Inc. All rights reserved.
RETICULOCYTE CHANNEL
Operational EfficiencyReduced Interference From:
WBCs
Howell Jolley Bodies
Parasites
Sickle cells
Quick and automatic
Monitor RBC development at the cellular level IRF for Retic production
RET-He for iron incorporation in hemoglobin of the erythron
Clinically relevant information for the management of anemia in conjunction with other available clinical information.
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BODY FLUID ANALYSIS
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BODY FLUID ANALYSIS
Cerebrospinal fluid (CSF)
Body fluid mode (target species)
Pleural fluid
Peritoneal fluid
Synovial fluid
HF-BF
MN
PMN
MO-BF
LY-BF
EO-BFNE-BF
WDF Scattergram
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BODY FLUID ANALYSIS
No pre-analysis preparation
No additional reagents
Automated background counts
Rapid analysis
© 2015 Sysmex America, Inc. All rights reserved.© 2015 Sysmex America, Inc. All rights reserved.
XN TECHNOLOGY SUMMARY
WNR ChannelMaximized efficiency
NRBC the first time – all the time
Accurate WBC Counts in the presence of NRBCs
WDF, Low WBCEnhanced Flagging
6-part differential (including IG)
Improved Sensitivity and Specificity
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© 2015 Sysmex America, Inc. All rights reserved.© 2015 Sysmex America, Inc. All rights reserved.
XN TECHNOLOGY SUMMARY
Low WBCBetter accuracy and precision on counts < 0.50 x 103
No Vote Outs – Differential results on all counts
Increased Reportable differentials
PLT-FFluorescent Dye specific for platelet organelle
Extended count time (6 times) for accurate low platelet enumeration
Good comparison with CD41/CD61
Automated Action message and reflex with on board rules
© 2015 Sysmex America, Inc. All rights reserved.© 2015 Sysmex America, Inc. All rights reserved.
XN Technology
Hematology Technology of the Future Today
N E X T G E N E R AT I O N D I A G N O S T I C S