www.alamancecc.edu Graham, North Carolina

History of Biotechnology in North CarolinaSignificant Events

1958 – established the Research Triangle ParkUNC, NCSU and Duke University

1984 – NC Biotechnology CenterQuasi-governmental agency to integrate industry, academia and financial interests

1985 – Alamance Community College (aka, TCA)2 year program in Biotechnology Workforce training

2005 – Ernst and Young reportNorth Carolina 3rd in nation in Biotechnology

Due to Biomanufacturing industry

Alamance Community College• Originally (1985), R&D focus w/ general

lab skills, few “biotech” specific• Cell Culture• Chromatography• Immune reactions etc

• 1993 = added first bioreactors• Meet growing industry needs• 1L bench top units for bacterial growth• Tangential Flow Filtration

Alamance Community College

• 2005 = 15L CIP/SIP bioreactor• Dissolved Oxygen• Bacterial and mammalian cell growth• Steam generator• Computer controls• Basic engineering with valves and

gauges

Alamance Community College

• 2006 = FPLC• Fast Protein Liquid Chromatography• Large volume protein purification

• To accommodate larger bioreactor• SEC, IEC, HIC, AC

Alamance Community College

• 2007 • 4 new A+ 1 – 7 liter bioreactors

• Mammalian & bacterial cell capable• Fully computerized