WP5: Database interface for risk-benefit assessment
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Transcript of WP5: Database interface for risk-benefit assessment
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WP5: Database interface for risk-benefit assessment
Antonella Guzzon, Luca Bucchini (Hylobates).
Jouni Tuomisto (THL).
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Overview
• Background• Objectives of the work• Compound intake estimator• Developmental needs• Conclusions
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Background
• Need for safe use of plant food supplements.• Science-based understanding and decision-
making is the key.– Regulators– Food chain operators– Customers.
• Quality-assured tools and data banks are needed.
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Objectives
• To develop an Internet-based interface where users can access, combine, by plant and compound, and discuss information for risk-benefit assessment.
• To make selected case-studies available to the public through Opasnet web workspace.
• To develop guidance for conducting risk-benefit assessments of plants, extracts, preparations and individual products online.
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The product: Compound intake estimator
• An online tool for estimating concentrations and intakes of various compounds in a PFS product.
• http://en.opasnet.org/w/Compound_intake_estimator
• Some data comes from ePlantLIBRA database.• The user may add own data for own
calculations.
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Products covered
• Currently, the compound intake estimator contains information about these PFSs:– Cinnamon dried bark essential oil– Bitter fennel essential oil– Fennel fruit– Green tea leaf– Ginkgo leaf– St John’s wort
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User interface
• Fill in form.• Click and run
model.• See code if
interested.• Default values
produce a plausible outcome.
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Intake calculations
• These equations are used to calculate intakes and level of concern:– intakecomp (mg /kg /d) = intake (g /d) * conccomp (mg
/g) / 60 (kg)– concern indicatorcomp,i = intakecomp (mg /kg /d) /
guidance valuecomp,i (mg /kg /d) * safety factori
• comp = index for compounds• i = index for indicators
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Interface for compound concentrations
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Results: compounds in cinnamon
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Results: intake concerns
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Existing data in the tool: guidance values
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Guidance values used• In the order of preference:– ADI (acceptable daily intake)– TDI (tolerable daily intake)– BMDL10 (lower confidence interval for benchmark
dose 10• This is often used to calculate MOE = margin of
exposure
– TTC (threshold for toxicological concern) • Based on Cramer classes
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Existing data in the tool: product data
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Model specifications• Probabilistic model using R statistical software.• The model is on and can be run from a web page in
Opasnet. (MediaWiki)• Data comes from a database that has an interface on
Opasnet page. (MongoDB)• The model code can be copied and run on own
computer. (requires R package OpasnetUtils from CRAN)
• Discussions about the results are possible on the same webpage.
• Opasnet will be maintained by THL, where it is being actively used by several projects.
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Development needs
• Guidance value data for new compounds would make the tool more versatile.
• Concentration data exists so far only for PlantLIBRA case products.– However, EFSA has collected data of hundreds of food
supplements from 8 countries. This is a potentially useful data source.
• Currently the concentration data is not publicly available. Opening the data would increase the usability of the tool.
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Conclusions
• Compound intake estimator is a usable tool for increasing understanding of risks and benefits of food supplements.
• It offers a platform for shared learning and online discussions.
• However, currently its usability is limited by a fairly small amount of concentration data openly available.
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Additional information
• http://en.opasnet.org/w/Compound_intake_estimator • http://en.opasnet.org/w/File:Compound_intake_estimator.ppt• http://en.opasnet.org/w/Plantlibra_deliverable_DWP5-6