Wound Healing Drugs From Medicinal Plants
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WOUND HEALING DRUGS FORM MEDICINAL PLANTS Dr. S. GOPALA KRISHNAN. Senior Professor of Chemistry & Controller of Examinations, Noorul Islam University, Kumaracoil – 629 180 K.K.District, Tamil Nadu. Email:[email protected] ABSTRACT Wound care can be traced back to early civilizations and many of these treatments were based on the use of herbal remedies. Approximately one third of all the traditional medicine in use is for the treatment of wounds and skin disorders, compared to only 1-3% of modern drugs. Medicinal plants have been used since time immemorial for the treatment of various ailments of skin and dermatological disorders especially cuts, wounds and burns. Healing of wounds is an important area of clinical medicine explained in most of the Ayurvedic texts under the heading, “Vranaropaka’. Current estimates indicate that nearly 6 million people suffer from chronic wounds world wide. There are only very few Indian studies on the epidemiology of chronic wounds. The prevalence of chronic wounds in the Community was reported as 4.5 per 1000 population where as that of acute wounds was nearly doubled at 10.5 per 1000 population. A wide range of antibiotics is being used at present for treating wound infections. But they are now proved to have adverse side effects such as liver damage, liver failure and miner side effects such as head ache, stomach upset, diarrhea, itches and rashes in human body. Also these pathogens developed resistance to the antibiotics targeted against them. Side effects associated with allopathic drugs and synthetic compounds, has prompted
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Transcript of Wound Healing Drugs From Medicinal Plants
WOUND HEALING DRUGS FORM MEDICINAL PLANTS
Dr. S. GOPALA KRISHNAN.Senior Professor of Chemistry & Controller of Examinations,
Noorul Islam University,Kumaracoil – 629 180
K.K.District, Tamil Nadu.Email:[email protected]
ABSTRACT
Wound care can be traced back to early civilizations and many of these treatments were based on the use of herbal remedies. Approximately one third of all the traditional medicine in use is for the treatment of wounds and skin disorders, compared to only 1-3% of modern drugs. Medicinal plants have been used since time immemorial for the treatment of various ailments of skin and dermatological disorders especially cuts, wounds and burns. Healing of wounds is an important area of clinical medicine explained in most of the Ayurvedic texts under the heading, “Vranaropaka’.
Current estimates indicate that nearly 6 million people suffer from chronic wounds world wide. There are only very few Indian studies on the epidemiology of chronic wounds. The prevalence of chronic wounds in the Community was reported as 4.5 per 1000 population where as that of acute wounds was nearly doubled at 10.5 per 1000 population.
A wide range of antibiotics is being used at present for treating wound infections. But they are now proved to have adverse side effects such as liver damage, liver failure and miner side effects such as head ache, stomach upset, diarrhea, itches and rashes in human body. Also these pathogens developed resistance to the antibiotics targeted against them. Side effects associated with allopathic drugs and synthetic compounds, has prompted research into herbal and natural products for wound healing. A large number of plants, plants extracts, decoctions and pastes are equally used by Tribal and Folklore traditions in India for treatment of cuts, wounds and burns.
In the present investigation, the in viva wound healing activity studies of the ethanolic extracts of four medicinal plants, Viz; Bauhinia tomentosa L. (Bark) Mussaenda frondosa L.(Whole plant) Acalypha fruticosa Forsk. (Aerial Parts) and Dipteracanthus patulus (Jacq) Nees.(Leaves) have been performed using different experimental animal models such as excision, incision and dead space models. Histopathological studies of the granulama tissue have also been performed. The results indicate that all the four medicinal plants have very good wound healing activity. These plants satisfy the criteria of the wound healing agents by increasing the rate of contraction of wound, weight of granulation tissue, tensile strength of granulation tissue and formation of collagen. The findings will be discussed in detail.
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