World’s Oldest Person

• Super centenarian Jeanne Louis Calment has been documented as the World’s Oldest Person

– Lived until age 122

– From Arles, France

• Her secrets to longevity included red wine, a diet rich in olive oil and 2lbs of chocolate per week

– Doctors advised Madame Calment to give up sweets at the age of 119

ResVitále’s Original Story

• The French Paradox

– The French suffer less incidences of heart disease, despite a diet high in saturated fats

– Over a glass of red wine in France, Naomi Whittel and her cousin, Eric Lafforgue, a leading French M.D., began to discuss timeless observations about the French secrets to longevity, ageless beauty and positive sense of well being and happiness

Positive Elements of the French Lifestyle

• Eating whole-food meals

– Unprocessed, all-natural foods

• Ingesting the whole fruit, including the skins

• Seasonal and freshly harvested

• Drinking red wine

– Created with the whole grape and whole polyphenol, full-spectrum blend

• 70% Environment & Lifestyle

• Inflammation• Oxidative stress• Cancer• Heart Disease

• 30% Genes

70/30 Principle

• 70% Environment & Lifestyle

• Anti-Inflammatory• Anti-oxidant• Anti-Mutation• Longevity

• 30% Genes

70/30 Principle

What is a Polyphenol?

• Naturally occurring substance in plants with multiple health benefits including antioxidant properties that protect against common health problems and effects of aging

• Polyphenols are found in a wide array of nutritious foods and drinks:– Red wine– Chocolate– Legumes– Fruits/Vegetables– Green tea– Olive oil– Grains

• Resveratrol is a polyphenol that stands out among the rest

What is Resveratrol?• An active polyphenol found in

the skins, seeds and stems of grapes and other dark fruits, in addition to Japanese Knotweed which has been shown in studies to be a key element in red wine that increases cellular productivity and longevity, leading to a longer and healthier life

– trans : The only bioactive, gene-activating form of Resveratrol

– Cis : non-bioactive form of Resveratrol

– The only supplement shown to mimic caloric restriction

trans-Resveratrol for Gene Activation

• SIRT 1 Pathway Stimulation• SIRT 1 = “longevity gene”• 20 mg trans-Resveratrol

for 2 weeks for gene activation

• Must be trans-Resveratrol• Repairs cells/DNA• Helps fight age related

illness• Youthful cellular response

to help you look and feel younger

Koo SH, Montminy M, In Vino Veritas: A Tale of Two Sirt1s?. Cell 127, December 15, 2006

Anti Aging Breakthrough

• Resveratrol: Health and Beauty-Global SuperStar

• Need for bio-active trans-Resveratrol: Harvard Sinclair study

• The only molecule known to mimic Caloric Restriction

• Importance of correct ratio for maximum benefit: University of Bordeaux

• Over 3000 Clinical Studies

Commitment to Research• ResVitále’s high-quality Resveratrol was selected for leading

clinical studies

• University of Florida

– A randomized control study sponsored by the Department of Aging and Geriatric Research

– 3 month study using 300 mg and 1,000 mg of Resveratrol

– Male and female subjects ages 65 to 100 years

– Tested for improved memory, physical performance and quality of life

– Complete report in 2011

• University of Miami

– A dose/response trial funded by the National Institute of Health

– 14 day study increasing dosage from 50 mg to 1000 mg of Resveratrol

– Evaluate the response and health effects of increasing doses of Resveratrol in stroke patients

– Study will initiate within the next 6 months with preliminary data available in 2011

Benefits of ResVitále Resveratrol

• ResVitále Full Spectrum Resveratrol = Powerful Whole-Body Benefits

• Quantity of Life– Anti-aging (↑ longevity)

• Quality of Life– Skin health – Tone and appearance– Whole-body Anti-Inflammatory– Long-term sustainable energy– Weight loss benefits– Heart health– Brain health– Joint/bone health– Immune health

Exclusive Science Based Formulas

• High potency trans-Resveratrol – Every product has enough trans-Resveratrol for

gene activation from wild crafted Japanese Knotweed plus organic whole-food polyphenols from the whole grape.

• ResVine™ Proprietary Blend

– Polyphenols from organic whole grape (skins, seeds, stems, vines)

• Quercetin (polyphenol in red wine)

– Works synergistically with Resveratrol

– Promotes optimal absorption and maximized health benefits when combined with Resveratrol

– Natural anti-inflammatory with many health benefits

The Importance of Organic

• Organically grown grapes produce higher levels of full spectrum polyphenols

• Grapes produce Resveratrol as a defensive reaction to fungi. Spraying a plant with pesticides kills the fungi and eliminates the need for the grape to produce Resveratrol

• ResVitále only uses 100% pure organic grapes in our Resveratrol products

Vine-to-Capsule TechnologyTM

• Patent-pending, proprietary process

• Testing at vine for significant polyphenol levels

• Raw material collected and transported to extraction facility in a temperature- controlled, dark environment

• Raw material tested for full-spectrum potency and purity

• Raw material processed in nitrogen-rich, oxygen-free environment

The ResVitále Difference

ResVitále is exclusive to GNC and can only be purchased at GNC stores or GNC.com

Traceability - Exclusively sourced ingredients you can trust from seventh generation, award -winning, organic and biodynamic French vineyards

Science based formulas featuring the perfect balance of polyphenols from Muscadine and French Red grapes which means they work faster and more effectively than any other Resveratrol product

Global Market Leader - The largest exporter of Resveratrol, sourced from French vineyards. ResVitále has more than 38% of the market share of Resveratrol.

Offer organic ingredients at a non-organic price

Guaranteed purity and freshness by incorporating our proprietary, patent-pending, Vine-to-CapsuleTM technology

Products chosen for two major University human clinical studies

Award Winning Company: American Business Awards, Vitamin Retailer, Better Nutrition

2010 & 2009 American Business Awards

• ResVitále was a 2010 finalist:

• Best Overall Company of the Year

• Most Innovative Company of the Year

• Fastest-Growing Company of the Year

• Founder and CEO, Naomi Whittel, was named a finalist for both the Best Entrepreneur and Best Executive awards

• 2009 Finalist for the “Best New Company of the Year” Award

ConsumerLab Approved

• ConsumerLab is the leading provider of independent test results and information to help consumers and healthcare professionals identify high-quality health and nutrition products

• Products are tested for identity, strength (quantity), purity and disintegration

• Resveratrol 250 mg contained the amount of Resveratrol claimed on the label and did not exceed contamination limits for cadmium and lead

• Based on the ingredients and the price comparison per 100 mg as presented by ConsumerLab, our Resveratrol 250mg is shown to offer the best value

• Among ten products selected by ConsumerLab for testing, eight contained their claimed amounts of Resveratrol

The ResVitále Customer• Men and women

– Both men and women benefit equally from the products

• 20’s and beyond - Longevity Gene shuts off age 18-20

• Customers seeking to:

– Recapture beautiful, youthful skin

– Feel energized and mentally focused

– Improve heart health

– Maximize workouts and improve endurance

– Burn more calories and lose weight

– Build foundational health

– Protect cells from free radical damage

– Have a high level of resistance to disease and illness

Resveratrol 250 mg• Activate and

maintain youthful DNA in your 30s and 40s

• Recommended dosage on 60 Minutes and in Harvard Studies

• Antioxidant power of 1,000 glasses of red wine

• Clinically proven to trigger the SIRT1 'longevity gene’

Resveratrol 500 mg• Activate and

maintain youthful DNA in your 40s and beyond

• Clinically proven to trigger the SIRT1 'longevity gene’

• Antioxidant power of 2,000 glasses of red wine

• Most potent Resveratrol formula

Premium ProtectionBuilding the Upsell

FAQsQ: Are there any side effects?A: There are no known side effects of Resveratrol – up to 5 grams has been studied without issue.

From customer feedback, very small percentage had an upset stomach if beginning with too large of a dosage.

Q: Can I take this product with other medications?A: Individuals taking prescription blood thinners should be wary of taking resveratrol, as it

increase blood flow and circulation, therefore potentially increasing the effects of blood thinners. Children and pregnant and nursing women should also avoid Resveratrol due to lack of study in this regard

Q: Why can’t I just drink red wine?A: It takes 20 mg of Resveratrol at a time to activate the longevity gene, and only approximately 3

mg in the average bottle of wine. In one capsule of our 250mg, the customer received the benefits of 1,000 glasses of red wine.

Q: How quickly will I feel results?A: The customer may begin to feel results within 1-2 weeks of consistent product use.

Q: What will I feel?A: With any of ResVitále’s pure Resveratrol formulas, the first change will be an increase in

natural energy and endurance. Some individuals have reported a reduction in aging spots as well as healthier levels of blood pressure and cholesterol. Those taking the collagen should notice an improvement in skin glow and appearance in as little as 1-2 weeks as well.

ReferencesJim Kleinedler, Cytotoxicity and efficacy evaluation of polymeric nanoparticles containing resveratrol and quercetin for use on drug eluting stents, FASEB J. 2009 23:640.2

Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-does study in healthy volunteers, Luis Almeida, Manuael Vaz-da-Silva, Amilcar Falcao, Eva Soares, 2009 , 53 S7-S15 DO110.1002/mnfr. 200800177

Abejibdam T,S,. Resveratrol-a boon for treating Alzheimer’s disease? Brain Res. Rev 2006m 52, 316-326

Kumar, A., Kaundal, R.K., Iyer, S., Sharma, S. S., Effects of resveratrol on nerve functions, oxidative stress and DNA fragmentation in experimental diabetic neuropathy, Life Sci 2007, 80, 1236-1244

Wine molecule slows aging process:Scientists drink to that. URL: ttp://www.news.harvard.edu/gazette/2003/09.18/12-antiaging.html [27 Dec 2004]

Stivala L et al. Specific Structural Determinants Are Responsible for the Antioxidant Activity and the Cell Cycle Effects of Resveratrol. J of Biological Chemistry 2001 276(25):22586-22594

An Antiinflammatory and Reactive Oxygen Species Suppressive Effects of an Extract of Polygonum Cuspidatum Containing Resveratrol Ajay Chaudhuri and Paresh Dandona, Husam Ghanim, Chang Ling Sia, Sanaa Abuaysheh, Kelly Korzeniewski, Priyanka Patnaik, Anuritha Marumganti,

J. Clin. Endocrinol. Metab. 2010 95:E1-E8 originally published online Jun 9, 2010; , doi: 10.1210/jc.2010-0482

Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation1–3 David O Kennedy, Emma LWightman, ½AQ1 Jonathon L Reay, Georg Leitz, Edward J Okello, Anthea Wilde, and Crystal F Haskell

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